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https://www.readbyqxmd.com/read/28531143/a-4-phenoxyphenol-derivative-exerts-inhibitory-effects-on-human-hepatocellular-carcinoma-cells-through-regulating-autophagy-and-apoptosis-accompanied-by-downregulating-%C3%AE-tubulin-expression
#1
Wen-Tsan Chang, Wangta Liu, Yi-Han Chiu, Bing-Hung Chen, Shih-Chang Chuang, Yen-Chun Chen, Yun-Tzh Hsu, Mei-Jei Lu, Shean-Jaw Chiou, Chon-Kit Chou, Chien-Chih Chiu
Hepatocellular carcinoma (HCC) is a leading cancer worldwide. Advanced HCCs are usually resistant to anticancer drugs, causing unsatisfactory chemotherapy outcomes. In this study, we showed that a 4-phenoxyphenol derivative, 4-[4-(4-hydroxyphenoxy)phenoxy]phenol (4-HPPP), exerts an inhibitory activity against two HCC cell lines, Huh7 and Ha22T. We further investigated the anti-HCC activities of 4-HPPP, including anti-proliferation and induction of apoptosis. Our results showed that higher dosage of 4-HPPP downregulates the expression of α-tubulin and causes nuclear enlargement in both the Huh-7 and Ha22T cell lines...
May 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28529625/tuberostemonine-reverses-multidrug-resistance-in-chronic-myelogenous-leukemia-cells-k562-adr
#2
Yu Jia Wang, Huan Dong Zhao, Cai Feng Zhu, Jian Li, Hong Juan Xie, Yu Xiang Chen
Objective: To investigate the reversal effect of tuberostemonine on MDR in myelogenous leukemia cells K562/ADR. Methods: Human myelogenous leukemia cells K562 and their adriamycin-resistance cells K562/ADR were used. The growth curve of cells treated by tuberostemonine and the Non-toxic concentration of tuberostemonine were determined by MTT, Cell apoptosis was determined by MTT and flow cytometry. The expression of MDR1, Survivin and Livin was detected by RT-PCR. The activity of P-gp was detected by flow cytometry...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28529566/tgf-%C3%AE-1-signaling-pathway-serves-a-role-in-hepg2-cell-regulation-by-affecting-the-protein-expression-of-pcna-gankyrin-p115-xiap-and-survivin
#3
Xin-Hong Wang, Zhi-Guo Chen, Rui-Ling Xu, Cheng-Qian Lv, Jing Liu, Bing Du
The transforming growth factor-β (TGF-β) signaling pathway serves a key role in the pathogenesis of liver cancer. To investigate the association between TGF-β1 and the following proteins: Proliferating cell nuclear antigen (PCNA), gankyrin, general vesicular transport factor p115 (p115), X-linked inhibitor of apoptosis protein (XIAP) and survivin, HepG2 liver cancer cells were transfected with small interfering RNA (siRNA) directed against TGF-β1, or were treated with exogenous TGF-β1. TGF-β1 protein expression levels were assessed at 72 and 96 h using western blotting, cell growth was evaluated using a Cell Counting kit-8 assay, and flow cytometry was used to examine cell cycle distribution and apoptosis...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28529560/ruanjian-sanjie-decoction-exhibits-antitumor-activity-by-inducing-cell-apoptosis-in-breast-cancer
#4
Xiumei Zhao, Jing Zhao, Renjie Hu, Qiang Yao, Guixian Zhang, Hongsheng Shen, Ernesto Yagüe, Yunhui Hu
Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, including Ban xia (Pinellia ternata), Xia ku cao (Prunella vulgaris), Shan ci gu (Cremastra appendiculata) and Hai zao (Sargassum pallidum), and has traditionally been used for softening hard lumps and resolving hard tissue masses...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28529481/topical-ophthalmic-formulation-of-trichostatin-a-and-surr9-c84a-for-quick-recovery-post-alkali-burn-of-corneal-haze
#5
Kislay Roy, Chun Hei Antonio Cheung, Rupinder K Kanwar, Rajat Sandhir, Jagat R Kanwar
Alkali burn injury is a true ocular emergency of the conjunctiva and cornea that requires immediate precision. Lack of an immediate therapy can lead to a substantial damage in the ocular surface and anterior segment further causing visual impairment and disfigurement. We explored the regenerative capability of dominant negative survivin protein (SurR9-C84A) and histone deacetylase inhibitor trichostatin-A (TSA) in vivo, in a rat alkali burn model. A topical insult in rat eyes with NaOH led to degradation of the conjunctival and corneal epithelium...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28525387/sestrin-2-suppresses-cells-proliferation-through-ampk-mtorc1-pathway-activation-in-colorectal-cancer
#6
Jin-Lai Wei, Min Fang, Zhong-Xue Fu, Shou-Ru Zhang, Jin-Bao Guo, Rong Wang, Zhen-Bing Lv, Yong-Fu Xiong
