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Adolfo Rubinstein, Mariela Barani, Analía S Lopez
No abstract text is available yet for this article.
November 2018: Lancet Global Health
Mariela Scortti, Lei Han, Sonsiray Alvarez, Alexandre Leclercq, Alexandra Moura, Marc Lecuit, Jose Vazquez-Boland
[This corrects the article DOI: 10.1371/journal.pgen.1007525.].
October 2018: PLoS Genetics
Facundo Cabezas-Cartes, Jorgelina Mariela Boretto, Nora Ruth Ibargüengoytía
Longevity and age at maturity are key life-history traits, directly linked to fitness attributes such as survival and reproductive output. It has been proposed that these traits are strongly influenced by environmental factors, such as temperature, seasonality, and precipitations, which determine the existence of a continuum of life-histories that goes from the "slow" life histories characterized by late maturity and high longevity of cold and highly seasonal climates to the "fast" life histories characterized by early maturity and low longevity, typical of the tropical climates...
October 11, 2018: Integrative and Comparative Biology
Carlos Alberto Vaccaro, Francisco López-Kostner, Adriana Della Valle, Edenir Inez Palmero, Benedito Mauro Rossi, Marina Antelo, Angela Solano, Dirce Maria Carraro, Nora Manoukian Forones, Mabel Bohorquez, Leonardo S Lino-Silva, Jose Buleje, Florencia Spirandelli, Kiyoko Abe-Sandes, Ivana Nascimento, Yasser Sullcahuaman, Carlos Sarroca, Maria Laura Gonzalez, Alberto Ignacio Herrando, Karin Alvarez, Florencia Neffa, Henrique Campos Reis Galvão, Patricia Esperon, Mariano Golubicki, Daniel Cisterna, Florencia C Cardoso, Giovana Tardin Torrezan, Samuel Aguiar Junior, Célia Aparecida Marques Pimenta, Maria Nirvana da Cruz Formiga, Erika Santos, Caroline U Sá, Edite P Oliveira, Ricardo Fujita, Enrique Spirandelli, Geiner Jimenez, Rodrigo Santa Cruz Guindalini, Renata Gondim Meira Velame de Azevedo, Larissa Souza Mario Bueno, Sonia Tereza Dos Santos Nogueira, Mariela Torres Loarte, Jorge Padron, Maria Del Carmen Castro-Mujica, Julio Sanchez Del Monte, Carmelo Caballero, Carlos Mario Muñeton Peña, Joseph Pinto, Claudia Barletta-Carrillo, Melva Gutiérrez Angulo, Tamara Piñero, Paola Montenegro Beltran, Patricia Ashton-Prolla, Yenni Rodriguez, Richard Quispe, Norma Teresa Rossi, Claudia Martin, Sergio Chialina, Pablo German Kalfayan, Juan Carlos Bazo-Alvarez, Alcides Recalde Cañete, Constantino Dominguez-Barrera, Lina Nuñez, Sabrina Daniela Da Silva, Yesilda Balavarca, Patrik Wernhoff, John-Paul Plazzer, Pål Møller, Eivind Hovig, Mev Dominguez-Valentin
Colorectal cancer (CRC) is one of the most common cancers in Latin America and the Caribbean, with the highest rates reported for Uruguay, Brazil and Argentina. We provide a global snapshot of the CRC patterns, how screening is performed, and compared/contrasted to the genetic profile of Lynch syndrome (LS) in the region. From the literature, we find that only nine (20%) of the Latin America and the Caribbean countries have developed guidelines for early detection of CRC, and also with a low adherence. We describe a genetic profile of LS, including a total of 2...
