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JOURNAL ARTICLE
Davide Agnoletti, Guido Arcaro, Giuliana Scaturro, Emanuela Turcato, Elisa Grison, Elena Ferrari, Stefano Bonapace, Giovanni Targher, Filippo Valbusa
BACKGROUND: Heart failure (HF) is a major cause of death among the elderly. Its prevalence increases dramatically with age. The prevalence of malnourished subjects is high in hospitalized elderly patients. We aimed to investigate the prognostic role of malnutrition, assessed by controlling nutritional status (CONUT) score, on adverse clinical outcomes in the elderly admitted for acute HF. METHODS: We enrolled 293 patients (mean age 84 years; 48% men) consecutively admitted for acute HF to the Internal Medicine or Geriatrics Divisions at the 'IRCCS Sacro Cuore-Don Calabria' Hospital of Negrar (Verona, Italy) from 2013 to 2015...
June 2023: Internal and Emergency Medicine
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JOURNAL ARTICLE
Maura Ravera, Paolo Mené, Luca Degli Esposti, Diego Sangiorgi, Paolo Di Rienzo
Background. This real-world study aimed to provide insights on the characteristics, drug utilization, and economic burden of chronic kidney disease non-dialysis-dependent (NDD-CKD) patients with anemia prescribed Erythropoiesis Stimulating Agents (ESA) in Italian clinical practice settings. Methods. A retrospective analysis was performed based on administrative and laboratory databases covering around 1.5 million subjects across Italy. Adult patients with a record for NDD-CKD stage 3a-5 and anemia during 2014-2016 were identified...
February 27, 2023: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
#23
JOURNAL ARTICLE
Silvio Buscemi, Chiara Davoli, Enrico Maria Trecarichi, Helen Linda Morrone, Bruno Tassone, Carola Buscemi, Cristiana Randazzo, Anna Maria Barile, Piero Colombrita, Maurizio Soresi, Lydia Giannitrapani, Antonio Cascio, Nicola Scichilone, Carlo Cottone, Paolo Sbraccia, Valeria Guglielmi, Frida Leonetti, Alexis Elias Malavazos, Sara Basilico, Michele Carruba, Ferruccio Santini, Alessandro Antonelli, Nicola Viola, Marcello Romano, Bruno Mario Cesana, Carlo Torti
BACKGROUND: There is a scarcity of information in literature regarding the clinical differences and comorbidities of patients affected by Coronavirus disease 2019 (COVID-19), which could clarify the different prevalence of the outcomes (composite and only death) between several Italian regions. OBJECTIVE: This study aimed to assess the heterogeneity of clinical features of patients with COVID-19 upon hospital admission and disease outcomes in the northern, central, and southern Italian regions...
April 2023: Journal of Infection and Public Health
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JOURNAL ARTICLE
Silvio Borrelli, Carlo Garofalo, Francis B Gabbai, Maria Elena Liberti, Paolo Chiodini, Vittorio Simeon, Luca De Nicola, Roberto Minutolo
BACKGROUND: Progression of chronic kidney disease (CKD) has proven to be faster in men than in women. Whether the same holds true for cardiovascular risk remains ill-defined. METHODS: We conducted a pooled analysis of 4 cohort studies from 40 nephrology clinics in Italy including patients with CKD (estimated GFR<60 ml/min/1.73m2 or higher if proteinuria > 0.15 g/day). The aim was to compare multivariable-adjusted risk (Hazard Ratio, 95% Confidence Interval) of a composite cardiovascular endpoint (cardiovascular death and non-fatal myocardial infarction, congestive heart failure, stroke, revascularization, peripheral vascular disease, and non-traumatic amputation) in women (n = 1 192) versus men (n = 1 635)...
February 16, 2023: Nephrology, Dialysis, Transplantation
#25
JOURNAL ARTICLE
Sara Mahdavi, Paolo Palatini, Ahmed El-Sohemy
IMPORTANCE: Caffeine is detoxified by cytochrome P450 1A2 (CYP1A2), and genetic variation in CYP1A2 impacts the rate of caffeine clearance. Factors that may modify the association between coffee intake and kidney disease remain unclear. OBJECTIVE: To assess whether CYP1A2 genotype modifies the association between coffee intake and kidney dysfunction. DESIGN, SETTING, AND PARTICIPANTS: The Hypertension and Ambulatory Recording Venetia Study (HARVEST) was a prospective cohort study of individuals with stage 1 hypertension in Italy; HARVEST began on April 1, 1990, and follow-up is ongoing...
