Hanfei Sun, Yi Feng, Shaoqin Tu, Jianwu Zhou, Yuxuan Wang, Jiaming Wei, Sai Zhang, Yuluan Hou, Yiting Shao, Hong Ai, Zheng Chen
INTRODUCTION: Orthodontic tooth movement (OTM) involves complex interactions between mechanical forces and periodontal tissue adaptation, mainly mediated by periodontal ligament cells, including periodontal ligament stem cells (PDLSCs), osteoblasts, and osteoclasts. Dopamine (DA), a neurotransmitter known for its critical role in bone metabolism, is investigated in this study for its potential to enhance osteogenic differentiation in PDLSCs, which are pivotal in OTM. This study examined the potential of DA to facilitate OTM by binding to DA receptors (D1R and D2R) and activating the ERK1/2 signaling pathway...
December 2024: Regenerative Therapy