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JOURNAL ARTICLE
Larry Zeitlin, Robert W Cross, Courtney Woolsey, Brandyn R West, Viktoriya Borisevich, Krystle N Agans, Abhishek N Prasad, Daniel J Deer, Lauren Stuart, Maria McCavitt-Malvido, Do H Kim, James Pettitt, James E Crowe, Kevin J Whaley, David Veesler, Antony Dimitrov, Dafna M Abelson, Thomas W Geisbert, Christopher C Broder
No licensed vaccines or therapies exist for patients infected with Nipah virus (NiV), although an experimental human monoclonal antibody (mAb) cross-reactive to the NiV and Hendra virus (HeV) G glycoprotein, m102.4, has been tested in a phase 1 trial and has been provided under compassionate use for both HeV and NiV exposures. NiV is a highly pathogenic zoonotic paramyxovirus causing regular outbreaks in humans and animals in South and Southeast Asia. The mortality rate of NiV infection in humans ranges from 40% to more than 90%, making it a substantial public health concern...
April 3, 2024: Science Translational Medicine
#2
JOURNAL ARTICLE
David A Crowe, Andrew Willow, Rachael K Blackman, Adele L DeNicola, Matthew V Chafee, Bagrat Amirikian
Schizophrenia results in part from a failure of prefrontal networks but we lack full understanding of how disruptions at a synaptic level cause failures at the network level. This is a crucial gap in our understanding because it prevents us from discovering how genetic mutations and environmental risks that alter synaptic function cause prefrontal network to fail in schizophrenia. To address that question, we developed a recurrent spiking network model of prefrontal local circuits that can explain the link between NMDAR synaptic and 0-lag spike synchrony deficits we recently observed in a pharmacological monkey model of prefrontal network failure in schizophrenia...
February 6, 2024: ELife
#3
JOURNAL ARTICLE
Rachael K Blackman, David A Crowe, Adele L DeNicola, Sofia Sakellaridi, Jacob A Westerberg, Anh M Huynh, Angus W MacDonald, Scott R Sponheim, Matthew V Chafee
To better understand how prefrontal networks mediate forms of cognitive control disrupted in schizophrenia, we translated a variant of the AX continuous performance task (AX-CPT) that measures specific deficits in the human disease to two male monkeys and recorded neurons in prefrontal and parietal cortex during task performance. In the task, contextual information instructed by cue stimuli determines the response required to a subsequent probe stimulus. We found parietal neurons encoding the behavioral context instructed by cues that exhibited nearly identical activity to their prefrontal counterparts (Blackman et al...
March 9, 2023: Journal of Neuroscience
#4
JOURNAL ARTICLE
Lukas Alexander Hahn, Dmitry Balakhonov, Erica Fongaro, Andreas Nieder, Jonas Rose
Complex cognition relies on flexible working memory, which is severely limited in its capacity. The neuronal computations underlying these capacity limits have been extensively studied in humans and in monkeys, resulting in competing theoretical models. We probed the working memory capacity of crows ( Corvus corone ) in a change detection task, developed for monkeys ( Macaca mulatta ), while we performed extracellular recordings of the prefrontal-like area nidopallium caudolaterale. We found that neuronal encoding and maintenance of information were affected by item load, in a way that is virtually identical to results obtained from monkey prefrontal cortex...
December 3, 2021: ELife
#5
JOURNAL ARTICLE
Jennifer L Zick, David A Crowe, Rachael K Blackman, Kelsey Schultz, David W Bergstrand, Adele L DeNicola, Russell E Carter, Timothy J Ebner, Lorene M Lanier, Theoden I Netoff, Matthew V Chafee
Schizophrenia results from hundreds of known causes, including genetic, environmental, and developmental insults that cooperatively increase risk of developing the disease. In spite of the diversity of causal factors, schizophrenia presents with a core set of symptoms and brain abnormalities (both structural and functional) that particularly impact the prefrontal cortex. This suggests that many different causal factors leading to schizophrenia may cause prefrontal neurons and circuits to fail in fundamentally similar ways...
