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https://www.readbyqxmd.com/read/30501620/efficacy-of-a-long-term-home-parenteral-nutrition-regimen-containing-fish-oil-derived-n-3-polyunsaturated-fatty-acids-a-single-centre-randomized-double-blind-study
#1
Helene Bohnert, Max Maurer, Philip C Calder, Johann Pratschke, Paul Thul, Verena Müller
BACKGROUND: Data on the use of lipid emulsions containing fish-oil (FO) derived n-3 polyunsaturated fatty acids (n-3 PUFAs) in addition to medium- and long-chain triglycerides (MCT/LCT) for long-term home parenteral nutrition (HPN) are limited. This study aimed to compare HPN regimens containing either MCT/LCT/FO-derived n-3 PUFAs (test group) or MCT/LCT (control group) with respect to efficacy and safety during 8 weeks of HPN using a non-inferiority trial design with change of body mass index (BMI) as primary endpoint...
November 30, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/30482171/can-clinical-signs-or-symptoms-combined-with-basic-hematology-data-be-used-to-predict-the-presence-of-bacterial-infections-in-febrile-children-under-5-years
#2
Francois Kiemde, Massa Dit Achille Bonko, Marc Christian Tahita, Palpouguini Lompo, Halidou Tinto, Petra F Mens, Henk D F H Schallig, Michael Boele van Hensbroek
BACKGROUND: Infectious diseases in children living in resource-limited settings are often presumptively managed on the basis of clinical signs and symptoms. Malaria is an exception. However, the interpretation of clinical signs and symptoms in relation to bacterial infections is often challenging, which may lead to an over prescription of antibiotics when a malaria infection is excluded. The present study aims to determine the association between clinical signs and symptoms and basic hematology data, with laboratory confirmed bacterial infections...
November 27, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/30474706/outcome-and-safety-of-rechallenge-177-lu-lu-psma-617-in-patients-with-metastatic-prostate-cancer
#3
Anna Yordanova, Paula Linden, Stefan Hauser, Michael Meisenheimer, Stefan Kürpig, Georg Feldmann, Florian C Gaertner, Markus Essler, Hojjat Ahmadzadehfar
BACKGROUND: Data are sparse regarding the feasibility of radioligand therapy (RLT) with [177 Lu]Lu-PSMA-617 as a retreatment. We aimed to assess the outcome and safety of rechallenge PSMA-RLT in patients with progressive prostatic cancer who previously benefited from this therapy. MATERIALS AND METHODS: Patients who received rechallenge therapy at our department from January 2015 to March 2018 were assessed. Non-haematological and haematological adverse events were evaluated from laboratory data and clinical reports and were graded according to the Common Terminology Criteria for Adverse Events (CTCAE v...
November 24, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30472761/demand-management-and-weekend-haematology-and-clinical-biochemistry-requests
#4
Tim M Reynolds, Anthony S Wierzbicki
BACKGROUND: Increasing demand for laboratory testing at weekends is common but little is known about its appropriateness. METHODS: An audit was conducted in a large district hospital of routine haematology and clinical biochemistry requests ordered over 2 weekends. Appropriateness was assessed by review of ordered tests compared with clinical records by a qualified chemical pathologist. RESULTS: Profiles requested on phlebotomy included full blood count (76%), renal profile (91%), C-Reactive protein (41%), liver function tests (18%) and another test in 18%...
November 25, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/30459954/a-ten-year-review-of-the-sickle-cell-program-in-muhimbili-national-hospital-tanzania
#5
Julie Makani, Furahini Tluway, Abel Makubi, Deogratius Soka, Siana Nkya, Raphael Sangeda, Josephine Mgaya, Stella Rwezaula, Fenella J Kirkham, Christina Kindole, Elisha Osati, Elineema Meda, Robert W Snow, Charles R Newton, David Roberts, Muhsin Aboud, Swee Lay Thein, Sharon E Cox, Lucio Luzzatto, Bruno P Mmbando
Background: Africa has the highest burden of Sickle cell disease (SCD) but there are few large, systematic studies providing reliable descriptions of the disease spectrum. Tanzania, with 11,000 SCD births annually, established the Muhimbili Sickle Cell program aiming to improve understanding of SCD in Africa. We report the profile of SCD seen in the first 10 years at Muhimbili National Hospital (MNH). Methods: Individuals seen at MNH known or suspected to have SCD were enrolled at clinic and laboratory testing for SCD, haematological and biochemical analyses done...
