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Nano Drug

Pavan Walvekar, Ramesh Gannimani, Thirumala Govender
Current drug therapy against infections is threatening to become obsolete due to the poor physical, chemical, biological and pharmacokinetic properties of drugs, followed by high risk of acquiring resistance. Taking into account the significant benefits of nanotechnology, nano-based delivery of anti-infectious agents is emerging as a potential approach to combat several lethal infections. Co-delivery of multiple anti-infectious agents in a single nano-based system is beginning to show significant advantages over mono-therapy, such as synergism, enhanced anti-microbial activity, broad anti-microbial spectrum, reduced resistance development, and improved and cost-effective treatment...
October 17, 2018: European Journal of Pharmaceutical Sciences
Liat Soudry-Kochavi, Natalya Naraykin, Rosanna Di Paola, Enrico Gugliandolo, Alessio Peritore, Salvatore Cuzzocrea, Ehud Ziv, Taher Nassar, Simon Benita
One of the major disadvantages associated with macromolecules therapy is that most of them can only be administered parenterally. Exenatide, an efficient anti-diabetic drug, incretin mimetic, is currently administered subcutaneously (SC) causing compliance issues. Nanoparticles (NPs) are considered a promising solution for oral delivery of this drug. In order to overcome exenatide's inability to cross the enterocytes and to increase its stability in the gastrointestinal (GI) tract, we encapsulated exenatide into a nano-in-micro delivery system...
October 17, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Carl P Goodrich, Michael P Brenner, Katharina Ribbeck
Creating a selective gel that filters particles based on their interactions is a major goal of nanotechnology, with far-reaching implications from drug delivery to controlling assembly pathways. However, this is particularly difficult when the particles are larger than the gel's characteristic mesh size because such particles cannot passively pass through the gel. Thus, filtering requires the interacting particles to transiently reorganize the gel's internal structure. While significant advances, e.g., in DNA engineering, have enabled the design of nano-materials with programmable interactions, it is not clear what physical principles such a designer gel could exploit to achieve selective permeability...
October 19, 2018: Nature Communications
Vijay Mishra, Kuldeep K Bansal, Asit Verma, Nishika Yadav, Sourav Thakur, Kalvatala Sudhakar, Jessica M Rosenholm
Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide...
October 18, 2018: Pharmaceutics
Yixia Qian, Yuehua Wang, Fei Jia, Zihua Wang, Chunyan Yue, Weikai Zhang, Zhiyuan Hu, Weizhi Wang
Mild acidity matrix, rich blood vessels and special biomarkers constitute the primary tumor microenvironment. Nanoparticles could change their physicochemical characteristics by functionalizing a series of moieties which is responsive towards pH or specific markers. So precise regulation of nanocarrier-based drug delivery systems by the tumor microenvironment has showed great potential for theranostics. Herein, we developed a smart nano delivery system STD-NM, showing tumor microenvironment responsive targeting, efficient drug delivery and precise evaluation of therapeutic effect in vivo...
October 9, 2018: Biomaterials
S Pawłowska, T A Kowalewski, F Pierini
Over the past few decades, there has been strong interest in the development of new micro- and nanomaterials for biomedical applications. Their use in the form of capsules, particles or filaments suspended in body fluids is associated with conformational changes and hydrodynamic interactions responsible for their transport. The dynamics of fibres or other long objects in Poiseuille flow is one of the fundamental problems in a variety of biomedical contexts, such as mobility of proteins, dynamics of DNA or other biological polymers, cell movement, tissue engineering, and drug delivery...
October 19, 2018: Soft Matter
Rita B Restani, Rita F Pires, Anna Tolmatcheva, Rita Cabral, Pedro V Baptista, Alexandra R Fernandes, Teresa Casimiro, Vasco D B Bonifácio, Ana Aguiar-Ricardo
POxylated polyurea dendrimer (PUREG4 OOx48 )-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2 -assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4 OOx48 nanoparticles were much more cytotoxic than the free drug...
