keyword
https://read.qxmd.com/read/38218903/brain-targeted-delivery-of-neuroprotective-survival-gene-minimizing-hematopoietic-cell-contamination-implications-for-parkinson-s-disease-treatment
#1
JOURNAL ARTICLE
Min Hak Lee, Sukyeong Kang, Ki-Hwan Um, Seok Won Lee, Hyorin Hwang, Kyunghwa Baek, Jin Woo Choi
BACKGROUND: Neurodegenerative diseases, including Parkinson's disease, Amyotropic Lateral Sclerosis (ALS) and Alzheimer's disease, present significant challenges for therapeutic development due to drug delivery restrictions and toxicity concerns. Prevailing strategies often employ adeno-associated viral (AAV) vectors to deliver neuroprotective survival genes directly into the central nervous system (CNS). However, these methods have been limited by triggering immunogenic responses and risk of tumorigenicity, resulting from overexpression of survival genes in peripheral blood mononuclear cells (PBMC), thereby increasing the risk of tumorigenicity in specific immune cells...
January 13, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/37546945/international-perspective-on-physician-knowledge-attitude-and-practices-related-to-medical-cannabis
#2
Shariful A Syed, Jatinder Singh, Hussien Elkholy, Irena Rojnic Palavra, Marko Tomicevic, Anamarija Petek Eric, Mariana Pinto da Costa, Sinan Guloksuz, Rajiv Radhakrishnan
BACKGROUND: The trends of recreational use of cannabis and use of cannabis for medical indications (i.e. "medical cannabis") have grown in recent years. Despite that, there is still limited scientific evidence to guide clinical decision-making and the strength of evidence for the medical use of cannabis is currently considered to be low. In contrast, there's growing evidence for negative health outcomes related to use of cannabis. In this rapidly shifting landscape, the role of physician's attitudes regarding the therapeutic value of cannabis has become essential...
July 27, 2023: medRxiv
https://read.qxmd.com/read/37027074/the-use-of-stem-cells-as-a-potential-treatment-method-for-selected-neurodegenerative-diseases-review
#3
REVIEW
Elżbieta Cecerska-Heryć, Maja Pękała, Natalia Serwin, Marta Gliźniewicz, Bartłomiej Grygorcewicz, Anna Michalczyk, Rafał Heryć, Marta Budkowska, Barbara Dołęgowska
Stem cells have been the subject of research for years due to their enormous therapeutic potential. Most neurological diseases such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) are incurable or very difficult to treat. Therefore new therapies are sought in which autologous stem cells are used. They are often the patient's only hope for recovery or slowing down the progress of the disease symptoms. The most important conclusions arise after analyzing the literature on the use of stem cells in neurodegenerative diseases...
August 2023: Cellular and Molecular Neurobiology
https://read.qxmd.com/read/34682454/potential-implications-of-mammalian-transient-receptor-potential-melastatin-7-in-the-pathophysiology-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome-a-review
#4
REVIEW
Stanley Du Preez, Helene Cabanas, Donald Staines, Sonya Marshall-Gradisnik
The transient receptor potential (TRP) superfamily of ion channels is involved in the molecular mechanisms that mediate neuroimmune interactions and activities. Recent advancements in neuroimmunology have identified a role for TRP cation channels in several neuroimmune disorders including amyotropic lateral sclerosis, multiple sclerosis, and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS is a debilitating disorder with an obscure aetiology, hence considerable examination of its pathobiology is warranted...
October 12, 2021: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/33580145/mechanism-of-karyopherin-%C3%AE-2-binding-and-nuclear-import-of-als-variants-fus-p525l-and-fus-r495x
#5
JOURNAL ARTICLE
Abner Gonzalez, Taro Mannen, Tolga Çağatay, Ayano Fujiwara, Hiroyoshi Matsumura, Ashley B Niesman, Chad A Brautigam, Yuh Min Chook, Takuya Yoshizawa
Mutations in the RNA-binding protein FUS cause familial amyotropic lateral sclerosis (ALS). Several mutations that affect the proline-tyrosine nuclear localization signal (PY-NLS) of FUS cause severe juvenile ALS. FUS also undergoes liquid-liquid phase separation (LLPS) to accumulate in stress granules when cells are stressed. In unstressed cells, wild type FUS resides predominantly in the nucleus as it is imported by the importin Karyopherin-β2 (Kapβ2), which binds with high affinity to the C-terminal PY-NLS of FUS...