2018: BMC Hematology
https://www.readbyqxmd.com/read/30453891/correlation-between-antifungal-consumption-and-the-distribution-of-candida-species-in-different-hospital-departments-of-a-lebanese-medical-centre
#6
Lyn Awad, Hani Tamim, Dania Abdallah, Mohammad Salameh, Anas Mugharbil, Tamima Jisr, Kamal Zahran, Nabila Droubi, Ahmad Ibrahim, Rima Moghnieh
BACKGROUND: In recent years, there has been a significant increase in the incidence of fungal infections attributed to Candida species worldwide, with a major shift toward non-albicans Candida (NAC). In this study, we have described the distribution of Candida species among different hospital departments and calculated the antifungal consumption in our facility. We also correlated the consumption of certain antifungals and the prevalence of specific Candida species. METHODS: This was a retrospective review of all the Candida isolates recovered from the computerised microbiology laboratory database of Makassed General Hospital, a tertiary care centre in Beirut, Lebanon, between January 2010 and December 2015...
November 20, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30452730/hepatitis-b-assessment-without-hepatitis-b-virus-dna-quantification-a-prospective-cohort-study-in-uganda
#7
Nicolas Laing, Henry Tufton, Emmanuel Ochola, Ojok Godfrey P'Kingston, Mala K Maini, Nicholas Easom
Background: Chronic hepatitis B infection affects 240 million people, with the highest prevalence in Africa and Asia, and results in 700 000 deaths annually. Access to diagnostics, particularly for hepatitis B virus viral load quantification (HBV DNA), is a major barrier to treatment. We aimed to test World Health Organization guidelines for hepatitis B management in resource-limited settings. Methods: We compared treatment allocation with and without the use of HBV DNA in a cohort in Uganda...
November 17, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/30429683/effect-of-cold-agglutinins-on-red-blood-cell-parameters-in-a-trauma-patient-a-case-report
#8
Anita Topic, Lara Milevoj Kopcinovic, Ana Bronic, Marina Pavic
The presence of cold agglutinins (CAs) in samples intended for complete blood count (CBC) using automated haematology analysers might cause serious preanalytical errors. In this report we describe the case of a 90-year old female patient admitted to the Emergency department following trauma injuries. A blood testing on admission revealed surprisingly low red blood cell count (0.99 x 1012 /L), low haematocrit (0.102 L/L) which did not correlate with haemoglobin concentration (100 g/L), and high erythrocytes indices (mean corpuscular haemoglobin, 101 pg; mean corpuscular haemoglobin concentration, 980 g/L)...
October 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/30429674/computer-physician-order-entry-cpoe-as-a-strategy-to-estimate-laboratory-activity-and-costs-associated-with-cancer-clinical-trials
#9
Enrique Rodriguez-Borja, Africa Corchon-Peyrallo, Macarena Diaz-Gimenez, Arturo Carratala-Calvo
Introduction: Most of clinical laboratories are not properly reimbursed for their activity related to clinical trials (CTs) conducted in their institutions due to a lack of measurement strategies. We implemented a specific computer physician order entry (CPOE) environment for CTs in order to facilitate ordering to providers and estimate the associated costs to be compared with the standard of care (SOC). Materials and methods: Four specific electronic formularies, restricted to two new virtual CTs clinical services (onco - CT and haemo - CT), were implemented in January 2015...
October 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/30429672/haematology-specimen-acceptability-a-national-survey-in-chinese-laboratories
#10
Yuanyuan Ye, Wei Wang, Haijian Zhao, Falin He, Kun Zhong, Shuai Yuan, Yuxuan Du, Bingquan Chen, Zhiguo Wang
Introduction: Specimen adequacy is a crucial preanalytical factor affecting accuracy and usefulness of test result. The aim of this study was to determine the frequency and reasons for rejected haematology specimens, preanalytical variables which may affect specimen quality, and consequences of rejection, and provide suggestions on monitoring quality indicators as to obtain a quality improvement. Materials and methods: A cross-sectional survey was conducted and a questionnaire was sent to 1586 laboratories...
