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Nano Drug

Karishma Khan, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Thasleem Moolakkadath, Yasmin Sultana, Mohd Mujeeb
The aim was to formulate an optimized ursolic acid (UA) loaded lipid vesicle using formulation by design approach (FbD) for improving the drug targeting by nasal route for brain tumor. Three factors were evaluated at three different levels using anethole (terpene) (A), ethanol (B) and phospholipid90 G (C) as independent variables and their individual and combined effects were observed for PDI (Y1 ), vesicle size (Y2 ) and encapsulation efficiency (Y3 ) to select an optimal system (UALVopt). The optimized formulation was further converted into gel and evaluated for drug release, nasal permeation study, brain/plasma uptake and histopathology study...
July 27, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Chia-Wei Jui, Amy J C Trappey, Chien-Chung Fu
Nanotechnology, like 3D printing, is one of the richest fields in research and progress in the past few years. Two Photon Polymerization (TPP) technology allows the 3D printing of nanoscale objects, so the nanoscale additive manufacturing has been no longer the thing in the future. This research investigates related US patent documents through the claim-based approach. By virtue of systematic analysis of the claims of patent documents, we can explicitly define technical features of patent document and the accurate patent classification, monitor the direction of enterprises' patent application portfolio and effectively grasp the trend of technological development of important manufacturers related to this technology...
August 17, 2018: Recent Patents on Nanotechnology
Jesmin Mondal, Mousumi Patra, Ashis Kumar Panigrahi, Anisur Rahman Khuda-Bukhsh
BACKGROUND: Cisplatin is a widely-used potent anti-cancer drug having severe side-effects precluding its sustained use. OBJECTIVES: Poly (lactide-co-glycolide) (PLGA)-nanoparticles loaded Boldine, an antioxidant ingredient of ethanolic extract of Boldo plant (Peumus boldus) was tested in cancer mice model, Mus musculus to examine if it could reduce unwanted Cisplatin-induced toxicity in normal tissue. MATERIAL AND METHODS: Nano-encapsulation of Boldine was done by following the standardized solvent displacement method...
August 13, 2018: Journal of Ayurveda and Integrative Medicine
Guangzhong Ma, Guan-Da Syu, Xiaonan Shan, Brandon Henson, Shaopeng Wang, Prashant Desai, Heng Zhu, Nongjian Tao
Membrane proteins play vital roles in cellular signaling processes and serve as the most popular drug targets. A key task in studying cellular functions and developing drugs is to measure the binding kinetics of ligands with the membrane proteins. However, this has been a long-standing challenge because one must perform the measurement in a membrane environment to maintain the conformations and functions of the membrane proteins. Here we report a new method to measure ligand binding kinetics to membrane proteins using self-assembled virion-oscillators...
August 16, 2018: Journal of the American Chemical Society
Jianming Liang, Caifang Gao, Ying Zhu, Chengli Ling, Qi Wang, Yongzhuo Huang, Jing Qin, Jue Wang, Weigen Lu, Jianxin Wang
The unsatisfactory therapeutic outcome for glioma is mainly due to the poor BBB permeability and inefficient accumulation in the glioma area of chemotherapeutic agents. The existing drug delivery strategies can increase drug transport to the brain but are restricted by side effects and/or poor delivery efficiency. In this study, potent brain penetration enhancers were screened from the active components of aromatic resuscitation drugs used in traditional Chinese medicine. A novel glioma-targeting system based on enhancer-modified albumin nanoparticles was developed to safely and efficiently deliver drugs to the glioma regions in the brain...
August 16, 2018: ACS Applied Materials & Interfaces
Leen M 't Hart, Nicole Vogelzangs, Dennis O Mook-Kanamori, Adela Brahimaj, Jana Nano, Amber A W A van der Heijden, Ko Willems van Dijk, Roderick C Slieker, Ewout Steyerberg, M Arfan Ikram, Marian Beekman, Dorret I Boomsma, Cornelia M van Duijn, P Eline Slagboom, Coen D A Stehouwer, Casper G Schalkwijk, Ilja C W Arts, Jacqueline M Dekker, Abbas Dehghan, Taulant Muka, Carla J H van der Kallen, Giel Nijpels, Marleen van Greevenbroek
Objective: We studied in people with type 2 diabetes whether blood metabolomic measures are associated with insufficient glycemic control and if this association is influenced differentially by various diabetes drugs. We then tested whether the same metabolomic profiles associate with initiation of insulin therapy. Methods: One-hundred-and-sixty-two metabolomic measures were analyzed using a NMR-based method in people with type 2 diabetes from four cohort studies (n=2641) and one replication cohort (n=395)...
