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Evelia Edith Oyhenart, María Fernanda Torres, María Antonia Luis, María Eugenia Luna, Luis Eduardo Castro, Mariela Garraza, Bárbara Navazo, María Cecilia Fucini, Fabián Aníbal Quintero, María Florencia Cesani
The aim of this study was to evaluate and compare the nutritional status of child populations living in four counties of the province of Buenos Aires to observe differences related to particular environmental and socioeconomic contexts in the framework of the nutrition transition. During the school years corresponding to the 2008-2012 period, weight and height were measured and body mass index was calculated for 7,873 school children between the ages of 4 and 12 years from the counties of La Plata, Brandsen, Magdalena and Punta Indio...
July 2018: Salud Colectiva
Stephanie Castro-Arechaga, Lucia Ronceros-Salas, Sthefanny Vega-Centeno, Mariela Moreno, Alonso Soto
OBJECTIVE: To know the five-year survival and its associated factors in patients with Acute Lymphoblastic Leukemia (ALL) in Peru. MATERIALS AND METHODS: A retrospective cohort of patients with ALL treated with chemotherapy in a Peruvian hospital for 13 years was studied. The dependent variables were overall survival (OS) and disease-free survival (DFS). Possible factors that might be associated with diagnosis and response to treatment were evaluated using the Cox proportional risk method...
July 2018: Revista Peruana de Medicina Experimental y Salud Pública
Mariela Faykoo-Martinez, Skyler J Mooney, Melissa M Holmes
The social decision-making network (SDMN) is a conserved neural circuit that modulates a range of social behaviors via context-specific patterns of activation that may be controlled in part by oxytocinergic signaling. We have previously characterized oxytocin's (OT) influence on prosociality in the naked mole-rat, a eusocial mammalian species, and its altered neural distribution between animals of differing social status. Here, we asked two questions: (1) do patterns of activation in the SDMN vary by social context and (2) is functional connectivity of the SDMN altered by OT manipulation? Adult subordinate naked mole-rats were exposed to one of three types of stimuli (three behavioral paradigms: familiar adult conspecific, unfamiliar adult conspecific, or familiar pups) while manipulating OT (three manipulations: saline, OT, or OT antagonist)...
2018: Frontiers in Behavioral Neuroscience
Eliana F Castro, Juan J Casal, María J España de Marco, Leandro Battini, Matías Fabiani, Gabriela A Fernández, Ana M Bruno, Lucía V Cavallaro, Mariela Bollini
Bovine viral diarrhea virus (BVDV) is a pestivirus whose infection in cattle is globally distributed. The use of antivirals could complement vaccination as a tool of control and reduce economic losses. The RNA-dependent RNA polymerase (RdRp) of the virus is essential for its genome replication and constitutes an attractive target for the identification of antivirals. With the aim of obtaining selective BVDV inhibitors, the crystal structure of BVDV RdRp was used to perform a virtual screening. Approximately 15,000 small molecules from commercial and in-house databases were evaluated and several structurally different compounds were tested in vitro for antiviral activity...
November 23, 2018: Bioorganic & Medicinal Chemistry Letters
Iván P Moreno-Espíndola, María J Ferrara-Guerrero, Marco L Luna-Guido, Daniel A Ramírez-Villanueva, Arit S De León-Lorenzana, Selene Gómez-Acata, Elizabeth González-Terreros, Blanca Ramírez-Barajas, Yendi E Navarro-Noya, Luis M Sánchez-Rodríguez, Mariela Fuentes-Ponce, Juan U Macedas-Jímenez, Luc Dendooven
Agricultural practices affect the bacterial community structure, but how they determine the response of the bacterial community to drought, is still largely unknown. Conventional cultivated soil, i.e., inorganic fertilization, tillage, crop residue removal and maize ( Zea mays L.) monoculture, and traditional organic farmed soil "milpa," i.e., minimum tillage, rotation of maize, pumpkin ( Cucurbita sp.) and beans ( Phaseolus vulgaris L.) and organic fertilization were sampled. Both soils from the central highlands of Mexico were characterized and incubated aerobically at 5% field capacity (5%FC) and 100% field capacity (FC) for 45 days, while the C and N mineralization, enzyme activity and the bacterial community structure were monitored...
2018: Frontiers in Microbiology
Simón Guerrero, Mariela Inostroza-Riquelme, Pamela Contreras-Orellana, Victor Diaz-Garcia, Pablo Lara, Andrea Vivanco-Palma, Areli Cárdenas, Victor Miranda, Paz Robert, Lisette Leyton, Marcelo J Kogan, Andrew F G Quest, Felipe Oyarzun-Ampuero
Curcumin is widely considered beneficial to human health, but insolubility and instability greatly hamper reproducible exploitation of the advantageous traits. Here we report on the development, characterization and evaluation of a curcumin-loaded nanoemulsion (CUR-NEM) that is highly effective in preventing post-surgery tumor reincidence and metastasis. The method of fabrication utilized safe excipients and generated particles of 200 nm (PDI ≤ 0.2) with negative zeta potential (-30 mV) and a high yield of curcumin (95%), which can be converted by lyophilization to a dry powder...