January 3, 2023: JAMA Network Open
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JOURNAL ARTICLE
Davide Voci, Ugo Fedeli, Luca Valerio, Elena Schievano, Marc Righini, Nils Kucher, David Spirk, Stefano Barco
BACKGROUND AND AIMS: Peripheral arterial disease (PAD) is one of the most prevalent cardiovascular diseases with more than 230 million people being affected worldwide. As highlighted by the recent European Society of Cardiology guidelines, data on the epidemiology of PAD is urgently needed. METHODS AND RESULTS: We accessed the vital registration data of the Veneto region (Northern Italy, approximately five millions inhabitants) covering the period 2008-2019. We computed annual age-standardized rates for PAD reported as the underlying cause of death (UCOD) or as one of multiple causes of death (MCOD)...
November 28, 2022: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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JOURNAL ARTICLE
Irene Dell'Anno, Silvia Calabria, Letizia Dondi, Giulia Ronconi, Leonardo Dondi, Alice Addesi, Antonella Pedrini, Immacolata Esposito, Aldo Pietro Maggioni, Nello Martini, Carlo Piccinni
INTRODUCTION: The adoption of a Care Pathway (CP) allows the healthcare management of patients suffering from high-epidemiological impact chronic diseases. The continuity of care of these patients is one of the main purposes of the community-based healthcare reform, foreseen in the 6th Mission of the National recovery and resilience plan. Fondazio-ne Ricerca e Salute (ReS) collects and analyses regional CPs approved in Italy, through the Pdta Net database. METHODS: Fondazione ReS has retrieved all the CPs approved by Italian Regions and Autonomous provinces until 12/31/2021 within institutional websites, through specific keywords...
January 2023: Recenti Progressi in Medicina
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JOURNAL ARTICLE
Pasquale Mone, Angela Lombardi, Luigi Salemme, Angelo Cioppa, Grigore Popusoi, Fahimeh Varzideh, Antonella Pansini, Stanislovas S Jankauskas, Imma Forzano, Roberta Avvisato, Xujun Wang, Tullio Tesorio, Gaetano Santulli
OBJECTIVE: Ischemia with nonobstructive coronary arteries (INOCA) is a prevailing finding in patients with angina. However, the main factors underlying the risk of being rehospitalized for chest pain in patients with INOCA remain mostly unknown. RESEARCH DESIGN AND METHODS: We evaluated INOCA patients referred to the "Casa di Cura Montevergine" in Mercogliano (Avellino), Italy, from January 2016 to January 2021 for percutaneous coronary intervention (PCI). In these subjects, we assessed the impact of the stress hyperglycemia ratio (SHR), defined as the ratio of mmol/L blood glucose and % HbA1c, on the risk of rehospitalization for chest pain...
February 1, 2023: Diabetes Care
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JOURNAL ARTICLE
Domenica Matranga, Laura Maniscalco, Marco Enea, Dario De Luca, Davide Brancato, Emanuele La Spada, Alessandro Scorsone, Paola Di Carlo
INTRODUCTION: Clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in old adults from Southern Italy is little known. This study aims to investigate the mortality risk related to risk factors, therapy and clinical course and to suggest prognostic indicators based on day-to-day follow-up of clinical and laboratory findings. MATERIAL AND METHODS: It was designed as a retrospective longitudinal cohort study of adult SARS-CoV-2 patients admitted at Partinico COVID Hospital in Palermo, Southern Italy...
2022: Archives of Medical Science: AMS
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JOURNAL ARTICLE
Federica Piani, Emanuela Di Salvo, Matteo Landolfo, Ilaria Maria Saracino, Davide Agnoletti, Claudio Borghi, Giulia Fiorini
BACKGROUND AND AIMS: COVID-19-associated acute kidney injury (AKI) represents an independent risk factor for all-cause in-hospital death in patients with COVID-19. Chronic statin therapy use is highly prevalent in individuals at risk for severe COVID-19. Our aim is to assess whether patients under treatment with statins have a lower risk of AKI and in-hospital mortality during hospitalization for interstitial SARS-CoV2 pneumonia. METHODS AND RESULTS: Our study is a prospective observational study on 269 consecutive patients admitted for COVID-19 pneumonia at the Internal Medicine Unit of IRCCS Sant'Orsola Hospital in Bologna, Italy...
October 18, 2022: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#31
JOURNAL ARTICLE
Luke E Barry, Grainne E Crealey, Paul Cockwell, Stephen J Elliman, Matthew D Griffin, Alexander P Maxwell, Timothy O'Brien, Norberto Perico, Ciaran O'Neill
BACKGROUND AND OBJECTIVES: To simulate the cost-effectiveness of Mesenchymal Stromal Cell (MSC) therapy compared to sodium/glucose co-transporter 2 inhibitors (SGLT2i) or usual care (UC) in treating patients with Diabetic Kidney Disease (DKD). DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: This Markov-chain Monte Carlo model adopted a societal perspective and simulated 10,000 patients with DKD eligible for MSC therapy alongside UC using a lifetime horizon. This cohort was compared with an SGLT2i alongside UC arm and a UC only arm...