October 20, 2021: Current Biology: CB
#6
JOURNAL ARTICLE
Trygve E Bakken, Nikolas L Jorstad, Qiwen Hu, Blue B Lake, Wei Tian, Brian E Kalmbach, Megan Crow, Rebecca D Hodge, Fenna M Krienen, Staci A Sorensen, Jeroen Eggermont, Zizhen Yao, Brian D Aevermann, Andrew I Aldridge, Anna Bartlett, Darren Bertagnolli, Tamara Casper, Rosa G Castanon, Kirsten Crichton, Tanya L Daigle, Rachel Dalley, Nick Dee, Nikolai Dembrow, Dinh Diep, Song-Lin Ding, Weixiu Dong, Rongxin Fang, Stephan Fischer, Melissa Goldman, Jeff Goldy, Lucas T Graybuck, Brian R Herb, Xiaomeng Hou, Jayaram Kancherla, Matthew Kroll, Kanan Lathia, Baldur van Lew, Yang Eric Li, Christine S Liu, Hanqing Liu, Jacinta D Lucero, Anup Mahurkar, Delissa McMillen, Jeremy A Miller, Marmar Moussa, Joseph R Nery, Philip R Nicovich, Sheng-Yong Niu, Joshua Orvis, Julia K Osteen, Scott Owen, Carter R Palmer, Thanh Pham, Nongluk Plongthongkum, Olivier Poirion, Nora M Reed, Christine Rimorin, Angeline Rivkin, William J Romanow, Adriana E Sedeño-Cortés, Kimberly Siletti, Saroja Somasundaram, Josef Sulc, Michael Tieu, Amy Torkelson, Herman Tung, Xinxin Wang, Fangming Xie, Anna Marie Yanny, Renee Zhang, Seth A Ament, M Margarita Behrens, Hector Corrada Bravo, Jerold Chun, Alexander Dobin, Jesse Gillis, Ronna Hertzano, Patrick R Hof, Thomas Höllt, Gregory D Horwitz, C Dirk Keene, Peter V Kharchenko, Andrew L Ko, Boudewijn P Lelieveldt, Chongyuan Luo, Eran A Mukamel, António Pinto-Duarte, Sebastian Preissl, Aviv Regev, Bing Ren, Richard H Scheuermann, Kimberly Smith, William J Spain, Owen R White, Christof Koch, Michael Hawrylycz, Bosiljka Tasic, Evan Z Macosko, Steven A McCarroll, Jonathan T Ting, Hongkui Zeng, Kun Zhang, Guoping Feng, Joseph R Ecker, Sten Linnarsson, Ed S Lein
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals1 . Here, using high-throughput transcriptomic and epigenomic profiling of more than 450,000 single nuclei in humans, marmoset monkeys and mice, we demonstrate a broadly conserved cellular makeup of this region, with similarities that mirror evolutionary distance and are consistent between the transcriptome and epigenome. The core conserved molecular identities of neuronal and non-neuronal cell types allow us to generate a cross-species consensus classification of cell types, and to infer conserved properties of cell types across species...
October 2021: Nature
#7
REVIEW
Andreas Nieder
Humans and other animals share a number sense', an intuitive understanding of countable quantities. Having evolved independent from one another for hundreds of millions of years, the brains of these diverse species, including monkeys, crows, zebrafishes, bees, and squids, differ radically. However, in all vertebrates investigated, the pallium of the telencephalon has been implicated in number processing. This suggests that properties of the telencephalon make it ideally suited to host number representations that evolved by convergent evolution as a result of common selection pressures...
July 2021: Trends in Cognitive Sciences
#8
REVIEW
Andreas Nieder
Many species from diverse and often distantly related animal groups (e.g. monkeys, crows, fish and bees) have a sense of number. This means that they can assess the number of items in a set - its 'numerosity'. The brains of these phylogenetically distant species are markedly diverse. This Review examines the fundamentally different types of brains and neural mechanisms that give rise to numerical competence across the animal tree of life. Neural correlates of the number sense so far exist only for specific vertebrate species: the richest data concerning explicit and abstract number representations have been collected from the cerebral cortex of mammals, most notably human and nonhuman primates, but also from the pallium of corvid songbirds, which evolved independently of the mammalian cortex...
