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Stress Related Pathologies

Jiaqi Gao, Zepeng Yu, Shu Jing, Weihai Jiang, Cong Liu, Chunyan Yu, Jinghui Sun, Chunmei Wang, Jianguang Chen, He Li
Background: Liver aging is a significant risk factor for chronic liver diseases. Oxidative stress has been considered as a conjoint pathological mechanism for the initiation and progression of liver aging. It has been reported that d-galactose (d-gal)-induced hepatic injury is an experimental model well established closely similar to morphological and functional features of liver aging. Schisandra sphenanthera Rehd. et Wils (S. sphenanthera, Schisandraceae), as a famous tradi-tional Chinese medicine, has been used for thousands of years in China to treat various disorders, including liver dysfunctions...
2018: Clinical Interventions in Aging
Antonella Tramutola, Giulia Abate, Chiara Lanzillotta, Francesca Triani, Eugenio Barone, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, Mariagrazia Marziano, Maurizio Memo, Emirena Garrafa, D Allan Butterfield, Marzia Perluigi, Fabio Di Domenico, Daniela Uberti
Alzheimer's disease (AD) is a progressive form of dementia characterized by increased production of amyloid-β plaques and hyperphosphorylated tau protein, mitochondrial dysfunction, elevated oxidative stress, reduced protein clearance, among other. Several studies showed systemic modifications of immune and inflammatory systems due, in part, to decreased levels of CD3+ lymphocytes in peripheral blood in AD. Considering that oxidative stress, both in the brain and in the periphery, can influence the activation and differentiation of T-cells, we investigated the 3-nitrotyrosine (3-NT) proteome of blood T-cells derived from AD patients compared to non-demented (ND) subjects by using a proteomic approach...
October 12, 2018: Free Radical Biology & Medicine
Cheng-Long Xie, Jun-Li Li, En-Xing Xue, Hai-Cheng Dou, Jin-Ti Lin, Kai Chen, Hong-Qiang Wu, Long Wu, Jun Xuan, Qi-Shan Huang
Excessive extracellular matrix degradation and chondrocyte apoptosis are the pathological features of osteoarthritis (OA). The ability of flavonoid compounds isolated from Chinese hawthorn leaves to exert protective effects on several diseases, via inhibition of oxidative stress and inflammation, has been demonstrated in several studies. This study explored the effects of vitexin on chondrocytes, and the underlying mechanisms thereof. Vitexin, an active ingredient in hawthorn leaf extracts, was shown to exert protective effects on chondrocytes, by inhibiting the expression of GRP78 and PDI, and an apoptotic protein (CHOP) induced by interleukin-1β...
October 15, 2018: Food & Function
Cheng Li, Xiao Miao, Yan Lou, Zhengyang Lu, Binay Kumar Adhikari, Yangwei Wang, Quan Liu, Jian Sun, Yonggang Wang
AIM: Diabetic cardiomyopathy is an independent cardiac injury that can develop in diabetic individuals. Our previous study showed that C66, a curcumin analogue, protects against diabetes-induced cardiac damage. The present study sought to reveal the underlying mechanisms of C66-mediated cardioprotection. METHODS: An experimental diabetic model was established using JNK2-/- and wild-type (WT) mice. C66 (5 mg/kg) was administered orally every other day for 3 months...
October 15, 2018: Journal of Cellular and Molecular Medicine
A Mohankumar, G Shanmugam, D Kalaiselvi, C Levenson, S Nivitha, G Thiruppathi, P Sundararaj
East Indian Sandalwood Oil (EISO) has diverse beneficial effects and has been used for thousands of years in traditional folk-medicine for treatment of different human ailments. However, there has been no in-depth scientific investigation to decipher the neuroprotective and geroprotective mechanism of EISO and its principle components, α- and β-santalol. Hence the current study was undertaken to assess the protective effects of EISO, and α- and β-santalol against neurotoxic (6-OHDA/6-hydroxydopamine) and proteotoxic (α-synuclein) stresses in a Caenorhabditis elegans model...
October 3, 2018: RSC Advances
Lu Fan, Ye Fan, Li Liu, Weiwei Tao, Xin Shan, Yu Dong, Lin Li, Sen Zhang, Hanqing Wang
Chelerythrine (CH), is a kind of benzo[c] phenanthridine alkaloid isolated from plants such as Chelidonium, with pharmacological activities as antitumor, antibiosis and anti-inflammation. However, few studies have demonstrated whether CH could protect against lipopolysaccharide (LPS)-induced acute lung injury (ALI), and the underlying mechanism is also uncertain. The purpose of the present study was to investigate the anti-inflammatory effects of CH on LPS-induced ALI in mice and in RAW264.7 cells. In this study, we demonstrated that treatment with CH significantly ameliorated LPS-induced pathological changes in the lung...
