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https://www.readbyqxmd.com/read/30554250/triple-therapy-at-discharge-from-internal-medicine-wards-in-heart-failure-patients-with-reduced-ejection-fraction-results-from-an-observational-study
#1
A Fortini, V Verdiani, G Panigada, C Angotti, L Masotti
BACKGROUND: Guidelines recommend triple therapy (TT) with ACE inhibitors or ARBs, beta-blockers and mineralcorticoid receptor antagonists in symptomatic heart failure patients with ejection fraction <35 % (HFrEF). Nevertheless, many patients remain untreated. This study was aimed to evaluate the use of TT in HFrEF patients discharged from internal medicine wards of Tuscany, Italy. METHODS AND RESULTS: We analyzed the database of a multicenter observational study which included 770 patients consecutively hospitalized for HF in 32out of 36 Internal Medicine Units of Tuscany, Italy...
November 2018: La Clinica Terapeutica
https://www.readbyqxmd.com/read/30548967/applicability-of-telemedicine-in-the-screening-of-diabetic-retinopathy-dr-the-first-multicentre-study-in-italy-the-no-blind-study
#2
Ferdinando Carlo Sasso, Pia Clara Pafundi, Aldo Gelso, Valeria Bono, Ciro Costagliola, Raffaele Marfella, Celestino Sardu, Luca Rinaldi, Raffaele Galiero, Carlo Acierno, Chiara de Sio, Luigi Elio Adinolfi
AIMS: Diabetic retinopathy (DR) represents the main cause of blindness among adults in the industrialized Countries. Use of telemedicine could offer an easy, smart specialist fundus oculi examination, as well as putting in a screening program many patients who otherwise would be excluded. MATERIALS AND METHODS: The NO Blind is a transversal, multicentre, observational study. Its pilot phase involved nine public outpatient clinics for six months. As endpoint of the study, we assessed the prevalence of DR by retinography in a subset of the Italian population...
December 13, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30544688/risk-factors-for-abdominal-aortic-aneurysm-in-population-based-studies-a-systematic-review-and-meta-analysis
#3
REVIEW
Emma Altobelli, Leonardo Rapacchietta, Valerio F Profeta, Roberto Fagnano
Abdominal aortic aneurysm (AAA) represents an important public health problem with a prevalence between 1.3% and 12.5%. Several population-based randomized trials have evaluated ultrasound screening for AAA providing evidence of a reduction in aneurysm-related mortality in the screened population. The aim of our study was to perform a systematic review and meta-analysis of the risk factors for AAA. We conducted a systematic review of observational studies and we performed a meta-analysis that evaluated the following risk factors: gender, smoking habits, hypertension, coronary artery disease and family history of AAA...
December 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30539910/research-trends-of-macrophage-polarization-a-bibliometric-analysis
#4
Han Gao, Feng-Yan Huang, Zhi-Ping Wang
Background: Macrophage polarization is involved in the development of many diseases such as obesity, diabetes, and cancer. This study aimed to understand the trends and hotspots of macrophage polarization research. Methods: We searched through the Web of Science Core Collection database to obtain original articles in this research domain. CiteSpace, HistCite, and VOSviewer software were used to facilitate the analysis and visualization of scientific productivity and emerging trends...
December 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/30533423/c-reactive-protein-levels-at-the-midpregnancy-can-predict-gestational-complications
#5
Alessandra Vecchié, Aldo Bonaventura, Federico Carbone, Davide Maggi, Antonella Ferraiolo, Beatrice Carloni, Gabriella Andraghetti, Laura Affinito Bonabello, Luca Liberale, Franco Dallegri, Fabrizio Montecucco, Renzo Cordera
Although essential for a successful pregnancy, a growing body of evidence suggests that maternal inflammation, when dysregulated, may represent a risk factor for both maternal and neonatal outcomes. Here, we assessed the accuracy of maternal C-reactive protein (CRP) concentrations at the middle phase of pregnancy in the identification of maternal adverse outcomes (MAO) until delivery. A correlation between CRP and a complicated pregnancy including both maternal and neonatal adverse outcomes has been investigated, too...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30527222/central-pancreatectomy-for-benign-or-low-grade-malignant-pancreatic-lesions-a-single-center-retrospective-analysis-of-116-cases
#6
Salvatore Paiella, Matteo De Pastena, Federico Faustini, Luca Landoni, Tommaso Pollini, Deborah Bonamini, Tommaso Giuliani, Claudio Bassi, Alessandro Esposito, Massimiliano Tuveri, Roberto Salvia
BACKGROUND: Central pancreatectomy (CP) is a parenchyma-sparing surgery for benign or low-grade malignant pancreatic tumors. This study aimed to evaluate the safety of the procedure and to analyze the long-term pancreatic function. The age-specific incidence ratio (IR) was calculated based on the incidence of diabetes mellitus in the general Italian population of Italy. MATERIALS AND METHODS: Patients submitted to CP from January 1990 to December 2017 at the Department of General and Pancreatic Surgery of the Pancreas Institute of Verona, Italy, were evaluated...
