Fabio Coppedè, Michelangelo Mancuso, Annalisa Lo Gerfo, Cecilia Carlesi, Selina Piazza, Anna Rocchi, Lucia Petrozzi, Claudia Nesti, Dario Micheli, Andrea Bacci, Lucia Migliore, Luigi Murri, Gabriele Siciliano
Amyotropic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease causing the loss of motoneurons of the brain and the spinal cord. The etiology of ALS is still uncertain, but males are at increased risk for the disease than females. Several studies have suggested that motoneurons in ALS might be subjected to the double insult of increased DNA oxidative damage and deficiencies in DNA repair systems. Particularly, increased levels of 8-oxoguanine and impairments of the DNA base excision repair system have been observed in neurons of ALS patients...
June 13, 2007: Neuroscience Letters