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David M. Sabatini

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https://www.readbyqxmd.com/read/30542996/genome-wide-crispr-cas9-screening-for-identification-of-cancer-genes-in-cell-lines
#1
Charles H Adelmann, Tim Wang, David M Sabatini, Eric S Lander
In this protocol, pooled sgRNA libraries targeting thousands of genes are computationally designed, generated using microarray-based synthesis techniques, and packaged into lentiviral particles. Target cells of interest are transduced with the lentiviral sgRNA pools to generate a collection of knockout mutants-via Cas9-mediated genomic cleavage-and screened for a phenotype of interest. The relative abundance of each mutant in the population can be monitored over time through high-throughput sequencing of the integrated sgRNA expression cassettes...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30541894/mito-tag-mice-enable-rapid-isolation-and-multimodal-profiling-of-mitochondria-from-specific-cell-types-in-vivo
#2
Erol C Bayraktar, Lou Baudrier, Ceren Özerdem, Caroline A Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Andrew L Cangelosi, David M Sabatini, Kıvanç Birsoy, Walter W Chen
Mitochondria are metabolic organelles that are essential for mammalian life, but the dynamics of mitochondrial metabolism within mammalian tissues in vivo remains incompletely understood. While whole-tissue metabolite profiling has been useful for studying metabolism in vivo, such an approach lacks resolution at the cellular and subcellular level. In vivo methods for interrogating organellar metabolites in specific cell types within mammalian tissues have been limited. To address this, we built on prior work in which we exploited a mitochondrially localized 3XHA epitope tag (MITO-Tag) for the fast isolation of mitochondria from cultured cells to generate MITO-Tag Mice...
December 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30517796/combination-of-the-searches-for-pair-produced-vectorlike-partners-of-the-third-generation-quarks-at-sqrt-s-13-tev-with-the-atlas-detector
#3
M Aaboud, G Aad, B Abbott, O Abdinov, B Abeloos, D K Abhayasinghe, S H Abidi, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adam, L Adamczyk, J Adelman, M Adersberger, A Adiguzel, T Adye, A A Affolder, Y Afik, C Agheorghiesei, J A Aguilar-Saavedra, F Ahmadov, G Aielli, S Akatsuka, T P A Åkesson, E Akilli, A V Akimov, G L Alberghi, J Albert, P Albicocco, M J Alconada Verzini, S Alderweireldt, M Aleksa, I N Aleksandrov, C Alexa, T Alexopoulos, M Alhroob, B Ali, G Alimonti, J Alison, S P Alkire, C Allaire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M I Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, Y Amaral Coutinho, A Ambler, L Ambroz, C Amelung, D Amidei, S P Amor Dos Santos, S Amoroso, C S Amrouche, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, C R Anelli, S Angelidakis, I Angelozzi, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, M Antonelli, D J A Antrim, F Anulli, M Aoki, J A Aparisi Pozo, L Aperio Bella, G Arabidze, J P Araque, V Araujo Ferraz, R Araujo Pereira, A T H Arce, R E Ardell, F A Arduh, J-F Arguin, S Argyropoulos, A J Armbruster, L J Armitage, A Armstrong, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, E M Asimakopoulou, L Asquith, K Assamagan, R Astalos, R J Atkin, M Atkinson, N B Atlay, K Augsten, G Avolio, R Avramidou, M K Ayoub, A M Azoulay, G Azuelos, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, P Bagnaia, M Bahmani, H Bahrasemani, A J Bailey, J T Baines, M Bajic, C Bakalis, O K Baker, P J Bakker, D Bakshi Gupta, S Balaji, E M Baldin, P Balek, F Balli, W K Balunas, J Balz, E Banas, A Bandyopadhyay, S Banerjee, A A E Bannoura, L Barak, W M Barbe, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, J Barkeloo, T Barklow, R Barnea, S L Barnes, B M Barnett, R M Barnett, Z Barnovska-Blenessy, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, S Batlamous, J R Batley, M Battaglia, M Bauce, F Bauer, K T Bauer, H S Bawa, J B Beacham, T Beau, P H Beauchemin, P Bechtle, H C Beck, H P Beck, K Becker, M Becker, C Becot, A Beddall, A J Beddall, V A Bednyakov, M Bedognetti, C P Bee, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, P Bellos, K Belotskiy, N L Belyaev, O Benary, D Benchekroun, M Bender, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, M Benoit, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, L J Bergsten, J Beringer, S Berlendis, N R Bernard, G Bernardi, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, I A Bertram, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, A Bethani, S Bethke, A Betti, A J Bevan, J Beyer, R Bi, R M B Bianchi, O Biebel, D Biedermann, R Bielski, K Bierwagen, N V Biesuz, M Biglietti, T R V Billoud, M Bindi, A Bingul, C Bini, S Biondi, M Birman, T Bisanz, J P Biswal, C Bittrich, D M Bjergaard, J E Black, K M Black, T Blazek, I Bloch, C Blocker, A Blue, U Blumenschein, Dr Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, D Boerner, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, A E Bolz, M Bomben, M Bona, J S Bonilla, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, D Boscherini, M Bosman, J D Bossio Sola, K Bouaouda, J Boudreau, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, D Boye, I R Boyko, A J Bozson, J Bracinik, N Brahimi, A Brandt, G Brandt, O Brandt, F Braren, U Bratzler, B Brau, J E Brau, W D Breaden Madden, K Brendlinger, L Brenner, R Brenner, S Bressler, B Brickwedde, D L Briglin, D Britton, D Britzger, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, A Bruni, G Bruni, L S Bruni, S Bruno, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, M K Bugge, O Bulekov, D Bullock, T J Burch, S Burdin, C D Burgard, A M Burger, B Burghgrave, K Burka, S Burke, I Burmeister, J T P Burr, V Büscher, E Buschmann, P Bussey, J M Butler, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, G Cabras, S Cabrera Urbán, D Caforio, H Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, G Callea, L P Caloba, S Calvente Lopez, D Calvet, S Calvet, T P Calvet, M Calvetti, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Camplani, A Campoverde, V Canale, M Cano Bret, J Cantero, T Cao, Y Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R M Carbone, R Cardarelli, F C Cardillo, I Carli, T Carli, G Carlino, B T Carlson, L Carminati, R M D Carney, S Caron, E Carquin, S Carrá, G D Carrillo-Montoya, D Casadei, M P Casado, A F Casha, D W Casper, R Castelijn, F L Castillo, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, E Cavallaro, D Cavalli, M Cavalli-Sforza, V Cavasinni, E Celebi, F Ceradini, L Cerda Alberich, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, S K Chan, W S Chan, Y L Chan, J D Chapman, B Chargeishvili, D G Charlton, C C Chau, C A Chavez Barajas, S Che, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, C H Chen, H Chen, J Chen, J Chen, S Chen, S J Chen, X Chen, Y Chen, Y-H Chen, H C Cheng, H J Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, A Chitan, I Chiu, Y H Chiu, M V Chizhov, K Choi, A R Chomont, S Chouridou, Y S Chow, V Christodoulou, M C Chu, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, D Cinca, V Cindro, I A Cioară, A Ciocio, F Cirotto, Z H Citron, M Citterio, A Clark, M R Clark, P J Clark, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, H Cohen, A E C Coimbra, L Colasurdo, B Cole, A P Colijn, J Collot, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, S Constantinescu, F Conventi, A M Cooper-Sarkar, F Cormier, K J R Cormier, L D Corpe, M Corradi, E E Corrigan, F Corriveau, A Cortes-Gonzalez, M J Costa, F Costanza, D Costanzo, G Cottin, G Cowan, B E Cox, J Crane, K Cranmer, S J Crawley, R A Creager, G Cree, S Crépé-Renaudin, F Crescioli, M Cristinziani, V Croft, G Crosetti, A Cueto, T Cuhadar Donszelmann, A R Cukierman, S Czekierda, P Czodrowski, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, F Dallaire, C Dallapiccola, M Dam, G D'amen, J Damp, J R Dandoy, M F Daneri, N P Dang, N D Dann, M Danninger, V Dao, G Darbo, S Darmora, O Dartsi, A Dattagupta, T Daubney, S D'Auria, W Davey, C David, T Davidek, D R Davis, E Dawe, I Dawson, K De, R De Asmundis, A De Benedetti, M De Beurs, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, M De