keyword
https://read.qxmd.com/read/38509327/spatialdata-an-open-and-universal-data-framework-for-spatial-omics
#1
JOURNAL ARTICLE
Luca Marconato, Giovanni Palla, Kevin A Yamauchi, Isaac Virshup, Elyas Heidari, Tim Treis, Wouter-Michiel Vierdag, Marcella Toth, Sonja Stockhaus, Rahul B Shrestha, Benjamin Rombaut, Lotte Pollaris, Laurens Lehner, Harald Vöhringer, Ilia Kats, Yvan Saeys, Sinem K Saka, Wolfgang Huber, Moritz Gerstung, Josh Moore, Fabian J Theis, Oliver Stegle
Spatially resolved omics technologies are transforming our understanding of biological tissues. However, the handling of uni- and multimodal spatial omics datasets remains a challenge owing to large data volumes, heterogeneity of data types and the lack of flexible, spatially aware data structures. Here we introduce SpatialData, a framework that establishes a unified and extensible multiplatform file-format, lazy representation of larger-than-memory data, transformations and alignment to common coordinate systems...
March 20, 2024: Nature Methods
https://read.qxmd.com/read/38479185/communication-efficient-distributed-cubic-newton-with-compressed-lazy-hessian
#2
JOURNAL ARTICLE
Zhen Zhang, Keqin Che, Shaofu Yang, Wenying Xu
Recently, second-order distributed optimization algorithms have been becoming a research hot in distributed learning, due to their faster convergence rate than the first-order algorithms. However, second-order algorithms always suffer from serious communication bottleneck. To conquer such challenge, we propose communication-efficient second-order distributed optimization algorithms in the parameter-server framework, by incorporating cubic Newton methods with compressed lazy Hessian. Specifically, our algorithms require each worker communicate compressed Hessians with the server only at some particular iterations, which can save both communication bits and communication rounds...
February 27, 2024: Neural Networks: the Official Journal of the International Neural Network Society
https://read.qxmd.com/read/38470927/motor-laziness-constrains-fixation-selection-in-real-world-tasks
#3
JOURNAL ARTICLE
Charlie S Burlingham, Naveen Sendhilnathan, Oleg Komogortsev, T Scott Murdison, Michael J Proulx
Humans coordinate their eye, head, and body movements to gather information from a dynamic environment while maximizing reward and minimizing biomechanical and energetic costs. However, such natural behavior is not possible in traditional experiments employing head/body restraints and artificial, static stimuli. Therefore, it is unclear to what extent mechanisms of fixation selection discovered in lab studies, such as inhibition-of-return (IOR), influence everyday behavior. To address this gap, participants performed nine real-world tasks, including driving, visually searching for an item, and building a Lego set, while wearing a mobile eye tracker (169 recordings; 26...
March 19, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38435939/knowledge-and-awareness-regarding-amblyopia-among-parents-in-riyadh-saudi-arabia-a-cross-sectional-study
#4
JOURNAL ARTICLE
Othman J AlJarallah, Mohammed S AlFehaid, Aseel A Alnadawi, Saleh Ghulaysi, Alwaleed K Almouzan, Talal K Aljurayyan, Abdulaziz M Alnemari, Khalid Aldawsari, Hussam Almalki
Introduction Amblyopia is an abnormal development of usually one eye, leading to permanent decreased vision in the affected eye if not treated early. The condition is primarily caused by strabismus, cataract, anisometropic refractive error, or genetic factors and can manifest from birth to seven years of age, with a worldwide prevalence of 1.75%. This study examines parental knowledge of amblyopia in an effort to improve its early detection and intervention. Improving awareness can have a direct impact by lowering the incidence of untreated amblyopia and its related visual impairment...