November 29, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30515666/transsphenoidal-surgery-for-pituitary-adenomas-early-results-from-a-single-center
#7
I Karamouzis, M Caputo, C Mele, A Nuzzo, M Zavattaro, P Car, G Panzarasa, F Prodam, P Marzullo, Gianluca Aimaretti
OBJECTIVE: To evaluate early results of transsphenoidal surgery for pituitary adenomas. DESIGN: Retrospective evaluation of 90 consecutive patients undergoing endoscopic pituitary adenoma surgery (2007-2016) at "Maggiore della Carità" Hospital in Novara, Italy. Age at diagnosis, sex, symptoms at presentation, hormonal and radiological data, complications of surgery, and short-term follow-up information were collected. RESULTS: The majority of patients were male (M/F: 1...
December 4, 2018: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30478783/clinical-and-socio-demographic-determinants-of-inadequate-self-care-in-adults-with-type-1-diabetes-mellitus-the-leading-role-of-self-care-confidence
#8
Rosario Caruso, Paola Rebora, Federica Dellafiore, Diletta Fabrizi, Barbara Riegel, Davide Ausili, Stefania Di Mauro
AIMS: To describe self-care maintenance, monitoring, and management behaviors in adults with type 1 diabetes (T1DM), and to identify clinical and socio-demographic determinants of inadequate self-care. METHODS: A cross-sectional study was conducted in two diabetes outpatient clinics in Italy. Clinical and socio-demographic characteristics were collected from the medical records of 181 consecutively enrolled T1DM patients. The Self-Care of Diabetes Inventory was used to measure self-care maintenance, self-care monitoring, self-care management and self-care confidence...
November 27, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/30473178/increased-circulating-granzyme-b-in-type-2-diabetes-patients-with-low-grade-systemic-inflammation
#9
Flavia Agata Cimini, Donatella D'Eliseo, Ilaria Barchetta, Laura Bertoccini, Francesca Velotti, Maria Gisella Cavallo
In metabolic diseases, like type 2 diabetes (T2D), adipose tissue (AT) is infiltrated by macrophages and other leukocytes - which secrete many bioactive peptides leading to local and systemic low-grade chronic inflammation - and undergoes remodeling and aberrant fibrosis. Granzyme B (GrB) is a serine protease produced by some leukocytes, including cytotoxic lymphocytes and macrophages. It exerts both intracellular apoptotic function and extracellular functions, leading to tissue injury, inflammation and repair...
November 22, 2018: Cytokine
https://www.readbyqxmd.com/read/30465248/type-2-diabetes-treatment-and-progression-of-chronic-kidney-disease-in-italian-family-practice
#10
G Ermini, C Tosetti, D Zocchi, M Mandreoli, M T Caletti, G Marchesini
AIMS: Progressive chronic kidney disease represents a dreadful complication of type 2 diabetes mellitus (T2DM). We tested the pattern of use and the renal effects of old glucose-lowering drugs in T2DM patients cared for by Italian general practitioners (GPs). METHODS: Data of 2606 T2DM patients were extracted from the databases of GPs, who do not have access to the most recent glucose-lowering drugs in Italy. The rate of kidney function decline was calculated by CKD-EPIcr , based on two consecutive creatinine values...