2022: PloS One
#32
JOURNAL ARTICLE
Filippo Aucella, Andrea Corsonello, Luca Soraci, Paolo Fabbietti, Michele Antonio Prencipe, Giuseppe Gatta, Fabrizia Lattanzio, Livio Cortese, Maria Rosaria Pagnotta, Raffaele Antonelli Incalzi
Older hospitalized patients with chronic kidney disease (CKD) are part of the geriatric population with a substantial risk of potentially inappropriate medication (PIM) use. The high rates of multimorbidity and polypharmacy, along with the progressive decline of eGFR, contribute to increasing the risk of drug-drug and drug-disease interactions, overdosing, and adverse drug reactions (ADRs). In this multicenter cross-sectional study, we aimed to evaluate the prevalence of CKD under-reporting and PIMs among older patients discharged from acute geriatric and nephrology units throughout Italy...
2022: Frontiers in Pharmacology
#33
JOURNAL ARTICLE
Riccardo Rinaldi, Mattia Basile, Carmine Salzillo, Domenico Luca Grieco, Andrea Caffè, Carlotta Masciocchi, Livia Lilli, Andrea Damiani, Giulia La Vecchia, Giulia Iannaccone, Alice Bonanni, Gennaro De Pascale, Rita Murri, Massimo Fantoni, Giovanna Liuzzo, Tommaso Sanna, Massimo Massetti, Antonio Gasbarrini, Vincenzo Valentini, Massimo Antonelli, Filippo Crea, Rocco Antonio Montone, On Behalf Of The Gemelli Against Covid Group
Background: Cardiovascular sequelae after COVID-19 are frequent. However, the predictors for their occurrence are still unknown. In this study, we aimed to assess whether myocardial injury during COVID-19 hospitalization is associated to CV sequelae and death after hospital discharge. Methods: In this prospective observational study, consecutive patients who were admitted for COVID-19 in a metropolitan COVID-19 hub in Italy, between March 2021 and January 2022, with a ≥ 1 assessment of high sensitivity cardiac troponin I (hs-cTnI) were included in the study, if they were alive at hospital discharge...
October 10, 2022: Journal of Clinical Medicine
#34
REVIEW
Manuela Tamburro, Giancarlo Ripabelli, Angelo Salzo, Michela Lucia Sammarco
OBJECTIVES: to provide an outline of the factors mainly influencing severe disease and fatal outcome among Italian COVID-19 patients in the pre-vaccination phase, also describing the impact of the scenarios driven by variants, vaccines, and available therapies. DESIGN: a literature search was carried out for peer-reviewed articles searching for COVID-19 and prognosis, including severe disease and death. SETTING AND PARTICIPANTS: Italian patients with COVID-19...
May 2022: Epidemiologia e Prevenzione
#35
JOURNAL ARTICLE
Cecilia Acuti Martellucci, Maria Elena Flacco, Graziella Soldato, Giuseppe Di Martino, Roberto Carota, Antonio Caponetti, Lamberto Manzoli
We performed a cohort analysis of the entire population of Abruzzo, Italy, to evaluate the real-world effectiveness of SARS-CoV-2 vaccines against infection, COVID-19 hospitalization or death, over time and during the Omicron wave. All resident or domiciled subjects were included, and official vaccination, COVID-19, demographic, hospital and co-pay exemption datasets were extracted up to 18 February 2022. Multivariable analyses were adjusted for age, gender, hypertension, diabetes, major cardio- and cerebrovascular events, COPD, kidney diseases, and cancer...
April 22, 2022: Vaccines
#36
JOURNAL ARTICLE
Kristin Kostka, Talita Duarte-Salles, Albert Prats-Uribe, Anthony G Sena, Andrea Pistillo, Sara Khalid, Lana Y H Lai, Asieh Golozar, Thamir M Alshammari, Dalia M Dawoud, Fredrik Nyberg, Adam B Wilcox, Alan Andryc, Andrew Williams, Anna Ostropolets, Carlos Areia, Chi Young Jung, Christopher A Harle, Christian G Reich, Clair Blacketer, Daniel R Morales, David A Dorr, Edward Burn, Elena Roel, Eng Hooi Tan, Evan Minty, Frank DeFalco, Gabriel de Maeztu, Gigi Lipori, Hiba Alghoul, Hong Zhu, Jason A Thomas, Jiang Bian, Jimyung Park, Jordi Martínez Roldán, Jose D Posada, Juan M Banda, Juan P Horcajada, Julianna Kohler, Karishma Shah, Karthik Natarajan, Kristine E Lynch, Li Liu, Lisa M Schilling, Martina Recalde, Matthew Spotnitz, Mengchun Gong, Michael E Matheny, Neus Valveny, Nicole G Weiskopf, Nigam Shah, Osaid Alser, Paula Casajust, Rae Woong Park, Robert Schuff, Sarah Seager, Scott L DuVall, Seng Chan You, Seokyoung Song, Sergio Fernández-Bertolín, Stephen Fortin, Tanja Magoc, Thomas Falconer, Vignesh Subbian, Vojtech Huser, Waheed-Ul-Rahman Ahmed, William Carter, Yin Guan, Yankuic Galvan, Xing He, Peter R Rijnbeek, George Hripcsak, Patrick B Ryan, Marc A Suchard, Daniel Prieto-Alhambra
Purpose: Routinely collected real world data (RWD) have great utility in aiding the novel coronavirus disease (COVID-19) pandemic response. Here we present the international Observational Health Data Sciences and Informatics (OHDSI) Characterizing Health Associated Risks and Your Baseline Disease In SARS-COV-2 (CHARYBDIS) framework for standardisation and analysis of COVID-19 RWD. Patients and Methods: We conducted a descriptive retrospective database study using a federated network of data partners in the United States, Europe (the Netherlands, Spain, the UK, Germany, France and Italy) and Asia (South Korea and China)...