Santis, A De Santo, K De Vasconcelos Corga, J B De Vivie De Regie, C Debenedetti, D V Dedovich, N Dehghanian, M Del Gaudio, J Del Peso, Y Delabat Diaz, D Delgove, F Deliot, C M Delitzsch, M Della Pietra, D Della Volpe, A Dell'Acqua, L Dell'Asta, M Delmastro, C Delporte, P A Delsart, D A DeMarco, S Demers, M Demichev, S P Denisov, D Denysiuk, L D'Eramo, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, M R Devesa, P O Deviveiros, A Dewhurst, S Dhaliwal, F A Di Bello, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, G Di Gregorio, B Di Micco, R Di Nardo, K F Di Petrillo, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, T Dias Do Vale, M A Diaz, J Dickinson, E B Diehl, J Dietrich, S Díez Cornell, A Dimitrievska, J Dingfelder, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B Do Vale, M Dobre, D Dodsworth, C Doglioni, J Dolejsi, Z Dolezal, M Donadelli, J Donini, A D'onofrio, M D'Onofrio, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, E Dreyer, T Dreyer, Y Du, F Dubinin, M Dubovsky, A Dubreuil, E Duchovni, G Duckeck, A Ducourthial, O A Ducu, D Duda, A Dudarev, A C Dudder, E M Duffield, L Duflot, M Dührssen, C Dülsen, M Dumancic, A E Dumitriu, A K Duncan, M Dunford, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, D Duvnjak, M Dyndal, S Dysch, B S Dziedzic, C Eckardt, K M Ecker, R C Edgar, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, R El Kosseifi, V Ellajosyula, M Ellert, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, A Emerman, Y Enari, J S Ennis, M B Epland, J Erdmann, A Ereditato, S Errede, M Escalier, C Escobar, O Estrada Pastor, A I Etienvre, E Etzion, H Evans, A Ezhilov, M Ezzi, F Fabbri, L Fabbri, V Fabiani, G Facini, R M Faisca Rodrigues Pereira, R M Fakhrutdinov, S Falciano, P J Falke, S Falke, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, E M Farina, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, W J Fawcett, L Fayard, O L Fedin, W Fedorko, M Feickert, S Feigl, L Feligioni, C Feng, E J Feng, M Feng, M J Fenton, A B Fenyuk, L Feremenga, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, F Fiedler, A Filipčič, F Filthaut, K D Finelli, M C N Fiolhais, L Fiorini, C Fischer, W C Fisher, N Flaschel, I Fleck, P Fleischmann, R R M Fletcher, T Flick, B M Flierl, L M Flores, L R Flores Castillo, F M Follega, N Fomin, G T Forcolin, A Formica, F A Förster, A C Forti, A G Foster, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, S Franchino, D Francis, L Franconi, M Franklin, M Frate, M Fraternali, A N Fray, D Freeborn, S M Fressard-Batraneanu, B Freund, W S Freund, E M Freundlich, D C Frizzell, D Froidevaux, J A Frost, C Fukunaga, E Fullana Torregrosa, T Fusayasu, J Fuster, O Gabizon, A Gabrielli, A Gabrielli, G P Gach, S Gadatsch, P Gadow, G Gagliardi, L G Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, R Gamboa Goni, K K Gan, S Ganguly, J Gao, Y Gao, Y S Gao, C García, J E García Navarro, J A García Pascual, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, K Gasnikova, A Gaudiello, G Gaudio, I L Gavrilenko, A Gavrilyuk, C Gay, G Gaycken, E N Gazis, C N P Gee, J Geisen, M Geisen, M P Geisler, K Gellerstedt, C Gemme, M H Genest, C Geng, S Gentile, S George, D Gerbaudo, G Gessner, S Ghasemi, M Ghasemi Bostanabad, M Ghneimat, B Giacobbe, S Giagu, N Giangiacomi, P Giannetti, A Giannini, S M Gibson, M Gignac, D Gillberg, G Gilles, D M Gingrich, M P Giordani, F M Giorgi, P F Giraud, P Giromini, G Giugliarelli, D Giugni, F Giuli, M Giulini, S Gkaitatzis, I Gkialas, E L Gkougkousis, P Gkountoumis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, M Goblirsch-Kolb, J Godlewski, S Goldfarb, T Golling, D Golubkov, A Gomes, R Goncalves Gama, R Gonçalo, G Gonella, L Gonella, A Gongadze, F Gonnella, J L Gonski, S González de la Hoz, S Gonzalez-Sevilla, L Goossens, P A Gorbounov, H A Gordon, B Gorini, E Gorini, A Gorišek, A T Goshaw, C Gössling, M I Gostkin, C A Gottardo, C R Goudet, D Goujdami, A G Goussiou, N Govender, C Goy, E Gozani, I Grabowska-Bold, P O J Gradin, E C Graham, J Gramling, E Gramstad, S Grancagnolo, V Gratchev, P M Gravila, F G Gravili, C Gray, H M Gray, Z D Greenwood, C Grefe, K Gregersen, I M Gregor, P Grenier, K Grevtsov, N A Grieser, J Griffiths, A A Grillo, K Grimm, S Grinstein, Ph Gris, J-F Grivaz, S Groh, E Gross, J Grosse-Knetter, G C Grossi, Z J Grout, C Grud, A Grummer, L Guan, W Guan, J Guenther, A Guerguichon, F Guescini, D Guest, R Gugel, B Gui, T Guillemin, S Guindon, U Gul, C Gumpert, J Guo, W Guo, Y Guo, Z Guo, R Gupta, S Gurbuz, G Gustavino, B J Gutelman, P Gutierrez, C Gutschow, C Guyot, M P Guzik, C Gwenlan, C B Gwilliam, A Haas, C Haber, H K Hadavand, N Haddad, A Hadef, S Hageböck, M Hagihara, H Hakobyan, M Haleem, J Haley, G Halladjian, G D Hallewell, K Hamacher, P Hamal, K Hamano, A Hamilton, G N Hamity, K Han, L Han, S Han, K Hanagaki, M Hance, D M Handl, B Haney, R Hankache, P Hanke, E Hansen, J B Hansen, J D Hansen, M C Hansen, P H Hansen, K Hara, A S Hard, T Harenberg, S Harkusha, P F Harrison, N M Hartmann, Y Hasegawa, A Hasib, S Hassani, S Haug, R Hauser, L Hauswald, L B Havener, M Havranek, C M Hawkes, R J Hawkings, D Hayden, C Hayes, C P Hays, J M Hays, H S Hayward, S J Haywood, M P Heath, V Hedberg, L Heelan, S Heer, K K Heidegger, J Heilman, S Heim, T Heim, B Heinemann, J J Heinrich, L Heinrich, C Heinz, J Hejbal, L Helary, A Held, S Hellesund, S Hellman, C Helsens, R C W Henderson, Y Heng, S Henkelmann, A M Henriques Correia, G H Herbert, H Herde, V Herget, Y Hernández Jiménez, H Herr, M G Herrmann, T Herrmann, G Herten, R Hertenberger, L Hervas, T C Herwig, G G Hesketh, N P Hessey, S Higashino, E Higón-Rodriguez, K Hildebrand, E Hill, J C Hill, K K Hill, K H Hiller, S J Hillier, M Hils, I Hinchliffe, M Hirose, D Hirschbuehl, B Hiti, O Hladik, D R Hlaluku, X Hoad, J Hobbs, N Hod, M C Hodgkinson, A Hoecker, M R Hoeferkamp, F Hoenig, D Hohn, D Hohov, T R Holmes, M Holzbock, M Homann, S Honda, T Honda, T M Hong, A Hönle, B H Hooberman, W H Hopkins, Y Horii, P Horn, A J Horton, L A Horyn, J-Y Hostachy, A Hostiuc, S Hou, A Hoummada, J Howarth, J Hoya, M Hrabovsky, I Hristova, J Hrivnac, A Hrynevich, T Hryn'ova, P J Hsu, S-C Hsu, Q Hu, S Hu, Y Huang, Z Hubacek, F Hubaut, M Huebner, F Huegging, T B Huffman, M Huhtinen, R F H Hunter, P Huo, A M Hupe, N Huseynov, J Huston, J Huth, R Hyneman, G Iacobucci, G Iakovidis, I Ibragimov, L Iconomidou-Fayard, Z Idrissi, P Iengo, R Ignazzi, O Igonkina, R Iguchi, T Iizawa, Y Ikegami, M Ikeno, D Iliadis, N Ilic, F Iltzsche, G Introzzi, M Iodice, K Iordanidou, V Ippolito, M F Isacson, N Ishijima, M Ishino, M Ishitsuka, W Islam, C Issever, S Istin, F Ito, J M Iturbe Ponce, R Iuppa, A Ivina, H Iwasaki, J M Izen, V Izzo, P Jacka, P Jackson, R M Jacobs, V Jain, G Jäkel, K B Jakobi, K Jakobs, S Jakobsen, T Jakoubek, D O Jamin, R Jansky, J Janssen, M Janus, P A Janus, G Jarlskog, N Javadov, T Javůrek, M Javurkova, F Jeanneau, L Jeanty, J Jejelava, A Jelinskas, P Jenni, J Jeong, N Jeong, S Jézéquel, H Ji, J Jia, H Jiang, Y Jiang, Z Jiang, S Jiggins, F A Jimenez Morales, J Jimenez Pena, S Jin, A Jinaru, O Jinnouchi, H Jivan, P Johansson, K A Johns, C A Johnson, W J Johnson, K Jon-And, R W L Jones, S D Jones, S Jones, T J Jones, J Jongmanns, P M Jorge, J Jovicevic, X Ju, J J Junggeburth, A Juste Rozas, A Kaczmarska, M Kado, H Kagan, M Kagan, T Kaji, E Kajomovitz, C W Kalderon, A Kaluza, S Kama, A Kamenshchikov, L Kanjir, Y Kano, V A Kantserov, J Kanzaki, B Kaplan, L S Kaplan, D Kar, M J Kareem, E Karentzos, S N Karpov, Z M Karpova, V Kartvelishvili, A N Karyukhin, L Kashif, R D Kass, A Kastanas, Y Kataoka, C Kato, J Katzy, K Kawade, K Kawagoe, T Kawamoto, G Kawamura, E F Kay, V F Kazanin, R Keeler, R Kehoe, J S Keller, E Kellermann, J J Kempster, J Kendrick, O Kepka, S Kersten, B P Kerševan, S Ketabchi Haghighat, R A Keyes, M Khader, F Khalil-Zada, A Khanov, A G Kharlamov, T Kharlamova, E E Khoda, A Khodinov, T J Khoo, E Khramov, J Khubua, S Kido, M Kiehn, C R Kilby, Y K Kim, N Kimura, O M Kind, B T King, D Kirchmeier, J Kirk, A E Kiryunin, T Kishimoto, D Kisielewska, V Kitali, O Kivernyk, E Kladiva, T Klapdor-Kleingrothaus, M H Klein, M Klein, U Klein, K Kleinknecht, P Klimek, A Klimentov, T Klingl, T Klioutchnikova, F F Klitzner, P Kluit, S Kluth, E Kneringer, E B F G Knoops, A