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https://www.readbyqxmd.com/read/29667123/peritoneal-carcinomatosis-arising-from-rectal-or-colonic-adenocarcinoma-treated-with-cytoreductive-surgery-crs-hyperthermic-intraperitoneal-chemotherapy-hipec-two-different-diseases
#1
M Tonello, G Ortega-Perez, O Alonso-Casado, P Torres-Mesa, G Guiñez, S Gonzalez-Moreno
PURPOSE: Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) has poor survival. Multi-modal treatment including systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC) can be used in selected patients with curative intent. The majority published works consider PC of CRC origin as a homogenous disease. Aim of this study is to stress the different biological behaviors and survival of PC according to colonic or rectal origin. METHODS: Data of CRS and HIPEC procedures for PC of CRC origin performed at MD Anderson Cancer Center-Madrid (Spain) have been collected, dividing patients into two groups according to colonic or rectal PC...
April 17, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29656069/-microscopic-peritoneal-metastases-of-epithelial-ovarian-cancers-clinical-relevance-diagnostic-and-therapeutic-tools
#2
Y Kerbage, G Canlorbe, J P Estevez, A Grabarz, S Mordon, C Uzan, P Collinet, H Azaïs
Understanding the biology and progression mechanisms of peritoneal metastases in ovarian epithelial cancers (EOC) is important because peritoneal carcinomatosis is present or will occur during surveillance of a majority of patients. Despite the clinical remission achieved after complete macroscopic cytoreductive surgery and platinum-based chemotherapy, 60% of patients will develop peritoneal recurrence. This suggests that microscopic lesions, which are not eradicated by surgery may be present and may participate in the mechanisms leading to peritoneal recurrence...
April 11, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29651643/splenosis-a-great-mimicker-of-neoplastic-disease
#3
REVIEW
Yasmeen K Tandon, Christopher P Coppa, Andrei S Purysko
Splenosis is a benign condition that can occur after splenic trauma or after surgery involving the spleen. These splenic implants are most often seen within the abdominal and pelvic cavities. On imaging, splenosis can be confused with multiple additional entities including metastatic disease, peritoneal carcinomatosis, peritoneal mesothelioma, abdominal lymphoma, renal cancer, hepatic adenomas, or endometriosis depending on its distribution. In all patients with history of splenic surgery or trauma, splenosis should be on the differential diagnosis of soft tissue nodules in the abdomen and pelvis, especially in the absence of systemic symptoms, to avoid unnecessary biopsy, chemotherapy, or surgery...
April 12, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29643915/prognostic-significance-of-blood-serum-and-ascites-parameters-in-patients-with-malignant-peritoneal-mesothelioma-or-peritoneal-carcinomatosis
#4
Shan-Shan Su, Guo-Qi Zheng, Wen-Jie Yin, Yu-Fei Liang, Ying-Ying Liu, Hui Song, Ning-Ning Sun, Yu-Xin Yang
To determine effects of the biochemical and cytological properties of blood, serum, and ascites on survival of patients with malignant peritoneal effusion (MPeE), including malignant peritoneal mesothelioma (MPeM) and peritoneal carcinomatosis (PC), we conducted a retrospective study of patients with MPeE and healthy controls. Potential prognostic factors were identified as follows: age, sex, blood neutrophil-to-lymphocyte ratio (NLR), serum parameters, ascites parameters, serum-ascites albumin gradient, and the ascites-serum LDH ratio...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29643552/anaesthetic-management-and-perioperative-outcomes-of-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-a-retrospective-analysis
#5
Kalpana P Balakrishnan, Sreedevi Survesan
Background and Aims: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is becoming the standard treatment option for peritoneal carcinomatosis but is associated with high rates of morbidity and mortality. Our aim was to retrospectively analyse and evaluate intra-operative factors associated with morbidity and mortality of CRS and HIPEC. Methods: Intra-operative data were collected for cases done over 1 year (24 cases) and analysed for the primary outcome of post-operative ventilation >24 h, and secondary outcome of length of the Intensive Care Unit (ICU) stay >5 days...
