Wenjiao Fu, Mengyu Guo, Xuemei Zhou, Zhenzhen Wang, Jiufeng Sun, Yaling An, Tong Guan, Mingdi Hu, Jiayang Li, Ziwei Chen, Jinmin Ye, Xingfa Gao, George Fu Gao, Lianpan Dai, Yaling Wang, Chunying Chen
Intranasal vaccines, eliciting mucosal immune responses, can prevent early invasion, replication, and transmission of pathogens in the respiratory tract. However, the effective delivery of antigens through the nasal barrier and boosting of a robust systematic and mucosal immune remain challenges in intranasal vaccine development. Here, we describe an intranasally administered self-healing hydrogel vaccine with a reversible strain-dependent sol-gel transition by precisely modulating the self-assembly processes between the natural drug rhein and aluminum ions...
April 15, 2024: ACS Nano