February 12, 2021: Scientific Reports
https://read.qxmd.com/read/33410456/ceramide-contributes-to-pathogenesis-and-may-be-targeted-for-therapy-in-vcp-inclusion-body-myopathy
#6
JOURNAL ARTICLE
Lan Weiss, Kwang-Mook Jung, Angele Nalbandian, Katrina Llewellyn, Howard Yu, Lac Ta, Isabela Chang, Marco Migliore, Erica Squire, Faizy Ahmed, Daniele Piomelli, Virginia Kimonis
Knock-in homozygote VCPR155H/R155H mutant mice are a lethal model of valosin-containing protein (VCP)-associated inclusion body myopathy associated with Paget disease of bone, frontotemporal dementia and amyotrophic lateral sclerosis. Ceramide (d18:1/16:0) levels are elevated in skeletal muscle of the mutant mice, compared to wild-type controls. Moreover, exposure to a lipid-enriched diet reverses lethality, improves myopathy and normalizes ceramide levels in these mutant mice, suggesting that dysfunctions in lipid-derived signaling are critical to disease pathogenesis...
February 25, 2021: Human Molecular Genetics
https://read.qxmd.com/read/33369921/severe-hyponatremia-secondary-to-riluzole-therapy-in-amyotropic-lateral-sclerosis
#7
JOURNAL ARTICLE
Ajay Tambe, Stephen Knohl, Harvir Singh Gambhir, Vikrant Tambe
No abstract text is available yet for this article.
January 2021: American Journal of Therapeutics
https://read.qxmd.com/read/32967368/genome-wide-analysis-points-towards-subtype-specific-diseases-in-different-genetic-forms-of-amyotrophic-lateral-sclerosis
#8
JOURNAL ARTICLE
Banaja P Dash, Marcel Naumann, Jared Sterneckert, Andreas Hermann
Amyotropic lateral sclerosis (ALS) is a lethally progressive and irreversible neurodegenerative disease marked by apparent death of motor neurons present in the spinal cord, brain stem and motor cortex. While more and more gene mutants being established for genetic ALS, the vast majority suffer from sporadic ALS (>90%). It has been challenging, thus, to model sporadic ALS which is one reason why the underlying pathophysiology remains elusive and has stalled the development of therapeutic strategies of this progressive motor neuron disease...
September 21, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/32162127/neurodegeneration-by-oxidative-stress-a-review-on-prospective-use-of-small-molecules-for-neuroprotection
#9
REVIEW
Ekta Singh, Giles Devasahayam
The intricate physiology of many Central Nervous System (CNS) disorders points towards oxidative damages of neurons. Various studies have established that oxidative stress is a big threat to integrity of neurons. All the sections of central nervous system are exposed to free radicals and charged species formed during oxidative degradation of catecholamines and polyunsaturated fatty acids which are present abundantly in CNS. By products of other biochemical reactions also contribute to oxidative stress in central nervous system...
April 2020: Molecular Biology Reports
https://read.qxmd.com/read/29970123/dnmt1-regulates-expression-of-mhc-class-i-in-post-mitotic-neurons
#10
JOURNAL ARTICLE
Julie Ry Gustafsson, Georgia Katsioudi, Matilda Degn, Patrick Ejlerskov, Shohreh Issazadeh-Navikas, Birgitte Rahbek Kornum
Major Histocompability Complex I (MHC-I) molecules present cellularly derived peptides to the adaptive immune system. Generally MHC-I is not expressed on healthy post-mitotic neurons in the central nervous system, but it is known to increase upon immune activation such as viral infections and also during neurodegenerative processes. MHC-I expression is known to be regulated by the DNA methyltransferase DNMT1 in non-neuronal cells. Interestingly DNMT1 expression is high in neurons despite these being non-dividing...
