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Diabetes italy

Antonio Furlan, Roberto Stramare
PURPOSE: To investigate the frequency of thickening of pulleys for flexor tendons in patients with early arthritis in their hands, and to evaluate it as a predictive sign of PsA. METHODS: A prospective observational study involving 228 consecutive patients presenting with recent onset of arthritis in their hands was conducted at rheumatology outpatient clinics in the Veneto region of Italy between October 2014 and September 2017. Diabetic patients were excluded because of the high frequency of trigger finger...
October 15, 2018: Journal of Ultrasound
S Toselli, E Gualdi-Russo, F Campa
BACKGROUND: The present study compared the prevalence of obesity, fat distribution, body image perception and lifestyle among diabetic African and Albanian immigrants living in Italy, as well as diabetic Italians, aiming to identify health risks and their possible causes. METHODS: The study sample consisted of 200 diabetic subjects living in Italy. A questionnaire regarding socio-demographic and lifestyle information was administered to participants, and anthropometric measurements and body image perception were assessed...
October 14, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
Albino Carrizzo, Carmine Izzo, Marco Oliveti, Antonia Alfano, Nicola Virtuoso, Mario Capunzo, Paola Di Pietro, Mariaconsiglia Calabrese, Eros De Simone, Sebastiano Sciarretta, Giacomo Frati, Serena Migliarino, Antonio Damato, Mariateresa Ambrosio, Francesco De Caro, Carmine Vecchione
Diabetes mellitus is a common disease that affects 3⁻5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6⁻8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients...
September 28, 2018: International Journal of Molecular Sciences
Michael A Nauck, John B Buse, Johannes F E Mann, Stuart Pocock, Heidrun Bosch-Traberg, Helle Frimer-Larsen, Qing Ye, Alastair Gray
AIMS: Health-related quality of life (HRQoL) is an important outcome for patients with type 2 diabetes (T2D). HRQoL was assessed in the LEADER cardiovascular outcomes trial using the European Quality of Life - 5 Dimensions (EQ-5D) instrument. MATERIALS AND METHODS: The EQ-5D was administered every 12 months in a subset of patients from Canada, Denmark, Germany, Ireland, Italy, Netherlands, Spain, Sweden, UK and US. We compared changes in utility index scores and visual analogue scale (VAS) scores from baseline to 36 months in patients treated with liraglutide and placebo...
September 27, 2018: Diabetes, Obesity & Metabolism
Vera Frison, Natalino Simioni, Alberto Marangoni, Sara Balzano, Carmela Vinci, Luciano Zenari, Lorena De Moliner, Federica Tadiotto, Michele D'Ambrosio, Loris Confortin, Narciso Marin, Simonetta Lombardi, Silvana Costa, Giuseppe Prosperini, Annunziata Lapolla
INTRODUCTION: Based on existing data regarding the durability of liraglutide in type 2 diabetes, this study aimed to assess its long-term effectiveness at 5 years and its overall impact on cardiovascular (CV) risk. METHODS: This was a multicenter retrospective observational study. Liraglutide was used under routine clinical practice conditions. Changes from baseline to 60 months in HbA1c, fasting plasma glucose (FPG), body weight, blood pressure, and lipid profile were assessed...
September 20, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Claudia Torino, Patrizia Pizzini, Sebastiano Cutrupi, Maurizio Postorino, Giovanni Tripepi, Francesca Mallamaci, Jochen Reiser, Carmine Zoccali
Introduction: The soluble receptor of urokinase plasminogen activator (suPAR) is an innate immunity/inflammation biomarker predicting cardiovascular (CV) and non-CV events in various conditions, including type 2 diabetic patients on dialysis. However, the relationship between suPAR and clinical outcomes in the hemodialysis population at large has not been tested. Methods: We measured plasma suPAR levels (R&D enzyme-linked immunosorbent assay [ELISA]) in 1038 hemodialysis patients with a follow-up of 2...
September 2018: KI Reports
Marco DiBonaventura, Antonio Nicolucci, Henrik Meincke, Agathe Le Lay, Janine Fournier
Purpose: This study investigated the association between body mass index (BMI) and three comorbid conditions (type 2 diabetes [T2D], prediabetes, and hypertension) on humanistic and economic outcomes. Patients and methods: This retrospective observational study collected data from German (n=14286) and Italian (n=9433) respondents to the 2013 European Union National Health and Wellness Survey, a cross-sectional, nationally representative online survey of the general adult population...
