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Preterm AND Stress

Vanessa Arizo-Luque, Ana M García, Marisa Estarlich, Ferran Ballester, Guillermo Fernández-Tardón, Adonina Tardón, Mónica Guxens, Martine Vrijheid, Aitana Lertxundi, Loreto Santa-Marina, Elena Ronda-Pérez
OBJECTIVE: Published studies are not conclusive on the impact of certain occupational exposures in pregnancy, stressing the need to consider the double role, professional and family, of women. The objective of this study is to evaluate the effect of employment and domestic load on the duration of pregnancy and fetal development. METHODS: Using Univariate and Multivariate regression models, we studied the association of preterm deliveries (PPT) (<37 weeks), full term newborns with low weight (BPT) (<2500g) and small for their gestational age (PEG) (<10th percentile) in weight, length and head circumference according to work situation (employment/non-employment) and domestic load (low/ medium/ high) in 2506 women...
August 17, 2018: Revista Española de Salud Pública
Junyi Wang, Wenbin Dong
With the progress of modern medicine, oxygen therapy has become a crucial measure for the treatment of premature infants. As an environmental stimulus, in the normal development of lungs, oxygen plays a very important regulatory role. However, the problem is that long-term exposure to hyperoxia can interfere with the development of lungs, leading to irreversible developmental abnormalities. Now, the incidence of bronchopulmonary dysplasia (BPD) is increasing year by year. The existing related research shows that although BPD is a multi-factor triggered disease, its main risk factors are the premature exposure to hyperoxia and the role of reactive oxygen species (ROS)...
August 8, 2018: Gene
Ling-Ju Chuang, Shih-Hao Wang, Mi-Chia Ma, Chia-Ni Lin, Chih-Ling Chen, Mei-Chih Huang
AIMS AND OBJECTIVES: To determine the comparative efficacy of developmental care versus standard care for reducing pain and stress in preterm infants during examinations for retinopathy of prematurity (ROP). BACKGROUND: ROP examinations are routinely performed in neonatal intensive care units to detect these lesions. Pain scores recorded during and after eye examinations have revealed physiological and behavioral manifestations of pain and stress. DESIGN: A randomized crossover trial was conducted...
August 9, 2018: Journal of Clinical Nursing
Alan Hall Jobe
Antenatal corticosteroids (ACS) are standard of care for women at risk of preterm delivery between 24 -34 weeks gestation. Their use decreases preterm morbidities and mortality. However, ACS treatments mimic a stress response by increasing fetal steroid levels at early gestational ages when the fetus is normally protected from high glucocorticoid levels. Within the context of concept of the developmental origins of adult health and disease, ACS are effective stressors in fetal animal models that alter developmental programs and outcome in adult animals...
August 8, 2018: Canadian Journal of Physiology and Pharmacology
Emily S Barrett, Wendy Vitek, Omar Mbowe, Sally W Thurston, Richard S Legro, Ruben Alvero, Valerie Baker, G Wright Bates, Peter Casson, Christos Coutifaris, Esther Eisenberg, Karl Hansen, Stephen Krawetz, Randal Robinson, Mitchell Rosen, Rebecca Usadi, Heping Zhang, Nanette Santoro, Michael Diamond
STUDY QUESTION: Among infertile women undergoing ovarian stimulation, is allostatic load (AL), a measure of chronic physiological stress, associated with subsequent fertility and pregnancy outcomes? SUMMARY ANSWER: AL at baseline was not associated with conception, spontaneous abortion or live birth, however, it was significantly associated with increased odds of pre-eclampsia and preterm birth among women who had a live birth in the study. WHAT IS KNOWN ALREADY: Several studies have linked AL during pregnancy to adverse outcomes including preterm birth and pre-eclampsia, hypothesizing that it may contribute to well-documented disparities in pregnancy and birth outcomes...
August 1, 2018: Human Reproduction
Ola Olén, Olof Stephansson, Ann-Sofie Backman, Hans Törnblom, Magnus Simrén, Maria Altman
BACKGROUND: The etiology of irritable bowel syndrome (IBS) is poorly understood. Animal and human data suggest that early life stress may induce long-term changes in the nociceptive circuitry, but conclusive studies are lacking. METHODS: We identified all Swedish children born between 1973 and 1992 in the Swedish Medical Birth Register. We had access to all diagnostic codes for specialized (nonprimary care) outpatient visits 2001-2009 (the National Patient Register) and identified individuals who were diagnosed with IBS (ICD-10 code: K58) after 18 years of age...