Knue, A Kobayashi, D Kobayashi, T Kobayashi, M Kobel, M Kocian, P Kodys, P T Koenig, T Koffas, E Koffeman, N M Köhler, T Koi, M Kolb, I Koletsou, T Kondo, N Kondrashova, K Köneke, A C König, T Kono, R Konoplich, V Konstantinides, N Konstantinidis, B Konya, R Kopeliansky, S Koperny, K Korcyl, K Kordas, G Koren, A Korn, I Korolkov, E V Korolkova, N Korotkova, O Kortner, S Kortner, T Kosek, V V Kostyukhin, A Kotwal, A Koulouris, A Kourkoumeli-Charalampidi, C Kourkoumelis, E Kourlitis, V Kouskoura, A B Kowalewska, R Kowalewski, T Z Kowalski, C Kozakai, W Kozanecki, A S Kozhin, V A Kramarenko, G Kramberger, D Krasnopevtsev, M W Krasny, A Krasznahorkay, D Krauss, J A Kremer, J Kretzschmar, P Krieger, K Krizka, K Kroeninger, H Kroha, J Kroll, J Kroll, J Krstic, U Kruchonak, H Krüger, N Krumnack, M C Kruse, T Kubota, S Kuday, J T Kuechler, S Kuehn, A Kugel, F Kuger, T Kuhl, V Kukhtin, R Kukla, Y Kulchitsky, S Kuleshov, Y P Kulinich, M Kuna, T Kunigo, A Kupco, T Kupfer, O Kuprash, H Kurashige, L L Kurchaninov, Y A Kurochkin, A Kurova, M G Kurth, E S Kuwertz, M Kuze, J Kvita, T Kwan, A La Rosa, J L La Rosa Navarro, L La Rotonda, F La Ruffa, C Lacasta, F Lacava, J Lacey, D P J Lack, H Lacker, D Lacour, E Ladygin, R Lafaye, 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Zemaityte, J C Zeng, Q Zeng, O Zenin, D Zerwas, M Zgubič, D F Zhang, D Zhang, F Zhang, G Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, Y Zhao, Z Zhao, A Zhemchugov, Z Zheng, D Zhong, B Zhou, C Zhou, L Zhou, M S Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H L Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
A combination of the searches for pair-produced vectorlike partners of the top and bottom quarks in various decay channels (T→Zt/Wb/Ht, B→Zb/Wt/Hb) is performed using 36.1  fb^{-1} of pp collision data at sqrt[s]=13  TeV with the ATLAS detector at the Large Hadron Collider. The observed data are found to be in good agreement with the standard model background prediction in all individual searches. Therefore, combined 95% confidence-level upper limits are set on the production cross section for a range of vectorlike quark scenarios, significantly improving upon the reach of the individual searches...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517793/observation-of-centrality-dependent-acoplanarity-for-muon-pairs-produced-via-two-photon-scattering-in-pb-pb-collisions-at-sqrt-s_-nn-5-02-tev-with-the-atlas-detector
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Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, P Zhao, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M S Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H L Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
This Letter presents a measurement of γγ→μ^{+}μ^{-} production in Pb+Pb collisions recorded by the ATLAS detector at the Large Hadron Collider at sqrt[s_{NN}]=5.02  TeV with an integrated luminosity of 0.49  nb^{-1}. The azimuthal angle and transverse momentum correlations between the muons are measured as a function of collision centrality. The muon pairs are produced from γγ through the interaction of the large electromagnetic fields of the nuclei. The contribution from background sources of muon pairs is removed using a template fit method...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30468613/search-for-resonant-and-nonresonant-higgs-boson-pair-production-in-the-bb-over-%C3%A2-%C3%AF-%C3%AF-decay-channel-in-pp-collisions-at-sqrt-s-13-tev-with-the-atlas-detector
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Terron, S Terzo, M Testa, R J Teuscher, S J Thais, T Theveneaux-Pelzer, F Thiele, D W Thomas, J P Thomas, A S Thompson, P D Thompson, L A Thomsen, E Thomson, Y Tian, R E Ticse Torres, V O Tikhomirov, Yu A Tikhonov, S Timoshenko, P Tipton, S Tisserant, K Todome, S Todorova-Nova, S Todt, J Tojo, S Tokár, K Tokushuku, E Tolley, K G Tomiwa, M Tomoto, L Tompkins, K Toms, B Tong, P Tornambe, E Torrence, H Torres, E Torró Pastor, C Tosciri, J Toth, F Touchard, D R Tovey, C J Treado, T Trefzger, F Tresoldi, A Tricoli, I M Trigger, S Trincaz-Duvoid, M F Tripiana, W Trischuk, B Trocmé, A Trofymov, C Troncon, M Trovatelli, F Trovato, L Truong, M Trzebinski, A Trzupek, F Tsai, J C-L Tseng, P V Tsiareshka, A Tsirigotis, N Tsirintanis, V Tsiskaridze, E G Tskhadadze, I I Tsukerman, V Tsulaia, S Tsuno, D Tsybychev, Y Tu, A Tudorache, V Tudorache, T T Tulbure, A N Tuna, S Turchikhin, D Turgeman, I Turk Cakir, R Turra, P M Tuts, E Tzovara, G Ucchielli, I Ueda, M Ughetto, F Ukegawa, G Unal, A Undrus, G Unel, F C Ungaro, Y Unno, K Uno, J Urban, P Urquijo, P Urrejola, G Usai, J Usui, L Vacavant, V Vacek, B Vachon, K O H Vadla, A Vaidya, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, L Valéry, R A Vallance, A Vallier, J A Valls Ferrer, T R Van Daalen, H Van der Graaf, P Van Gemmeren, J Van Nieuwkoop, I Van Vulpen, M Vanadia, W Vandelli, A Vaniachine, P Vankov, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, K E Varvell, G A Vasquez, J G Vasquez, F Vazeille, D Vazquez Furelos, T Vazquez Schroeder, J Veatch, V Vecchio, L M Veloce, F Veloso, S Veneziano, A Ventura, M Venturi, N Venturi, V Vercesi, M Verducci, C M Vergel Infante, C Vergis, W Verkerke, A T Vermeulen, J C Vermeulen, M C Vetterli, N Viaux Maira, M Vicente Barreto Pinto, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, L Vigani, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, A Vishwakarma, C Vittori, I Vivarelli, S Vlachos, M Vogel, P Vokac, G Volpi, S E von Buddenbrock, E Von Toerne, V Vorobel, K Vorobev, M Vos, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, T Šfiligoj, R Vuillermet, I Vukotic, T Ženiš, L Živković, P Wagner, W Wagner, J Wagner-Kuhr, H Wahlberg, S Wahrmund, K Wakamiya, V M Walbrecht, J Walder, R Walker, S D Walker, W Walkowiak, V Wallangen, A M Wang, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, P Wang, Q Wang, R-J Wang, R Wang, R Wang, S M Wang, W T Wang, W Wang, W X Wang, Y Wang, Z Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, A Washbrook, P M Watkins, A T Watson, M F Watson, G Watts, S Watts, B M Waugh, A F Webb, S Webb, C Weber, M S Weber, S A Weber, S M Weber, A R Weidberg, B Weinert, J Weingarten, M Weirich, C Weiser, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M D Werner, P Werner, M Wessels, T D Weston, K Whalen, N L Whallon, A M Wharton, A S White, A White, M J White, R White, D Whiteson, B W Whitmore, F J Wickens, W Wiedenmann, M Wielers, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, F Wilk, H G Wilkens, L J Wilkins, H H Williams, S Williams, C Willis, S Willocq, J A Wilson, I Wingerter-Seez, E Winkels, F Winklmeier, O J Winston, B T Winter, M Wittgen, M Wobisch, A Wolf, T M H Wolf, R Wolff, M W Wolter, H Wolters, V W S Wong, N L Woods, S D Worm, B K Wosiek, K W Woźniak, K Wraight, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, Z Xi, L Xia, D Xu, H Xu, L Xu, T Xu, W Xu, B Yabsley, S Yacoob, K Yajima, D P Yallup, D Yamaguchi, Y Yamaguchi, A Yamamoto, T Yamanaka, F Yamane, M Yamatani, T Yamazaki, Y Yamazaki, Z Yan, H J Yang, H T Yang, S Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, J Ye, S Ye, I Yeletskikh, E Yigitbasi, E Yildirim, K Yorita, K Yoshihara, C J S Young, C Young, J Yu, J Yu, X Yue, S P Y Yuen, B Zabinski, G Zacharis, E Zaffaroni, R Zaidan, A M Zaitsev, T Zakareishvili, N Zakharchuk, J Zalieckas, S Zambito, D Zanzi, D R Zaripovas, S V Zeißner, C Zeitnitz, G Zemaityte, J C Zeng, Q Zeng, O Zenin, D Zerwas, M Zgubič, D F Zhang, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M S Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H L Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
A search for resonant and nonresonant pair production of Higgs bosons in the bb[over ¯]τ^{+}τ^{-} final state is presented. The search uses 36.1  fb^{-1} of pp collision data with sqrt[s]=13  TeV recorded by the ATLAS experiment at the LHC in 2015 and 2016. Decays of the τ-lepton pairs with at least one τ lepton decaying to final states with hadrons and a neutrino are considered. No significant excess above the expected background is observed in the data. The cross-section times branching ratio for nonresonant Higgs boson pair production is constrained to be less than 30...