2018: Frontiers in Pharmacology
X X Mi, J Yan, X D Zeng, J P Shi
Objective: To establish overfed zebrafish model for non-alcoholic steatohepatitis. Methods: The wild-type zebrafish was fed 3 times a day with normal diet. Body length, weight, and triglyceride levels were measured after 20 days of feeding. The changes in expression of genes associated with cholesterol metabolism, lipid metabolism, endoplasmic reticulum stress, and inflammation were detected by quantitative PCR. Liver tissue sections were stained with H&E. Statistical analyses between groups were compared using t-test...
July 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Xiangcheng Xiao, Qiongjing Yuan, Yusa Chen, Zhihua Huang, Xi Fang, Haixia Zhang, Ling Peng, Ping Xiao
Although long noncoding RNA (LncRNA) are important players in the initiation and progression of many pathological processes, the role of LncRNAENST00000453774.1 (LncRNA 74.1) in renal fibrosis still remains unclear. Lentivirus mediated LncRNA 74.1 overexpressing HK2 cells and overexpression mice models were constructed. HK2 cells induced by transforming growth factor-β (TGF-β) in vitro, and the mice UUO model in vivo were used to simulate renal fibrosis. The expression of LncRNA 74.1 was significantly downregulated in the TGF-β-induced HK-2 cell fibrosis and clinical renal fibrosis specimens...
October 14, 2018: Journal of Cellular Physiology
Yu-Ying Lian, Hong-Hui He, Chao-Zheng Zhang, Xin-Cang Li, Yi-Hong Chen
Matrix metalloproteinases (MMPs) contribute to both normal and pathological tissue remodeling. They act as regulatory molecules by working in enzyme cascades as well as processing matrix proteins, cytokines, growth factors and adhesion molecules to generate fragments with biological effects. So MMPs could play distrinct roles in the process of pathogen infection. In present study, we cloned a MMP-2 (LvMMP-2) gene from Litopenaeus vannamei. LvMMP-2, highly expressed in epidermis, located to endoplasmic reticulum in S2 cells...
October 11, 2018: Fish & Shellfish Immunology
Yuanyuan Liu, Mengying Wei, Kexin Yue, Mingxin Hu, Shizhe Li, Lihui Men, Zifeng Pi, Zhiqiang Liu, Zhongying Liu
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with no effective method for its treatment so far. The pathogenesis of AD has been reported, but the endogenous metabolic profile and disease-related biomarkers are still not clear. To better understand AD, an AD model induced by injecting β-amyloid 25-35 (Aβ 25-35) solution into bilateral hippocampus was developed on Sprague-Dawley rats. After 8 weeks of modeling, the impairment of spatial learning and memory ability in AD rats were assessed by Morris water maze task...
October 11, 2018: Neuroscience
Bo Chen
OBJECTIVES: Schizophrenia is a predominant product of pathological alterations distributed throughout interconnected neural systems. Designing new objectively diagnostic methods are burning questions. Dynamical functional connectivity (DFCs) methodology based on fMRI data is an effective lever to investigate changeability evolution in macroscopic neural activity patterns underlying critical aspects of cognition and behavior. However, region properties of brain architecture have been less investigated by special indexes of dynamical graph in general mental disorders...
October 11, 2018: Journal of Neuroscience Methods
Simone Colombo, Carmen Martín-Sierra, Tânia Melo, Paula Laranjeira, Artur Paiva, Pedro Domingues, M Rosário Domingues
Aminophospholipids (APL), phosphatidylethanolamine (PE) and phosphatidylserine (PS), can be oxidized upon oxidative stress. Oxidized PE and PS have been detected in clinical samples of different pathologies and may act as modulators of the inflammatory response. However, few studies have focused on the effects of oxidized APL (ox-APL) esterified with arachidonic acid, even though a considerable number of studies have assessed the modulation of the immune system by oxidized 1-palmitoyl-2-arachidonoyl-sn-3-glycerophosphocholine (OxPAPC)...
October 10, 2018: Archives of Biochemistry and Biophysics
Violeta Rodriguez-Ruiz, José Ángel Salatti-Dorado, Abolfazl Barzegari, Alba Nicolas-Boluda, Amel Houaoui, Carmen Caballo, Noelia Caballero-Casero, Dolores Sicilia, Jorge Bastias Venegas, Emmanuel Pauthe, Yadollah Omidi, Didier Letourneur, Soledad Rubio, Virginie Gueguen, Graciela Pavon-Djavid
Astaxanthin is a xanthophyll carotenoid showing efficient scavenging ability and represents an interesting candidate in the development of new therapies for preventing and treating oxidative stress-related pathologies. However, its high lipophilicity and thermolability often limits its antioxidant efficacy in human applications. Here, we developed a formulation of lipid carriers to protect astaxanthin's antioxidant activity. The synthesis of natural astaxanthin-loaded nanostructured lipid carriers using a green process with sunflower oil as liquid lipid is presented...
