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https://www.readbyqxmd.com/read/29452077/clinical-outcomes-and-factors-related-with-colonic-perforations-in-patients-receiving-self-expandable-metal-stent-insertion-for-malignant-colorectal-obstruction
#1
Yoo Jin Lee, Jin Young Yoon, Jae Jun Park, Soo Jung Park, Jie-Hyun Kim, Young Hoon Youn, Tae Il Kim, Hyojin Park, Won Ho Kim, Jae Hee Cheon
BACKGROUND AND AIMS: Although colonic perforation is a dreadful adverse event associated with stent placement, data on this topic are sparse. We aimed to investigate the clinical outcomes of colonic perforation and factors related with its occurrence in patients who receiving self-expanding metal stents (SEMSs) for malignant colorectal obstruction. METHODS: We retrospectively reviewed the data of 474 patients with malignant colorectal obstruction who received endoscopic SEMS insertion from April 2004 to May 2011 in the Severance and Gangnam Severance Hospital...
February 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29444581/-the-effect-of-circulating-tumor-cells-on-the-survival-of-patients-with-pancreatic-cancer-5-year-results
#2
L Bébarová, P Skalický, J Srovnal, A Prokopová, J Zapletalová, M Hajdúch, M Loveček
INTRODUCTION: Pancreatic cancer (PDAC) is one of the most aggressive malignancies. Its incidence increases worldwide and, despite the developments in cancer research, mortality rates have not decreased. Poor prognosis of the disease is due to many factors, mainly late diagnosis. Distant metastases and peritoneal carcinomatosis are caused by hematogenous and lymphogenous spreading of the tumorous cells. One of the factors that may influence patient survival are so-called circulating tumor cells (CTCs)...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29440231/-ex-vivo-activity-of-cytotoxic-drugs-and-targeted-agents-in-small-intestinal-nets
#3
Kosmas Daskalakis, Olov Norlen, Andreas Karakatsanis, Per Hellman, Rolf Larsson, Peter Nygren, Peter Stalberg
Small intestinal endocrine tumours (SI-NETs) are generally considered resistant to systemic treatment. To date, predictive markers for drug activity are lacking. Tumour samples from 27 patients with SI-NETs were analyzed ex vivo for sensitivity to a panel of cytotoxic drugs and targeted agents using a short-term total cell kill assay. Samples of renal cancer, colorectal cancer (CRC), ovarian cancer, and chronic lymphocytic leukemia (CLL) were included for comparison. For the SI-NET subset, drug sensitivity was analyzed in relation to clinico-pathological variables and pre-treatment biomarkers...
February 12, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29439668/hipect4-multicentre-randomized-clinical-trial-to-evaluate-safety-and-efficacy-of-hyperthermic-intra-peritoneal-chemotherapy-hipec-with-mitomycin-c-used-during-surgery-for-treatment-of-locally-advanced-colorectal-carcinoma
#4
A Arjona-Sánchez, P Barrios, E Boldo-Roda, B Camps, J Carrasco-Campos, V Concepción Martín, A García-Fadrique, A Gutiérrez-Calvo, R Morales, G Ortega-Pérez, E Pérez-Viejo, A Prada-Villaverde, J Torres-Melero, E Vicente, P Villarejo-Campos, J M Sánchez-Hidalgo, A Casado-Adam, Ruben García-Martin, Manuel Medina, T Caro, C Villar, Enrique Aranda, M T Cano-Osuna, C Díaz-López, E Torres-Tordera, F J Briceño-Delgado, S Rufián-Peña
BACKGROUND: Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall survival of 6%. There are promising results using prophylactic HIPEC in this group of patients, and it is estimated that up to 26% of all T4 colon cancer could benefit from this treatment with a minimal morbidity. Adjuvant HIPEC is effective to avoid the possibility of peritoneal seeding after surgical resection...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29434454/sequential-spinal-and-intracranial-dural-metastases-in-gastric-adenocarcinoma-a-case-report
#5
Hongsik Kim, Kyung Sik Yi, Won-Dong Kim, Seung-Myoung Son, Yaewon Yang, Jihyun Kwon, Hye Sook Han
Dural metastasis from primary gastric adenocarcinoma has been rarely reported, and its prognosis is very poor because it frequently leads to acute subdural hematoma. Here, we describe a case with sequential spinal and cranial dural metastases from gastric adenocarcinoma without subdural hematoma. A 43-year-old woman with gastric adenocarcinoma and well-controlled peritoneal carcinomatosis presented with back pain, right radiating leg pain, left facial palsy, and hearing loss. Magnetic resonance imaging of the spine and brain revealed dural masses at the lumbosacral junction with invasion to the L5 and S1 nerve roots and at the skull base with invasion to the internal auditory canal...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29434183/plasmacytoid-urothelial-carcinoma-of-ureter-with-retroperitoneal-metastasis-a-case-report
#6
Alexis Jibril, Andrew C Stevens
BACKGROUND Plasmacytoid is a rare histological variant of urothelial carcinoma (UC). Since the first reported case of plasmacytoid urothelial carcinoma (PUC), in 1991, only about 100 cases have since been reported, with most cases involving the bladder. Urothelial carcinomas of the upper urinary tract represent only 5% of urothelial cancers. To the best of our knowledge, there has only been 1 reported case of PUC of the ureter. PUC is a highly aggressive disease, with a poor prognosis. We present a rare biopsy-proven case of PUC of the ureter with retroperitoneal metastasis...