August 7, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Amrit Kumar Shrestha, Renuka T Menon, Binoy Shivanna
Hyperoxia-induced oxidative stress contributes to the pathogenesis of bronchopulmonary dysplasia (BPD), the most common respiratory morbidity of preterm infants. Importantly, the disease lack specific therapies and is associated with long-term cardio-pulmonary and neurodevelopmental morbidities, signifying the need to discover novel therapies and decrease the disease burden. We and others have demonstrated that leflunomide, a food and drug administration approved drug to treat humans with rheumatoid arthritis, increases the expression of the anti-oxidant enzymes, NAD(P)H quinone dehydrogenase 1 (NQO1), catalase, and superoxide dismutase (SOD)...
August 1, 2018: Biochemical and Biophysical Research Communications
Arianna Aceti, Isadora Beghetti, Silvia Martini, Giacomo Faldella, Luigi Corvaglia
This review will examine the role of oxidative stress (OS) in the pathogenesis of necrotizing enterocolitis (NEC) and explore potential preventive and therapeutic antioxidant strategies. Preterm infants are particularly exposed to OS as a result of several perinatal stimuli and constitutive defective antioxidant defenses. For this reason, OS damage represents a contributing factor to several complications of prematurity, including necrotizing enterocolitis (NEC). Being NEC a multifactorial disease, OS may act as downstream component of the pathogenetic cascade...
2018: Oxidative Medicine and Cellular Longevity
Yuko Arita, Matthew Pressman, Darios Getahun, Ramkumar Menon, Morgan R Peltier
OBJECTIVE: Polybrominated diphenyl ethers (PBDEs) enhance basal and bacteria-stimulated production of proinflammatory cytokines by the placenta and may also increase the risk of preterm birth and neurodevelopmental disorders. Whether or not other brominated flame retardants such as Tetrabromobisphenol A (TBBPA) have similar properties is unclear. Therefore, we evaluated the effects of TBBPA on the production of steroids, as well as biomarkers for inflammation, oxidative stress, and neurodevelopment by the placenta...
August 2018: Placenta
Silvana Andréa Molina Lima, Regina Paolucci El Dib, Meline Rossetto Kron Rodrigues, Guilherme Augusto Rago Ferraz, Ana Claudia Molina, Carlos Alberto Pilan Neto, Marcelo Aparecido Ferraz de Lima, Marilza Vieira Cunha Rudge
Antenatal stress is linked to fetal risks that increase the chances of neonatal complications and reduction of child cognitive ability. Therefore, we aimed to evaluate if maternal stress affects fetal, neonatal or child development. The following databases were searched: MEDLINE (1966 to May 2016), Embase (1980 to May 2016), LILACS (1982 to May 2016) and CENTRAL (1972 to May 2016). Observational studies published in English and Portuguese were included whether there was any relationship between fetal and neonatal outcome, such as birth weight, preterm labor, child development with pregnant women that were subjected to any stress type during at least one month of follow-up...
2018: PloS One
Yang Liu, Wen-Bin Dong
With the increase in the rescue success rate of critically ill preterm infants and extremely preterm infants, the incidence rate of bronchopulmonary dysplasia (BPD) is increasing year by year. BPD has a high mortality rate and high possibility of sequelae, which greatly affects the quality of life of preterm infants and brings a heavy burden to their families, and so the treatment of BPD is of vital importance. At present, no consensus has been reached on the treatment measures for BPD. However, recent studies have shown that early application of caffeine can prevent BPD...
July 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Moira Szilagyi
No abstract text is available yet for this article.
August 2018: Pediatrics
Can Liu, Bo Vinnerljung, Viveca Östberg, Karl Gauffin, Sol Juarez, Sven Cnattingius, Anders Hjern
OBJECTIVES: Adverse early-life experience may affect preterm delivery later in life through priming of stress response. We aim to investigate the links between out-of-home care (OHC) experience in childhood, as a proxy of severe adversities, on subsequent risk of preterm delivery. METHODS: A register-based national cohort of all women born in Sweden between 1973 and 1977 ( N = 175 821) was crosslinked with information on these women's subsequent deliveries as recorded in the Swedish medical birth register...
August 2018: Pediatrics
C Pisoni, S Spairani, F Fauci, G Ariaudo, C Tzialla, C Tinelli, P Politi, U Balottin, M Stronati, S Orcesi
BACKGROUND: The literature shows that parents of preterm infants are at risk of psychological distress and that this may impact on the quality of the parent-child relationship and on the child's development. AIM: This longitudinal study was conducted to examine in preterm infants relationships between maternal psychological variables, parental protective factors, perinatal infant variables, and neurodevelopmental outcome. Furthermore, we explored the impact of these variables on the quality of the mother-infant relationship (dyadic synchrony)...