October 2018: ChemistryOpen
Hossam Samir El-Sawy, Ahmed Al-Abd, Tarek Ahmed, Khalid M El-Say, Vladimir P Torchilin
The microenvironment characteristics of solid tumors, renowned as barriers that harshly impeded many drug delivery approaches, were precisely studied, investigated, categorized, divided and subdivided into a complex diverse of barriers. These categories were further studied with a particular perspective, which makes all barriers found in solid tumors micromilieu turned into different types of stimuli, and considered as triggers that can increase and hasten drug release targeting efficacy. This review is gathering the data concerning the nature of solid tumors micromilieu, the past directions focused on treatment of such tumors, the recent efforts employed for engineering smart nano-architectures with the utilization of the specified stimuli categories, the possibility of combining more than one stimuli for much more targeting enhancement, examples of the approved nano-architectures that already translated clinically as well as the obstacles faced by these nano-structures, and lastly overview the possible future implementations of smart chemical engineering for designing more efficient drug delivery/theranostic systems and for making nano-systems with much higher level of specificity and penetrability features...
October 17, 2018: ACS Nano
Mengyu He, Jiali Zhu, Na Yu, Hui Kong, Xiaoning Zeng, Weiping Xie, Huae Xu
OBJECTIVES: Paclitaxel (Ptx) has been regarded as one of the most effective chemotherapeutic drugs for lung cancers. Increasing studies focused on the nano-delivery system of Ptx due to its poor solubility and hypersensitivity. The aim of the resent study was to investigate the antitumor effects of self-assembled Ptx nano-filaments for lung cancer cells. METHODS: In the present study, we designed and synthesized novel Ptx-loaded nano-filaments through conjugation of Ptx and succinic acid (SA) (Ptx-SA, P-NFs)...
October 16, 2018: Current Drug Delivery
Yanping Lu, Shunping Han, Hongyue Zheng, Rui Ma, Yuting Ping, Jiafeng Zou, Hongxia Tang, Yongping Zhang, Xiuling Xu, Fanzhu Li
Background: The Traditional Chinese Medicine, arsenic trioxide (ATO, As2 O3 ) could inhibit growth and induce apoptosis in a variety of solid tumor cells, but it is severely limited in the treatment of glioma due to its poor BBB penetration and nonspecifcity distribution in vivo. Purpose: The objective of this study was encapsulating ATO in the modified PAMAM den-drimers to solve the problem that the poor antitumor effect of ATO to glioma, which provide a novel angle for the study of glioma treatment...
2018: International Journal of Nanomedicine
Juhi Singh, Pooja Mittal, Gunjan Vasant Bonde, Gufran Ajmal, Brahmeshwar Mishra
Quercetin (Qu), is a flavonoid known to have anti-diabetic effects owing to its antioxidant property, thus promoting regeneration of the pancreatic islets, ultimately increasing insulin secretion. But the therapeutic application of Qu is hampered by its low oral bioavailability and its unfavourable physicochemical characteristics. The present work aimed at formulation of Quercetin loaded Soluplus® micelles (SMs) so as to enhance its bioavailability and provide prolonged release for the management of diabetes...
October 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
G Cerrato, C L Bianchi, F Galli, C Pirola, S Morandi, V Capucci
The ingredients of Pharmaceuticals and Personal Care Products (PPCPs) persist in water and conventional treatment plants are not able to remove them efficiently. Sonochemical treatment is insufficient to mineralize organics such as ibuprofen into CO2 and H2 O. TiO2 degrades ibuprofen (IBP) under UV light; however, it does not reach a high grade of conversion. Here, we investigated the mineralization of ibuprofen to CO2 by TiO2 UV-C photocatalysis. We replaced nano-sized P25 (the standard catalyst) with a micro-sized commercial sample of TiO2 to preclude the use of nanoparticles which are dangerous for human health and because typical filtration systems are expensive and inefficient...
September 25, 2018: Journal of Hazardous Materials
J Carreto Escobar, M Salazar Villanueva, A Bautista Hernández, D Cortés-Arriagada, E Chigo Anota
In the search of nanomaterials to be used in drug delivery applications, Density Functional Theory calculations were implemented to study the interaction between graphene (G) and hexagonal boron nitride nanosheet (hBNN) with octahedral B12 N12 fullerenes. These B12 N12 fullerenes were considered in two cases: pristine and the modified one with boron-boron, nitrogen-nitrogen (tetragon) and boron-boron-boron (hexagon) homo-nuclear bonds. The whole systems were analyzed in the gas and aqueous phases. The results reveal for all these systems that the interaction is in the range of physisorption (Eads  = from -0...
October 5, 2018: Journal of Molecular Graphics & Modelling
Primiano Pio Di Mauro
A dual-targeting drug delivery system for paclitaxel (PTX) was developed by functionalizing novel polyester-based nanoparticles (NPs) with peptides possessing special affinity for low-density lipoprotein receptor (LDLR), overcoming the limitations of the current chemotherapeutics, to transport drug from blood to brain, and then target glioma cells. Employing novel biodegradable block co-polymers (P and 2P), PTX loaded and peptide-functionalized nanoparticles were prepared by a modified nano-co-precipitation method, carried out in one step only without emulsifier, allowing to obtain spherical nanometric (<200 nm), monodisperse (PDI∼0...
