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laboratory haematology

Luca Trotta, Anna Norberg, Mervi Taskinen, Vivien Béziat, Sofie Degerman, Ulla Wartiovaara-Kautto, Hannamari Välimaa, Kirsi Jahnukainen, Jean-Laurent Casanova, Mikko Seppänen, Janna Saarela, Minna Koskenvuo, Timi Martelius
BACKGROUND: The telomere biology disorders (TBDs) include a range of multisystem diseases characterized by mucocutaneous symptoms and bone marrow failure. In dyskeratosis congenita (DKC), the clinical features of TBDs stem from the depletion of crucial stem cell populations in highly proliferative tissues, resulting from abnormal telomerase function. Due to the wide spectrum of clinical presentations and lack of a conclusive laboratory test it may be challenging to reach a clinical diagnosis, especially if patients lack the pathognomonic clinical features of TBDs...
August 17, 2018: Orphanet Journal of Rare Diseases
Massimo Luca Castellazzi, Susanna Esposito, Laura Elisabetta Claut, Valeria Daccò, Carla Colombo
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a serious life-treating condition characterized by skin eruption, fever, haematologic abnormalities, and multi-organ involvement that can be fatal if unrecognized, especially in patients with liver failure. Diagnosis may be difficult because it is rarely described in children and can mimic many different conditions. CASE PRESENTATION: We report two cases of DRESS syndrome due to prolonged antibiotic treatment in young children in whom recovery occurred following different therapeutic approaches...
August 15, 2018: Italian Journal of Pediatrics
M Martini, F Paluan
Between nineteenth and twentieth centuries, medicine knew the beginning of an incessant development: the birth of new medical specialties (radiology, for instance), the introduction of new devices in medical and surgical wards, and the discovery of bacteria represented important milestones in that first historical period. The Medical School of the University of Genoa, head by Edoardo Maragliano, full professor of internal medicine, took on a relevant role in the battle against tuberculosis, through the experimental demonstration of the existence of an immune response against M...
June 2018: Journal of Preventive Medicine and Hygiene
Joanna Wyszkowska, Tomasz Jędrzejewski, Jakub Piotrowski, Anna Wojciechowska, Maria Stankiewicz, Wieslaw Kozak
PURPOSE: Epidemiological data suggest that there is a link between exposure to extremely low-frequency magnetic fields (ELF-MFs), immune response and the occurrence of neurodegenerative diseases. The exact nature of this phenomenon remains speculative and requires detailed laboratory investigation. In the present study we evaluate changes in plasma concentration of pro-inflammatory and regulatory cytokines as well as alternations of the haematological parameters in rats exposed to an ELF-MF...
July 20, 2018: International Journal of Radiation Biology
Emmanuel Liénard, Adriana Nabuco, Sophie Vandenabeele, Bertrand Losson, Irène Tosi, Émilie Bouhsira, Françoise Prévot, Shukri Sharif, Michel Franc, Caroline Vanvinckenroye, Yannick Caron
BACKGROUND: Besnoitiosis is caused by different species of intracellular protozoan parasites belonging to the family Sarcocystidae and affecting multiple host species worldwide. Including B. besnoiti, ten species are described infecting animals. Among ungulates, Besnoitia bennetti infects horses, donkeys and zebras and was described in Africa and in the USA where donkey besnoitiosis is considered as an emerging disease. CASE PRESENTATION: A two-year-old male donkey was purchased in May 2016 in poor body condition (cachexia, alopetic areas and pruritus mainly on neck and head) by the present owner in Le Roeulx (Belgium) from a milk producing donkey farm in Frasnes-lez-Buissenal (Belgium)...
July 18, 2018: Parasites & Vectors
M Samarkos, O Kampouropoulou, V Theofanis, G Tsoumi, I Eliadi, S Smilakou, G L Daikos
OBJECTIVES: The '3-day rule' for stool culture ordering suggests that only selected inpatients with nosocomial diarrhoea should have stool cultures for enteropathogenic bacteria (EPBs). Patients with haematological malignancies are not included in this group. We have analysed the ordering of stool cultures at Laikon Hospital to investigate whether all patients with haematological malignancies should be excluded from the 3-day rule. METHODS: We have retrospectively analysed all inpatient stool specimens sent to the microbiology laboratory for enteropathogenic bacteria culture at Laikon Hospital, Athens, Greece, between January 1, 2014 and December 31, 2014...