November 9, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30455437/global-trait-environment-relationships-of-plant-communities
#6
Helge Bruelheide, Jürgen Dengler, Oliver Purschke, Jonathan Lenoir, Borja Jiménez-Alfaro, Stephan M Hennekens, Zoltán Botta-Dukát, Milan Chytrý, Richard Field, Florian Jansen, Jens Kattge, Valério D Pillar, Franziska Schrodt, Miguel D Mahecha, Robert K Peet, Brody Sandel, Peter van Bodegom, Jan Altman, Esteban Alvarez-Dávila, Mohammed A S Arfin Khan, Fabio Attorre, Isabelle Aubin, Christopher Baraloto, Jorcely G Barroso, Marijn Bauters, Erwin Bergmeier, Idoia Biurrun, Anne D Bjorkman, Benjamin Blonder, Andraž Čarni, Luis Cayuela, Tomáš Černý, J Hans C Cornelissen, Dylan Craven, Matteo Dainese, Géraldine Derroire, Michele De Sanctis, Sandra Díaz, Jiří Doležal, William Farfan-Rios, Ted R Feldpausch, Nicole J Fenton, Eric Garnier, Greg R Guerin, Alvaro G Gutiérrez, Sylvia Haider, Tarek Hattab, Greg Henry, Bruno Hérault, Pedro Higuchi, Norbert Hölzel, Jürgen Homeier, Anke Jentsch, Norbert Jürgens, Zygmunt Kącki, Dirk N Karger, Michael Kessler, Michael Kleyer, Ilona Knollová, Andrey Y Korolyuk, Ingolf Kühn, Daniel C Laughlin, Frederic Lens, Jacqueline Loos, Frédérique Louault, Mariyana I Lyubenova, Yadvinder Malhi, Corrado Marcenò, Maurizio Mencuccini, Jonas V Müller, Jérôme Munzinger, Isla H Myers-Smith, David A Neill, Ülo Niinemets, Kate H Orwin, Wim A Ozinga, Josep Penuelas, Aaron Pérez-Haase, Petr Petřík, Oliver L Phillips, Meelis Pärtel, Peter B Reich, Christine Römermann, Arthur V Rodrigues, Francesco Maria Sabatini, Jordi Sardans, Marco Schmidt, Gunnar Seidler, Javier Eduardo Silva Espejo, Marcos Silveira, Anita Smyth, Maria Sporbert, Jens-Christian Svenning, Zhiyao Tang, Raquel Thomas, Ioannis Tsiripidis, Kiril Vassilev, Cyrille Violle, Risto Virtanen, Evan Weiher, Erik Welk, Karsten Wesche, Marten Winter, Christian Wirth, Ute Jandt
Plant functional traits directly affect ecosystem functions. At the species level, trait combinations depend on trade-offs representing different ecological strategies, but at the community level trait combinations are expected to be decoupled from these trade-offs because different strategies can facilitate co-existence within communities. A key question is to what extent community-level trait composition is globally filtered and how well it is related to global versus local environmental drivers. Here, we perform a global, plot-level analysis of trait-environment relationships, using a database with more than 1...
November 19, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/30442778/sfxn1-is-a-mitochondrial-serine-transporter-required-for-one-carbon-metabolism
#7
Nora Kory, Gregory A Wyant, Gyan Prakash, Jelmi Uit de Bos, Francesca Bottanelli, Michael E Pacold, Sze Ham Chan, Caroline A Lewis, Tim Wang, Heather R Keys, Yang Eric Guo, David M Sabatini
One-carbon metabolism generates the one-carbon units required to synthesize many critical metabolites, including nucleotides. The pathway has cytosolic and mitochondrial branches, and a key step is the entry, through an unknown mechanism, of serine into mitochondria, where it is converted into glycine and formate. In a CRISPR-based genetic screen in human cells for genes of the mitochondrial pathway, we found sideroflexin 1 (SFXN1), a multipass inner mitochondrial membrane protein of unclear function. Like cells missing mitochondrial components of one-carbon metabolism, those null for SFXN1 are defective in glycine and purine synthesis...
November 16, 2018: Science
https://www.readbyqxmd.com/read/30362803/probing-the-quantum-interference-between-singly-and-doubly-resonant-top-quark-production-in-pp-collisions-at-sqrt-s-13-tev-with-the-atlas-detector
#8
M Aaboud, G Aad, B Abbott, O Abdinov, B Abeloos, D K Abhayasinghe, S H Abidi, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adamczyk, J Adelman, M Adersberger, A Adiguzel, T Adye, A A Affolder, Y Afik, C Agheorghiesei, J A Aguilar-Saavedra, F Ahmadov, G Aielli, S Akatsuka, T P A Åkesson, E Akilli, A V Akimov, G L Alberghi, J Albert, P Albicocco, M J Alconada Verzini, S Alderweireldt, M Aleksa, I N Aleksandrov, C Alexa, T Alexopoulos, M Alhroob, B Ali, G Alimonti, J Alison, S P Alkire, C Allaire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M I Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, Y Amaral Coutinho, L Ambroz, C Amelung, D Amidei, S P Amor Dos Santos, S Amoroso, C S Amrouche, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, C R Anelli, S Angelidakis, I Angelozzi, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, M Antonelli, D J A Antrim, F Anulli, M Aoki, L Aperio Bella, G Arabidze, J P Araque, V Araujo Ferraz, R Araujo Pereira, A T H Arce, R E Ardell, F A Arduh, J-F Arguin, S Argyropoulos, A J Armbruster, L J Armitage, A Armstrong, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, A Ashkenazi, E M Asimakopoulou, L Asquith, K Assamagan, R Astalos, R J Atkin, M Atkinson, N B Atlay, K Augsten, G Avolio, R Avramidou, M K Ayoub, G Azuelos, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, P Bagnaia, M Bahmani, H Bahrasemani, A J Bailey, J T Baines, M Bajic, C Bakalis, O K Baker, P J Bakker, D Bakshi Gupta, E M Baldin, P Balek, F Balli, W K Balunas, J Balz, E Banas, A Bandyopadhyay, S Banerjee, A A E Bannoura, L Barak, W M Barbe, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, J Barkeloo, T Barklow, N Barlow, R Barnea, S L Barnes, B M Barnett, R M Barnett, Z Barnovska-Blenessy, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, S Batlamous, J R Batley, M Battaglia, M Bauce, F Bauer, K T Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, P Bechtle, H C Beck, H P Beck, K Becker, M Becker, C Becot, A Beddall, A J Beddall, V A Bednyakov, M Bedognetti, C P Bee, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, P Bellos, K Belotskiy, N L Belyaev, O Benary, D Benchekroun, M Bender, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, M Benoit, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, L J Bergsten, J Beringer, S Berlendis, N R Bernard, G Bernardi, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, I A Bertram, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, A Bethani, S Bethke, A Betti, A J Bevan, J Beyer, R M Bianchi, O Biebel, D Biedermann, R Bielski, K Bierwagen, N V Biesuz, M Biglietti, T R V Billoud, M Bindi, A Bingul, C Bini, S Biondi, M Birman, T Bisanz, J P Biswal, C Bittrich, D M Bjergaard, J E Black, K M Black, T Blazek, I Bloch, C Blocker, A Blue, U Blumenschein, Dr Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, D Boerner, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, A E Bolz, M Bomben, M Bona, J S Bonilla, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, D Boscherini, M Bosman, J D Bossio Sola, K Bouaouda, J Boudreau, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, I R Boyko, A J Bozson, J Bracinik, N Brahimi, A Brandt, G Brandt, O Brandt, F Braren, U Bratzler, B Brau, J E Brau, W D Breaden Madden, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, B Brickwedde, D L Briglin, D Britton, D Britzger, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, A Bruni, G Bruni, L S Bruni, S Bruno, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, M K Bugge, O Bulekov, D Bullock, T J Burch, S Burdin, C D Burgard, A M Burger, B Burghgrave, K Burka, S Burke, I Burmeister, J T P Burr, D Büscher, V Büscher, E