January 2024: Curēus
https://read.qxmd.com/read/38434946/young-women-s-leisure-time-physical-activity-determinants-a-mixed-methods-approach
#5
JOURNAL ARTICLE
Uxue Fernandez-Lasa, Olaia Eizagirre-Sagastibeltza, Ruth Cayero, Estibaliz Romaratezabala, Judit Martínez-Abajo, Oidui Usabiaga
INTRODUCTION: The aim of the study was to analyze the habits, motives and barriers related to Leisure Time Physical Activity (LTPA) among young women of Gipuzkoa, from a mixed approach. METHODS: A total of 526 women aged 18-29 (24.60 ± 3.30 years) responded to the Gipuzkoa Women's Physical Activity Questionnaire (GWPAQ), seven of which were later interviewed. RESULTS: The main motives for LTPA were intrapersonal - related to health and enjoyment - and to interpersonal networks...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38406640/adenine-s-impact-on-mice-s-gut-and-kidney-varies-with-the-dosage-administered-and-relates-to-intestinal-microorganisms-and-enzyme-activities
#6
JOURNAL ARTICLE
Mengsi Zhou, Xiaoya Li, Jin Liu, Yi Wu, Zhoujin Tan, Na Deng
This study aimed to investigate the effects of different dosages of adenine on intestinal microorganisms and enzyme activities, laying the experimental groundwork for subsequent exploration of the microbial mechanisms underlying diarrhea with kidney yang deficiency syndrome. Twenty-four mice were assigned to the following four groups: the control (NC) group, low-dosage adenine (NML) group, middle-dosage adenine (NMM) group, and high-dosage adenine (NMH) group. Mice in the NML, NMM, and NMH groups received 25 mg/(kg·d), 50 mg/(kg·d), and 100 mg/(kg·d) of adenine, respectively, 0...
March 2024: 3 Biotech
https://read.qxmd.com/read/38396652/do-deeper-rooting-1-homologs-regulate-the-lateral-root-slope-angle-in-cucumber-cucumis-sativus
#7
JOURNAL ARTICLE
Alexey S Kiryushkin, Elena L Ilina, Tatyana Y Kiikova, Katharina Pawlowski, Kirill N Demchenko
The architecture of the root system is fundamental to plant productivity. The rate of root growth, the density of lateral roots, and the spatial structure of lateral and adventitious roots determine the developmental plasticity of the root system in response to changes in environmental conditions. One of the genes involved in the regulation of the slope angle of lateral roots is DEEPER ROOTING 1 ( DRO1 ). Its orthologs and paralogs have been identified in rice, Arabidopsis, and several other species. However, nothing is known about the formation of the slope angle of lateral roots in species with the initiation of lateral root primordia within the parental root meristem...
February 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38345877/a-unique-case-of-a-giant-popliteal-artery-aneurysm-presenting-as-popliteal-mass
#8
JOURNAL ARTICLE
Panagiotis Volteas, Stefanos Giannopoulos, Sonakshi Vatsa, Edwin C Cheung, Dimitrios Virvilis
INTRODUCTION: Popliteal artery aneurysms (PAA) can be very challenging, especially in cases of very large PAAs, with a minimal number of case reports published in the literature. METHODS: This is a case report of a 68-year-old male patient with hypertension, hyperlipidemia, diabetes, and schizophrenia who was found to have a giant (10x8x6cm) partially thrombosed PAA, treated with interposition polytetrafluoroethylene (PTFE) graft via a posterior approach. RESULTS: Under general anesthesia, the patient was placed in a prone position, and an extended lazy "S" incision was made on the popliteal fossa...
February 9, 2024: Port J Card Thorac Vasc Surg
https://read.qxmd.com/read/38336789/diagnosis-and-management-of-achilles-tendon-ailments-the-scottish-mist
#9
REVIEW
Nicola Maffulli, John B King, Filippo Migliorini, Otto Chan, Nat Padhiar, Filippo Spiezia
The diagnosis and management of Achilles tendon ailments continue to be widely discussed by the scientific community. Also, the nomenclature used to describe the tendinopathic lesion in patients changed over the last decades together with the evolution in the knowledge of the physiopathology of Achilles tendinopathy, and unfortunately, through ignorance and possibly laziness, confusion still abounds. To emerge from these foggy paths, some clarifications are still necessary. The present Editorial tries to clarify some of these issues...