November 21, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/30398941/evaluation-of-fluorescence-biomodulation-in-the-real-life-management-of-chronic-wounds-the-eureka-trial
#11
Marco Romanelli, Alberto Piaggesi, Giovanni Scapagnini, Valentina Dini, Agata Janowska, Elisabetta Iacopi, Carlotta Scarpa, Stéphane Fauverghe, Franco Bassetto
OBJECTIVE: Fluorescence biomodulation (FB), a form of photobiomodulation (PBM) that is also known as low energy level light (LELL), has become an increasingly used clinical tool to induce wound healing in wounds that remain recalcitrant to treatment. In a real-life clinical setting, the aim of the EUREKA (EvalUation of Real-lifE use of Klox biophotonic system in chronic wound mAnagement) study was to confirm the efficacy and safety of LumiHeal, a system based on FB, in the treatment of chronic wounds such as venous leg ulcers (VLUs), diabetic foot ulcers (DFUs) and pressure ulcers (PUs)...
November 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/30397361/relationship-between-cardiovascular-health-metrics-and-physical-performance-in-community-living-people-results-from-the-longevity-check-up-lookup-7-project
#12
Francesco Landi, Riccardo Calvani, Anna Picca, Matteo Tosato, Emanuela D'Angelo, Anna Maria Martone, Elisabetta Serafini, Elena Ortolani, Giulia Savera, Sara Salini, Nicola Acampora, Roberto Bernabei, Emanuele Marzetti
Cardiovascular health metrics (CHMs) may predict disability independent of vascular events. Though, the link between CHMs and physical performance is unclear. This relationship was explored using data from the Longevity check-up (Lookup) 7+ project. Lookup 7+ is an ongoing cross-sectional survey conducted in unconventional settings across Italy. People who are at least 18-year-old and provide written informed consent are eligible. CHMs [i.e., smoking status, healthy diet, body mass index (BMI), blood pressure, blood cholesterol, and diabetes status] are assessed through closed questions and objective measurements...
November 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30370733/-validation-of-algorithms-for-the-identification-of-subjects-with-chronic-disease-using-health-information-systems
#13
Riccardo Di Domenicantonio, Giovanna Cappai, Silvia Cascini, Silvia Narduzzi, Daniela Porta, Lisa Bauleo, Adele Lallo, Matteo Renzi, Giulia Cesaroni, Nera Agabiti, Francesco Forastiere, Riccardo Pistelli, Marina Davoli
OBJECTIVES: to test the validity of algorithms to identify diabetes, chronic obstructive pulmonary disease (COPD), hypertension, and hypothyroidism from routinely collected health data using information from self-reported diagnosis and laboratory or functional test. SETTING AND PARTICIPANTS: clinical or self-reported diagnosis from three surveys conducted in Lazio Region (Central Italy) between year 2010 and 2014 were assumed as gold standard and compared to the results of the algorithms application to administrative data...
September 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/30366850/failure-to-conceive-in-women-with-cf-is-associated-with-pancreatic-insufficiency-and-advancing-age
#14
Michal Shteinberg, Adi Ben Lulu, Damian G Downey, Zeev Blumenfeld, Christine Rousset-Jablonski, Marie Perceval, Alessandra Colombo, Nili Stein, Galit Livnat, Michal Gur, Lea Bentur, Huda Mussaffi, Hannah Blau, Ifat Sarouk, Adi Dagan, Eitan Kerem, Micha Aviram, Elie Picard, Stefano Aliberti, Antonio Álvarez, Javier Perez Miranda, Eva Polverino, Isabelle Durieu, J Stuart Elborn, Malena Cohen-Cymberknoh
OBJECTIVE: The causes of subfertility in women with CF though multifactorial are not well described. Our aim in this study was to determine the prevalence and factors associated with female subfertility among women with CF. METHODS: A retrospective multinational study from 11 CF centers in 5 countries (Israel, France, Spain, Italy, UK) including women with CF was undertaken. Sub/infertility was defined as not achieving a spontaneous pregnancy after one year of unprotected sexual intercourse...
October 23, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/30333012/effects-of-nutrition-motivational-intervention-in-patients-affected-by-type-2-diabetes-mellitus-a-longitudinal-study-in-naples-south-italy
#15
Valeria Di Onofrio, Francesca Gallé, Mirella Di Dio, Patrizia Belfiore, Giorgio Liguori
BACKGROUND: Type 2 diabetes (T2D) is associated with a prion diminished quality of life, especially due to the severe complications that it implicates. Changing dietary habits is an absolute priority, as well as implementing nutritional motivational programs. The aim of this study was to verify the effectiveness of a nutritional intervention in improving the health of patients affected by T2D. METHODS: A total of 69 patients participated in a nine-months motivational program focused on the principles of the Mediterranean diet, the classes of nutrients, the distribution of the meals during the day and the dietary choices...