July 12, 2018: Clinical Microbiology and Infection
Zhao-Qi Tang, Rui-Hua Jiang, Hong-Bin Xu
WHAT IS KNOWN AND OBJECTIVE: In this study, the effectiveness of pharmaceutical care on treatment outcomes for patients with first-time pulmonary tuberculosis in China was assessed. METHODS: In this study, patients were randomized either to the usual care (UC) group (n = 72) where patients received routine medical and nursing care or to the pharmaceutical care (PC) group (n = 59) where patients were simultaneously provided with pharmaceutical care. The primary objectives were to evaluate whether treatment outcomes and patient adherence improved more in the PC group than in the UC group...
July 12, 2018: Journal of Clinical Pharmacy and Therapeutics
Emmanuelle A Kuntz, Srinivas Kammanadiminti
BACKGROUND: Lotilaner is a new member of the isoxazoline class for treatment of flea and tick infestations in cats. This laboratory study with lotilaner vanilla-yeast flavoured chewable tablets (CredelioTM , Elanco) investigated the safety in healthy kittens starting at 8 weeks of age in a randomized, blinded, parallel-group design. Lotilaner tablets were given orally once a month over eight months at one, three and five times the upper level of the maximum recommended dose range (26 mg/kg)...
July 13, 2018: Parasites & Vectors
Muhammed Majeed, Sarang Bani, Beena Bhat, Anjali Pandey, Lakshmi Mundkur, Prakriti Neupane
The present study was taken up to evaluate the single dose acute toxicity, 28 days and 90 days repeated dose toxicity and reproductive/developmental toxicity of standardized 40% Garcinol in experimental rodents. The studies were conducted in compliance with OECD principles of good laboratory practice, guidelines for testing of chemicals no.420, 407, 408 and 421 respectively. Single dose acute oral toxicity was conducted on female Wistar rats as sighting study step-I (300 mg/kg) & sighting study step-II (2000 mg/kg) and main study (2000 mg/kg)...
2018: Toxicology Reports
Fiona Chatterton, Vanessa Kay
BACKGROUND: Infertility is a devastating consequence of some medical and surgical interventions. Men can protect their fertility by storing or 'banking' sperm before beginning treatment. This is called fertility preservation. Fertility preservation is traditionally offered to cancer patients undergoing gonadotoxic therapy. AIMS: This study reports the results of an audit of the Ninewells Hospital fertility preservation service. It aims to characterise the patients who attended our service and assess their utilisation rate and outcome of treatment...
July 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
María Martínez, Jesica Montero, Adriana Pineda, Víctor Mijares, María Lares, Emily Catalano, Elizabeth Ferrer
Background: Toxocariasis is a widespread zoonosis caused by canine and feline Toxocara spp. In Venezuela, seroepidemiological studies in Aragua State have been carried out only in preschool children. The objective of this study was to determine the prevalence of anti-Toxocara spp. antibodies and identify clinical symptoms and risk factors of Toxocara spp. infection in school children in two municipalities of Aragua State of Venezuela. Methods: A cross-sectional field study with 259 children between 6 and 12 y of age was conducted in six schools in Aragua State...
June 1, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
Nadine Schmidt, Tim Luhmann, Liane Hüther, Ulrich Meyer, Stefanie A Barth, Lutz Geue, Christian Menge, Jana Frahm, Sven Dänicke
Vitamin E (vit E), an essential antioxidant for maintaining the stability of biological membranes and the function of the immune system, is considered to support adaptive immune responses and performance in cattle. The principal virulence factor of Shiga toxin (Stx)-producing Escherichia coli (STEC), the eponymous Stx, modulates cellular immune responses in cattle, the primary STEC reservoir. Active and passive immunization of calves with Shiga toxoids (rStxMUT ) was recently shown to reduce the STEC shedding...
June 15, 2018: Journal of Animal Physiology and Animal Nutrition
Lauren Kearney, Mary Kynn, Rachel Reed, Lisa Davenport, Jeanine Young, Keppel Schafer
BACKGROUND: In industrialised countries the incidence of postpartum haemorrhage (PPH) is increasing, for which exact etiology is not well understood. Studies have relied upon retrospective data with estimated blood loss as the primary outcome, known to be underestimated by clinicians. This study aimed to explore variables associated with PPH in a cohort of women birthing vaginally in coastal Queensland, Australia, using the gravimetric method to measure blood loss. METHODS: Women were prospectively recruited to participate using an opt-out consent process...
June 7, 2018: BMC Pregnancy and Childbirth
H Y Lim, F S Hong
INTRODUCTION: Flow cytometry is used in the diagnosis of haematological diseases including chronic lymphoproliferative disorders. This audit aims to ascertain the real-world indications for peripheral blood (PB) flow cytometry and which of these are associated with higher diagnostic yields. METHODS: All PB flow cytometry requests for chronic lymphoproliferative disorders from 1 January 2014 to 31 December 2014 were identified using the laboratory information system...