Buschmann, P Bussey, J M Butler, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, G Cabras, S Cabrera Urbán, D Caforio, H Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, G Callea, L P Caloba, S Calvente Lopez, D Calvet, S Calvet, T P Calvet, M Calvetti, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Camplani, A Campoverde, V Canale, M Cano Bret, J Cantero, T Cao, Y Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R M Carbone, R Cardarelli, F C Cardillo, I Carli, T Carli, G Carlino, B T Carlson, L Carminati, R M D Carney, S Caron, E Carquin, S Carrá, G D Carrillo-Montoya, D Casadei, M P Casado, A F Casha, M Casolino, D W Casper, R Castelijn, F L Castillo, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, E Cavallaro, D Cavalli, M Cavalli-Sforza, V Cavasinni, E Celebi, F Ceradini, L Cerda Alberich, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, S K Chan, W S Chan, Y L Chan, J D Chapman, D G Charlton, C C Chau, C A Chavez Barajas, S Che, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, C H Chen, H Chen, J Chen, J Chen, S Chen, S J Chen, X Chen, Y Chen, Y-H Chen, H C Cheng, H J Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, A Chitan, I Chiu, Y H Chiu, M V Chizhov, K Choi, A R Chomont, S Chouridou, Y S Chow, V Christodoulou, M C Chu, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, D Cinca, V Cindro, I A Cioară, A Ciocio, F Cirotto, Z H Citron, M Citterio, A Clark, M R Clark, P J Clark, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, A E C Coimbra, L Colasurdo, B Cole, A P Colijn, J Collot, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, S Constantinescu, F Conventi, A M Cooper-Sarkar, F Cormier, K J R Cormier, M Corradi, E E Corrigan, F Corriveau, A Cortes-Gonzalez, M J Costa, D Costanzo, G Cottin, G Cowan, B E Cox, J Crane, K Cranmer, S J Crawley, R A Creager, G Cree, S Crépé-Renaudin, F Crescioli, M Cristinziani, V Croft, G Crosetti, A Cueto, T Cuhadar Donszelmann, A R Cukierman, J Cúth, S Czekierda, P Czodrowski, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, F Dallaire, C Dallapiccola, M Dam, G D'amen, J Damp, J R Dandoy, M F Daneri, N P Dang, N D Dann, M Danninger, V Dao, G Darbo, S Darmora, O Dartsi, A Dattagupta, T Daubney, S D'Auria, W Davey, C David, T Davidek, D R Davis, E Dawe, I Dawson, K De, R De Asmundis, A De Benedetti, M De Beurs, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, A De Santo, K De Vasconcelos Corga, J B De Vivie De Regie, C Debenedetti, D V Dedovich, N Dehghanian, M Del Gaudio, J Del Peso, Y Delabat Diaz, D Delgove, F Deliot, C M Delitzsch, M Della Pietra, D Della Volpe, A Dell'Acqua, L Dell'Asta, M Delmastro, C Delporte, P A Delsart, D A DeMarco, S Demers, M Demichev, S P Denisov, D Denysiuk, L D'Eramo, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, M R Devesa, P O Deviveiros, A Dewhurst, S Dhaliwal, F A Di Bello, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, B Di Micco, R Di Nardo, K F Di Petrillo, A Di Simone, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, T Dias Do Vale, M A Diaz, J Dickinson, E B Diehl, J Dietrich, S Díez Cornell, A Dimitrievska, J Dingfelder, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B Do Vale, M Dobre, D Dodsworth, C Doglioni, J Dolejsi, Z Dolezal, M Donadelli, J Donini, A D'onofrio, M D'Onofrio, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, E Dreyer, T Dreyer, Y Du, J Duarte-Campderros, F Dubinin, M Dubovsky, A Dubreuil, E Duchovni, G Duckeck, A Ducourthial, O A Ducu, D Duda, A Dudarev, A C Dudder, E M Duffield, L Duflot, M Dührssen, C Dülsen, M Dumancic, A E Dumitriu, A K Duncan, M Dunford, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, D Duvnjak, M Dyndal, S Dysch, B S Dziedzic, C Eckardt, K M Ecker, R C Edgar, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, R El Kosseifi, V Ellajosyula, M Ellert, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, J S Ennis, M B Epland, J Erdmann, A Ereditato, S Errede, M Escalier, C Escobar, O Estrada Pastor, A I Etienvre, E Etzion, H Evans, A Ezhilov, M Ezzi, F Fabbri, L Fabbri, V Fabiani, G Facini, R M Faisca Rodrigues Pereira, R M Fakhrutdinov, S Falciano, P J Falke, S Falke, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, E M Farina, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, W J Fawcett, L Fayard, O L Fedin, W Fedorko, M Feickert, S Feigl, L Feligioni, C Feng, E J Feng, M Feng, M J Fenton, A B Fenyuk, L Feremenga, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, F Fiedler, A Filipčič, F Filthaut, K D Finelli, M C N Fiolhais, L Fiorini, C Fischer, W C Fisher, N Flaschel, I Fleck, P Fleischmann, R R M Fletcher, T Flick, B M Flierl, L M Flores, L R Flores Castillo, N Fomin, G T Forcolin, A Formica, F A Förster, A C Forti, A G Foster, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, S Franchino, D Francis, L Franconi, M Franklin, M Frate, M Fraternali, D Freeborn, S M Fressard-Batraneanu, B Freund, W S Freund, D Froidevaux, J A Frost, C Fukunaga, E Fullana Torregrosa, T Fusayasu, J Fuster, O Gabizon, A Gabrielli, A Gabrielli, G P Gach, S Gadatsch, P Gadow, G Gagliardi, L G Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, R Gamboa Goni, K K Gan, S Ganguly, Y Gao, Y S Gao, C García, J E García Navarro, J A García Pascual, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, K Gasnikova, A Gaudiello, G Gaudio, I L Gavrilenko, A Gavrilyuk, C Gay, G Gaycken, E N Gazis, C N P Gee, J Geisen, M Geisen, M P Geisler, K Gellerstedt, C Gemme, M H Genest, C Geng, S Gentile, C Gentsos, S George, D Gerbaudo, G Gessner, S Ghasemi, M Ghasemi Bostanabad, M Ghneimat, B Giacobbe, S Giagu, N Giangiacomi, P Giannetti, A Giannini, S M Gibson, M Gignac, D Gillberg, G Gilles, D M Gingrich, M P Giordani, F M Giorgi, P F Giraud, P Giromini, G Giugliarelli, D Giugni, F Giuli, M Giulini, S Gkaitatzis, I Gkialas, E L Gkougkousis, P Gkountoumis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, M Goblirsch-Kolb, J Godlewski, S Goldfarb, T 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This Letter presents a normalized differential cross-section measurement in a fiducial phase-space region where interference effects between top-quark pair production and associated production of a single top quark with a W boson and a b-quark are significant. Events with exactly two leptons (ee, μμ, or eμ) and two b-tagged jets that satisfy a multiparticle invariant mass requirement are selected from 36.1  fb^{-1} of proton-proton collision data taken at sqrt[s]=13  TeV with the ATLAS detector at the LHC in 2015 and 2016...
October 12, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30215627/search-for-new-phenomena-using-the-invariant-mass-distribution-of-same-flavour-opposite-sign-dilepton-pairs-in-events-with-missing-transverse-momentum-in-s-13-te-pp-collisions-with-the-atlas-detector
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Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
A search for new phenomena in final states containing an <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mi>e</mml:mi> <mml:mo>+</mml:mo> </mml:msup> <mml:msup> <mml:mi>e</mml:mi> <mml:mo>-</mml:mo> </mml:msup> </mml:mrow> </mml:math> or <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mi>μ</mml:mi> <mml:mo>+</mml:mo> </mml:msup> <mml:msup> <mml:mi>μ</mml:mi> <mml:mo>-</mml:mo> </mml:msup> </mml:mrow> </mml:math> pair, jets, and large missing transverse momentum is presented...
