Haotian Yang, Yongping Chen, Zhiqiang Wang, Yuxiang Huang, Zhigang Ma, Yue Zou, Jiaqiang Dong, Hong Zhang, Mingdong Huo, Mingzhe Lv, Xuesong Liu, Guohua Zhang, Shuang Wang, Kun Yang, Peng Zhong, Botao Jiang, Yuhong Kou, Zhifeng Chen
OBJECTIVES: The study aimed to investigate the protective effects of dexmedetomidine (DEX) on renal injury caused by acute stress in rats and explore the protective pathways of DEX on rat kidneys in terms of oxidative stress. METHODS: An acute restraint stress model was utilized, where rats were restrained for 3 hours after a 15-minute swim. Biochemical tests and histopathological sections were conducted to evaluate renal function, along with the measurement of oxidative stress and related pathway proteins...
April 16, 2024: Journal of Pharmacy and Pharmacology