August 2, 2018: Journal of Clinical Endocrinology and Metabolism
Hongguang Li, Shengju Zhou, Linwen Zhang, Mengjun Chen, Wei Pan, Jingcheng Hao, Yongqiang Feng
Fullerenols have been known for decades. However, their photoluminescent (PL) properties and applications in supramolecular chemistry have not been well addressed. In this paper, we developed a strategy to purify the as-prepared fullerenols and systematically studied their photoluminescence and capabilities to form supramolecular self-assemblies. It was found that fullerenols show wavelength-dependent emission with an absolute fluorescent quantum yield of ∼3.5%. The PL characteristics are reminiscent of carbon dots, especially those obtained from top-down method...
August 16, 2018: Chemistry: a European Journal
Mona M Saber, Abdulaziz M Al-Mahallawi, Noha N Nassar, Björn Stork, Samia A Shouman
BACKGROUND: Colorectal cancer (CRC) remains a leading cause of death worldwide. Utilizing cisplatin in CRC is correlated with severe adverse effects and drug-resistance. Combined anticancer drug-treatment, along with, their enhanced delivery, can effectively kill cancer through multiple pathways. Nano-cubosomes are emerging as nanocarriers for anticancer therapies, hence, we constructed nano-cubosomes bearing cisplatin and cisplatin-metformin combination for investigation on HCT-116 cells...
August 15, 2018: BMC Cancer
Md Abul Barkat, Harshita, Faheem Hyder Pottoo, Satya Prakash Singh, Farhan J Ahmad
The current work focuses on the formulation development, optimization, and in vivo assessment of nano-sized silver sulfadiazine ( nSSD) and micron-sized silver sulfadiazine ( mSSD) topical gel composed of Aloe vera gel ( Aloe gel) and Carbopol 940 for the management of second-degree burn wound. The optimized concentration of gel-forming agent (Carbopol 940) was chosen based on best possible consistency and spreadability of the gel. The second-degree burn infliction was developed in the posterior region of rats followed by anesthesia...
August 16, 2018: International Journal of Lower Extremity Wounds
Bhagyashri S Thorat Gadgil, Naresh Killi, Gundloori V N Rathna
Polyhydroxyalkanoates (PHAs) are biopolymers synthesized by bacteria under unbalanced growth conditions. These biopolymers are considered as potential biomaterials for future applications because they are biocompatible, biodegradable, and easy to produce and functionalize with strong mechanical strength. Currently, PHAs are being extensively innovated for biomedical applications due to their prerequisite properties. The wide range of biomedical applications includes drug delivery systems, implants, tissue engineering, scaffolds, artificial organ constructs, etc...
September 1, 2017: MedChemComm
Chandrababu Rejeeth, Raju Vivek, Varukattu NipunBabu, Alok Sharma, Xianting Ding, Kun Qian
An innovative approach for the distinctively efficient action of smart targeted drug delivery to a specific cell type is obtained through the modification of the surface of nanoparticles. Specifically, the work identifies a cell surface receptor targeting drug delivery nanosystem based on mesoporous silica loaded with the anticancer drug cisplatin ( cis -DDP) and poly-acrylic acid (PAA). A specific target is the PDGF receptors expressed in cervical cancer cells, thus making the PAA functionalized nanocomposite a suitable and promising nano-medicine for the targeting of PDGF-overexpressing cancers in the near future...
November 1, 2017: MedChemComm
Yun Hu, Zongmin Zhao, Theresa Harmon, Paul R Pentel, Marion Ehrich, Chenming Zhang
Polyethylene glycol (PEG) has long been used in nanoparticle-based drug or vaccine delivery platforms. In this study, nano-nicotine vaccines (NanoNicVac) were PEGylated to different degrees to investigate the impact of PEG on the immunological efficacy of the vaccine. Hybrid nanoparticles with various degrees of PEGylation (2.5%-30%) were assembled. It was found that 30% PEGylation resulted in a hybrid nanoparticle of a compromised core-shell structure. A higher concentration of PEG also led to a slower cellular uptake of hybrid nanoparticles by dendritic cells...
August 7, 2018: Biomaterials
M Junaid Dar, Fakhar Ud Din, Gul Majid Khan
Topical drug delivery against cutaneous leishmaniasis (CL) signifies an effective alternate for improving the availability and reducing the toxicity associated with the parenteral administration of conventional sodium stibogluconate (SSG) injection. The basic aim of the study was to develop nano-deformable liposomes (NDLs) for the dermal delivery of SSG against CL. NDLs were formulated by a modified thin film hydration method and optimized via Box-Behnken statistical design. The physicochemical properties of SSG-NDLs were established in terms of vesicle size (195...