2022: Clinical Epidemiology
#37
JOURNAL ARTICLE
Mariam Al Harbi, Nawal Al Kaabi, Asma Al Nuaimi, Jehad Abdalla, Tehmina Khan, Huda Gasmelseed, Asad Khan, Osama Hamdoun, Stefan Weber
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019. The severity of coronavirus disease 2019 (COVID-19) ranges from asymptomatic to severe and potentially fatal. We aimed to describe the clinical and laboratory features and outcomes of hospitalised patients with COVID-19 within the Abu Dhabi Healthcare Services Facilities (SEHA). METHODS: Our retrospective analysis of patient data collected from electronic health records (EHRs) available from the SEHA health information system included all patients admitted from 1 March to 31 May 2020 with a laboratory-confirmed PCR diagnosis of SARS-CoV-2 infection...
February 8, 2022: BMC Infectious Diseases
#38
JOURNAL ARTICLE
Valerio Bertino, Olga Credendino, Livia Sorrentino, Pietro Alinei, Deborah Avino, Marianna Bencivenga, Claudia Coppola, Marco Del Prete, Tito Di Muro, Ciriana Evangelista, Paolo Giannattasio, MariaRosaria Iannuzzi, Giacomo Lus, Raffaele Meo, Davide Stellato, Francesca Iacobellis, Luigia Romano, Valentina De Angelis, Margherita Perrotta, Silvio Borrelli
Background: SARS‑CoV‑2-induced severe acute respiratory syndrome is associated with high mortality in the general population; however, the data on chronic haemodialysis (HD) patients are currently scarce. Methods: We performed a retrospective analysis to evaluate the onset of acute respiratory distress syndrome (ARDS) in patients with SARS‑CoV‑2-induced interstitial pneumonia diagnosed by PCR test and detected by high resolution computed tomography (HRCT). For each patient, we calculated a CT score between 0 and 24, based on the severity of pneumonia...
December 16, 2021: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
#39
JOURNAL ARTICLE
Paola Senia, Francesca Vella, Nicola Mucci, George Dounias, Antonio Trovato, Andrea Marconi, Caterina Ledda, Venerando Rapisarda, Ermanno Vitale
According to the Centre for Disease Control and Prevention in 2020, a cluster of pneumonia cases of unknown etiology caused by the severe acute respiratory syndrome (SARS)-coronavirus 2 was reported in Wuhan, China. The present review examined the literature to reveal the incidence of novel coronavirus-2019 disease (COVID-19) infections, underlying comorbidities, workplace infections and case fatality rates. A review was performed to identify the relevant publications available up to May 15, 2020. Since the early stages of the COVID-19 outbreak, the case fatality rate among healthcare workers (HCWs) has stood at 0...
January 2022: Experimental and Therapeutic Medicine
#40
JOURNAL ARTICLE
Alessandro Nuzzo, Andrea Brignoli, Maria C Ponziani, Marco Zavattaro, Flavia Prodam, Luigi M Castello, Gian C Avanzi, Paolo Marzullo, Gianluca Aimaretti
BACKGROUND AND AIMS: To assess the risk of hospitalization and mortality within 1 year of severe hypoglycaemia and theirs clinical predictors. METHODS AND RESULTS: We retrospectively examined 399 admissions for severe hypoglycemia in adults with DM at the Emergency Department (ED) of the University Hospital of Novara (Italy) between 2012-2017, and we compared the clinical differences between older (aged ≥65 years) and younger individuals (aged 18-64 years). A logistic regression model was used to explore predictors of hospitalization following ED access and 1-year later, according to cardiovascular (CV) or not (no-CV) reasons; 1-year all-cause mortality was also detected...
January 2022: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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