October 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/30427065/assessment-of-haemoglobin-measurement-by-several-methods-blood-gas-analyser-capillary-and-venous-hemocue-%C3%A2-non-invasive-spectrophotometry-and-laboratory-assay-in-term-and-preterm-infants
#11
E Wittenmeier, L Lesmeister, N Pirlich, F Dette, I Schmidtmann, E Mildenberger
A laboratory haematology analyser is the gold standard for measuring haemoglobin concentration but has disadvantages, especially in neonates. This study compared alternative blood-sparing and non-invasive methods of haemoglobin concentration measurement with the gold standard. Haemoglobin concentrations were measured using a laboratory haematology analyser (reference method), blood gas analyser, HemoCue® using venous and capillary blood samples and a newly developed non-invasive sensor for neonates < 3 kg...
November 14, 2018: Anaesthesia
https://www.readbyqxmd.com/read/30410139/tumour-lysis-syndrome-in-children-with-haematological-cancers-experience-at-a-tertiary-care-hospital-in-karachi
#12
Farhan Saeed, Mohammad Shahzad Ali, Muhammad Shamvil Ashraf, Khadija Vadsaria, Durre-E-Fatima Siddiqui
OBJECTIVE: To determine the incidence of tumour lysis syndrome and to identify associated factors and mortality rate in paediatric haematological patients. METHODS: The prospective study was conducted from April to September 2016 at Indus Children Cancer Hospital, Karachi, and collected data for all new paediatric oncology patients registered with diagnosis of haematological malignancies. Each patient was monitored for a period of three days before and seven days after the start of the treatment...
November 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30375342/evaluation-of-reference-intervals-of-haematological-and-biochemical-markers-in-an-austrian-adolescent-study-cohort
#13
Barbara Bogner, Karin Schwenoha, Michael Vogl, Daniel Weghuber, Caroline Roth, Ulrike Kipman, Janne Cadamuro, Gertie J Oostingh
Background Reference intervals are a prerequisite for the interpretation of laboratory data related to diagnostic issues and treatment strategies. In adolescents, biomarker concentrations change with age, necessitating a continuous age-related definition of the reference intervals. The purpose of this pilot study was to evaluate the reference intervals for a healthy population of adolescents in Salzburg and compare these, when possible, with age- and gender-matched published data. Methods Anthropometrical parameters and blood samples were collected from adolescents (male and female; 14-17 years) in a school setting...
October 30, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30370735/-network-references-for-rare-diseases-state-of-the-art-for-the-paroxysmal-nocturnal-hemoglobinuria
#14
Rossella Alfano, Raffele Palladino, Antonio Risitano, Teresa De Pascale, Maddalena Raia, Davide Castrianni, Marina Silvia Scamardo, Vincenza Cerbone, Daniela Schiavone, Gaetano D'Onofrio, Gaetano Buonocore, Maria Triassi, Luigi Del Vecchio, Fabiana Rubba
BACKGROUND: recently, healthcare network models have been proposed to improve general awareness of rare diseases for patients and specific knowledge about diagnosis, treatment, and management for healthcare services. Paroxysmal nocturnal hemoglobinuria (PNH) is a rare haematological disease that still has no framing in an official network. OBJECTIVES: to describe the use of network models in diagnosis, treatment, and management of PNH patients both in Italy and abroad and its impact on patients and healthcare service...
September 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/30357778/role-of-routine-laboratory-tests-in-assessing-risk-of-recurrent-venous-thrombosis-results-from-the-mega-follow-up-study
#15
Vânia M Morelli, Willem M Lijfering, Suely M Rezende, Astrid van Hylckama Vlieg, Frits R Rosendaal, Suzanne C Cannegieter
BACKGROUND:  Kidney function, measured as estimated glomerular filtration rate (eGFR), glucose levels and haematologic variables (blood cell count) are easily obtainable tests, and have been associated with increased risk of first venous thrombosis (VT). Whether these routine tests can identify patients at risk of recurrence is unclear. AIM:  Our aim was to investigate the predictive value of serum glucose levels, eGFR and haematologic variables in patients at risk of recurrent VT...