July 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
Shikha Pundir, Johanna Mäkelä, Anu Nuora, Niina Junttila, Clare Rosemary Wall, Kaisa Linderborg, David Cameron-Smith, Hanna Lagström
BACKGROUND & AIMS: Human milk (HM) contains a wide array of non-nutritive bioactive elements, including glucocorticoid hormones (glucocorticoid; cortisol and cortisone). The relationship between milk-borne glucocorticoids, measures of maternal health and patterns of breast-feeding is not yet established. This study was conducted to determine the influence of maternal and infant related biological and socio-demographic factors on the levels of glucocorticoids hormones in HM. METHODS: Samples were obtained from lactating mothers (n = 656) participating in the Finnish cohort the STEPS study (Steps to the Healthy Development and Well-being of Children) when the infants were 11...
July 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Enoch Odame Anto, William K B A Owiredu, Samuel Asamoah Sakyi, Cornelius Archer Turpin, Richard K D Ephraim, Linda Ahenkorah Fondjo, Christian Obirikorang, Eric Adua, Emmanuel Acheampong
BACKGROUND: Advanced maternal age (AMA) has been associated with negative pregnancy outcomes. Oxidative stress (OS) and defective placental dysfunction are contributing factors. This study determined the association between AMA and adverse pregnancy outcomes, OS biomarkers and angiogenic growth mediators (AGMs) in normal pregnancies. METHODS: This prospective cohort study conducted at the Obstetrics and Gynaecology (O&G) Department of the Komfo Anokye Teaching Hospital (KATH) finally included 175 normal pregnant women comprising, 58 AMA (35-45 years), 55 (30-34 years) and 62 optimal childbearing age (20-29 years)...
2018: PloS One
Ufuk Cakir, Cuneyt Tayman, Utku Serkant, Halil Ibrahim Yakut, Esra Cakir, Ufuk Ates, Ismail Koyuncu, Eyyup Karaogul
ETHNOPHARMACOLOGICAL RELEVANCE: Necrotizing enterocolitis (NEC) is the most important gastrointestinal emergency affecting especially preterm infants and causes severe morbidities and mortality. However, there is no cure. Oxidant stress, inflammation, apoptosis, as well as prematurity are believed to responsible in the pathogenesis of the disease. Ginger and its compounds have anti-inflammatory, antimicrobial, anti-oxidant properties and immunomodulatory, cytoprotective/regenerative actions...
October 28, 2018: Journal of Ethnopharmacology
Janet M Bronstein, Martha S Wingate, Anne E Brisendine
The portion of newborns delivered before term is considerably higher in the United States than in other developed countries. We compare the array of risk exposures and protective factors common to women across national settings, using national, regional, and international databases, review articles, and research reports. We find that U.S. women have higher rates of obesity, heart disease, and poor health status than women in other countries. This is in part because more U.S. women are exposed to the stresses of racism and income disparity than women in other national settings, and stress loads are known to disrupt physiological functions...
January 1, 2018: International Journal of Health Services: Planning, Administration, Evaluation
Jenny Carter, Rachel M Tribe, Andrew H Shennan, Jane Sandall
BACKGROUND: Preterm birth is a major cause of neonatal death and severe morbidity, so pregnant women experiencing symptoms of threatened preterm labour may be very anxious. The risk assessment and management that follows recognition of threatened preterm labour has the potential to either increase or decrease this anxiety. The aim of this study was to explore women's experience of threatened preterm labour, risk assessment and management in order to identify potential improvements in practice...
September 2018: Midwifery
Mariane Bertagnolli, Li Feng Xie, Katryn Paquette, Ying He, Anik Cloutier, Rafael Oliveira Fernandes, Chanel Béland, Megan R Sutherland, Jacques Delfrate, Daniel Curnier, Jean-Luc Bigras, Alain Rivard, Bernard Thébaud, Thuy Mai Luu, Anne Monique Nuyt
BACKGROUND: Preterm birth is linked to cardiovascular risks and diseases. Endothelial progenitor cells play a critical role in vascular development and repair. Cord blood endothelial progenitor cells of preterm-born infants, especially endothelial colony-forming cells (ECFC), show enhanced susceptibility to prematurity-related pro-oxidant stress. Whether ECFC dysfunction is present in adulthood following preterm birth is unknown. METHODS AND RESULTS: This cross-sectional observational study includes 55 preterm-born (≤29 gestational weeks) young adults (18-29 years old, 38% male) and 55 sex- and age-matched full-term controls...
July 9, 2018: Journal of the American Heart Association
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