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Trabeculectomy outcome

Hamed Esfandiari, Priyal Shah, Pooya Torkian, Ian P Conner, Joel S Schuman, Kiana Hassanpour, Nils A Loewen
PURPOSE: To analyze the 5-year results of trabectome ab interno trabeculectomy of a single glaucoma center. METHOD: In this retrospective interventional single-center case series, data of 93 patients undergoing ab interno trabeculotomy between September 2010, and December 2012 were included. Kaplan-Meier analysis was performed using success criteria defined as postoperative intraocular pressure (IOP) ≤ 21 mmHg, and > 20% reduction from preoperative IOP, and no need for further glaucoma surgery...
September 26, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Rachida Bouhenni, Mirela Krasniqi, Jeffrey Dunmire, Evan Lagouros, Todd Woodruff, James Bates, Deepak P Edward
PURPOSE: To determine the five-year success rate for Baerveldt glaucoma implant (BGI) in patients who received the implant as a primary (primary BGI, used as the initial surgical procedure) or secondary (secondary BGI, used after trabeculectomy) by a single surgeon between year 1994 and 2010. PATIENTS AND METHODS: A total of 117 eyes from patients who underwent BGI placement as a primary or secondary procedure were included in this study. Demographics, previous history, type of glaucoma, intraocular pressure (IOP), visual acuity (VA), glaucoma medication use, and early and late postoperative complications were collected...
September 25, 2018: Journal of Glaucoma
Desirée Murray, Peter Shah
Objective: The objective of the study was to present evidence of successful skills transfer of the Moorfields Safer Surgery System (MSSS) from the UK to Trinidad and Tobago and the safety and efficacy of this technique. Methods: Hospital-based retrospective, consecutive, non-comparative case series study of 33 eyes (24 African-Caribbean patients; 16 male patients) with primary open-angle glaucoma undergoing trabeculectomy + mitomycin C (MSSS) by a single surgeon with UK Glaucoma Fellowship training...
2018: Clinical Ophthalmology
Kirti Singh, Mainak Bhattacharyya, Ankush Mutreja, Sonal Dangda
Purpose: To report long-term safety and efficacy of trabeculectomy with collagen implant in Indian population. Methods: All cases of trabeculectomy with Ologen® Collagen Matrix implant performed over a 7-year period from May 2008 through April 2015 at a tertiary referral institute were reviewed. A total of 30 eyes of 28 patients were included in the study with two patients undergoing bilateral trabeculectomy. Outcomes measured included intraocular pressure (IOP) control, number of antiglaucoma medications used, bleb morphology, and complications/reoperations...
October 2018: Indian Journal of Ophthalmology
Amir Almatlouh, Daniella Bach-Holm, Line Kessel
Surgical outcome after trabeculectomy depends on maintaining a functional bleb which requires a delicate balance between incomplete wound healing to prevent fibrosis and enough wound healing to prevent hyperfiltration. Thus, controlling the inflammatory response is essential. We conducted a systematic review and meta-analysis to compare the effectiveness of different formulations of steroids (topical, systemic and depot) and nonsteroidal anti-inflammatory drugs (NSAIDs) in achieving long-term pressure control with fewer antiglaucomatous medications, preserving visual acuity and visual fields while considering surgical and postoperative complications...
September 21, 2018: Acta Ophthalmologica
Anand Pasari, Marianne O Price, Matthew T Feng, Francis W Price
PURPOSE: To evaluate outcomes and graft survival of Descemet membrane endothelial keratoplasty (DMEK) for failed penetrating keratoplasty (PK). METHODS: Ninety-three DMEK procedures performed in 84 eyes of 77 patients with failed PK were retrospectively reviewed. The main outcomes were corrected distance visual acuity and graft survival assessed with Kaplan-Meier survival analysis and proportional hazards modeling taking follow-up into consideration. RESULTS: Sixty-nine eyes had 1 previous failed PK, 13 had 2, 1 had 3, and 1 had 4...
September 14, 2018: Cornea
Xue Yin, Qinhua Cai, Run Song, Xuefei He, Peirong Lu
PURPOSE: To explore the relationship between the bleb vasculature and surgical outcome after trabeculectomy (TRAB) using optical coherence tomography angiography (OCT-A). METHODS: A prospective study was conducted, which included 26 eyes of 26 primary glaucoma patients in the final analysis. Thereinto, six patients underwent TRAB combined 5-FU and 12 patients received subconjunctival 5-FU injection postoperation. The bleb vessel was evaluated using OCT-A 1 week, 2 weeks, 1 month, 3 months, and 6 months after TRAB...