October 17, 2018: BMC Public Health
https://www.readbyqxmd.com/read/30324460/the-thickening-of-flexor-tendons-pulleys-a-useful-ultrasonographical-sign-in-the-diagnosis-of-psoriatic-arthritis
#16
Antonio Furlan, Roberto Stramare
PURPOSE: To investigate the frequency of thickening of pulleys for flexor tendons in patients with early arthritis in their hands, and to evaluate it as a predictive sign of PsA. METHODS: A prospective observational study involving 228 consecutive patients presenting with recent onset of arthritis in their hands was conducted at rheumatology outpatient clinics in the Veneto region of Italy between October 2014 and September 2017. Diabetic patients were excluded because of the high frequency of trigger finger...
December 2018: Journal of Ultrasound
https://www.readbyqxmd.com/read/30318634/ethnic-differences-in-body-image-perception-in-patients-with-type-2-diabetes
#17
S Toselli, E Gualdi-Russo, F Campa
BACKGROUND: The present study compared the prevalence of obesity, fat distribution, body image perception and lifestyle among diabetic African and Albanian immigrants living in Italy, as well as diabetic Italians, aiming to identify health risks and their possible causes. METHODS: The study sample consisted of 200 diabetic subjects living in Italy. A questionnaire regarding socio-demographic and lifestyle information was administered to participants, and anthropometric measurements and body image perception were assessed...
October 14, 2018: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/30274207/the-main-determinants-of-diabetes-mellitus-vascular-complications-endothelial-dysfunction-and-platelet-hyperaggregation
#18
REVIEW
Albino Carrizzo, Carmine Izzo, Marco Oliveti, Antonia Alfano, Nicola Virtuoso, Mario Capunzo, Paola Di Pietro, Mariaconsiglia Calabrese, Eros De Simone, Sebastiano Sciarretta, Giacomo Frati, Serena Migliarino, Antonio Damato, Mariateresa Ambrosio, Francesco De Caro, Carmine Vecchione
Diabetes mellitus is a common disease that affects 3⁻5% of the general population in Italy. In some countries of northern Europe or in North America, it can even affect 6⁻8% of the population. Of great concern is that the number of cases of diabetes is constantly increasing, probably due to the increase in obesity and the sedentary nature of the population. According to the World Health Organization, in the year 2030 there will be 360 million people with diabetes, compared to 170 million in 2000. This has important repercussions on the lives of patients and their families, and on health systems that offer assistance to patients...
September 28, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30260088/health-related-quality-of-life-in-people-with-type-2-diabetes-participating-in-the-leader-trial
#19
Michael A Nauck, John B Buse, Johannes F E Mann, Stuart Pocock, Heidrun Bosch-Traberg, Helle Frimer-Larsen, Qing Ye, Alastair Gray
AIMS: To assess health-related quality of life (HRQoL) in people with type 2 diabetes (T2D) participating in the LEADER cardiovascular outcomes trial using the five-dimension European Quality of Life questionnaire (EQ-5D). MATERIALS AND METHODS: The EQ-5D was administered every 12 months in a subset of patients from Canada, Denmark, Germany, Ireland, Italy, Netherlands, Spain, Sweden, the United Kingdom and the United States. We compared changes in utility index scores and visual analogue scale (VAS) scores from baseline to 36 months in participants treated with liraglutide and placebo...
September 27, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30238228/clinical-impact-of-5-years-of-liraglutide-treatment-on-cardiovascular-risk-factors-in-patients-with-type-2-diabetes-mellitus-in-a-real-life-setting-in-italy-an-observational-study
#20
Vera Frison, Natalino Simioni, Alberto Marangoni, Sara Balzano, Carmela Vinci, Luciano Zenari, Lorena De Moliner, Federica Tadiotto, Michele D'Ambrosio, Loris Confortin, Narciso Marin, Simonetta Lombardi, Silvana Costa, Giuseppe Prosperini, Annunziata Lapolla
INTRODUCTION: Based on existing data regarding the durability of liraglutide in type 2 diabetes, this study aimed to assess its long-term effectiveness at 5 years and its overall impact on cardiovascular (CV) risk. METHODS: This was a multicenter retrospective observational study. Liraglutide was used under routine clinical practice conditions. Changes from baseline to 60 months in HbA1c, fasting plasma glucose (FPG), body weight, blood pressure, and lipid profile were assessed...
September 20, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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