February 9, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38290700/identifying-the-factors-influencing-plagiarism-in-higher-education-an-evidence-based-review-of-the-literature
#10
JOURNAL ARTICLE
Raj Kishor Kampa, Dhirendra Kumar Padhan, Nalini Karna, Jayaram Gouda
The present study explores the major reasons for committing plagiarism, as reported in published literature. One hundred sixty-six peer-reviewed articles, which were retrieved from the Scopus database, were carefully examined to find out the research studies conducted to explore the most common reasons for academic cheating among students and researchers in different disciplines in higher education. A meta-analysis of collected literature reveals that 19 studies were conducted to identify the perceived reasons of committing plagiarism...
January 30, 2024: Accountability in Research
https://read.qxmd.com/read/38287925/peach-lazy1-and-dro1-protein-protein-interactions-and-co-expression-with-praf-rld-family-support-conserved-gravity-related-protein-interactions-across-plants
#11
JOURNAL ARTICLE
Jessica M Waite, Courtney A Hollender, Jon R Eilers, Erik Burchard, Chris Dardick
IGT/LAZY proteins play a central role in determining gravitropic set point angle and orientation of lateral organs across plant species. Recent work in model systems has demonstrated that interactions between IGT/LAZY proteins and BREVIS RADIX (BRX)-domain containing proteins, such as PH, RCC1, AND FYVE/RCC1-LIKE DOMAIN (PRAF/RLD), and BREVIS RADIX LIKE (BRXL) family members, are mechanistically important for setting gravitropic set point angle. Here, we identified peach PRAF/RLD proteins as interactors of the peach IGT/LAZY proteins PpeLAZY1 and DEEPER ROOTING 1 (PpeDRO1) from a yeast-two-hybrid screen...
2024: microPublication. Biology
https://read.qxmd.com/read/38233837/igt-lazy-genes-are-differentially-influenced-by-light-and-required-for-light-induced-change-to-organ-angle
#12
JOURNAL ARTICLE
Jessica Marie Waite, Christopher Dardick
BACKGROUND: Plants adjust their growth orientations primarily in response to light and gravity signals. Considering that the gravity vector is fixed and the angle of light incidence is constantly changing, plants must somehow integrate these signals to establish organ orientation, commonly referred to as gravitropic set-point angle (GSA). The IGT gene family contains known regulators of GSA, including the gene clades LAZY, DEEPER ROOTING (DRO), and TILLER ANGLE CONTROL (TAC). RESULTS: Here, we investigated the influence of light on different aspects of GSA phenotypes in LAZY and DRO mutants, as well as the influence of known light signaling pathways on IGT gene expression...
January 17, 2024: BMC Biology
https://read.qxmd.com/read/38226076/knowledge-and-attitude-of-the-public-toward-bariatric-weight-loss-surgery-and-its-impact-on-candidates-and-patients-in-the-al-qassim-region-saudi-arabia
#13
JOURNAL ARTICLE
Bilal S Al-Mushaigah, Rakan A Almesned, Osamah A Alsolai, Noor M Alfahhad, Abdulelah A Almesned
Background Obesity is defined as abnormal or excessive fat accumulation that presents a serious health risk and is a major public health concern. Obesity prevention and management require evidence-based strategies that emphasize diet and physical activity. Bariatric surgery is also a life-changing procedure that can improve physical and mental health, but the stigma associated with it can prevent people from seeking treatment and affect their lives adversely. Studies have shown that bariatric surgery patients face discrimination from the public and healthcare professionals, which can lead to adverse psychological outcomes and hinder access to quality care...
