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Diabetes italy

Elena Raffetti, Francesco Donato, Fabrizio Speziani, Carmelo Scarcella, Alice Gaia, Michele Magoni
BACKGROUND AND AIMS: Exposure to polychlorinated biphenyls (PCBs) has been linked to the onset of cardiovascular, endocrine, and metabolic diseases, but no conclusive evidence has been provided so far. A chemical factory produced PCBs from 1938 to 1984 in Brescia (North Italy) resulting in environmental contamination and human exposure. We aimed to evaluate the association between PCB serum levels and subsequent incidence of chronic diseases through a prospective cohort study design. METHODS: Based on surveys conducted in Brescia province between 2001 and 2013, a cohort of 1331 subjects with at least one measure of PCB serum levels during the period was selected and followed longitudinally...
August 10, 2018: Environment International
Lidia Castagneto Gissey, James R Casella Mariolo, Alfredo Genco, Alfonso Troisi, Nicola Basso, Giovanni Casella
BACKGROUND: Sleeve gastrectomy (SG) has grown into the most popular bariatric operation. Nevertheless, a scarcity of long-term outcomes are available. OBJECTIVES: This study aims at evaluating the long-term percent weight loss (%WL), excess weight loss (%EWL), weight regain (WR), and co-morbidity resolution rates in a single-center cohort undergoing SG as a primary procedure, with a minimum 10-year follow-up. SETTING: University hospital, Italy...
July 2, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Roberto Ferraresi, Andrea Casini, Maurizio Caminiti, Fabrizio Losurdo, Giacomo Clerici
The diabetic foot represents one of the most dangerous complications of diabetic disease, and it is characterized by the presence of infection, ulceration, or necrosis of the foot tissues associated with various degrees of neuropathy or ischemia. If not correctly and promptly treated, it leads to high rates of major amputations. Although in Italy diabetics are about 5% of the population, more than 50% of major amputations are performed in diabetic patients. Compared to non-diabetic patients, diabetic peripheral artery disease localizes more distally, mostly in the below-the-knee vessels, is typically bilateral with multi-level involvement, and presents earlier onset and more aggressive course...
September 2018: Giornale Italiano di Cardiologia
Adriano Mollica, Azzurra Stefanucci, Gokhan Zengin, Marcello Locatelli, Giorgia Macedonio, Giustino Orlando, Claudio Ferrante, Luigi Menghini, Lucia Recinella, Sheila Leone, Annalisa Chiavaroli, Lidia Leporini, Chiara Di Nisio, Luigi Brunetti, Eltayeb Tayrab, Islam Ali, Taha H Musa, Hassan H Musa, Abdelkareem A Ahmed
In this study, three different extracts (soxhlet, microwave and decoction) from two species of broccoli: Brassica oleracea L. convar. Italica botrytis (L.) Alef. var. cymosa Duch. (Broccolo Fiolaro) and Brassica oleracea acephala L. convar. acephala (DC.) Alef. var. sabellica L. (Cavolo Nero), which are commonly spread in north-central Italy, were tested for their enzyme inhibitory effects. Enzyme inhibitory effects were investigated against cholinesterases, tyrosinase, α-amylase and α-glucosidase. The soxhlet extracts had the highest inhibitory AChE effects with 1...
August 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Fabrizio D'Ovidio, James P K Rooney, Anne E Visser, Umberto Manera, Ettore Beghi, Giancarlo Logroscino, Roel C H Vermeulen, Jan Herman Veldink, Leonard H van den Berg, Orla Hardiman, Adriano Chiò
OBJECTIVES: Several studies focused on the association between alcohol consumption and amyotrophic lateral sclerosis (ALS), although with inconsistent findings. Antioxidants may play a role since lyophilised red wine was found to prolong SOD1 mice lifespan. The aim of this international population-based case-control study performed in Ireland, The Netherlands and Italy was to assess the role of alcohol, and red wine in particular, in developing ALS. METHODS: Euro-MOTOR is a case-control study where patients with incident ALS and controls matched for gender, age and area of residency were recruited in a population-based design...
August 3, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Alexandros Patsilinakos, Rino Ragno, Simone Carradori, Stefania Petralito, Stefania Cesa
Fruits of Lycium barbarum L. have been used in Chinese traditional medicine for centuries. In the last decade, there has been much interest in the potential health benefits of many biologically constituents of these fruits. The high level of carotenoids offers protection against development of cardiovascular diseases, diabetes and related comorbidities. In the present work two different selections of Lycium barbarum L., cultivated in Italy and coming from three discrete harvest stages, were subjected to two different grinding procedure and to a simplified extraction method of carotenoid component...
December 1, 2018: Food Chemistry
Paola Bertuccio, Gianfranco Alicandro, Gabriella Sebastiani, Nicolas Zengarini, Giuseppe Costa, Carlo La Vecchia, Luisa Frova
OBJECTIVES: Evaluating socio-economic inequality in cause-specific mortality among the working population requires large cohort studies. Through this census-based study, we aimed to quantify disparities in mortality across occupation-based social classes in Italy. METHODS: We conducted a historical cohort study on a sample of more than 16 million workers. We estimated the mortality rate ratios for each social class, considering upper non-manual workers as reference...