October 12, 2018: International Journal of Pharmaceutics
Roberta Guagliardo, Jésus Pérez-Gil, Stefaan De Smedt, Koen Raemdonck
Pulmonary surfactant (PS) has been extensively studied because of its primary role in mammalian breathing. The deposition of this surface-active material at the alveolar air-water interface is essential to lower surface tension, thus avoiding alveolar collapse during expiration. In addition, PS is involved in host defense, facilitating the clearance of potentially harmful particulates. PS has a unique composition, including 92% of lipids and 8% of surfactant proteins (SPs) by mass. Although they constitute the minor fraction, SPs to a large extent orchestrate PS-related functions...
October 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Sajad Moradi, Elnaz Hosseini, Mohadese Abdoli, Solmaz Khani, Mohsen Shahlaei
Carbohydrate biopolymer of biocompatible biodegradable chitosan, currently become one of the most usable polymer in medical and pharmaceutical sciences. In this regard a large number of protein and peptide drugs are used as therapeutic agents which can be exposed to temperature stresses either in transporting or storage. These stresses can make the protein structure unstable, change the active structure and disrupt its therapeutic function that limits their using as successful drug. In order to overcome these disadvantages associated with protein drugs, different materials such as natural or synthetic polymers are used to make protein loaded biocompatible nano and microspheres...
January 1, 2019: Carbohydrate Polymers
Yuzhi Mu, Yangmu Fu, Jing Li, Xiaoping Yu, Yang Li, Yanan Wang, Xuanjin Wu, Kaichao Zhang, Ming Kong, Chao Feng, Xiguang Chen
In this study, quercetin-chitosan conjugate (QT-CS) was synthesized for oral delivery of doxorubicin (DOX) to improve its oral bioavailability by increasing its water solubility, opening tight junction and bypassing the P-glycoprotein (P-gp). The prepared QT-CS self-assembled into micelles which could encapsulate DOX with high encapsulation rate, small particle size (136.9 nm) and strong zeta potential (+16.2 mV). QT-CS-DOX micelles displayed sustained-release profile in gastrointestinal simulation fluid (pH 1...
January 1, 2019: Carbohydrate Polymers
Mohsin Qureshi, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Yasmin Sultana
The present work was designed to explore the efficacy of neuroactive drug (risperidone) loaded chitosan lipid nano particle (RIS-CH-LNPs) to enhance the bioactivity in schizophrenia via nasal route. The three-factor and three-level formulation by design approach was used for optimization and their effects were observed on (Y1) size in nm, (Y2) % drug loading, and (Y3) % drug release. The optimized formulation RIS-CH-LNPopt was further evaluated for its surface morphology, ex-vivo permeation study, in-vivo behavior study, and stability study...
October 11, 2018: Current Drug Delivery
Zhe Zhang, Na Niu, Xi Gao, Fuqin Han, Zhijun Chen, Shujun Li, Jian Li
Hypoxia is the main characteristic of tumor microenvironment, and the one of the key factors that cause the drug resistance of cancer cells for chemotherapy. Anticancer drug such as DOX cannot react with sufficient oxygen to produce reactive oxygen species (ROS) in hypoxic environment, which affects the therapeutic efficiency of the drug. In this work, we constructed a multi-functional nano-carrier (named as FeSiAuO) containing Fe3 O4 , mesoporous SiO2 and Au2 O3 with magnetic, large surface ratio and light induced oxygen production properties...
October 5, 2018: Colloids and Surfaces. B, Biointerfaces
Zhe Wang, Yaou Duan, Yanwen Duan
Inspired by the bionics of marine mussels, polydopamine (PDA), a new polymer with unique physicochemical properties was discovered. Due to its simple preparation, good biocompatibility, unique drug-loading methods, PDA has attracted tremendous attentions in field of drug delivery and imaging, and the combination of chemotherapy and other therapies or diagnostic methods, such as photothermotherapy (PTT), photoacoustic imaging (PAI), magnetic resonance imaging (MRI), etc. As an excellent drug carrier in tumor targeted drug delivery system, the drug release behavior of drug-loaded PDA-based nanoparticles is also an important factor to be considered in the establishment of drug delivery systems...
October 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
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