December 2023: Curēus
https://read.qxmd.com/read/38223576/exploring-the-barriers-and-facilitators-towards-physical-activity-among-church-members-in-lagos-nigeria-a-qualitative-study
#14
JOURNAL ARTICLE
Oluwakemi Ololade Odukoya, Omoladun Olukemi Odediran, Charles R Rogers, Folasade Ogunsola, Kolawole S Okuyemi
BACKGROUND: Physical inactivity is substantially linked to the rise in the global burden of non-communicable diseases. Faith-based organizations are recognized as potential partners for sustainable health interventions. OBJECTIVE: This study aims to explore the facilitators and barriers towards physical activity among adult church members in Lagos, Nigeria. METHODS: Sixteen focus group discussions (n-163) were conducted among adult male and female church members in twelve Anglican churches...
June 2023: African Health Sciences
https://read.qxmd.com/read/38178034/design-and-validation-of-a-questionnaire-on-the-factors-influencing-self-care-behaviors-in-patients-with-multiple-sclerosis-qfasms
#15
JOURNAL ARTICLE
Fahimeh Pourhaji, Jamshid Jamali, Mousa Mahdizadeh Taraghdar, Nooshin Peyman, Hadi Tehrani
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS). Since MS does not have a definitive cure, individuals affected by it need to adapt and coordinate with their chronic illness in order to fulfill their duties and responsibilities. The first step in helping patients to better care for and manage their illness is to engage in self-care behaviors. This study was conducted with the aim of design and validation of a questionnaire on the factors influencing self-care behaviors in patients with Multiple sclerosis...
January 4, 2024: BMC Neurology
https://read.qxmd.com/read/38173311/identification-of-biomarker-genes-from-multiple-studies-for-abiotic-stress-in-maize-through-machine-learning
#16
JOURNAL ARTICLE
Leyla Nazari, Zahra Zinati, Paolo Bagnaresi
Abiotic stresses are major limiting factors for maize growth. Therefore, exploration of the mechanisms underlying the response to abiotic stress in maize is of great interest. Toward this end, we performed integration of the feature selection method into the meta-analysis of microarray gene expression. Following extraction of raw data, normalization, and batch effect removal, the data were merged into one expression profile. Differentially expressed genes (DEGs) between control and abiotic conditions were used for the feature selection algorithm to find the minimum features for high-performance classification...
2024: Journal of Biosciences
https://read.qxmd.com/read/38148591/globalizing-transit-worker-stress
#17
JOURNAL ARTICLE
Mark D Fleming
Health scientists have claimed that urban transit workers suffer from higher rates of stress-related disease than workers in most other occupations. This paper examines how a network of scientists and labor organizers constructed the problem of transit worker stress as a global phenomenon. According to study participants, transit workers worldwide are subject to a similar set of stress-related risks, which can serve as a basis for worker solidarity. This paper analyzes how the concept of stress has been used to identify pathogenic environments and considers anthropological claims that the concept often abstracts and depoliticizes harmful arrangements...
December 26, 2023: Anthropology & Medicine
https://read.qxmd.com/read/38054064/opportunities-of-measuring-hierarchical-models-of-psychopathology
#18
JOURNAL ARTICLE
Erik Pettersson
All psychiatric phenomena are positively associated, and several different models can account for this observation. These include the correlated factors, network, general psychopathology as outcome, and hierarchical models. Advantages of hierarchical models, which consist of one general and several (general factor-residualized) specific factors, is that the general factor provides an opportunity to reliably measure global distress and impairment, while the specific factors might improve the ability to discriminate between individuals with different kinds of problems...
December 2023: JCPP Adv
https://read.qxmd.com/read/38052169/gravitropism-the-lazy-way-of-intracellular-hitchhiking
#19
JOURNAL ARTICLE
Sophie Farkas, Jürgen Kleine-Vehn
Plant gravitropism has fascinated scientists for centuries. A new study provides a major mechanistic update of the so-called starch/statolith hypothesis, revealing how gravity perception is converted into a physiological response.
December 4, 2023: Current Biology: CB
https://read.qxmd.com/read/37949947/lazy-sedimentation
#20
JOURNAL ARTICLE
Guillaume Tena
No abstract text is available yet for this article.
November 10, 2023: Nature Plants
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