Sestrin 2 is a conserved antioxidant protein that reduces reactive oxygen species (ROS) and inhibits mammalian target of rapamycin complex 1 (mTORC1). We previously showed that sestrin 2 is abnormally decreased in colorectal cancer (CRC). To elucidate the molecular mechanism behind the potential contribution of sestrin 2 to CRC, we used a lentiviral expression vector system to determine the effects of sestrin 2 overexpression on human CRC cells. We found that sestrin 2 overexpression decreased ROS production, inhibited cell growth, and stimulated apoptosis in two CRC cell lines...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28518147/survivin-a-key-player-in-cancer-progression-increases-in-obesity-and-protects-adipose-tissue-stem-cells-from-apoptosis
#7
Miriam Ejarque, Victòria Ceperuelo-Mallafré, Carolina Serena, Gisela Pachón, Yaiza Núñez-Álvarez, Margarida Terrón-Puig, Enrique Calvo, Catalina Núñez-Roa, Wilfredo Oliva-Olivera, Francisco J Tinahones, Miguel Angel Peinado, Joan Vendrell, Sonia Fernández-Veledo
Adipose tissue (AT) has a central role in obesity-related metabolic imbalance through the dysregulated production of cytokines and adipokines. In addition to its known risk for cardiovascular disease and diabetes, obesity is also a major risk for cancer. We investigated the impact of obesity for the expression of survivin, an antiapoptotic protein upregulated by adipokines and a diagnostic biomarker of tumor onset and recurrence. In a cross-sectional study of 111 subjects classified by body mass index, circulating levels of survivin and gene expression in subcutaneous AT were significantly higher in obese patients and positively correlated with leptin...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28512247/targetable-t-type-calcium-channels-drive-glioblastoma
#8
Ying Zhang, Nichola Cruickshanks, Fang Yuan, Baomin Wang, Mary Pahuski, Julia Wulfkuhle, Isela Gallagher, Alexander F Koeppel, Sarah Hatef, Christopher Papanicolas, Jeongwu Lee, Eli E Bar, David Schiff, Stephen Turner, Emanuel F Petricoin, Lloyd S Gray, Roger Abounader
Glioblastoma stem-like cells (GSC) promote tumor initiation, progression and therapeutic resistance. Here we show how GSC can be targeted by the FDA approved drug mibefradil which inhibits the T-type calcium channel Cav3.2. This calcium channel was highly expressed in human GBM specimens and enriched in GSC. Analyses of the TCGA and REMBRANDT databases confirmed upregulation of Cav3.2 in a subset of tumors and showed that overexpression associated with worse prognosis. Mibefradil treatment or RNAi-mediated attenuation of Cav3...
May 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/28509321/evaluation-of-tissue-metalloproteinase-inhibitor-timp-1-and-survivin-levels-during-third-trimester-pregnancy-a-preliminary-report
#9
Agata Karowicz-Bilińska, Urszula Kowalska-Koprek, Dorota Estemberg, Anita Sikora-Szubert
OBJECTIVES: A proper implantation of trophoblastic cells and an appropriate metalloproteinases activity is required to cause disintegration of basal membranes of cells. The activity of tissue matrix metaloproteinases can be inhibited by their matrix inhibitors - TIMP-s. Survivin is a member of inhibitor of apoptosis proteins family (IAP), that suppresses caspase activation, influences VEGF expression and promotes proliferative action of endothelial cells. MATERIAL AND METHODS: The aim of the study was to assess concentrations of two independent anti-apoptotic factors...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28509313/decreased-expression-of-survivin-2b-in-human-pituitary-adenomas-a-preliminary-study
#10
Joanna Waligorska-Stachura, Nadia Sawicka-Gutaj, Maciej Zabel, Wlodzimierz Liebert, Pawel Gut, Agata Czarnywojtek, Marek Ruchala
INTRODUCTION: We aimed to investigate survivin and its splice variants DEx3 and 2B expressions in pituitary adenomas and normal pituitary glands using immunohistochemistry. MATERIAL AND METHODS: The study group consisted of eight pituitary adenomas: five of non-functional tumors, two of GH-secreting tumors, and one PRL-secreting tumor. Eight healthy pituitary tissue samples obtained after autopsy served as controls. RESULTS: Survivin expression was found in 87...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28508718/frondoside-a-induces-aif-associated-caspase-independent-apoptosis-in-burkitt-lymphoma-cells
#11
Sergey A Dyshlovoy, Stefanie Rast, Jessica Hauschild, Katharina Otte, Winfried H Alsdorf, Ramin Madanchi, Vladimir I Kalinin, Alexandra S Silchenko, Sergey A Avilov, Judith Dierlamm, Friedemann Honecker, Valentin A Stonik, Carsten Bokemeyer, Gunhild von Amsberg
For patients with refractory or relapsed Burkitt lymphoma (BL), no standard therapy is available for second-line treatment to date. Nonfunctional caspases-dependent apoptosis pathways, inactivating p53 mutations and pro-survival autophagy prevent activity of conventional chemotherapy. Thus, new drugs bypassing these mechanisms of resistance are required. Here, we investigated the efficacy of the marine natural compound frondoside A (FrA) in eight BL cell lines. FrA revealed cytotoxic effects in all cell lines tested including the multiresistant CA46 cells...