September 12, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Taiki Kokubun, Satoru Tsuda, Hiroshi Kunikata, Noriko Himori, Yu Yokoyama, Kazuko Omodaka, Shiho Kunimatsu-Sanuki, Toru Nakazawa
PURPOSE: To determine the potential of anterior-segment optical coherence tomography (AS-OCT) to predict post-trabeculectomy outcomes in NVG. PATIENTS AND METHODS: We recruited fifty-five eyes of 40 NVG patients who underwent trabeculectomy. The patients were divided into success and failure groups based on the post-trabeculectomy outcome after 12 months. AS-OCT findings were compared in the success and failure groups at 1 and 2 weeks and 1, 3, 6, and 12 months...
September 4, 2018: Journal of Glaucoma
Naoki Tojo, Atsushi Hayashi, Tomoko Consolvo-Ueda, Shuichiro Yanagisawa
PURPOSE: We compared the outcomes of Baerveldt glaucoma implant (BGI) surgery between vitreous cavity and anterior chamber insertion. METHODS: We retrospectively analyzed a total of 105 consecutive eyes that underwent BGI surgery and were followed up for ≥ 12 months. BGI surgery was performed via the anterior chamber (AC group 48 eyes) or the pars plana into the vitreous cavity (VC group 57 eyes). Patients' data were examined at 3, 6, and 12 months, and then every 6 months after surgery...
August 31, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
S Lin, D Byles, M Smith
OBJECTIVES: To describe the 3-year outcomes of mitomycin C (MMC)-augmented bleb needling procedures following late trabeculectomy failure. METHODS: A retrospective, observational chart review of 44 eyes that underwent MMC-augmented bleb needling following late trabeculectomy failure. The primary outcome measure was IOP at 3 years post-operatively. Secondary outcome measures were the number of topical glaucoma medications and success rate at 3 years. Success was defined on the basis of IOP (≤21 mmHg and ≥5 mmHg with a reduction of ≥ 20% from pre-operative baseline), need for ocular hypotensive medications, and need for further laser or surgical intervention...
August 29, 2018: Eye
Safia A Nazarali, Karim F Damji
OBJECTIVE: To compare the intraocular pressure-lowering efficacy and complication rate of ab interno trabeculectomy with the Trabectome between African American (AA) and Caucasian patients with open-angle glaucoma. METHODS: A total of 164 patients (82 AA and 82 Caucasian) who underwent ab interno trabeculectomy over an 8-year period were included in this prospective, case-control study. The Neomedix database was used to look for AA or Caucasian patients with open-angle glaucoma who underwent Trabectome with or without phacoemulsification...
August 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Zoya Rabkin-Mainer, Alvit Wolf, Nurit Mathalone, Alina Melamud, Gila Buckman, Beth Edmunds, Nili Stein, David M Steinberg, Orna Geyer
PURPOSE: The aim of this study was to compare the 3-year outcome of Ex-PRESS miniature glaucoma shunt versus Ahmed glaucoma valve in pseudophakic patients. PATIENTS AND METHODS: We retrospectively reviewed the records of patients with a history of clear corneal phacoemulsification alone, or failed trabeculectomy following phacoemulsification, who subsequently underwent Ahmed glaucoma valve (AGV) implantation or Ex-PRESS shunt surgery. The main outcome measure, surgical success, was defined as an intraocular pressure between 5 and 21 mm Hg and a 20% intraocular pressure reduction from baseline (with/without glaucoma medications) without glaucoma reoperation...
October 2018: Journal of Glaucoma
Deepti Mittal, Madhu Bhoot, Suneeta Dubey
No abstract text is available yet for this article.
August 7, 2018: Journal of Glaucoma
Zhihua Zhang, Yuyu Miao, Jing Wang, Minwen Zhou, Mingshui Fu, Ying Wang
Purpose: The purpose of this study was to quantify levels of three matricellular proteins in the aqueous humor in patients with previous acute primary angle closure (APAC) and investigate their correlation with bleb morphology and surgical outcomes of trabeculectomy. Methods: In this prospective study, aqueous humor samples were collected from 40 previous APAC eyes. Concentrations of three matricellular proteins-secreted protein acidic and rich in cysteine (SPARC), thrombospondin-2, and osteopontin-were measured using multiplexed immunoassays kits...