November 2018: Drug Delivery
Prakash Gangadaran, Chae Moon Hong, Ji Min Oh, Ramya Lakshmi Rajendran, Senthilkumar Kalimuthu, Seung Hyun Son, Arunnehru Gopal, Liya Zhu, Se Hwan Baek, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Exosomes are natural nano-sized membrane vesicles that have garnered recent interest owing to their potential as drug delivery vehicles. Though exosomes are effective drug carriers, their production and in vivo biodistribution are still not completely elucidated. We analyzed the production of exosome mimetics (EMs) from red blood cells (RBCs) and the radio-labeling of the RBC-EMs for in vivo imaging. Engineered EMs from RBCs were produced in large-scale by a one-step extrusion method, and further purified by density-gradient centrifugation...
2018: Frontiers in Pharmacology
Srishti Munjal, Smriti R Deka, Santosh Yadav, Preeti Goyal, Ashwani K Sharma, Pradeep Kumar
Small molecule-based amphiphiles self-assemble into nanostructures (micelles) in aqueous medium which are currently being explored as novel drug delivery systems. Here, naproxen-polyethylene glycol (N-PEG), a small molecule-derived amphiphile, has been synthesised, characterised and evaluated as hydrophobic drug carrier. 1 H, 13 C Nuclear magnetic resonance (NMR), mass spectrometry (MS) and Fourier-transform infrared spectroscopy (FTIR) confirmed the formation of N-PEG and dynamic light scattering (DLS) revealed the formation of nano-sized structures of ∼228 nm...
September 2018: IET Nanobiotechnology
Sweet Naskar, Ketousetuo Koutsu, Suraj Sharma
Chitosan (CS) is one of the most functional natural biopolymer widely used in the pharmaceutical field due to its biocompatibility and biodegradability. These privileges lead to its application in the synthesis of NPs for the drug during the last two decades. This article gives rise to a general review of the different chitosan nanoparticles (CSNPs) preparation techniques: Ionic gelation, emulsion cross-linking, spray-drying, emulsion-droplet coalescence method, nanoprecipitation, reverse micellar method, desolvation method, modified ionic gelation with radial polymerization and emulsion solvent diffusion, from the point of view of the methodological and mechanistic aspects involved...
August 14, 2018: Journal of Drug Targeting
Madhulika Pradhan, Amit Alexander, Manju Rawat Singh, Deependra Singh, Swarnlata Saraf, Shailendra Saraf, Ajazuddin
Psoriasis is a consistently recurring, inflammatory, autoimmune disorder of the skin, affecting about 2-5% of the world population. Abundant therapeutic agents are accessible for the treatment of psoriasis. Nevertheless, none of them are entirely secure and effective to treat the disease without compromising patient compliance. Furthermore, already existing drugs are supposed to restrain the ailment and alleviate the sign and symptoms with no complete cure. However, they focus on restraining the disease and alleviating the symptoms without providing an absolute cure...
August 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Lingtong Meng, Yali Cheng, Xiaoning Tong, Shaoju Gan, Yawen Ding, Yu Zhang, Chao Wang, Lei Xu, Yishen Zhu, Jinhui Wu, Yiqiao Hu, Ahu Yuan
Hypoxia, and hypoxia-inducible factor-1 (HIF-1), can induce tumor resistance to radiation therapy. To overcome hypoxia-induced radiation resistance, recent studies have described nano-systems to improve tumor oxygenation for immobilizing DNA damage and simultaneously initiate oxygen-dependent HIF-1α degradation. However, HIF-1α degradation is incomplete during tumor oxygenation treatment alone. Therefore, tumor oxygenation combined with residual HIF-1 functional inhibition is crucial to optimizing therapeutic outcomes of radiotherapy...
August 13, 2018: ACS Nano
Erfaneh Ghassami, Jaleh Varshosaz, Somayeh Taymouri
BACKGROUND: Among the numerous bio-responsive polymeric drug delivery systems developed recently, redox-triggered release of molecular payloads have gained great deal of attention, especially in the field of anticancer drug delivery. In most cases, these systems rely on disulfide bonds located either in the matrix cross-link, or in auxiliary chains to achieve stimuli-responsive drug release. These bonds keep their stability in extracellular environments, yet, rapidly break by thiol-disulfide exchange reactions in the cytosol, due to the presence of greater levels of glutathione...
August 12, 2018: Current Pharmaceutical Design
Andrew Piper, Ben M Alston, Dave J Adams, Andrew R Mount
Nanoelectrodes and nanoelectrode arrays show enhanced diffusion and greater faradaic current densities and signal-to-noise ratios compared to macro and microelectrodes, which can lead to enhanced sensing and detection. One example is the microsquare nanoband edge electrode (MNEE) array system, readily formed through microfabrication and whose quantitative response has been established electroanalytically. Hydrogels have been shown to have applications in drug delivery, tissue engineering, and anti-biofouling; some also have the ability to be grown electrochemically...
August 13, 2018: Faraday Discussions
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