February 13, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29431339/validation-of-diagnostic-methods-for-peritoneal-carcinomatosis-secondary-to-ovarian-cancer-ct-scan-pet-ct-or-laparoscopy-what-is-the-best
#7
Israel Manzanedo, Beatriz Losada, Beatriz Martínez-Torres, Fernando Pereira, Ángel Serrano, Ignacio Juez, Estíbalitz Pérez-Viejo, David Gutiérrez, Virginia Peiró, Carolina Aulló
No abstract text is available yet for this article.
February 9, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29427002/long-term-oncological-outcomes-after-robotic-partial-nephrectomy-for-renal-cell-carcinoma-a-prospective-multicentre-study
#8
Jean-Baptiste Beauval, Benoit Peyronnet, Thibaut Benoit, Bastien Cabarrou, Thomas Seisen, Mathieu Roumiguié, Benjamin Pradere, Zine-Eddine Khene, Quentin Manach, Gregory Verhoest, Mathieu Thoulouzan, Jerome Parra, Nicolas Doumerc, Romain Mathieu, Christophe Vaessen, Michel Soulié, Morgan Roupret, Karim Bensalah
PURPOSE: This study aimed at reporting the long-term oncological outcomes of robotic partial nephrectomy (RPN) for renal cell carcinoma (RCC). METHODS: Data from all consecutive patients who underwent RAPN for RCC from July 2009 to January 2012 in three departments of urology were prospectively collected. Overall survival (OS), cancer-specific survival (CSS) and disease free-survival (DFS) were estimated using the Kaplan-Meier method. Prognostic factors associated with CSS were sought in univariate analysis...
February 9, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29423222/clinicopathological-characteristics-of-disseminated-carcinomatosis-of-the-bone-marrow-in-breast-cancer-patients
#9
Yoshiaki Shinden, Keishi Sugimachi, Fumiaki Tanaka, Kenji Fujiyoshi, Yuko Kijima, Shoji Natsugoe, Koshi Mimori
Disseminated carcinomatosis of the bone marrow (DCBM) is characterized by diffuse infiltrative growth of tumor cells in the bone marrow and is associated with systemic hematological disorders. Bone marrow metastases from breast cancer are not rare, and they may lead to serious life-threatening conditions when there is an associated hematological disorder. Therefore, DCBM necessitates a definitive diagnosis and prompt systemic therapy. We herein present 4 such cases and a review of the previous relevant literature...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29420428/prior-surgical-score-an-analysis-of-the-prognostic-significance-of-an-initial-nondefinitive-surgical-intervention-in-patients-with-peritoneal-carcinomatosis-of-a-colorectal-origin-undergoing-cytoreductive-surgery-and-perioperative-intraperitoneal-chemotherapy
#10
Bikram K Paul, Chukwuemeka Ihemelandu, Paul H Sugarbaker
BACKGROUND: The prior surgical score estimates the extent of previous surgical intervention by quantitating surgical dissection within 9 abdominopelvic regions. OBJECTIVE: Our aim was to analyze the prognostic significance of the prior surgical score in our cohort of patients undergoing cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis of a colorectal origin. DESIGN: This was a retrospective analysis of a prospectively maintained database for all patients treated for peritoneal carcinomatosis of a colorectal origin...
