Luca Marconato, Giovanni Palla, Kevin A Yamauchi, Isaac Virshup, Elyas Heidari, Tim Treis, Wouter-Michiel Vierdag, Marcella Toth, Sonja Stockhaus, Rahul B Shrestha, Benjamin Rombaut, Lotte Pollaris, Laurens Lehner, Harald Vöhringer, Ilia Kats, Yvan Saeys, Sinem K Saka, Wolfgang Huber, Moritz Gerstung, Josh Moore, Fabian J Theis, Oliver Stegle
Spatially resolved omics technologies are transforming our understanding of biological tissues. However, the handling of uni- and multimodal spatial omics datasets remains a challenge owing to large data volumes, heterogeneity of data types and the lack of flexible, spatially aware data structures. Here we introduce SpatialData, a framework that establishes a unified and extensible multiplatform file-format, lazy representation of larger-than-memory data, transformations and alignment to common coordinate systems...
March 20, 2024: Nature Methods