August 1, 2018: Investigative Ophthalmology & Visual Science
Nozomi Igarashi, Megumi Honjo, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Kuniyuki Kano, Junken Aoki, Makoto Aihara
We explored the potential relevance of aqueous lysophosphatidic acid (LPA) and autotaxin (ATX) levels on postoperative outcomes of trabeculectomy, and the effects of ATX on fibrotic response in cultured human conjunctiva fibroblast (HCF) cells. We enrolled 70 glaucomatous eyes which underwent trabeculectomy, and quantified aqueous LPA and ATX. Those eyes were followed up for 12 months, and postoperative filtering blebs were evaluated using anterior segment optical coherence tomography. Also, the ATX-induced fibrotic changes in HCFs and the effects of an ATX inhibitor were assessed...
July 27, 2018: Scientific Reports
Andrew H Nguyen, Nima Fatehi, Pablo Romero, Arezoo Miraftabi, EunAh Kim, Esteban Morales, JoAnn Giaconi, Anne L Coleman, Simon K Law, Joseph Caprioli, Kouros Nouri-Mahdavi
Importance: There is evidence that patients of African descent (AD) experience higher surgical failure rate after trabeculectomy without antimetabolites. Objective: To compare outcomes of initial trabeculectomy with mitomycin C in AD patients with those of patients of European descent (ED) and to identify prognostic factors for failure. Design, Setting, and Participants: In this retrospective matched cohort study, 135 eyes of 105 AD patients were matched with 135 eyes of 117 ED patients by age (within 5 years), surgeon, lens status, and follow-up time (within 1 year) from a single tertiary academic center...
October 1, 2018: JAMA Ophthalmology
Esma Islamaj, René J Wubbels, Peter W T de Waard
PURPOSE: To compare a Baerveldt implant and trabeculectomy with respect to intraocular pressure (IOP) and failure rate at 1 year of follow-up. Secondary outcomes are pharmacological therapy and complications at 1 year of follow-up. METHODS: This was a randomized, comparative study. A total of 119 glaucoma patients without previous ocular surgery were included at the Rotterdam Eye Hospital, the Netherlands. One eye of each subject was randomized to either a Baerveldt glaucoma drainage device (BGI) or trabeculectomy (TE)...
July 19, 2018: Acta Ophthalmologica
Phillip M Radke, Tal J Rubinstein, Steven R Hamilton, Annisa L Jamil, Bryan S Sires
INTRODUCTION: Trans-lamina cribrosa pressure has been postulated to be a contributor in the development of a glaucomatous optic nerve versus optic nerve edema, depending on the pressure gradient. Uncertainty remains in the therapeutic outcome of adjusting this gradient. CASE REPORT: We discuss a unique case of idiopathic intracranial hypertension presenting as asymmetric optic disc edema following trabeculectomy. It was treated via optic nerve fenestration due to the patient remaining symptomatic on maximum tolerated acetazolamide...
October 2018: Journal of Glaucoma
Ya-Long Dang, Xiao Wang, Wan-Wei Dai, Ping Huang, Nils A Loewen, Chun Zhang
AIM: To evaluate the 2-year efficacy and safety of ab interno trabeculectomy with the Trabectome in Chinese primary open angle glaucoma (POAG) patients. METHODS: This was a multicenter, retrospective, observational study and included POAG patients with or without visually-significant cataracts. The Chinese patients were enrolled from three glaucoma centers and a group of comparable Japanese POAG patients was analyzed from our international Trabectome database. The patients received Trabectome or a combined surgery with phacoemulsification and intraocular lens implantation...
2018: International Journal of Ophthalmology
Martin Q Diep, Michele C Madigan
Choroidal detachments occur when there is an accumulation of fluid or blood in the suprachoroidal space, a potential space situated between the choroid and the sclera. They are an uncommon ocular pathology. The most common cause of choroidal detachment is secondary to trabeculectomy; however, there are other causes such as trauma and inflammation. Clinically, choroidal detachments may vary in presentation from asymptomatic, to very poor vision, severe ocular pain, vomiting and nausea. Ocular findings associated with choroidal detachments include serous retinal detachment, secondary angle closure, and a very shallow anterior chamber...
July 4, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
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