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29417455/a-review-of-photodynamic-therapy-for-neoplasms-of-the-head-and-neck
#11
REVIEW
Francisco J Civantos, Barış Karakullukcu, Merrill Biel, Carl E Silver, Alessandra Rinaldo, Nabil F Saba, Robert P Takes, Vincent Vander Poorten, Alfio Ferlito
Photodynamic therapy (PDT) involves the use of a phototoxic drug which is activated by low powered laser light to destroy neoplastic cells. Multiple photosensitizers have been studied and tumors have been treated in a variety of head and neck sites over the last 30 years. PDT can effectively treat head and neck tumors, particularly those of the superficial spreading type, and the classic application of this technology has been in the patient with a wide field of dysplastic change and superficial carcinomatosis...
February 7, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29412465/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-pseudomyxoma-peritonei-of-appendicular-and-extra-appendicular-origin
#12
J-B Delhorme, F Severac, G Averous, O Glehen, G Passot, N Bakrin, F Marchal, M Pocard, R Lo Dico, C Eveno, S Carrere, O Sgarbura, F Quenet, G Ferron, D Goéré, C Brigand
BACKGROUND: The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra-appendicular PMP (EA-PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: All patients treated for PMP with CCRS and HIPEC between 1994 and 2016 were selected retrospectively from a French multicentre database...
February 7, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29409504/unusual-progression-of-renal-cell-carcinoma-with-carcinomatosis-peritoneii-and-krukenberg-tumour-and-alopecia-with-sunitinib-therapy-in-young-female
#13
Manoj Pandey, Mahendran Ramasamy, Mridula Shukla
BACKGROUND: Sunitinib is a multiple receptor tyrosine kinase inhibitor (TKI) used for the treatment of renal cell carcinoma (RCC). It increases the median survival considerably with minimum side effects. Alopecia is one of the rare side effects. Metastasis to the ovary is also rare. We report a case of RCC metastasizing to the ovary developing alopecia early on starting sunitinib. CASE PRESENTATION: A 22-year-old hypothyroid girl underwent right radical nephrectomy for T2N0 RCC...
February 6, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29404170/a-rare-case-of-progressive-dyspnea-and-bilateral-lung-infiltration-in-a-young-male
#14
Meltem Ağca, Fatma Tokgöz Akyıl, Merve Hörmet, Oğuzhan Akman, Canan Akman, Ayçim Şen, Tülin Sevim
Pulmonary lymphangitic carcinomatosis (PLC) is defined as infiltration of the lymphatic vessels and perilymphatic connective tissue with tumor cells, which is secondary to malignancy. Therefore, it rarely appears as an initial finding preceding a diagnosis of malignancy. A 30-year-old male patient was hospitalized in our clinic with a pre-diagnosis of interstitial lung disease owing to the complaints of dry cough, progressive dyspnea, and acute respiratory insufficiency. He was diagnosed with signet ring cell carcinoma, which is a histologic subtype of adenocarcinoma, via gastroscopy, and lung involvement was consistent with PLC...
July 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29399143/microscopic-peritoneal-carcinomatosis-in-gastric-cancer-prevalence-prognosis-and-predictive-factors
#15
Enrico Maria Pasqual, Serena Bertozzi, Ambrogio P Londero, Denise Brandolin, Laura Mariuzzi, Alessandro De Pellegrin, Stefano Bacchetti, Loris Zoratti, Roberto Petri, Carlo Della Bianca, Daniele Snidero, Giovanni Terrosu, Alessandro Uzzau, Andrea Risaliti, Carla Di Loreto, Stefano Pizzolitto, Maurizio Zilli, Giovanni de Manzoni
Peritoneal carcinomatosis (PC) is typically identified in advanced stage gastric cancer and is frequently considered to be an incurable disease. Along with macroscopic PC, microscopic PC may be diagnosed through pathological examination of tissue specimens and is not detectable during surgical intervention. The present study aimed to analyse the prevalence, prognostic value and predictive factors for microscopic PC. In the present retrospective study, data from patients with epithelial gastric cancer that were treated with curative intent surgery were examined...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29397879/systematic-second-look-surgery-plus-hipec-in-patients-without-evidence-of-recurrence-at-high-risk-of-carcinomatosis-after-colorectal-cancer-resection
#16
Ángel Serrano Del Moral, Estibalitz Pérez Viejo, Israel Manzanedo Romero, Gil Rodríguez Caravaca, Fernando Pereira Pérez
INTRODUCTION: To analyze the impact of systematic second-look surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC) performed 1 year after resection of the primary tumor, in asymptomatic patients at high risk of developing peritoneal carcinomatosis (PC). METHODS: Between 2012-2016, 33 patients without any sign of peritoneal recurrence on imaging studies were prospectively included in the study and underwent second-look surgery aimed at treating limited PC earlier and were prospectively recorded...