May 16, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28506699/cra-crosolic-acid-isolated-from-actinidia-valvata-dunn-radix-induces-apoptosis-of-human-gastric-cancer-cell-line-bgc823-in%C3%A2-vitro-via-down-regulation-of-the-nf-%C3%AE%C2%BAb-pathway
#12
Qi-Lai Cheng, Hong-Liang Li, Ying-Chen Li, Zhao-Wen Liu, Xiao-Hua Guo, Yi-Jian Cheng
A natural ursolic compound, 2α,3β-dihydroxy-urs-12-en-28-oic acid (corosolic acid, CRA) was isolated from the root of Actinidia valvata Dunn. (A. valvata Radix). Since a large number of triterpenoid compound has marked anticancer effects toward various types of cancer cell lines in vitro, this study was carried out to investigate the anticancer effect of CRA in human gastric cancer cell line BGC823 cells and the underlying apoptotic mechanism of CRA was examined in BGC823 cell lines. The results showed that CRA significantly suppressed the viability of BGC823 cells in a concentration- and time-dependent manner...
May 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28505590/apoptosis-induction-activity-and-molecular-docking-studies-of-survivin-sirna-carried-by-fe3o4-peg-lac-chitosan-pei-nanoparticles-in-mcf-7-human-breast-cancer-cells
#13
Sanam Arami, Majid Mahdavi, Mohammad-Reza Rashidi, Reza Yekta, Mohammad Rahnamay, Leila Molavi, Mohammad-Saeid Hejazi, Nasser Samadi
Delivery of small interfering RNAs (siRNAs) into cells still remains a challenge in gene delivery studies. Here, we investigated the ability of synthesized Fe3O4-PEG-LAC-chitosan-PEI nanoparticles for siRNA delivery of survivin as the model gene into cells. The cellular uptake of survivin siRNA carried by synthesized nanoparticles into MCF-7 breast cancer cell line was evaluated by florescent microscopy and flowcytometry, both proving the efficacy of nanoparticles in delivery of up to 64.7% in comparison with lipofectamine 2000...
May 6, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28498457/suvmax-of-18f-fdg-pet-ct-correlates-to-expression-of-major-chemotherapy-related-tumor-markers-and-serum-tumor-markers-in-gastric-adenocarcinoma-patients
#14
Lu Bai, Chi-Hua Guo, Yan Zhao, Jun-Gang Gao, Miao Li, Cong Shen, You-Min Guo, Xiao-Yi Duan
The expression of P53 was previously found by us significantly correlated with maximal standardized uptake value (SUVmax) in non-small cell lung cancer (NSCLC) patients. Hence, the aim of this study was to clarify the relationship between SUVmax and the status of the chemotherapy-related tumor marker expression or serum tumor markers in gastric adenocarcinoma patients. Sixty-four gastric adenocarcinoma patients who underwent 18F-FDG PET/CT prior to treatment were enrolled in this study. Immunohistochemistry was performed to detect changes of Her-2, P53 and Survivin in lesions, and electrochemiluminescence (ECL) method was used to quantify expression of serum CA72-4, CA19-9 and CEA of these patients...
May 5, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28494251/nitric-oxide-releasing-derivatives-of-brefeldin-a-as-potent-and-highly-selective-anticancer-agents
#15
Kangtao Tian, Fanxing Xu, Xiang Gao, Tong Han, Jia Li, Huaqi Pan, Linghe Zang, Dahong Li, Zhanlin Li, Takahiro Uchita, Ming Gao, Huiming Hua
A series of NO-donating mono- or diester derivatives of brefeldin A were designed, synthesized and biologically evaluated. Some derivatives exhibited potent antiproliferative activity with low IC50 values. The most potent NO-donating hybrid 13b exhibited stronger cytotoxicity against human prostate cancer PC-3 cells, human colon carcinoma HT-29 cells and human liver cancer HepG-2 cells than BFA with IC50 values of 25 nM, 160 nM and 180 nM, respectively. More importantly, compound 13b showed good selectivity between human normal and tumor liver cells with selectivity index of 33...