October 10, 2018: International Journal of Cancer. Journal International du Cancer
Carola Saure, Belisario Almeyra Ibarra, Carolina Caminiti, Mariela Krynski, Mercedes Montonati, Ricardo Rodriguez, María Althabe
BACKGROUND: After heart surgery requiring cardiopulmonary bypass, neonates have a profound metabolic response to stress. If adequate nutritional support is not provided this leads to loss of lean mass and deterioration of vital organs. Our objective was to describe the nutritional status and nutritional support achieved in infants younger than 3 months of life undergo in cardiovascular surgery. METHODS: A prospective, descriptive study was conducted in a Pediatric Cardiovascular intensive therapy at tertiary care center...
October 4, 2018: Minerva Pediatrica
Agustín Ramiro Miranda, Mariela Valentina Cortez, Silvana Valeria Serra, Elio Andres Soria
INTRODUCTION: Proteasome regulates proteostasis, and can be compromised in neurodegenerative diseases. Thus, our aim was to correlate the activity of proteasome to the level of polyphenols in telencephalon during murine adulthood. METHODS: Proteasome activity, polyphenols and other variables (glucose and hydroperoxides) were analysed in Balb/c female telencephala (n = 20, age = 4-12 months), using multivariate methods. RESULTS: The following values were found: proteasome activity = 3...
September 25, 2018: Revista de la Facultad de Ciencias Médicas
Mariela Bollini, Ana Maria Bruno, Maria Eugenia Nino, Juan Jose Casal, Leandro Daniel Sasiambarrena, Damian Ariel Gonzalez Valdez, Leandro Battini, Vanesa Rocio Puente, Maria Elisa Lombardo
BACKGROUND: Chagas disease affects about 7 million people worldwide. Only two drugs are currently available for the treatment for this parasite disease, namely, benznidazol (Bzn) and nifurtimox (Nfx). Both drugs have limited curative power in the chronic phase of the disease. Therefore, continuous research is an urgent need so as to discover novel therapeutic alternatives. OBJECTIVE: The development of safer and more efficient therapeutic anti-T. cruzi drugs continues to be a major goal in trypanocidal chemotherapy...
October 5, 2018: Medicinal Chemistry
Natasha N Tirko, Katherine W Eyring, Ioana Carcea, Mariela Mitre, Moses V Chao, Robert C Froemke, Richard W Tsien
Oxytocin is an important neuromodulator in the mammalian brain that increases information salience and circuit plasticity, but its signaling mechanisms and circuit effect are not fully understood. Here we report robust oxytocinergic modulation of intrinsic properties and circuit operations in hippocampal area CA2, a region of emerging importance for hippocampal function and social behavior. Upon oxytocin receptor activation, CA2 pyramidal cells depolarize and fire bursts of action potentials, a consequence of phospholipase C signaling to modify two separate voltage-dependent ionic processes...
September 26, 2018: Neuron
Rodrigo Gómez Alés, Juan Carlos Acosta, Vanesa Astudillo, Mariela Córdoba, Graciela Mirta Blanco, Donald Miles
Locomotion is relevant to the ecology of reptiles because of its presumed influence on an organism's Darwinian fitness. Moreover, in ectothermic species, physiological performance capacity is affected by body temperature. We analyzed two components of locomotor performance in three species of lizards, Phymaturus extrilidus, Liolaemus parvus, and Liolaemus ruibali, in the Puna environment of Argentina. First, we estimated the thermal sensitivity of locomotion by measuring sprint speed at four different body temperatures...
November 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
Carla R Angelani, Pablo Carabias, Karen M Cruz, José M Delfino, Marilina de Sautu, María V Espelt, Mariela S Ferreira-Gomes, Gabriela E Gómez, Irene C Mangialavori, Malena Manzi, María F Pignataro, Nicolás A Saffioti, Damiana M Salvatierra Fréchou, Javier Santos, Pablo J Schwarzbaum
Metabolic control analysis (MCA) is a promising approach in biochemistry aimed at understanding processes in a quantitative fashion. Here the contribution of enzymes and transporters to the control of a given pathway flux and metabolite concentrations is determined and expressed quantitatively by means of numerical coefficients. Metabolic flux can be influenced by a wide variety of modulators acting on one or more metabolic steps along the pathway. We describe a laboratory exercise to study metabolic regulation of human erythrocytes (RBCs)...