October 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Hongmei Chen, Yonghua Bi, Siyeong Ju, Linxia Gu, Xiaoyan Zhu, Xinwei Han
Hemodynamics may play an essential role in the initiation and progression of abdominal aortic aneurysm (AAA). We aimed to study the mechanism of self-healing process by the changes of hemodynamics and pathology in an enlarging AAA in rabbits. Seventy-two rabbits were randomly divided into three groups. Rabbits underwent extrinsic coarctation and received a 10-minute elastase incubation in Group A and Group B. Absorbable suture used in Group A was terminated by balloon dilation at week 4. Diameter was measured after 1, 3, 5, and 15 weeks, computational fluid dynamics analysis was performed at week 3 and week 15...
2018: PloS One
Chunyu Yuan, Congsong Sun, Yexiang Sun, Qincheng Wang, Biao Wang, Chunhua Wang, Yizhong Tang, Delin Hu, Xingzhao Li, Junhui Song
OBJECTIVE: To explore the mechanism of hypertonic salt solution (HS) alleviates lung injury of rats at the early stage of severe scald. METHODS: Thirty-two female Sprague-Dawley (SD) rats were randomly assigned to sham group, lactated Ringer solution (LR) group, HS200 group (200 mmol/L HS group, 1 L 200 mmol/L HS contained 955 mL LR and 45 mL 10% NaCl) and HS400 group (400 mmol/L HS group, 1 L 400 mmol/L HS contained 846 mL LR and 154 mL 10% NaCl), with 8 rats in each group...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Jia Jia, Na Li, Guofu Li, Bin Zang
OBJECTIVE: To investigate the pathogenesis of early biotrauma in ventilator-induced lung injury (VILI). METHODS: Twenty-four 8-week-old male specific-pathogen-free Sprague-Dawley (SD) rats weighing 250-300 g were randomly divided into sham group (S group), conventional mechanical ventilation group (L group) and high tidal volume (VT) mechanical ventilation group (H group) with 8 rats in each group. All rats received tracheostomy after anesthesia. Rats in S group received no mechanical ventilation but breathe room air spontaneously...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Emran Habibi, Milad Arab-Nozari, Pedram Elahi, Maryam Ghasemi, Fatemeh Shaki
Ethanol is the most widely abused drug in the world in which long term use of ethanol induces oxidative stress in the liver tissue. The aim of this study was to evaluate protective effect of V. odorata against ethanol-induced hepatotoxicity in wistar rat. Animals were divided into nine groups as follows: control (normal saline), ethanol (10 mg/kg, ip), ethanol with three doses (125, 250 and 500 mg/kg) of ethyl acetate flower and leaf extracts and positive control (vitamin E 80mg/kg) were gavaged 30 min before ethanol injection for 28 days...
October 11, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Weiqin Yin, Yongwei Jiang, Shiqing Xu, Zai Wang, Liang Peng, Qing Fang, Tingting Deng, Wanni Zhao, Wenjian Zhang, Jinning Lou
AIMS/INTRODUCTION: Blockade or reversal the progression of diabetic nephropathy is a clinical challenge. To study whether the recombinant human glucagon-like peptide-1 have an effect on alleviate urinary protein and urinary albumin levels in diabetic rats or not. MATERIALS AND METHODS: STZ induced Diabetes Rats were treated with rhGLP-1, Insulin, and Saline. Using Immunostaining, H&E, EM and PAS staining to study the pathology of DN, and we performed qRT-PCR, Western blot and IHC to identify the differentially expressed proteins...
October 11, 2018: Journal of Diabetes Investigation
Chiu-Fen Yang
Acute myocardial ischemia/reperfusion (I/R) injury is a significant, unsolved clinical puzzle. In the disease context of acute myocardial infarction, reperfusion remains the only effective strategy to salvage ischemic myocardium, but it also causes additional damage. Myocardial I/R injury is composed of four types of damage, and these events attenuate the benefits of reperfusion therapy. Thus, inventing new strategies to conquer I/R injury is an unmet clinical need. A variety of pathological processes and mediators, including changes in the pH, generation of reactive oxygen radicals, and intracellular calcium overload, are proposed to be crucial in I/R-related cell injury...
October 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
Alexandre S Hilel, Bruna Gysemans, Maria E M Lisbôa, Ana C Heymanns, Viviane Freiberger, Letícia Ventura, Rachel F Magnago, Clarissa M Comim, Verônica Horewics, Daniel F Martins, Franciane Bobinski, Anna P Piovezan
Citrus species are widely related to antihyperalgesic and anti-inflammatory effects. The aim of this study was to investigate if treatment with ethanolic extract from peels of mature Citrus reticulata Blanco causes antihyperalgesic effects on the referred mechanical hyperalgesia in a model of dextran sulphate of sodium (DSS)-induced colitis in mice, as well as the possible oxidative damage in different regions of the brain induced by its inflammatory reaction. Antihyperalgesia (30 to 300 mg/kg) was investigated by behavioral response (frequency of response to von Frey filament stimulation) in Swiss mice, while damage to central nervous system was investigated through techniques that evaluated oxidative stress using male black C57 BL6 mice (n=8)...
July 2018: Anais da Academia Brasileira de Ciências
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