March 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29623449/role-of-matrix-metalloproteinases-in-tumour-invasion-immunohistochemistry-of-peritoneum-from-peritoneal-carcinomatosis
#6
Peter Falk, Andreas Jonsson, Torbjörn Swartling, Dan Asplund, Marie-Lois Ivarsson
Colorectal cancer is one of the most common forms of cancer. Spread of tumour to the peritoneal cavity may lead to seeding of cancer cells that adhere to and invade the peritoneal membrane causing peritoneal carcinomatosis. Matrix metalloproteinases (MMPs) play an essential role in cancer cell invasion and dissemination. The aim of this study was to evaluate the morphology and presence of matrix metalloproteinases in peritoneal carcinomatosis. Biopsy samples of the parietal peritoneum were taken from patients undergoing cytoreductive surgery for peritoneal carcinomatosis...
April 5, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29623218/the-influence-of-a-peritoneovenous-shunt-for-cirrhotic-and-malignant-intractable-ascites-on-renal-function
#7
Takafumi Segawa, Kenichi Kato, Kazuya Kawashima, Tomohiro Suzuki, Shigeru Ehara
Background: Peritoneovenous shunts (PVS) are widely used for palliation of intractable ascites caused by peritoneal carcinomatosis (PC) or liver cirrhosis (LC). Some patients who need PVS have renal dysfunction. However, renal dysfunction is considered a relative contraindication. Therefore, it is important to assess renal function before PVS placement. Purpose: To evaluate the relationship between PVS and renal function. Material and Methods: Between October 2007 and July 2015, 60 patients (PC = 47; LC = 10; others = 3) underwent PVS placement for intractable ascites...
March 2018: Acta Radiologica Open
https://www.readbyqxmd.com/read/29619192/synthesis-of-poly-1-2-glycerol-carbonate-paclitaxel-conjugates-and-their-utility-as-a-single-high-dose-replacement-for-multi-dose-treatment-regimens-in-peritoneal-cancer
#8
Iriny Ekladious, Rong Liu, Heng Zhang, Daniel H Foil, Daniel A Todd, Tyler N Graf, Robert F Padera, Nicholas H Oberlies, Yolonda L Colson, Mark W Grinstaff
Current chemotherapeutic dosing strategies are limited by the toxicity of anticancer agents and therefore rely on multiple low-dose administrations. As an alternative, we describe a novel sustained-release, biodegradable polymeric nanocarrier as a single administration replacement of multi-dose paclitaxel (PTX) treatment regimens. The first synthesis of poly(1,2-glycerol carbonate)- graft -succinic acid-paclitaxel (PGC-PTX) is described, and its use enables high, controlled PTX loadings of up to 74 wt%. Moreover, the polymer backbone is composed of biocompatible building blocks-glycerol and carbon dioxide...
December 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29616123/overexpression-and-clinical-significance-of-ibp-in-epithelial-ovarian-carcinoma
#9
Yingjuan Xu, Yangming Hou, Tianbo Liu, Ge Lou
Interferon regulatory factor-4 binding protein (IBP) is as a type of ρ GTPase suggested to serve an important role in tumor occurrence and development through the effects of cytoskeletal remodeling, and cell conduction mechanism. IBP is widely expressed in the immune system and expressed in several types of tumors. However, its expression and prognostic value in epithelial ovarian carcinoma (EOC) remain unclear. The present study aimed to investigate the expression of IBP in EOC, and its effect on clinicopathological variables and prognosis...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29602696/preoperative-assessment-of-peritoneal-carcinomatosis-of-colorectal-origin
#10
A Dohan, C Hobeika, N H Najah, M Pocard, P Rousset, C Eveno
The goal of preoperative assessment of patients with peritoneal carcinomatosis (PC) from colorectal origin is to select candidates for curative surgery by evaluating the possibility of complete resection, and to plan the surgical procedure. Quantitative and qualitative evaluation of lesional localization remains difficult even with current technical progress in imaging. Computed tomography (CT), the reference imaging technique, allows detection of both peritoneal and extra-peritoneal lesions. Sensitivity and specificity for detecting PC are 83% (95%CI: 79-86%) and 86% (95%CI: 82-89%), respectively...