May 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28492491/magnetic-cationic-amylose-nanoparticles-used-to-deliver-survivin-small-interfering-rna-for-gene-therapy-of-hepatocellular-carcinoma-in-vitro
#16
Zhuo Wu, Xiao-Lin Xu, Jun-Zhao Zhang, Xu-Hong Mao, Ming-Wei Xie, Zi-Liang Cheng, Lie-Jing Lu, Xiao-Hui Duan, Li-Ming Zhang, Jun Shen
Amylose is a promising nanocarrier for gene delivery in terms of its good biocompatibility and high transfection efficiency. Small interfering RNA against survivin (survivin-siRNA) can cause tumor apoptosis by silencing a hepatocellular carcinoma (HCC)-specific gene at the messenger RNA level. In this study, we developed a new class of folate-functionalized, superparamagnetic iron oxide (SPIO)-loaded cationic amylose nanoparticles to deliver survivin-siRNA to HCC cells. The cellular uptake of nanocomplexes, cytotoxicity, cell apoptosis, and gene suppression mediated by siRNA-complexed nanoparticles were tested...
May 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28489881/hypoxia-activated-prodrug-th-302-decreased-survival-rate-of-canine-lymphoma-cells-under-hypoxic-condition
#17
Hiroki Yamazaki, Yu-Chang Lai, Morihiro Tateno, Asuka Setoguchi, Yuko Goto-Koshino, Yasuyuki Endo, Munekazu Nakaichi, Hajime Tsujimoto, Naoki Miura
We tested the hypotheses that hypoxic stimulation enhances growth potentials of canine lymphoma cells by activating hypoxia-inducible factor 1α (HIF-1α), and that the hypoxia-activated prodrug (TH-302) inhibits growth potentials in the cells. We investigated how hypoxic culture affects the growth rate, chemoresistance, and invasiveness of canine lymphoma cells and doxorubicin (DOX)-resistant lymphoma cells, and influences of TH-302 on survival rate of the cells under hypoxic conditions. Our results demonstrated that hypoxic culture upregulated the expression of HIF-1α and its target genes, including ATP-binding cassette transporter B1 (ABCB1), ATP-binding cassette transporter G2 (ABCG2), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and survivin, and enhanced the growth rate, DOX resistance, and invasiveness of the cells...
2017: PloS One
https://www.readbyqxmd.com/read/28477142/retraction-note-to-tgf-%C3%AE-regulates-survivin-to-affect-cell-cycle-and-the-expression-of-egfr-and-mmp9-in-glioblastoma
#18
Wenliang Chen, Xiao Zhong, Yi Wei, Yun Liu, Quan Yi, Genshui Zhang, Lishan He, Fajiang Chen, Yingping Liu, Jiandong Luo
No abstract text is available yet for this article.
May 6, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28477011/simultaneous-in-vitro-generation-of-cd8-and-cd4-t-cells-specific-to-three-universal-tumor-associated-antigens-of-wt1-survivin-and-tert-and-adoptive-t-cell-transfer-for-the-treatment-of-acute-myeloid-leukemia
#19
Hyun-Jung Sohn, Ji Yoon Lee, Hyun-Joo Lee, Dae-Hee Sohn, Hyun-Il Cho, Hee-Je Kim, Tai-Gyu Kim
Previously, we found that most patients with acute myeloid leukemia (AML) expressed at least one of the leukemic associated antigens (LAAs) WT1, survivin and TERT, and different combinations of the three LAAs predicted negative clinical outcomes. Multi-tumor antigen-specific T cells were generated to overcome antigenic variation and may be sufficient to maximize antitumoral effects. To generate triple antigen-specific (Tri)-T cells that recognize three LAAs, dendritic cells (DCs) were transfected with three tumor antigen-encoding RNAs...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28476037/increased-levels-of-laptm4b-vegf-and-survivin-are-correlated-with-tumor-progression-and-poor-prognosis-in-breast-cancer-patients
#20
Sha Li, Lu Wang, Yue Meng, Yanli Chang, Jianjun Xu, Qingyun Zhang
OBJECTIVE: This study explored the relationships among the expression of LAPTM4B, VEGF, and survivin and clinicopathological characteristics and prognosis in breast cancer patients. METHODS: The expression of these three molecules in 110 stage I-III breast cancer patients with clinicopathological and follow-up data was detected via immunohistochemistry. Kaplan-Meier and Cox proportional hazard regression analyses were performed to assess the prognostic significance of these markers in breast cancer...
April 18, 2017: Oncotarget
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