July 26, 2018: International Journal of Public Health
Lucia Borsari, Carlotta Malagoli, Martha M Werler, Kenneth J Rothman, Marcella Malavolti, Rossella Rodolfi, Gianfranco De Girolamo, Fausto Nicolini, Marco Vinceti
Smoking and pregestational diabetes (PGD) are recognized risk factors for adverse pregnancy outcomes, but to date, no population-based study has investigated their joint effects. Using hospital discharges, we identified all women with PGD delivering in Emilia-Romagna region during 2007-2010 matched 1 : 5 with parturients without diabetes. Our study endpoints were preterm births and congenital anomalies. We measured interaction between PGD and maternal smoking, by calculating excess prevalence and prevalence ratio due to interaction, relative excess risk due to interaction (RERI), attributable proportion (AP), and the synergy index (S)...
2018: Journal of Diabetes Research
Sabrina Picchi, Claudia Bonapitacola, Elisa Borghi, Silvia Cassanelli, Paola Ferrari, Barbara Iemmi, Emanuela Alfieri, Giovanna Artioli
INTRODUCTION: Due to the rise of the average age, chronic-degenerative diseases, including diabetes, are in constant increase, resulting in high complications, in terms of social-economical costs and of the quality of life of the people affected by it. For these reasons, adherence to therapeutic prescriptions becomes essential. Through the implementation of motivation, clear information and follow-up, health professionals can help patients with diabetes to increase therapeutic adherence and maintain healthy lifestyles...
July 18, 2018: Acta Bio-medica: Atenei Parmensis
David Seidel, Francesca Boggio Mesnil, Antonio Caruso
Reimbursement by payers (policy makers and budget holders) is critical for the uptake and use of new diabetes technologies. The purpose of this article is to describe the different reimbursement pathways that exist for new diabetes technologies in five selected European countries using examples of recent reimbursement decisions. Countries can be grouped into one of three categories: "top-down" (where reimbursement decisions are usually made by policy makers, eg, France), "bottom-up" (where reimbursement decisions are usually made by budget holders, eg, Italy and Spain) and "mixed" (where reimbursement decisions can be made by both policy makers and budget holders, eg, Germany and England)...
July 1, 2018: Journal of Diabetes Science and Technology
Valentino Cherubini, Edlira Skrami, Antonio Iannilli, Alessandra Cesaretti, Anna Maria Paparusso, Maria Cristina Alessandrelli, Flavia Carle, Lucia Ferrito, Rosaria Gesuita
OBJECTIVE: To evaluate the association of clinical, metabolic and socioeconomic factors with disordered eating behaviors (DEB) among adolescents with type 1 diabetes screened using the Diabetes Eating Problem Survey-Revised (DEPS-R). METHODS: A cross-sectional, population-based study involved 163 adolescents with type 1 diabetes, aged 11-20 years, recruited from the registry for type 1 diabetes of Marche Region, Italy, who completed the DEPS-R (response rate 74...
July 22, 2018: International Journal of Eating Disorders
Livia Savarese, Maria Bova, Raffaella De Falco, Maria Domenica Guarino, Raffaele De Luca Picione, Angelica Petraroli, Riccardo Senter, Claudia Traverso, Matteo Zabotto, Andrea Zanichelli, Eugenio Zito, Maria Alessio, Mauro Cancian, Marco Cicardi, Adriana Franzese, Roberto Perricone, Gianni Marone, Paolo Valerio, Maria Francesca Freda
BACKGROUND: Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is characterized by recurrent edema of unpredictable frequency and severity. Stress, anxiety, and low mood are among the triggering factors most frequently reported. Impaired regulation and processing of emotions, also known as alexithymia, may influence outcomes. The aim of this study was to confirm the presence of alexithymia and stress in children with C1-INH-HAE, to determine whether they are also present in children affected by other chronic diseases, and to investigate their relationship with C1-INH-HAE severity...
July 13, 2018: Orphanet Journal of Rare Diseases
Daniel Neunhäuserer, Andrea Gasperetti, Sara Ortolan, Francesca Battista, Pietro Pettenella, Marco Zaccaria, Marco Bergamin, Andrea Ermolao
INTRODUCTION: Increased inter-arm systolic blood pressure difference (ΔPsys) has been associated with cardiovascular (CV) disease in elderly patients with CV risk factors. However, its significance in healthy subjects is unclear. AIM: To determine the relationship between ΔPsys, the individual level of physical activity and the global CV risk in apparently healthy adults. METHODS: Systolic blood pressure was measured in both arms in 400 subjects aged 46...