2018: ClinicoEconomics and Outcomes Research: CEOR
Elena Olmastroni, Evgeny V Shlyakhto, Aleksandra O Konradi, Oxana P Rotar, Asiiat S Alieva, Maria A Boyarinova, Andrea Baragetti, Liliana Grigore, Fabio Pellegatta, Elena Tragni, Alberico L Catapano, Manuela Casula
We aimed to compare cardiovascular risk factors prevalence in Italy and Russia through cross-sectional database analysis. The study has been based on data from ESSE-RF and from baseline of PLIC study, two population-based epidemiological studies aimed to investigate prevalence of risk factors and evaluating contribution of traditional and new risk factors into morbidity and cardiovascular mortality. A total of 2203 patients with left and right intima-media thickness (IMT) measurements constituted the source population (1205 from PLIC study and 998 from ESSE-RF study)...
September 2018: Atherosclerosis. Supplements
G Alicandro, G Sebastiani, P Bertuccio, N Zengarini, G Costa, C La Vecchia, L Frova
OBJECTIVES: Monitoring socio-economic inequality has become a priority for many governments, especially after the socio-economic changes that followed the 2008 financial crisis. This study aimed at detecting the causes of death with the largest socio-economic inequality in relative and absolute terms in Italy. STUDY DESIGN: This is a historical cohort study. METHODS: We used two regression-based measures of socio-economic inequality, the relative index of inequality (RII) and the slope index of inequality (SII), to rank the causes of death with the highest relative and absolute socio-economic inequality...
August 30, 2018: Public Health
Gian Paolo Fadini, Anna Solini, Maria Laura Manca, Giuseppe Penno, Adriano Gatti, Roberto Anichini, Stefano Del Prato, Angelo Avogaro
AIM: To evaluate the changes in renal endpoints in type 2 diabetes patients treated with dapagliflozin versus other glucose-lowering medications in routine clinical practice. MATERIALS AND METHODS: DARWIN-T2D was a retrospective study conducted at 46 outpatient diabetes clinics in Italy. An automated software collected data on 17 285 patients who received dapagliflozin, glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 inhibitors, or gliclazide, 6751 of whom had a follow-up visit...
August 23, 2018: Diabetes, Obesity & Metabolism
Elena Raffetti, Francesco Donato, Fabrizio Speziani, Carmelo Scarcella, Alice Gaia, Michele Magoni
BACKGROUND AND AIMS: Exposure to polychlorinated biphenyls (PCBs) has been linked to the onset of cardiovascular, endocrine, and metabolic diseases, but no conclusive evidence has been provided so far. A chemical factory produced PCBs from 1938 to 1984 in Brescia (North Italy) resulting in environmental contamination and human exposure. We aimed to evaluate the association between PCB serum levels and subsequent incidence of chronic diseases through a prospective cohort study design. METHODS: Based on surveys conducted in Brescia province between 2001 and 2013, a cohort of 1331 subjects with at least one measure of PCB serum levels during the period was selected and followed longitudinally...
November 2018: Environment International
Lidia Castagneto Gissey, James R Casella Mariolo, Alfredo Genco, Alfonso Troisi, Nicola Basso, Giovanni Casella
BACKGROUND: Sleeve gastrectomy (SG) has grown into the most popular bariatric operation. Nevertheless, a scarcity of long-term outcomes are available. OBJECTIVES: This study aims at evaluating the long-term percent weight loss (%WL), excess weight loss (%EWL), weight regain (WR), and co-morbidity resolution rates in a single-center cohort undergoing SG as a primary procedure, with a minimum 10-year follow-up. SETTING: University hospital, Italy...
July 2, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Roberto Ferraresi, Andrea Casini, Maurizio Caminiti, Fabrizio Losurdo, Giacomo Clerici
The diabetic foot represents one of the most dangerous complications of diabetic disease, and it is characterized by the presence of infection, ulceration, or necrosis of the foot tissues associated with various degrees of neuropathy or ischemia. If not correctly and promptly treated, it leads to high rates of major amputations. Although in Italy diabetics are about 5% of the population, more than 50% of major amputations are performed in diabetic patients. Compared to non-diabetic patients, diabetic peripheral artery disease localizes more distally, mostly in the below-the-knee vessels, is typically bilateral with multi-level involvement, and presents earlier onset and more aggressive course...