October 3, 2018: Biochemistry and Molecular Biology Education
J Smith Torres-Roman, Eloy F Ruiz, Jose Fabian Martinez-Herrera, Sonia Faria Mendes Braga, Luis Taxa, Jorge Saldaña-Gallo, Mariela R Pow-Sang, Julio M Pow-Sang, Carlo La Vecchia
BACKGROUND: Prostate cancer is the fifth most prevalent cause of cancer death in men worldwide. A recent report described the mortality rates for prostate cancer in Peru, but a comprehensive evaluation of variations in prostate cancer epidemiology by geographic areas has not been performed, yet. Our aim is to evaluate the mortality rates of prostate cancer, according to geographical areas in Peru, between 2005 and 2014. METHODS: Information was extracted from the Deceased Registry of the Peruvian Ministry of Health...
October 3, 2018: BJU International
Joaquín Algranti, Mariela Mosqueira
In order to reconstruct the origin and development of neo-Pentecostal devices for the treatment of addictions in the City of Buenos Aires, Argentina, the article analytically puts into historical context the "therapeutic spiritualization" of addictive behavior undertaken by evangelical agents since the 1970s and explores the way in which the State and religious groups converge in the Recover Inclusion Program. Based on qualitative methodology and a sociological approach and carried out in 2015 and 2016, the study includes fourteen interviews with teachers, leaders and former users of the program, twelve interviews with state officials, participant observation in training courses and a corpus made up of documents related to both institutions...
April 2018: Salud Colectiva
Maria Dall'Era, Mariela L Pauli, Kelly Remedios, Keyon Taravati, Priscila M Sandoval, Amy L Putnam, Angela Lares, Anna Haemel, Qizhi Tang, Marc Hellerstein, Marc Fitch, James McNamara, Beverly Welch, Jeffrey A Bluestone, David Wofsy, Michael D Rosenblum
OBJECTIVE: Regulatory T cell (Treg) adoptive cell therapy has great potential to treat autoimmune disease. Currently, very little is known about how these cells impact inflamed tissues. The purpose of this study was to elucidate how autologous Treg therapy influences tissue inflammation in human autoimmune disease. METHODS: We describe a patient with systemic lupus erythematosus (SLE) with active skin disease that received adoptive Treg therapy. We comprehensively quantify Tregs and immune activation in peripheral blood and skin with time post-treatment...
October 1, 2018: Arthritis & Rheumatology
Edgar F Mendoza-Franco, Mariela Del Carmen Rosado Tun, Allan de Jesús Duarte Anchevida, Rodolfo E Del Rio Rodríguez
During the examination of 913 fish specimens belonging to four families in the Campeche Bank (Gulf of Mexico), 23 gill ectoparasitic monogenean species were found, which belong to three families: Dactylogyridae, Microcotylidae and Diclidophoridae. The species Euryhaliotremaamydrum , E.carbuncularium , E.dunlapae , E.fajeravilae , E.fastigatum , E.longibaculum , E.paracanthi , E.tubocirrus , Haliotrematoidescornigerum , H.gracilihamus , H.heteracantha , H.longihamus , H.magnigastrohamus , H.striatohamus , Hamatopedunculariabagre , Neotetraonchusbravohollisae , and N...
2018: ZooKeys
Patxi Galarraga, Miren Vives, David Cabrera-Manzano, Lucila Urda, Mariela Brito, Vicente Gea-Caballero
Urbanized and built-up environments are determinants of health as well as community health. Therefore, we intend to analyze the influence of urban development on both public and community health, from the perspective of gender, citizen participation in urban planning projects, and accessibility. From a bibliographic review and narrative analysis, based on the experience of the authors, we found several urban transformation projects focusing, in particular, on four large areas: school centres and playgrounds, empty urban spaces and disused buildings, pedestrian pathways, and various housing interventions...