May 23, 2018: International Journal of Laboratory Hematology
Ariadna Arbiol-Roca, Claudia Elizabeth Imperiali, Magdalena Macià Montserrat, Ana Sancho Cerro, Anna Cortés Bosch de Basea, Lourdes Sánchez Navarro, Dolors Dot Bach, José Valero Politi
Background: The examination of peripheral blood is routinely used as a basic test in daily medical practice. Reliable reference intervals are necessary to avoid misdiagnoses, and the establishment of those intervals is an important task for clinical laboratories.The aim of the present study was to establish the reference intervals for complete blood count (CBC) on a Sysmex XN haematology analyser in healthy adults from the southern metropolitan area of Barcelona (Spain). Methods: A total of 213 apparently healthy adults who received a general health examination at Hospital Universitari de Bellvitge were recruited to this study...
April 2018: EJIFCC
Safak Kaya, Nazif Elaldi, Ozcan Deveci, Ahmet Emre Eskazan, Muhammed Bekcibasi, Salih Hosoglu
Background & objectives: Brucellosis can lead to haematological abnormalities including cytopenia confusing with haematological malignancies. The aim of this study was to compare the main characteristics of brucellosis patients without cytopenia (Group 1) and with cytopenia (Group 2). Methods: This five-year period study which was performed in two referral hospitals in Turkey, included all adult brucellosis patients. Abnormally, low counts of leucocyte or haemoglobin or platelets in a patient were considered as cytopenia...
January 2018: Indian Journal of Medical Research
Alice Nentwig, Marina L Meli, Johanna Schrack, Iris M Reichler, Barbara Riond, Corinne Gloor, Judith Howard, Regina Hofmann-Lehmann, Barbara Willi
BACKGROUND: Cytauxzoonosis is an emerging tick-borne disease of domestic and wild felids. Cytauxzoon felis induces severe and often fatal disease in domestic cats. In Europe, clinical and subclinical infections caused by Cytauxzoon sp. are described. We report the first cases of Cytauxzoon sp. infection in domestic cats in Switzerland. METHODS: Clinical and laboratory data and results of PCR analyses were collected from Cytauxzoon sp. PCR-positive cats and the cats followed for up to 851 days...
May 10, 2018: Parasites & Vectors
Ian Roberts, Haleema Shakur, Bukola Fawole, Modupe Kuti, Oladapo Olayemi, Adenike Bello, Olayinka Ogunbode, Taiwo Kotila, Chris O Aimakhu, Tolulase Olutogun, Beverley J Hunt, Sumaya Huque
BACKGROUND: Early treatment with tranexamic acid reduces deaths due to bleeding after post-partum haemorrhage. We report the prevalence of haematological, coagulation and fibrinolytic abnormalities in Nigerian women with postpartum haemorrhage. METHODS: We performed a secondary analysis of the WOMAN trial to assess laboratory data and rotational thromboelastometry (ROTEM) parameters in 167 women with postpartum haemorrhage treated at University College Hospital, Ibadan, Nigeria...
May 9, 2018: BMC Pregnancy and Childbirth
Eva Stokhuijzen, Margaret L Rand, Marjon H Cnossen, Tina T Biss, Paula D James, Monique H Suijker, Marjolein Peters, Johanna H van der Lee, Bram Peters, Alexander B Meijer, Victor S Blanchette, Karin Fijnvandraat
INTRODUCTION: It is challenging to obtain a reliable bleeding history in children who are referred for a suspected inherited bleeding disorder. Bleeding symptoms may be subtle as children face fewer haemostatic challenges compared with adults. In order to standardise bleeding histories, questionnaires have been developed, called bleeding assessment tools (BATs). Although it has been shown that high bleeding scores are associated with the presence of a mucocutaneous bleeding disorder, these BATs lack sensitivity, efficiency and flexibility in the paediatric setting...
May 3, 2018: BMJ Open
M H F El-Shabrawi, N M Kamal, H R El-Khayat, E M Kamal, M M A H AbdElgawad, M Yakoot
BACKGROUND: No available data on the use of sofosbuvir/ledipasvir combination in treatment of hepatitis C virus (HCV) infection in children 6- to 12- year old. AIM: To assess the safety and efficacy of sofosbuvir plus ledipasvir in children 6- to 12- year old with chronic HCV genotype 4 infection. METHODS: This is a pilot prospective single arm observational open-label multicentre study. A total of 20 consecutive eligible chronic HCV infected children, aged from 6- to 12- years were included in this study and treated with a fixed sofosbuvir/ledipasvir combination in half the adult dose (200/45 mg) once daily for 12 weeks...
June 2018: Alimentary Pharmacology & Therapeutics
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