2018: European Physical Journal. C, Particles and Fields
https://www.readbyqxmd.com/read/30192593/search-for-low-mass-dijet-resonances-using-trigger-level-jets-with-the-atlas-detector-in-pp-collisions-at-sqrt-s-13-tev
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Romano, N Rompotis, M Ronzani, L Roos, S Rosati, K Rosbach, P Rose, N-A Rosien, E Rossi, L P Rossi, L Rossini, J H N Rosten, R Rosten, M Rotaru, J Rothberg, D Rousseau, D Roy, A Rozanov, Y Rozen, X Ruan, F Rubbo, F Rühr, A Ruiz-Martinez, Z Rurikova, N A Rusakovich, H L Russell, J P Rutherfoord, N Ruthmann, E M Rüttinger, Y F Ryabov, M Rybar, G Rybkin, S Ryu, A Ryzhov, G F Rzehorz, P Sabatini, G Sabato, S Sacerdoti, H F-W Sadrozinski, R Sadykov, F Safai Tehrani, P Saha, M Sahinsoy, A Sahu, M Saimpert, M Saito, T Saito, H Sakamoto, A Sakharov, D Salamani, G Salamanna, J E Salazar Loyola, D Salek, P H Sales De Bruin, D Salihagic, A Salnikov, J Salt, D Salvatore, F Salvatore, A Salvucci, A Salzburger, D Sammel, D Sampsonidis, D Sampsonidou, J Sánchez, A Sanchez Pineda, H Sandaker, C O Sander, M Sandhoff, C Sandoval, D P C Sankey, M Sannino, Y Sano, A Sansoni, C Santoni, H Santos, I Santoyo Castillo, A Sapronov, J G Saraiva, O Sasaki, K Sato, E Sauvan, P Savard, N Savic, R Sawada, C Sawyer, L Sawyer, C Sbarra, A Sbrizzi, T Scanlon, D A Scannicchio, J Schaarschmidt, P Schacht, B M Schachtner, D Schaefer, L Schaefer, J Schaeffer, S Schaepe, U Schäfer, A C Schaffer, D Schaile, R D Schamberger, N Scharmberg, V A Schegelsky, D Scheirich, F Schenck, M Schernau, C Schiavi, S Schier, L K Schildgen, Z M Schillaci, E J Schioppa, M Schioppa, K E Schleicher, S Schlenker, K R Schmidt-Sommerfeld, K Schmieden, C Schmitt, S Schmitt, S Schmitz, U Schnoor, L Schoeffel, A Schoening, E Schopf, M Schott, J F P Schouwenberg, J Schovancova, S Schramm, N Schuh, A Schulte, H-C Schultz-Coulon, M Schumacher, B A Schumm, Ph Schune, A Schwartzman, T A Schwarz, H Schweiger, Ph Schwemling, R Schwienhorst, A Sciandra, G Sciolla, M Scornajenghi, F Scuri, F Scutti, L M Scyboz, J Searcy, C D Sebastiani, P Seema, S C Seidel, A Seiden, T Seiss, J M Seixas, G Sekhniaidze, K Sekhon, S J Sekula, N Semprini-Cesari, S Sen, S Senkin, C Serfon, L Serin, L Serkin, M Sessa, H Severini, F Sforza, A Sfyrla, E Shabalina, J D Shahinian, N W Shaikh, L Y Shan, R Shang, J T Shank, M Shapiro, A S Sharma, A Sharma, P B Shatalov, K Shaw, S M Shaw, A Shcherbakova, C Y Shehu, Y Shen, N Sherafati, A D Sherman, P Sherwood, L Shi, S Shimizu, C O Shimmin, M Shimojima, I P J Shipsey, S Shirabe, M Shiyakova, J Shlomi, A Shmeleva, D Shoaleh Saadi, M J Shochet, S Shojaii, D R Shope, S Shrestha, E Shulga, P Sicho, A M Sickles, P E Sidebo, E Sideras Haddad, O Sidiropoulou, A Sidoti, F Siegert, Dj Sijacki, J Silva, M Silva, S B Silverstein, L Simic, S Simion, E Simioni, M Simon, P Sinervo, N B Sinev, M Sioli, G Siragusa, I Siral, S Yu Sivoklokov, J Sjölin, M B Skinner, P Skubic, M Slater, T Slavicek, M Slawinska, K Sliwa, R Slovak, V Smakhtin, B H Smart, J Smiesko, N Smirnov, S Yu Smirnov, Y Smirnov, L N Smirnova, O Smirnova, J W Smith, M N K Smith, R W Smith, M Smizanska, K Smolek, A A Snesarev, I M Snyder, S Snyder, R Sobie, A M Soffa, A Soffer, A Søgaard, D A Soh, G Sokhrannyi, C A Solans Sanchez, M Solar, E Yu Soldatov, U Soldevila, A A Solodkov, A Soloshenko, O V Solovyanov, V Solovyev, P Sommer, H Son, W Song, A Sopczak, F Sopkova, D Sosa, C L Sotiropoulou, S Sottocornola, R Soualah, A M Soukharev, D South, B C Sowden, S Spagnolo, M Spalla, M Spangenberg, F Spanò, D Sperlich, F Spettel, T M Spieker, R Spighi, G Spigo, L A Spiller, M Spousta, A Stabile, R Stamen, S Stamm, E Stanecka, R W Stanek, C Stanescu, M M Stanitzki, B S Stapf, S Stapnes, E A Starchenko, G H Stark, J Stark, S H Stark, P Staroba, P Starovoitov, S Stärz, R Staszewski, M Stegler, P Steinberg, B Stelzer, H J Stelzer, O Stelzer-Chilton, H Stenzel, T J Stevenson, G A Stewart, M C Stockton, G Stoicea, P Stolte, S Stonjek, A Straessner, J Strandberg, S Strandberg, M Strauss, P Strizenec, R Ströhmer, D M Strom, R Stroynowski, A Strubig, S A Stucci, B Stugu, J Stupak, N A Styles, D Su, J Su, S Suchek, Y Sugaya, M Suk, V V Sulin, D M S Sultan, S Sultansoy, T Sumida, S Sun, X Sun, K Suruliz, C J E Suster, M R Sutton, S Suzuki, M Svatos, M Swiatlowski, S P Swift, A Sydorenko, I Sykora, T Sykora, D Ta, K Tackmann, J Taenzer, A Taffard, R Tafirout, E Tahirovic, N Taiblum, H Takai, R Takashima, E H Takasugi, K Takeda, T Takeshita, Y Takubo, M Talby, A A Talyshev, J Tanaka, M Tanaka, R Tanaka, R Tanioka, B B Tannenwald, S Tapia Araya, S Tapprogge, A Tarek Abouelfadl Mohamed, S Tarem, G Tarna, G F Tartarelli, P Tas, M Tasevsky, T Tashiro, E Tassi, A Tavares Delgado, Y Tayalati, A C Taylor, A J Taylor, G N Taylor, P T E Taylor, W Taylor, A S Tee, P Teixeira-Dias, D Temple, H Ten Kate, P K Teng, J J Teoh, F Tepel, S Terada, K Terashi, J Terron, S Terzo, M Testa, R J Teuscher, S J Thais, T Theveneaux-Pelzer, F Thiele, J P Thomas, A S Thompson, P D Thompson, L A Thomsen, E Thomson, Y Tian, R E Ticse Torres, V O Tikhomirov, Yu A Tikhonov, S Timoshenko, P Tipton, S Tisserant, K Todome, S Todorova-Nova, S Todt, J Tojo, S Tokár, K Tokushuku, E Tolley, M Tomoto, L Tompkins, K Toms, B Tong, P Tornambe, E Torrence, H Torres, E Torró Pastor, C Tosciri, J Toth, F Touchard, D R Tovey, C J Treado, T Trefzger, F Tresoldi, A Tricoli, I M Trigger, S Trincaz-Duvoid, M F Tripiana, W Trischuk, B Trocmé, A Trofymov, C Troncon, M Trovatelli, F Trovato, L Truong, M Trzebinski, A Trzupek, F Tsai, J C-L Tseng, P V Tsiareshka, N Tsirintanis, V Tsiskaridze, E G Tskhadadze, I I Tsukerman, V Tsulaia, S Tsuno, D Tsybychev, Y Tu, A Tudorache, V Tudorache, T T Tulbure, A N Tuna, S Turchikhin, D Turgeman, I Turk Cakir, R Turra, P M Tuts, E Tzovara, G Ucchielli, I Ueda, M Ughetto, F Ukegawa, G Unal, A Undrus, G Unel, F C Ungaro, Y Unno, K Uno, J Urban, P Urquijo, P Urrejola, G Usai, J Usui, L Vacavant, V Vacek, B Vachon, K O H Vadla, A Vaidya, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, L Valéry, R A Vallance, A Vallier, J A Valls Ferrer, T R Van Daalen, W Van Den Wollenberg, H Van der Graaf, P Van Gemmeren, J Van Nieuwkoop, I Van Vulpen, M C van Woerden, M Vanadia, W Vandelli, A Vaniachine, P Vankov, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, A Vartapetian, K E Varvell, G A Vasquez, J G Vasquez, F Vazeille, D Vazquez Furelos, T Vazquez Schroeder, J Veatch, V Vecchio, L M Veloce, F Veloso, S Veneziano, A Ventura, M Venturi, N Venturi, V Vercesi, M Verducci, W Verkerke, A T Vermeulen, J C Vermeulen, M C Vetterli, N Viaux Maira, O Viazlo, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, L Vigani, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, A Vishwakarma, C Vittori, I Vivarelli, S Vlachos, M Vogel, P Vokac, G Volpi, S E Von Buddenbrock, E Von Toerne, V Vorobel, K Vorobev, M Vos, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, T Šfiligoj, R Vuillermet, I Vukotic, T Ženiš, L Živković, P Wagner, W Wagner, J Wagner-Kuhr, H Wahlberg, S Wahrmund, K Wakamiya, J Walder, R Walker, W Walkowiak, V Wallangen, A M Wang, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, P Wang, Q Wang, R-J Wang, R Wang, R Wang, S M Wang, W Wang, W X Wang, Y Wang, Z Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, A Washbrook, P M Watkins, A T Watson, M F Watson, G Watts, S Watts, B M Waugh, A F Webb, S Webb, C Weber, M S Weber, S A Weber, S M Weber, J S Webster, A R Weidberg, B Weinert, J Weingarten, M Weirich, C Weiser, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M D Werner, P Werner, M Wessels, T D Weston, K Whalen, N L Whallon, A M Wharton, A S White, A White, M J White, R White, D Whiteson, B W Whitmore, F J Wickens, W Wiedenmann, M Wielers, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, F Wilk, H G Wilkens, H H Williams, S Williams, C Willis, S Willocq, J A Wilson, I Wingerter-Seez, E Winkels, F Winklmeier, O J Winston, B T Winter, M Wittgen, M Wobisch, A Wolf, T M H Wolf, R Wolff, M W Wolter, H Wolters, V W S Wong, N L Woods, S D Worm, B K Wosiek, K W Woźniak, K Wraight, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, Z Xi, L Xia, D Xu, H Xu, L Xu, T Xu, W Xu, B Yabsley, S Yacoob, K Yajima, D P Yallup, D Yamaguchi, Y Yamaguchi, A Yamamoto, T Yamanaka, F Yamane, M Yamatani, T Yamazaki, Y Yamazaki, Z Yan, H J Yang, H T Yang, S Yang, Y Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, J Ye, S Ye, I Yeletskikh, E Yigitbasi, E Yildirim, K Yorita, K Yoshihara, C J S Young, C Young, J Yu, J Yu, X Yue, S P Y Yuen, I Yusuff, B Zabinski, G Zacharis, E Zaffaroni, R Zaidan, A M Zaitsev, N Zakharchuk, J Zalieckas, S Zambito, D Zanzi, D R Zaripovas, C Zeitnitz, G Zemaityte, J C Zeng, Q Zeng, O Zenin, D Zerwas, M Zgubič, D F Zhang, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M S Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H L Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
Searches for dijet resonances with sub-TeV masses using the ATLAS detector at the Large Hadron Collider can be statistically limited by the bandwidth available to inclusive single-jet triggers, whose data-collection rates at low transverse momentum are much lower than the rate from standard model multijet production. This Letter describes a new search for dijet resonances where this limitation is overcome by recording only the event information calculated by the jet trigger algorithms, thereby allowing much higher event rates with reduced storage needs...