September 21, 2018: Gaceta Sanitaria
Ignacio Dei-Cas, Daniela Carrizo, Mariela Giri, Gonzalo Boyne, Noelia Domínguez, Viviana Novello, Karina Acuña, Pablo Dei-Cas
BACKGROUND: Infectious skin disorders (ISDs) are commonly seen in pediatric emergency departments (PED), however the exact frequency is unknown. We provide an accurate evaluation of the incidence and characteristics of ISDs diagnosed in a PED from Buenos Aires, Argentina, over a 1-year period. METHODS: Prospectively, descriptive study of children evaluated in the PED with ISDs during 2016. ISDs were analyzed on the basis of their incidence, patient demographics, seasonal variations, and hospitalization rates...
September 24, 2018: International Journal of Dermatology
Andreas Kyburz, Angela Fallegger, Xiaozhou Zhang, Aleksandra Altobelli, Mariela Artola-Boran, Timothy Borbet, Sabine Urban, Petra Paul, Christian Münz, Stefan Floess, Jochen Huehn, Timothy L Cover, Martin J Blaser, Christian Taube, Anne Müller
BACKGROUND: The trans-maternal exposure to tobacco, microbes, nutrients and other environmental factors shapes the fetal immune system through epigenetic processes. The gastric microbe Helicobacter pylori represents an ancestral constituent of the human microbiota that causes gastric disorders on the one hand, and is inversely associated with allergies and chronic inflammatory conditions on the other. OBJECTIVE: Here, we investigate the consequences of trans-maternal exposure to H...
September 18, 2018: Journal of Allergy and Clinical Immunology
Chuhyon Corwin, Anastasia Nikolopoulou, Allen L Pan, Mariela Nunez-Santos, Shankar Vallabhajosula, Peter Serrano, John Babich, Maria E Figueiredo-Pereira
BACKGROUND: Prostaglandins are products of the cyclooxygenase pathway, which is implicated in Parkinson's disease (PD). Limited knowledge is available on mechanisms by which prostaglandins contribute to PD neurodegeneration. To address this gap, we focused on the prostaglandin PGD2/J2 signaling pathway, because PGD2 is the most abundant prostaglandin in the brain, and the one that increases the most under pathological conditions. Moreover, PGJ2 is spontaneously derived from PGD2. METHODS: In this study, we determined in rats the impact of unilateral nigral PGJ2-microinfusions on COX-2, lipocalin-type PGD2 synthase (L-PGDS), PGD2/J2 receptor 2 (DP2), and 15 hydroxyprostaglandin dehydrogenase (15-PGDH)...
September 20, 2018: Journal of Neuroinflammation
Glauteice Freitas Guedes, Inara Mariela da Silva Cavalcante, Vilanice Alves de Araújo Püschel
OBJECTIVE: To understand/reveal the experiences of undergraduate students of the Nursing School of the Universidade de São Paulo in international academic mobility. METHOD: A cross-sectional, descriptive study with a qualitative approach conducted between February and July 2017. Data were collected using a semi-structured interview and submitted to content analysis. RESULTS: Twenty-two (22) students participated in the study. Five analytical categories emerged from the analysis of the interviews: Interinstitutional Relationships Dimension, Personal Dimension, Professional Dimension, Academic Dimension and Cultural Dimension...
September 13, 2018: Revista da Escola de Enfermagem da U S P
Wilton Pérez, Mariela Contreras, Rodolfo Peña, Elmer Zelaya, Lars-Åke Persson, Carina Källestål
BACKGROUND: Access to food is a basic necessity, and food insecurity may impair the individual's well-being and health. Self-rated health measurements have frequently been used to assess population health. Little is known, however, as to whether food security is associated with self-rated health in low- and middle-income settings. This study aims at analyzing the association between food security and self-rated health among non-pregnant women of reproductive age in a rural Nicaraguan setting...
September 18, 2018: International Journal for Equity in Health
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