March 27, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29596522/could-texture-features-from-preoperative-ct-image-be-used-for-predicting-occult-peritoneal-carcinomatosis-in-patients-with-advanced-gastric-cancer
#11
Hae Young Kim, Young Hoon Kim, Gabin Yun, Won Chang, Yoon Jin Lee, Bohyoung Kim
PURPOSE: To retrospectively investigate whether texture features obtained from preoperative CT images of advanced gastric cancer (AGC) patients could be used for the prediction of occult peritoneal carcinomatosis (PC) detected during operation. MATERIALS AND METHODS: 51 AGC patients with occult PC detected during operation from January 2009 to December 2012 were included as occult PC group. For the control group, other 51 AGC patients without evidence of distant metastasis including PC, and whose clinical T and N stage could be matched to those of the patients of the occult PC group, were selected from the period of January 2011 to July 2012...
2018: PloS One
https://www.readbyqxmd.com/read/29593930/mucinous-carcinomatosis-a-rare-association-between-an-ovarian-tumor-and-an-e-gist
#12
Hugo Palma Rios, André Goulart, Pedro Leão
Pseudomyxoma peritonei (PMP) and extragastrointestinal stromal tumors (E-GISTs) are both rare entities. Most of the time, PMP is associated with an appendiceal tumor. An ovarian mucinous tumor can mimic appendiceal metastases. E-GIST is a mesenchymal tumor that can arise from the omentum, retroperitoneum, mesentery, or pleura. We present a case of an 87-year-old woman with mucinous carcinomatosis and acute intestinal occlusion submitted to an emergency laparotomy. She has found to have a borderline mucinous tumor of the ovary from the intestinal type with several lesions of pseudomyxoma peritonei and an E-GIST from the epiploons retrocavity (intermediated risk)...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29589675/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-risk-factors-for-morbidity-and-postoperative-outcome
#13
Manuela Robella, Marco Vaira, Armando Cinquegrana, Alice Borsano, Michele DE Simone
BACKGROUND: Cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) represents a treatment option for peritoneal surface malignancies. Even if it has been reported that this new approach improved survival of selected patients, it's still associated with high morbidity and mortality rates. METHODS: From October 1995 to December 2017, over 450 patients patients affected by peritoneal carcinomatosis (PC) underwent in our Institute to CRS associated with HIPEC...
March 28, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29587771/treatment-of-intraoperatively-detected-peritoneal-carcinomatosis-of-colorectal-origin-with-cytoreductive-surgery-and-intraperitoneal-chemotherapy
#14
Aras Emre Canda, Cigdem Arslan, Cem Terzi, Selman Sokmen, Tugba Yavuzsen, Sevda Ozkardesler, Mehtat Unlu, Funda Obuz, Mehmet Fuzun
BACKGROUND: Diagnosis of peritoneal carcinomatosis (PC) may be missed by preoperative imaging. We are presenting our experience with incidentally detected PC of colorectal origin treated with cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) at the same operation. METHODS: Between January 2010 and September 2016, 19 patients underwent CRS and IPC due to incidentally detected PC of colorectal origin. Data were analyzed from a prospectively collected database...
March 27, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29573122/peritoneal-carcinomatosis-or-something-else
#15
Joshua Lawson, David Simons
No abstract text is available yet for this article.