March 15, 2021: Journal of Experimental Biology
#9
JOURNAL ARTICLE
Erich Kummerfeld, Sisi Ma, Rachael K Blackman, Adele L DeNicola, A David Redish, Sophia Vinogradov, David A Crowe, Matthew V Chafee
BACKGROUND: The causal biology underlying schizophrenia is not well understood, but it is likely to involve a malfunction in how neurons adjust synaptic connections in response to patterns of activity in networks. We examined statistical dependencies between neural signals at the cell, local circuit, and distributed network levels in prefrontal and parietal cortices of monkeys performing a variant of the AX continuous performance task paradigm. We then quantified changes in the pattern of neural interactions across levels of scale following NMDA receptor (NMDAR) blockade and related these changes to a pattern of cognitive control errors closely matching the performance of patients with schizophrenia...
April 8, 2020: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
#10
JOURNAL ARTICLE
Adele L DeNicola, Min-Yoon Park, David A Crowe, Angus W MacDonald, Matthew V Chafee
The MD thalamus is reciprocally connected with the prefrontal cortex (PFC), and although the MD has been implicated in a range of PFC dependent cognitive functions (Watanabe and Funahashi, 2012; Mitchell and Chakraborty, 2013; Parnaudeau et al., 2018), little is known about how MD neurons in the primate participate specifically in cognitive control, a capability that reflects the ability to use contextual information (such as a rule) to modify responses to environmental stimuli. To learn how the MD-PFC thalamocortical network is engaged to mediate forms of cognitive control that are selectively disrupted in schizophrenia, we trained male monkeys to perform a variant of the AX continuous performance task (AX-CPT) that reliably measures cognitive control deficits in patients (Henderson et al...
January 13, 2020: Journal of Neuroscience
#11
JOURNAL ARTICLE
Rachael Miller, Anna Frohnwieser, Martina Schiestl, Dakota E McCoy, Russell D Gray, Alex H Taylor, Nicola S Clayton
Self-control underlies cognitive abilities such as decision making and future planning. Delay of gratification is a measure of self-control and involves obtaining a more valuable outcome in the future by tolerating a delay or investing a greater effort in the present. Contextual issues, such as reward visibility and type, may influence delayed gratification performance, although there has been limited comparative investigation between humans and other animals, particularly non-primate species. Here, we adapted an automated 'rotating tray' paradigm used previously with capuchin monkeys to test for delay of gratification ability that requires little pre-test training, where the subject must forgo an immediate, less preferred reward for a delayed, more preferred one...
October 19, 2019: Animal Cognition
#12
JOURNAL ARTICLE
Jennifer L Zick, Rachael K Blackman, David A Crowe, Bagrat Amirikian, Adele L DeNicola, Theoden I Netoff, Matthew V Chafee
We employed multi-electrode array recording to evaluate the influence of NMDA receptors (NMDAR) on spike-timing dynamics in prefrontal networks of monkeys as they performed a cognitive control task measuring specific deficits in schizophrenia. Systemic, periodic administration of an NMDAR antagonist (phencyclidine) reduced the prevalence and strength of synchronous (0-lag) spike correlation in simultaneously recorded neuron pairs. We employed transfer entropy analysis to measure effective connectivity between prefrontal neurons at lags consistent with monosynaptic interactions and found that effective connectivity was persistently reduced following exposure to the NMDAR antagonist...
June 27, 2018: Neuron
#13
JOURNAL ARTICLE
Matthew V Chafee, David A Crowe
In this issue, Loonis et al. (2017) provide the first description of unique synchrony patterns differentiating implicit and explicit forms of learning in monkey prefrontal networks. Their results have broad implications for how prefrontal networks integrate the two learning mechanisms to control behavior.
October 11, 2017: Neuron
#14
JOURNAL ARTICLE
Dmitry Balakhonov, Jonas Rose
The present study compares the 'bandwidth of cognition' between crows and primates. Working memory is the ability to maintain and manipulate information over short periods of time - a core component of cognition. The capacity of working memory is tightly limited, in humans correlated with individual intelligence and commonly used synonymously with cognitive capacity. Crows have remarkable cognitive skills and while birds and mammals share neural principles of working memory, its capacity has not been tested in crows...