July 3, 2018: Molecular Brain
https://read.qxmd.com/read/29207498/steppogenin-isolated-from-cudrania-tricuspidata-shows-antineuroinflammatory-effects-via-nf-%C3%AE%C2%BAb-and-mapk-pathways-in-lps-stimulated-bv2-and-primary-rat-microglial-cells
#11
JOURNAL ARTICLE
Dong-Cheol Kim, Tran Hong Quang, Hyuncheol Oh, Youn-Chul Kim
Excessive microglial stimulation has been recognized in several neurodegenerative diseases, including Parkinson's disease (PD), Alzheimer's disease (AD), amyotropic lateral sclerosis (ALS), HIV-associated dementia (HAD), multiple sclerosis (MS), and stroke. When microglia are stimulated, they produce proinflammatory mediators and cytokines, including nitric oxide (NO) derived from inducible NO synthase (iNOS), prostaglandin E2 (PGE₂) derived from cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-12 (IL-12), and interleukin-6 (IL-6)...
December 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/28904554/plants-derived-neuroprotective-agents-cutting-the-cycle-of-cell-death-through-multiple-mechanisms
#12
REVIEW
Taiwo Olayemi Elufioye, Tomayo Ireti Berida, Solomon Habtemariam
Neuroprotection is the preservation of the structure and function of neurons from insults arising from cellular injuries induced by a variety of agents or neurodegenerative diseases (NDs). The various NDs including Alzheimer's, Parkinson's, and Huntington's diseases as well as amyotropic lateral sclerosis affect millions of people around the world with the main risk factor being advancing age. Each of these diseases affects specific neurons and/or regions in the brain and involves characteristic pathological and molecular features...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/28525376/exploiting-ros-and-metabolic-differences-to-kill-cisplatin-resistant-lung-cancer
#13
JOURNAL ARTICLE
Medhi Wangpaichitr, Chunjing Wu, Ying Ying Li, Dan J M Nguyen, Hande Kandemir, Sumedh Shah, Shumei Chen, Lynn G Feun, Jeffrey S Prince, Macus T Kuo, Niramol Savaraj
Cisplatin resistance remains a major problem in the treatment of lung cancer. We have discovered that cisplatin resistant (CR) lung cancer cells, regardless of the signaling pathway status, share the common parameter which is an increase in reactive oxygen species (ROS) and undergo metabolic reprogramming. CR cells were no longer addicted to the glycolytic pathway, but rather relied on oxidative metabolism. They took up twice as much glutamine and were highly sensitive to glutamine deprivation. Glutamine is hydrolyzed to glutamate for glutathione synthesis, an essential factor to abrogate high ROS via xCT antiporter...
July 25, 2017: Oncotarget
https://read.qxmd.com/read/27867042/poly-adp-ribose-polymerase-1-hyperactivation-in-neurodegenerative-diseases-the-death-knell-tolls-for-neurons
#14
REVIEW
Parimala Narne, Vimal Pandey, Praveen Kumar Simhadri, Prakash Babu Phanithi
Neurodegeneration is a salient feature of chronic refractory brain disorders like Alzheimer's, Parkinson's, Huntington's, amyotropic lateral sclerosis and acute conditions like cerebral ischemia/reperfusion etc. The pathological protein aggregates, mitochondrial mutations or ischemic insults typifying these disease conditions collude with and intensify existing oxidative stress and attendant mitochondrial dysfunction. Interlocking these mechanisms is poly(ADP-ribose) polymerase (PARP-1) hyperactivation that invokes a distinct form of neuronal cell death viz...
March 2017: Seminars in Cell & Developmental Biology
https://read.qxmd.com/read/27731563/myasthenia-gravis-with-amyotropic-lateral-sclerosis-a-rare-co-existence
#15
JOURNAL ARTICLE
Smrati Bajpai, Nikhil Bhasin, Kavita Joshi, Milind Y Nadkar, A R Pazare
The co-occurrence of myasthenia gravis with motor neurone disease is not a very common association and may pose problem and confusion in the minds of the treating physician because of the gamut of neurological symptoms. This case intends to highlight these dilemmas.