March 23, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29567868/-surgical-resection-of-metastatic-brain-tumors-risk-of-local-recurrence-and-leptomeningeal-dissemination-and-implications-for-individualized-treatment
#16
Yoko Nakasu, Koichi Mitsuya, Shoichi Deguchi, Nakamasa Hayashi, Hideyuki Harada
Metastatic brain tumors are important complications in the overall management of cancers. We sought to determine the risk of local recurrence and leptomeningeal carcinomatosis(LC)in patients treated with surgical resection and adjuvant radiation therapy. We retrospectively reviewed 173 consecutive patients with metastatic brain tumors managed by surgical resection between 2002 and 2015 in a single institution. Eighty-seven percent of the patients underwent postoperative adjuvant radiotherapy. The median overall survival from surgery was 9...
March 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29564201/modelling-of-some-aspects-of-a-biomedical-process-application-to-the-treatment-of-digestive-cancer-hipec
#17
Taoufik Ladhari, Konrad Szafnicki
Usual therapies against malignant tumors, such as surgery, chemotherapy, radiation, is severe and when repeated their efficiency may decrease because tumorous cells may become resistant. Contrarily, hyperthermia has been known for some time as an effective auxiliary treatment, which can be applied repeatedly. In some cases of abdominal carcinomatosis, particularly those of digestive origin, HIPEC is considered as an promising therapeutic option. Chemotherapy and hyperthermia are combined via the perfusion of the abdominal cavity with hot fluids containing chemotherapeutic agents, thus, augmenting the influence of appropriate chemotherapeutic agents with heat...
April 2018: 3 Biotech
https://www.readbyqxmd.com/read/29551620/chronically-infected-urachal-remnant-mimicking-tumor-with-peritoneal-carcinomatosis
#18
Michael Froehner, Steffen Jahn, Verena Plodeck, Michael Laniado, Manfred P Wirth
A 51-year old male patient presented with lower abdominal pain persisting since about one year. Abdominal computed tomography scan showed a solid tumor interpreted as urachal carcinoma with peritoneal carcinomatosis. Histopathological examination revealed urachal abscess. Awareness of clinical signs and imaging findings of this rare but characteristic condition may avoid emotional distress of patients associated with erroneous suspicion of malignancy.
March 15, 2018: Urology
https://www.readbyqxmd.com/read/29548309/acantholytic-squamous-cell-carcinoma-of-the-lung-with-marked-lymphogenous-metastases-and-high-titers-of-myeloperoxidase-antineutrophil-cytoplasmic-antibodies-a-case-report
#19
Kenji Yorita, Kazuya Tsuji, Yoko Takano, Naoto Kuroda, Kei Sakamoto, Kaoru Arii, Yukio Yoshimoto, Kimiko Nakatani, Satoshi Ito
BACKGROUND: Acantholytic squamous cell carcinoma (ASQCC), histologically characterized by intercellular bridge loosening, is recognized as a rare variant of squamous cell carcinoma (SQCC). ASQCC may demonstrate a worse prognosis than conventional SQCC. Pulmonary ASQCC is particularly rare; its biological behavior and prognostic data have not been reported. CASE PRESENTATION: We report the clinical and autopsy findings of a 71-year-old Japanese man with pulmonary ASQCC...
March 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29543051/use-of-serum-and-peritoneal-cea-and-ca19-9-in-prediction-of-peritoneal-dissemination-and-survival-of-gastric-adenocarcinoma-patients-are-they-prognostic-factors
#20
M Hasbahceci, F U Malya, E Kunduz, M Guler, N Unver, A Akcakaya
Introduction To evaluate the impact of serum and peritoneal levels of tumour markers on peritoneal carcinomatosis and survival in gastric adenocarcinoma. Materials and methods Patients with gastric adenocarcinoma were evaluated with regard to serum and peritoneal carcinoembryonic antigen (CEA) and CA19-9. Numeric values and groupings based on serum and peritoneal cutoff values were used. Development of peritoneal carcinomatosis, including positive washing cytology, was regarded as main outcome. Gastric cancer outcomes as disease free and overall survival were analysed...
March 15, 2018: Annals of the Royal College of Surgeons of England
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