November 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/30347950/clinical-and-laboratory-profile-of-dengue-fever-in-a-north-indian-tertiary-hospital
#16
M U Rabbani, Mohd Aslam, Ms Zaheer S, Muhammad Uwais Ashraf
Objectives: The present study was done to ascertain the presentations of dengue fever in a North Indian tertiary care Hospital, and to compare the clinical and laboratory features among patients with and without warning signs in dengue fever. Methods: A total of 600 patients of dengue admitted to medical wards were included in the study. A detailed history as well as a general and systemic clinical examination were carried out. Haematological profiles and biochemical investigations were done at the time of admission and were followed daily or at times twice a day...
April 2018: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/30286087/human-immunodeficiency-virus-status-in-malnourished-children-seen-at-lagos
#17
Edamisan Olusoji Temiye, Oluwafunmilayo Funke Adeniyi, Iretiola Bamikeolu Fajolu, Ann Abiola Ogbenna, Taiwo Augustine Ladapo, Christopher Imokhuede Esezobor, Adebola Olumide Akinsulie, Cecilia Abimbola Mabogunje
INTRODUCTION: Human immunodeficiency virus and protein energy malnutrition are still prevalent in Nigeria and the occurrence of the two conditions together confers a poor prognosis. The aim of this study was to determine the current categories of malnutrition amongst under-5 children in Lagos, document their HIV status and determine any peculiarities in the clinical features, haematological and some biochemical profile in these children. METHODS: The study was a cross-sectional study conducted at the Paediatric departments of the Lagos University Teaching Hospital and the Massey Street Children's Hospital, both in Lagos, over a 6-month period...
2018: PloS One
https://www.readbyqxmd.com/read/30281654/utility-of-reticulocyte-haemoglobin-content-and-percentage-hypochromic-red-cells-as-markers-of-iron-deficiency-anaemia-among-black-ckd-patients-in-south-africa
#18
Aishatu Muhammad Nalado, Johnny N Mahlangu, Raquel Duarte, Graham Paget, Gbenga Olorunfemi, Barry F Jacobson, Saraladevi Naicker
INTRODUCTION: Iron deficiency anaemia (IDA) worsens the prognosis and outcomes of chronic kidney disease (CKD). However, while the haemoglobin level is unreliable for early detection of IDA, reticulocyte haemoglobin content (CHr) and hypochromic red cells (%HYPO) are early markers of IDA. METHODS: This was a cross sectional study of black adult participants (n = 258) with CKD and apparently healthy members of staff and patients' relatives (n = 141) at the Charlotte Maxeke Johannesburg Academic Hospital, South Africa, between 1 June 2016 and 31 December 2016...
2018: PloS One
https://www.readbyqxmd.com/read/30269129/can-haematology-blood-tests-at-time-of-diagnosis-predict-response-to-neoadjuvant-treatment-in-locally-advanced-rectal-cancer
#19
George Ramsay, Duncan T Ritchie, Craig MacKay, Craig Parnaby, Graeme Murray, Leslie Samuel
BACKGROUND: Outcomes in locally advanced rectal cancer are improved by neoadjuvant therapy followed by surgical resection. Some patients respond completely to preoperative treatment. Therefore, predicting the pathological response to preoperative therapy is of clinical importance. Accurate prediction would allow for tailored approaches to neoadjuvant therapy. METHODS: All patients undergoing resection of rectal adenocarcinoma after neoadjuvant therapy between 2006 and 2015 were included in this cohort study...
September 28, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/30255068/field-evaluation-and-confirmation-of-acute-peste-des-petits-ruminant-outbreak-in-a-flock-of-west-african-dwarf-goats-in-ibadan-nigeria
#20
F Adeola Balogun, O Gabriel Fasanmi, T Ademola Oladipo, M Abiola Popoola, J Folami Olona, Y Dorcas Adeoye
This study utilised epidemiological, haematological, pathological findings and serological detection of specific antibodies to evaluate and confirm a peste des petit ruminants (PPR) outbreak in a herd of West African dwarf (WAD) goats in Ibadan, Nigeria. The morbidity and mortality rates post exposure (PE) were 96% and 60% respectively. Laboratory analyses revealed significant differences ( P  < 0.05) in mean values of the haematological and serum biochemical indices between the PE and control groups. The PE group experienced a significant ( P  < 0...
December 2017: International Journal of Veterinary Science and Medicine
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