September 2018: Giornale Italiano di Cardiologia
Adriano Mollica, Azzurra Stefanucci, Gokhan Zengin, Marcello Locatelli, Giorgia Macedonio, Giustino Orlando, Claudio Ferrante, Luigi Menghini, Lucia Recinella, Sheila Leone, Annalisa Chiavaroli, Lidia Leporini, Chiara Di Nisio, Luigi Brunetti, Eltayeb Tayrab, Islam Ali, Taha H Musa, Hassan H Musa, Abdelkareem A Ahmed
In this study, three different extracts (soxhlet, microwave and decoction) from two species of broccoli: Brassica oleracea L. convar. Italica botrytis (L.) Alef. var. cymosa Duch. (Broccolo Fiolaro) and Brassica oleracea acephala L. convar. acephala (DC.) Alef. var. sabellica L. (Cavolo Nero), which are commonly spread in north-central Italy, were tested for their enzyme inhibitory effects. Enzyme inhibitory effects were investigated against cholinesterases, tyrosinase, α-amylase and α-glucosidase. The soxhlet extracts had the highest inhibitory AChE effects with 1...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Fabrizio D'Ovidio, James P K Rooney, Anne E Visser, Umberto Manera, Ettore Beghi, Giancarlo Logroscino, Roel C H Vermeulen, Jan Herman Veldink, Leonard H van den Berg, Orla Hardiman, Adriano Chiò
OBJECTIVES: Several studies focused on the association between alcohol consumption and amyotrophic lateral sclerosis (ALS), although with inconsistent findings. Antioxidants may play a role since lyophilised red wine was found to prolong SOD1 mice lifespan. The aim of this international population-based case-control study performed in Ireland, The Netherlands and Italy was to assess the role of alcohol, and red wine in particular, in developing ALS. METHODS: Euro-MOTOR is a case-control study where patients with incident ALS and controls matched for gender, age and area of residency were recruited in a population-based design...
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Alexandros Patsilinakos, Rino Ragno, Simone Carradori, Stefania Petralito, Stefania Cesa
Fruits of Lycium barbarum L. have been used in Chinese traditional medicine for centuries. In the last decade, there has been much interest in the potential health benefits of many biologically constituents of these fruits. The high level of carotenoids offers protection against development of cardiovascular diseases, diabetes and related comorbidities. In the present work two different selections of Lycium barbarum L., cultivated in Italy and coming from three discrete harvest stages, were subjected to two different grinding procedure and to a simplified extraction method of carotenoid component...
December 1, 2018: Food Chemistry
Paola Bertuccio, Gianfranco Alicandro, Gabriella Sebastiani, Nicolas Zengarini, Giuseppe Costa, Carlo La Vecchia, Luisa Frova
OBJECTIVES: Evaluating socio-economic inequality in cause-specific mortality among the working population requires large cohort studies. Through this census-based study, we aimed to quantify disparities in mortality across occupation-based social classes in Italy. METHODS: We conducted a historical cohort study on a sample of more than 16 million workers. We estimated the mortality rate ratios for each social class, considering upper non-manual workers as reference...
September 2018: International Journal of Public Health
Lucia Borsari, Carlotta Malagoli, Martha M Werler, Kenneth J Rothman, Marcella Malavolti, Rossella Rodolfi, Gianfranco De Girolamo, Fausto Nicolini, Marco Vinceti
Smoking and pregestational diabetes (PGD) are recognized risk factors for adverse pregnancy outcomes, but to date, no population-based study has investigated their joint effects. Using hospital discharges, we identified all women with PGD delivering in Emilia-Romagna region during 2007-2010 matched 1 : 5 with parturients without diabetes. Our study endpoints were preterm births and congenital anomalies. We measured interaction between PGD and maternal smoking, by calculating excess prevalence and prevalence ratio due to interaction, relative excess risk due to interaction (RERI), attributable proportion (AP), and the synergy index (S)...
2018: Journal of Diabetes Research
Sabrina Picchi, Claudia Bonapitacola, Elisa Borghi, Silvia Cassanelli, Paola Ferrari, Barbara Iemmi, Emanuela Alfieri, Giovanna Artioli
INTRODUCTION: Due to the rise of the average age, chronic-degenerative diseases, including diabetes, are in constant increase, resulting in high complications, in terms of social-economical costs and of the quality of life of the people affected by it. For these reasons, adherence to therapeutic prescriptions becomes essential. Through the implementation of motivation, clear information and follow-up, health professionals can help patients with diabetes to increase therapeutic adherence and maintain healthy lifestyles...
July 18, 2018: Acta Bio-medica: Atenei Parmensis
David Seidel, Francesca Boggio Mesnil, Antonio Caruso
Reimbursement by payers (policy makers and budget holders) is critical for the uptake and use of new diabetes technologies. The purpose of this article is to describe the different reimbursement pathways that exist for new diabetes technologies in five selected European countries using examples of recent reimbursement decisions. Countries can be grouped into one of three categories: "top-down" (where reimbursement decisions are usually made by policy makers, eg, France), "bottom-up" (where reimbursement decisions are usually made by budget holders, eg, Italy and Spain) and "mixed" (where reimbursement decisions can be made by both policy makers and budget holders, eg, Germany and England)...
July 1, 2018: Journal of Diabetes Science and Technology
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