August 24, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30181260/ragulator-and-slc38a9-activate-the-rag-gtpases-through-noncanonical-gef-mechanisms
#11
Kuang Shen, David M Sabatini
The mechanistic target of rapamycin complex 1 (mTORC1) growth pathway detects nutrients through a variety of sensors and regulators that converge on the Rag GTPases, which form heterodimers consisting of RagA or RagB tightly bound to RagC or RagD and control the subcellular localization of mTORC1. The Rag heterodimer uses a unique "locking" mechanism to stabilize its active (GTP RagA-RagCGDP ) or inactive (GDP RagA-RagCGTP ) nucleotide states. The Ragulator complex tethers the Rag heterodimer to the lysosomal surface, and the SLC38A9 transmembrane protein is a lysosomal arginine sensor that upon activation stimulates mTORC1 activity through the Rag GTPases...
September 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29995852/histidine-catabolism-is-a-major-determinant-of-methotrexate-sensitivity
#12
Naama Kanarek, Heather R Keys, Jason R Cantor, Caroline A Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Elizaveta Freinkman, Lawrence D Schweitzer, David M Sabatini
The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1 , which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2 . Depletion of tetrahydrofolate causes cell death by suppressing DNA and RNA production3 . Although methotrexate is widely used as an anticancer agent and is the subject of over a thousand ongoing clinical trials4 , its high toxicity often leads to the premature termination of its use, which reduces its potential efficacy5 . To identify genes that modulate the response of cancer cells to methotrexate, we performed a CRISPR-Cas9-based screen6,7 ...
July 2018: Nature
https://www.readbyqxmd.com/read/29969188/deptor-modulates-activation-responses-in-cd4-t-cells-and-enhances-immunoregulation-following-transplantation
#13
Johannes Wedel, Sarah Bruneau, Kaifeng Liu, Sek Won Kong, Peter T Sage, David M Sabatini, Mathieu Laplante, David M Briscoe
DEPTOR is an evolutionarily conserved cell-intrinsic binding partner of mTOR that functions as a negative regulator of signaling responses. In this study, we show that DEPTOR is expressed within CD4+ T cells, and we observed that its relative level of expression modulates differentiation as well as glucose utilization within CD4+ T effectors in vitro. Using knock-in mice, we also find that induced expression of DEPTOR within CD4+ T regulatory cells stabilizes Foxp3 expression, shifts metabolism toward oxidative phosphorylation, and increases survival and suppressive function...
July 3, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29849139/author-correction-high-fat-diet-enhances-stemness-and-tumorigenicity-of-intestinal-progenitors
#14
Semir Beyaz, Miyeko D Mana, Jatin Roper, Dmitriy Kedrin, Assieh Saadatpour, Sue-Jean Hong, Khristian E Bauer-Rowe, Michael E Xifaras, Adam Akkad, Erika Arias, Luca Pinello, Yarden Katz, Shweta Shinagare, Monther Abu-Remaileh, Maria M Mihaylova, Dudley W Lamming, Rizkullah Dogum, Guoji Guo, George W Bell, Martin Selig, G Petur Nielsen, Nitin Gupta, Cristina R Ferrone, Vikram Deshpande, Guo-Cheng Yuan, Stuart H Orkin, David M Sabatini, Ömer H Yilmaz
In Fig. 4e of this Article, the labels for 'Control' and 'HFD' were reversed ('Control' should have been labelled blue rather than purple, and 'HFD' should have been labelled purple rather than blue). Similarly, in Fig. 4f of this Article, the labels for 'V' and 'GW' were reversed ('V' should have been labelled blue rather than purple, and 'GW' should have been labelled purple instead of blue). The original figure has been corrected online.
August 2018: Nature
https://www.readbyqxmd.com/read/29756910/search-for-high-mass-resonances-decaying-to-%C3%AF-%C3%AE-in-pp-collisions-at-sqrt-s-13-tev-with-the-atlas-detector
#15
M Aaboud, G Aad, B Abbott, O Abdinov, B Abeloos, S H Abidi, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adamczyk, J Adelman, M Adersberger, T Adye, A A Affolder, Y Afik, C Agheorghiesei, J A Aguilar-Saavedra, S P Ahlen, F Ahmadov, G Aielli, S Akatsuka, T P A Åkesson, E Akilli, A V Akimov, G L Alberghi, J Albert, P Albicocco, M J Alconada Verzini, S Alderweireldt, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, T Alexopoulos, M Alhroob, B Ali, M Aliev, G Alimonti, J Alison, S P Alkire, C Allaire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M I Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, Y Amaral Coutinho, L Ambroz, C Amelung, D Amidei, S P Amor Dos Santos, S Amoroso, C S Amrouche, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, S Angelidakis, I Angelozzi, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, M Antonelli, D J Antrim, F Anulli, M Aoki, L Aperio Bella, G Arabidze, Y Arai, J P Araque, V Araujo Ferraz, R Araujo Pereira, A T H Arce, R E Ardell, F A Arduh, J-F Arguin, S Argyropoulos, A J Armbruster, L J Armitage, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, A Ashkenazi, E M Asimakopoulou, L Asquith, K Assamagan, R Astalos, R J Atkin, M Atkinson, N B Atlay, K Augsten, G Avolio, R Avramidou, B Axen, M K Ayoub, G Azuelos, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, P Bagnaia, M Bahmani, H Bahrasemani, J T Baines, M Bajic, O K Baker, P J Bakker, D Bakshi Gupta, E M Baldin, P Balek, F Balli, W K Balunas, E Banas, A Bandyopadhyay, Sw Banerjee, A A E Bannoura, L Barak, W M Barbe, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, J T Barkeloo, T Barklow, N Barlow, R Barnea, S L Barnes, B M Barnett, R M Barnett, Z Barnovska-Blenessy, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, J R Batley, M Battaglia, M Bauce, F Bauer, K T Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, P Bechtle, H P Beck, H C Beck, K Becker, M Becker, C Becot, A J Beddall, A Beddall, V A Bednyakov, M Bedognetti, C P Bee, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, K Belotskiy, N L Belyaev, O Benary, D Benchekroun, M Bender, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, M Benoit, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, L J Bergsten, J Beringer, S Berlendis, N R Bernard, G Bernardi, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, I A Bertram, C Bertsche, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, A Bethani, S Bethke, A Betti, A J Bevan, J Beyer, R M Bianchi, O Biebel, D Biedermann, R Bielski, K Bierwagen, N V Biesuz, M Biglietti, T R V Billoud, M Bindi, A Bingul, C Bini, S Biondi, T Bisanz, C Bittrich, D M Bjergaard, J E Black, K M Black, R E Blair, T Blazek, I Bloch, C Blocker, A Blue, U Blumenschein, Dr Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C Bock, D Boerner, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, A E Bolz, M Bomben, M Bona, J S Bonilla, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, D Boscherini, M Bosman, J D Bossio Sola, J Boudreau, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, I R Boyko, A J Bozson, J Bracinik, N Brahimi, A Brandt, G Brandt, O Brandt, F Braren, U Bratzler, B Brau, J E Brau, W D Breaden Madden, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, D L Briglin, T M Bristow, D Britton, D Britzger, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, A Bruni, G 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Proklova, K Prokofiev, F Prokoshin, S Protopopescu, J Proudfoot, M Przybycien, A Puri, P Puzo, J Qian, Y Qin, A Quadt, M Queitsch-Maitland, A Qureshi, S K Radhakrishnan, P Rados, F Ragusa, G Rahal, J A Raine, S Rajagopalan, T Rashid, S Raspopov, M G Ratti, D M Rauch, F Rauscher, S Rave, B Ravina, I Ravinovich, J H Rawling, M Raymond, A L Read, N P Readioff, M Reale, D M Rebuzzi, A Redelbach, G Redlinger, R Reece, R G Reed, K Reeves, L Rehnisch, J Reichert, A Reiss, C Rembser, H Ren, M Rescigno, S Resconi, E D Resseguie, S Rettie, E Reynolds, O L Rezanova, P Reznicek, R Richter, S Richter, E Richter-Was, O Ricken, M Ridel, P Rieck, C J Riegel, O Rifki, M Rijssenbeek, A