March 2016: Journal of the Association of Physicians of India
https://read.qxmd.com/read/27476503/dynamic-expression-of-the-mouse-orthologue-of-the-human-amyotropic-lateral-sclerosis-associated-gene-c9orf72-during-central-nervous-system-development-and-neuronal-differentiation
#16
JOURNAL ARTICLE
Ross Ferguson, Eleni Serafeimidou-Pouliou, Vasanta Subramanian
The hexanucleotide repeat in the first intron of the C9orf72 gene is the most significant cause of amyotropic lateral sclerosis as well as some forms of fronto-temporal dementia. The C9orf72 protein has been previously reported to be expressed in post-mortem human brain as well as in late embryonic and some postnatal stages in mice. Herein, we present a detailed study of the distribution of C9orf72 protein in the embryonic, postnatal and adult mouse brain, spinal cord as well as during the differentiation of P19 embryonal carcinoma cells to neurons including motor neurons...
December 2016: Journal of Anatomy
https://read.qxmd.com/read/24040821/therapeutic-effects-of-progesterone-in-animal-models-of-neurological-disorders
#17
REVIEW
Alejandro F De Nicola, Florencia Coronel, Laura I Garay, Gisella Gargiulo-Monachelli, Maria Claudia Gonzalez Deniselle, Susana L Gonzalez, Florencia Labombarda, Maria Meyer, Rachida Guennoun, Michael Schumacher
Substantial evidence supports that progesterone exerts many functions in the central and peripheral nervous system unrelated to its classical role in reproduction. In this review we first discussed progesterone effects following binding to the classical intracellular progesterone receptors A and B and several forms of membrane progesterone receptors, the modulation of intracellular signalling cascades and the interaction of progesterone reduced metabolites with neurotransmitter receptors. We next described our results involving animal models of human neuropathologies to elucidate the protective roles of progesterone...
December 2013: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/23983606/glutamate-signaling-in-benign-and-malignant-disorders-current-status-future-perspectives-and-therapeutic-implications
#18
REVIEW
Stacey S Willard, Shahriar Koochekpour
Glutamate, a nonessential amino acid, is the major excitatory neurotransmitter in the central nervous system. As such, glutamate has been shown to play a role in not only neural processes, such as learning and memory, but also in bioenergetics, biosynthetic and metabolic oncogenic pathways. Glutamate has been the target of intense investigation for its involvement not only in the pathogenesis of benign neurodegenerative diseases (NDDs) such as Parkinson's disease, Alzheimer's disease, schizophrenia, multiple sclerosis, and amyotropic lateral sclerosis (ALS), but also in carcinogenesis and progression of malignant diseases...
2013: International Journal of Biological Sciences
https://read.qxmd.com/read/23834335/fused-in-sarcoma-is-a-novel-regulator-of-manganese-superoxide-dismutase-gene-transcription
#19
JOURNAL ARTICLE
Sanjit Kumar Dhar, Jiayu Zhang, Jozsef Gal, Yong Xu, Lu Miao, Bert C Lynn, Haining Zhu, Edward J Kasarskis, Daret K St Clair
AIMS: FUsed in sarcoma (FUS) is a multifunctional DNA/RNA-binding protein that possesses diverse roles, such as RNA splicing, RNA transport, DNA repair, translation, and transcription. The network of enzymes and processes regulated by FUS is far from being fully described. In this study, we have focused on the mechanisms of FUS-regulated manganese superoxide dismutase (MnSOD) gene transcription. RESULTS: Here we demonstrate that FUS is a component of the transcription complex that regulates the expression of MnSOD...
April 1, 2014: Antioxidants & Redox Signaling
https://read.qxmd.com/read/23500882/effects-of-hominis-placenta-on-lps-induced-cell-toxicity-in-bv2-microglial-cells
#20
JOURNAL ARTICLE
Kang-Woo Lee, Hye Min Ji, Dong Woung Kim, Sun-Mi Choi, Sungchul Kim, Eun Jin Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Hominis placenta (HP) dried placenta extracted from pregnant women after delivery has been widely used to treat chronic inflammatory diseases. HP has been reported to be effective to alleviate the arthritic symptoms by modulating the expression of inflammatory factors in adjuvant-induced arthritis rats. However, the mechanism of action of HP is unknown. Neuroinflammation has been implicated in the pathogenesis of several neurodegenerative disease, including Alzheimer's disease (AD), Parkinson's disease (PD) and amyotropic lateral sclerosis (ALS)...
May 20, 2013: Journal of Ethnopharmacology
keyword
keyword
167255
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.