August 18, 2017: Scientific Reports
#15
JOURNAL ARTICLE
Rachael K Blackman, David A Crowe, Adele L DeNicola, Sofia Sakellaridi, Angus W MacDonald, Matthew V Chafee
UNLABELLED: Cognitive control is the ability to modify the behavioral response to a stimulus based on internal representations of goals or rules. We sought to characterize neural mechanisms in prefrontal cortex associated with cognitive control in a context that would maximize the potential for future translational relevance to human neuropsychiatric disease. To that end, we trained monkeys to perform a dot-pattern variant of the AX continuous performance task that is used to measure cognitive control impairment in patients with schizophrenia (MacDonald, 2008;Jones et al...
April 6, 2016: Journal of Neuroscience
#16
JOURNAL ARTICLE
Thomas Bugnyar, Stephan A Reber, Cameron Buckner
Recent studies purported to demonstrate that chimpanzees, monkeys and corvids possess a basic Theory of Mind, the ability to attribute mental states like seeing to others. However, these studies remain controversial because they share a common confound: the conspecific's line of gaze, which could serve as an associative cue. Here, we show that ravens Corvus corax take into account the visual access of others, even when they cannot see a conspecific. Specifically, we find that ravens guard their caches against discovery in response to the sounds of conspecifics when a peephole is open but not when it is closed...
2016: Nature Communications
#17
JOURNAL ARTICLE
John T Bates, Jennifer A Pickens, Jennifer E Schuster, Monika Johnson, Sharon J Tollefson, John V Williams, Nancy L Davis, Robert E Johnston, Nancy Schultz-Darken, James C Slaughter, Frances Smith-House, James E Crowe
Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are major causes of illness among children, the elderly, and the immunocompromised. No vaccine has been licensed for protection against either of these viruses. We tested the ability of two Venezuelan equine encephalitis virus-based viral replicon particle (VEE-VRP) vaccines that express the hRSV or hMPV fusion (F) protein to confer protection against hRSV or hMPV in African green monkeys. Animals immunized with VEE-VRP vaccines developed RSV or MPV F-specific antibodies and serum neutralizing activity...
February 10, 2016: Vaccine
#18
JOURNAL ARTICLE
Barry B McGuire, Richard S Matulewicz, Rian Zuccarino-Crowe, Robert B Nadler, Kent T Perry
INTRODUCTION: Recent evidence would suggest a low rate of metabolic assessment in stone formers, even in those deemed as high risk. We wished to assess the attitudes and practice patterns of metabolic work up in North American members of the Endourological Society as part of the management of stone-forming patients. METHODS: A 12-question online multiple-choice questionnaire (using Survey Monkey(®)) was distributed to all members of the Endourological Society through e-mail...
April 2016: Journal of Endourology
#19
JOURNAL ARTICLE
Anna Smirnova, Zoya Zorina, Tanya Obozova, Edward Wasserman
Analogical reasoning is vital to advanced cognition and behavioral adaptation. Many theorists deem analogical thinking to be uniquely human and to be foundational to categorization, creative problem solving, and scientific discovery. Comparative psychologists have long been interested in the species generality of analogical reasoning, but they initially found it difficult to obtain empirical support for such thinking in nonhuman animals (for pioneering efforts, see [2, 3]). Researchers have since mustered considerable evidence and argument that relational matching-to-sample (RMTS) effectively captures the essence of analogy, in which the relevant logical arguments are presented visually...
January 19, 2015: Current Biology: CB
#20
JOURNAL ARTICLE
Emiko Uchino, Shigeru Watanabe
Recognition of a self-image in a mirror is investigated using the mark test during which a mark is placed onto a point on the body that is not directly visible, and the presence or absence of self-directed behaviors is evaluated for the mirror-observing subjects. Great apes, dolphins, possibly elephants, and magpies have all passed the mark test, that is, displayed self-directed behaviors, whereas monkeys, crows, and other animals have failed the test even though they were able to use a mirror to find a not-directly-visible object...
November 2014: Journal of the Experimental Analysis of Behavior
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