November 28, 2018: Nanoscale
Mariela Dore, S Barrena, Paloma Triana Junco, Alba Sánchez Galán, Javier Jimenez Gomez, Leopoldo Martinez
INTRODUCTION:  Central venous port (CVP) placement is traditionally performed under fluoroscopy guidance. However, efforts for radiation dose reduction in children have allowed the introduction of ultrasound guidance (USG) and anatomic landmarks as an alternative technique for CVP placement. The aim of this study is to determine whether intraoperative fluoroscopy (IF) is required to confirm the correct position of the catheter tip in children. PATIENTS AND METHODS:  A prospective, single-center study was performed between July and December 2017...
November 23, 2018: European Journal of Pediatric Surgery
EeeLN Buckarma, Mariela Rivera, Henry Schiller, Erica Loomis
BACKGROUND: Treatment of cardiovascular implantable device pocket infections (CIDPIs) requires a multimodal approach that includes antimicrobials, device explantation, and local wound care. Our institution implemented a practice management guideline (PMG) to standardize the care of CIDPIs and engage our acute care surgeons in 2013. Our PMG includes wound culture, complete capsulectomy, pulse lavage, and the placement of a negative pressure wound therapy appliance at the time of device extraction...
December 2018: Journal of Surgical Research
Mariela C Aguilar, Alex Gonzalez, Cornelis Rowaan, Carolina de Freitas, Karam A Alawa, Heather Durkee, William J Feuer, Fabrice Manns, Shihab S Asfour, Byron L Lam, Jean-Marie A Parel
The Ocular Photosensitivity Analyzer (OPA), a new automated instrument to quantify the visual photosensitivity thresholds (VPT) in healthy and light sensitive subjects, is described. The OPA generates light stimuli of varying intensities utilizing unequal ascending and descending steps to yield the VPT. The performance of the OPA was evaluated in healthy subjects, as well as light sensitive subjects with achromatopsia or traumatic brain injury (TBI). VPT in healthy, achromatopsia, and TBI subjects were 3.2 ± 0...
November 1, 2018: Biomedical Optics Express
Bianca F Nieves-Pérez, Sullynette Guerrero-De Hostos, Mariela I Frontera-Hernández, Iadelisse Cruz González, José Josué Hernández Muñoz
OBJECTIVES: Prevalence of potentially inappropriate medications (PIMs) and potential prescribing omissions (PPOs). DESIGN: Cross-sectional study through review of residents' records. SETTING: Three nursing homes of Puerto Rico's metropolitan area. PARTICIPANTS: Nursing home residents. INTERVENTION: Records of residents 65 years of age and older with documented medications and chronic diseases were reviewed. Hospitalized and hospice/palliative care residents were excluded. Beers criteria-2015 and START-STOPP criteria-2014 were applied to identify PIMs and PPOs...
November 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Karen Gardner, Rachael Kearns, Lisa Woodland, Mariela Silveira, Myna Hua, Milena Katz, Klara Takas, Julie McDonald
Background: Waterpipe tobacco smoking is a traditional method of tobacco use, especially in the Eastern Mediterranean Region (EMR), but its prevalence is growing worldwide, especially among young people. Although often perceived as less harmful than other methods of tobacco use because the smoke passes through water, accumulating evidence shows harmful effects and that some smokers become addicted. Interventions that deglamourise and denormalise use have been recommended but little is known about the range and impact of different health prevention and promotion interventions...
2018: Frontiers in Public Health
Luciana Ferella, Juan Ignacio Bastón, Mariela Andrea Bilotas, José Javier Singla, Alejandro Martín González, Carla Noemí Olivares, Gabriela Fabiana Meresman
RESEARCH QUESTION: Can carnosic acid, (CA) rosmarinic acid (RA) and wogonin (WG) inhibit the growth of cultured human endometrial stromal cells and endometriotic-like lesions induced in a BALB/c model of endometriosis? DESIGN: Primary stromal cell cultures were established from endometrial biopsies from women with endometriosis and controls. The human endometrial stromal cell line T-HESC was also used for in-vitro experiments. Endometriosis was surgically induced in BALB/c mice, which were randomly assigned to CA 2 mg/kg/day (n = 11); CA 20 mg/kg/day (n = 10); RA 1 mg/kg/day (n = 11); RA 3 mg/kg/day (n = 10); WG 20 mg/kg/day (n = 12); intraperitoneal vehicle control (n = 8) or oral vehicle control (n = 11)...
October 26, 2018: Reproductive Biomedicine Online
Gabriel Hernández-Marcos, Mariela Hernández-Herrera, Eduardo Anitua
PURPOSE: This study evaluated the effect of the level of the prosthetic construction on the marginal bone stability around extra-short implants (≤ 6.5 mm in length) supporting a fixed prosthesis. MATERIALS AND METHODS: This retrospective study was performed at a private dental clinic. The patient charts were reviewed to select those who had an extra-short implant (≤ 6.5 mm in length) supporting a fixed prosthesis. A transmucosal abutment (transepithelial Multi-Im, BTI Biotechnology Institute) was used in those implants that were restored at the gingival level...