February 2, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29397633/analysis-of-patient-selection-policy-and-pattern-of-recurrence-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-colorectal-carcinomatosis
#17
Manuela Robella, Marco Vaira, Alice Borsano, Michele DE Simone
BACKGROUND: Actual cure rate and patterns of recurrence after cytoreductive surgery (CRS) associated to hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with colorectal peritoneal carcinomatosis (PC) are not yet well explored. Moreover, the selection policy to this resource-consuming treatment is still a matter of debate. METHODS: From a dataset of 400 CRS+HIPEC performed between October 1996 and December 2015, we selected 54 consecutive patients with colorectal PC...
February 1, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29394830/-prolonged-survival-following-chemotherapy-in-bone-marrow-carcinomatosis-due-to-esophagogastric-junctional-carcinoma-a-case-report
#18
Yusuke Fujii, Noriyuki Hirahara, Shunsuke Kaji, Yoshiko Miyazaki, Takashi Kishi, Takahito Taniura, Ryoji Hyakudomi, Tetsu Yamamoto, Takeshi Nishi, Hikota Hayashi, Yasunari Kawabata, Yoshitsugu Tajima
A 60s-year-old Japanese male underwent curative resection for an advanced adenocarcinoma of the esophagogastric junction(Stage III C), followed by adjuvant chemotherapy.Twenty -one months later, he was admitted to our hospital with a complaint of marked decline in activities of daily living(ADL).The patient was diagnosed with pancytopenia, disseminated intravascular coagulation(DIC), multiple lymph node and bone metastases, and bone marrow carcinomatosis.After completing a sufficient informed consent process, he received chemotherapy along with blood transfusion, and then DIC, pancytopenia, and ADL of the patient improved...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394674/-a-case-of-stage-iv-breast-cancer-with-extensive-metastasis-successfully-treated-with-s-1-plus-anastrozole-therapy
#19
Tatsuro Mugitani, Tomoya Hatakeyama, Toshinori Sakai, Atsushi Matsumura, Shiro Ogino, Toshikazu Akami, Shinji Okano
We report the case of a patient in which S-1 plus anastrozole was administered as first-line chemotherapy for Stage IV breast cancer with skin invasion, multiple lymph node metastasis, and lymphangitis carcinomatosis. A 77-year-old woman had a mass destroyed immediately outside the axilla with dry coughs. An 11mm unpalpable mass in the right breast and an axillary mass were confirmed to be scirrhous carcinoma(Luminal type B), respectively, by core needle biopsy. In one course, S- 1(100mg/day)therapy involves taking 2 courses of 14 days of administration and 7 days off the drug...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394644/-clinical-efficacy-of-paclitaxel-plus-bevacizumab-combination-therapy-for-bone-marrow-carcinomatosis-arising-from-breast-cancer-a-case-report
#20
Ichiro Nakayama
We report a case of a 42-year-old woman with bone marrow carcinomatosis in the course of metastatic breast cancer who responded well to paclitaxel plus bevacizumab(PTX plus Bev)combination therapy. Four years after initial breast conserving surgery, she was admitted to our hospital with back pain and general malaise and was diagnosed as multiple bone metastases with bone marrow carcinomatosis originating from previous breast cancer(ER+/HER2-). While administering denosumab, we initiated systemic chemotherapy with PTX plus Bev...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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