July 12, 2018: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
Paul E Drawz, Roland Brown, Luca De Nicola, Naohiko Fujii, Francis B Gabbai, Jennifer Gassman, Jiang He, Satoshi Iimuro, James Lash, Roberto Minutolo, Robert A Phillips, Kyle Rudser, Luis Ruilope, Susan Steigerwalt, Raymond R Townsend, Dawei Xie, Mahboob Rahman
BACKGROUND AND OBJECTIVES: Ambulatory BP is increasingly recognized as a better measure of the risk for adverse outcomes related to hypertension, an important comorbidity in patients with CKD. Varying definitions of white-coat and masked hypertension have made it difficult to evaluate differences in prevalence of these BP patterns across CKD cohorts. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The International Database of Ambulatory BP in Renal Patients collaborative group established a large database of demographic, clinical, and ambulatory BP data from patients with CKD from cohorts in Italy, Spain, the Chronic Renal Insufficiency Cohort (CRIC) and the African American Study of Kidney Disease and Hypertension Cohort Study (AASK) in the United States, and the CKD Japan Cohort (CKD-JAC)...
July 5, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Pamela Di Giovanni, Tonia Garzarella, Giuseppe Di Martino, Francesco Saverio Schioppa, Ferdinando Romano, Tommaso Staniscia
BACKGROUND: Primary caesarean section (PCS) rate is one of the main indicators of quality of care suggested by the Italian Government. Hospital rankings are usually based on it, therefore lower rates reflect more appropriate clinical practice. The aim of this study is to describe a five-year trend of PCS rate in Abruzzo region from 2009 to 2013 and to examine the medical indications for this mode of delivery. METHODS: Forty-five thousand one hundred forty-nine deliveries occurring from 2009 to 2013 were collected from all hospital discharge records (HDR) and analyzed...
July 3, 2018: BMC Health Services Research
Paolo Bianco, Antonia Rizzuto, Nunzio Velotti, Alessio Bocchetti, Domenico Manzolillo, Paola Maietta, Marco Milone, Maurizio Amato, Giovanni Conzo, Oreste Buonomo, Giuseppe Petrella, Mario Musella
BACKGROUND: Laparoscopic Sleeve Gastrectomy (LSG) represents the most performed bariatric surgical procedure worldwide. Morbid Overweight in elderly patients is becoming a significant health problem even in Italy. As well as in younger age groups, bariatric surgery could be indicated even in this subset of patients. However the advantages and results of LSG in patients over 60 years old have received minimal attention. METHODS: The records of 375 patients underwent LSG between 2008 and 2016 were reviewed...
June 29, 2018: Minerva Chirurgica
Kyriaki Hatziagapiou, George I Lambrou
BACKGROUND: Reactive oxygen species and reactive nitrogen species, which are collectively called reactive oxygen nitrogen species, are inevitable by-products of cellular metabolic redox reactions, such as oxidative phosphorylation in the mitochondrial respiratory chain, phagocytosis, reactions of biotransformation of exogenous and endogenous substrata in endoplasmic reticulum, eicosanoid synthesis, and redox reactions in the presence of metal with variable valence. Among medicinal plants there is growing interest in Crocus Sativus L...
June 27, 2018: Current Cardiology Reviews
Louis S Matza, Kristina S Boye, Jessica B Jordan, Kirsi Norrbacka, Raffaella Gentilella, Amara R Tiebout, Chantelle Browne, Marco Orsini Federici, Giovanni Biricolti, Katie D Stewart
Objectives: Several glucagon-like peptide-1 receptor agonists are administered as weekly injections for treatment of type 2 diabetes (T2D). These medications vary in their injection processes, and a recent study in the UK found that these differences had an impact on patient preference and health state utilities. The purpose of this study was to replicate the UK study in Italy to examine preferences of an Italian patient sample, while allowing for comparison between utilities in the UK and Italy...
2018: Patient Preference and Adherence
F Mazzolani, S Togni, L Giacomelli, R Eggenhoffner, F Franceschi
OBJECTIVE: The purpose of this open-label study was to investigate the effect of a curcumin-phospholipid lecithin formulation (Meriva®) on visual acuity and optical coherence tomography (OCT) retinal thickness in patients with chronic diabetic macular edema. PATIENTS AND METHODS: Curcumin-phospholipid lecithin formulation (Meriva®, Indena S.p.A, Milan, Italy) was administered as tablets (Norflo®, Eye Pharma, Genoa, Italy) twice a day. Visual acuity and macular edema as measured by OCT before and after curcumin-phospholipid formulation treatment were assessed...
June 2018: European Review for Medical and Pharmacological Sciences
Angelo Porreca, Marianna Noale, Walter Artibani, Pier Francesco Bassi, Filippo Bertoni, Sergio Bracarda, Giario Natale Conti, Renzo Corvò, Mauro Gacci, Pierpaolo Graziotti, Stefano Maria Magrini, Vincenzo Mirone, Rodolfo Montironi, Giovanni Muto, Stefano Pecoraro, Umberto Ricardi, Elvio Russi, Andrea Tubaro, Vittorina Zagonel, Gaetano Crepaldi, Stefania Maggi
BACKGROUND: The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed. METHODS: One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12)...
June 13, 2018: Health and Quality of Life Outcomes
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