November 2018: International Journal of Oral & Maxillofacial Implants
Jorge Herrera-Díaz, Mariela K Jelezova, Felipe Cruz-García, Tzvetanka D Dinkova
Barley malting quality depends on seed characteristics achieved during grain development and germination. One important parameter is protein accumulation in the mature seed, which may vary between cultivars. Here we conducted a protein pattern analysis in the range of pI 4-7 of mature grains from five Mexican barley cultivars, commonly used for malt and beer production. Reproducibly distinct protein spots, separated by 2D SDS PAGE, were identified by mass spectrometry and considered as potential markers for cultivars with distinct seed protein accumulation...
2018: PloS One
Nicolás A Saffioti, Marilina de Sautu, Mariela S Ferreira-Gomes, Rolando C Rossi, Joshua Berlin, Juan Pablo F C Rossi, Irene C Mangialavori
The plasma membrane Ca2+ ‑ATPase (PMCA) belongs to the family of P-type ATPases, which share the formation of an acid-stable phosphorylated intermediate as part of their reaction cycle. The crystal structure of PMCA is currently lacking. Its abundance is approximately 0.1% of the total protein in the membrane, hampering efforts to produce suitable crystals for X-ray structure analysis. In this work we characterized the effect of beryllium fluoride (BeFx ), aluminium fluoride (AlFx ) and magnesium fluoride (MgFx ) on PMCA...
November 9, 2018: Biochimica et biophysica acta. Biomembranes
Leandro Battini, Mariela Bollini
The type I human immunodeficiency virus (HIV-1) pandemic affecting over 37 million people worldwide continues, with 1.8 million people newly infected each year. Highly active antiretroviral therapy is efficient at reducing viral load and nearly one-half of the infected population is on treatment. One of the most successful approaches for the treatment of HIV infections is the use of inhibitors for human immunodeficiency virus type-1 reverse transcriptase (HIV-1 RT). At present, there are six nonnucleoside reverse transcriptase inhibitors (NNRTIs) approved for clinical use: nevirapine (NVP), delavirdine (DLV), efavirenz (EFV), etravirine (ETV), rilpivirine (RPV), and elsulfavirine...
November 11, 2018: Medicinal Research Reviews
Mariela Patrignani, Gustavo Juan Rinaldi, José Ángel Rufián-Henares, Cecilia Elena Lupano
The release of biscuit Maillard reaction products (MRP) with antioxidant capacity was compared by in vitro and in vivo studies. Antioxidant determinations were performed by DPPH, FRAP and ICRED . Results indicated that an intense heat treatment on biscuits increases the amount of MRP with antioxidant capacity (p < 0.05). Besides, a low amount of antioxidant compounds was obtained after enzymatic digestion, whereas the highest proportion was released by colonic bacteria. Moreover, a high amount of non-released antioxidant compounds remained in faeces of Wistar rats; this was only predicted by in vitro ICRED determination...
March 15, 2019: Food Chemistry
Pehuén Fernández, Shunko Oscar Fernández, Jacqueline Griselda Mariela Gonzalez, Tabaré Fernández, Cinthia Claudia Fernández, Segundo Pastor Fernández
Fabry disease is a rare inherited lysosomal storage disorder caused by the deficiency of the enzyme alpha-galactosidase A. There is uncertainty regarding the safety of enzyme replacement therapy during pregnancy. We describe the course and outcome of seven pregnancies in six patients with Fabry disease who continued or reinitiated enzyme replacement therapy during pregnancy. No adverse events, in both mothers and children, were observed.
November 8, 2018: JIMD Reports
Diane Hurd, Mariela Herrera, Jeannine M Brant, Nicholas C Coombs, Eric Arzubi
OBJECTIVE: The aim of this pilot study was to explore the feasibility and proof of concept of triple chronotherapy (TCT) as a nonpharmacological adjunctive treatment in the acute management of depression in the adolescent population. METHODS: Thirty-one adolescents with nonpsychotic moderate-to-severe depression were included in the study. The 4-day TCT intervention comprised one night of sleep deprivation followed by 3 days of sleep phase advancement and daily bright light therapy...
November 2, 2018: Journal of Child and Adolescent Psychopharmacology
Ankita Bachhawat Jaykumar, Paulo S Caceres, Keyona N King-Medina, Tang-Dong Liao, Indrani Datta, Dipak Maskey, Jürgen K Naggert, Mariela Mendez, William H Beierwaltes, Pablo A Ortiz
Elevated blood pressure (BP) and renal dysfunction are complex traits representing major global health problems. Single nucleotide polymorphisms identified by genome-wide association studies have identified the Alström syndrome 1 (ALMS1) gene locus to render susceptibility for renal dysfunction, hypertension, and chronic kidney disease (CKD). Mutations in the ALMS1 gene in humans causes Alström syndrome, characterized by progressive metabolic alterations including hypertension and CKD. Despite compelling genetic evidence, the underlying biological mechanism by which mutations in the ALMS1 gene lead to the above-mentioned pathophysiology is not understood...
November 2, 2018: JCI Insight
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