Rimoldi, M Rimoldi, L Rinaldi, G Ripellino, B Ristić, E Ritsch, I Riu, J C Rivera Vergara, F Rizatdinova, E Rizvi, C Rizzi, R T Roberts, S H Robertson, A Robichaud-Veronneau, D Robinson, J E M Robinson, A Robson, E Rocco, C Roda, Y Rodina, S Rodriguez Bosca, A Rodriguez Perez, D Rodriguez Rodriguez, A M Rodríguez Vera, S Roe, C S Rogan, O Røhne, R Röhrig, C P A Roland, J Roloff, A Romaniouk, M Romano, E Romero Adam, N Rompotis, M Ronzani, L Roos, S Rosati, K Rosbach, P Rose, N-A Rosien, E Rossi, L P Rossi, L Rossini, J H N Rosten, R Rosten, M Rotaru, J Rothberg, D Rousseau, D Roy, A Rozanov, Y Rozen, X Ruan, F Rubbo, F Rühr, A Ruiz-Martinez, Z Rurikova, N A Rusakovich, H L Russell, J P Rutherfoord, N Ruthmann, E M Rüttinger, Y F Ryabov, M Rybar, G Rybkin, S Ryu, A Ryzhov, G F Rzehorz, A F Saavedra, P Sabatini, G Sabato, S Sacerdoti, H F-W Sadrozinski, R Sadykov, F Safai Tehrani, P Saha, M Sahinsoy, M Saimpert, M Saito, T Saito, H Sakamoto, D Salamani, G Salamanna, J E Salazar Loyola, D Salek, P H Sales De Bruin, D Salihagic, A Salnikov, J Salt, D Salvatore, F Salvatore, A Salvucci, A Salzburger, D Sammel, D Sampsonidis, D Sampsonidou, J Sánchez, A Sanchez Pineda, H Sandaker, C O Sander, M Sandhoff, C Sandoval, D P C Sankey, M Sannino, Y Sano, A Sansoni, C Santoni, H Santos, I Santoyo Castillo, A Sapronov, J G Saraiva, O Sasaki, K Sato, E Sauvan, P Savard, N Savic, R Sawada, C Sawyer, L Sawyer, C Sbarra, A Sbrizzi, T Scanlon, D A Scannicchio, J Schaarschmidt, P Schacht, B M Schachtner, D Schaefer, L Schaefer, J Schaeffer, S Schaepe, U Schäfer, A C Schaffer, D Schaile, R D Schamberger, V A Schegelsky, D Scheirich, F Schenck, M Schernau, C Schiavi, S Schier, L K Schildgen, Z M Schillaci, E J Schioppa, M Schioppa, K E Schleicher, S Schlenker, K R Schmidt-Sommerfeld, K Schmieden, C Schmitt, S Schmitt, S Schmitz, U Schnoor, L Schoeffel, A Schoening, E Schopf, M Schott, J F P Schouwenberg, J Schovancova, S Schramm, N Schuh, A Schulte, H-C Schultz-Coulon, M Schumacher, B A Schumm, Ph Schune, A Schwartzman, T A Schwarz, H Schweiger, Ph Schwemling, R Schwienhorst, J Schwindling, A Sciandra, G Sciolla, M Scornajenghi, F Scuri, F Scutti, L M Scyboz, J Searcy, C D Sebastiani, P Seema, S C Seidel, A Seiden, J M Seixas, G Sekhniaidze, K Sekhon, S J Sekula, N Semprini-Cesari, S Senkin, C Serfon, L Serin, L Serkin, M Sessa, H Severini, T Šfiligoj, F Sforza, A Sfyrla, E Shabalina, J D Shahinian, N W Shaikh, L Y Shan, R Shang, J T Shank, M Shapiro, A Sharma, A S Sharma, P B Shatalov, K Shaw, S M Shaw, A Shcherbakova, C Y Shehu, Y Shen, N Sherafati, A D Sherman, P Sherwood, L Shi, S Shimizu, C O Shimmin, M Shimojima, I P J Shipsey, S Shirabe, M Shiyakova, J Shlomi, A Shmeleva, D Shoaleh Saadi, M J Shochet, S Shojaii, D R Shope, S Shrestha, E Shulga, P Sicho, A M Sickles, P E Sidebo, E Sideras Haddad, O Sidiropoulou, A Sidoti, F Siegert, Dj Sijacki, J Silva, M Silva, S B Silverstein, L Simic, S Simion, E Simioni, B Simmons, M Simon, P Sinervo, N B Sinev, M Sioli, G Siragusa, I Siral, S Yu Sivoklokov, J Sjölin, M B Skinner, P Skubic, M Slater, T Slavicek, M Slawinska, K Sliwa, R Slovak, V Smakhtin, B H Smart, J Smiesko, N Smirnov, S Yu Smirnov, Y Smirnov, L N Smirnova, O Smirnova, J W Smith, M N K Smith, R W Smith, M Smizanska, K Smolek, A A Snesarev, I M Snyder, S Snyder, R 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Tokár, K Tokushuku, E Tolley, M Tomoto, L Tompkins, K Toms, B Tong, P Tornambe, E Torrence, H Torres, E Torró Pastor, C Tosciri, J Toth, F Touchard, D R Tovey, C J Treado, T Trefzger, F Tresoldi, A Tricoli, I M Trigger, S Trincaz-Duvoid, M F Tripiana, W Trischuk, B Trocmé, A Trofymov, C Troncon, M Trovatelli, F Trovato, L Truong, M Trzebinski, A Trzupek, F Tsai, K W Tsang, J C-L Tseng, P V Tsiareshka, N Tsirintanis, S Tsiskaridze, V Tsiskaridze, E G Tskhadadze, I I Tsukerman, V Tsulaia, S Tsuno, D Tsybychev, Y Tu, A Tudorache, V Tudorache, T T Tulbure, A N Tuna, S Turchikhin, D Turgeman, I Turk Cakir, R Turra, P M Tuts, G Ucchielli, I Ueda, M Ughetto, F Ukegawa, G Unal, A Undrus, G Unel, F C Ungaro, Y Unno, K Uno, J Urban, P Urquijo, P Urrejola, G Usai, J Usui, L Vacavant, V Vacek, B Vachon, K O H Vadla, A Vaidya, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, L Valéry, R A Vallance, A Vallier, J A Valls Ferrer, T R Van Daalen, W Van Den Wollenberg, H van der Graaf, P van Gemmeren, J Van Nieuwkoop, I van Vulpen, M C van Woerden, M Vanadia, W Vandelli, A Vaniachine, P Vankov, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, A Vartapetian, K E Varvell, J G Vasquez, G A Vasquez, F Vazeille, D Vazquez Furelos, T Vazquez Schroeder, J Veatch, V Vecchio, L M Veloce, F Veloso, S Veneziano, A Ventura, M Venturi, N Venturi, V Vercesi, M Verducci, C Vergis, W Verkerke, A T Vermeulen, J C Vermeulen, M C Vetterli, N Viaux Maira, O Viazlo, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, L Vigani, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, A Vishwakarma, C Vittori, I Vivarelli, S Vlachos, M Vogel, P Vokac, G Volpi, S E von Buddenbrock, E von Toerne, V Vorobel, K Vorobev, M Vos, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, R Vuillermet, I Vukotic, P Wagner, W Wagner, J Wagner-Kuhr, H Wahlberg, S Wahrmund, K Wakamiya, J Walder, R Walker, W Walkowiak, V Wallangen, A M Wang, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, Q Wang, R-J Wang, R Wang, R Wang, S M Wang, T Wang, W Wang, W Wang, Y Wang, Z Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, A Washbrook, P M Watkins, A T Watson, M F Watson, G Watts, S Watts, B M Waugh, A F Webb, S Webb, C Weber, M S Weber, S M Weber, S A Weber, J S Webster, A R Weidberg, B Weinert, J Weingarten, M Weirich, C Weiser, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M D Werner, P Werner, M Wessels, T D Weston, K Whalen, N L Whallon, A M Wharton, A S White, A White, M J White, R White, D Whiteson, B W Whitmore, F J Wickens, W Wiedenmann, M Wielers, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, F Wilk, H G Wilkens, H H Williams, S Williams, C Willis, S Willocq, J A Wilson, I Wingerter-Seez, E Winkels, F Winklmeier, O J Winston, B T Winter, M Wittgen, M Wobisch, A Wolf, T M H Wolf, R Wolff, M W Wolter, H Wolters, V W S Wong, N L Woods, S D Worm, B K Wosiek, K W Wozniak, K Wraight, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, Z Xi, L Xia, D Xu, H Xu, L Xu, T Xu, W Xu, B Yabsley, S Yacoob, K Yajima, D P Yallup, D Yamaguchi, Y Yamaguchi, A Yamamoto, T Yamanaka, F Yamane, M Yamatani, T Yamazaki, Y Yamazaki, Z Yan, H Yang, H Yang, S Yang, Y Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, I Yeletskikh, E Yigitbasi, E Yildirim, K Yorita, K Yoshihara, C Young, C J S Young, J Yu, J Yu, X Yue, S P Y Yuen, I Yusuff, B Zabinski, G Zacharis, R Zaidan, A M Zaitsev, N Zakharchuk, J Zalieckas, S Zambito, D Zanzi, C Zeitnitz, G Zemaityte, J C Zeng, Q Zeng, O Zenin, T Ženiš, D Zerwas, M Zgubič, D Zhang, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, L Živković, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
A search for high-mass resonances decaying to τν using proton-proton collisions at sqrt[s]=13  TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1  fb^{-1}. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W^{'} bosons with masses less than 3...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29745899/identification-of-a-transporter-complex-responsible-for-the-cytosolic-entry-of-nitrogen-containing-bisphosphonates
#16
Zhou Yu, Lauren E Surface, Chong Yon Park, Max A Horlbeck, Gregory A Wyant, Monther Abu-Remaileh, Timothy R Peterson, David M Sabatini, Jonathan S Weissman, Erin K O'Shea
Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the mevalonate pathway in osteoclasts, the mechanism by which N-BPs enter the cytosol from the extracellular space to reach their molecular target is not understood. Here, we implemented a CRISPRi-mediated genome-wide screen and identified SLC37A3 (solute carrier family 37 member A3) as a gene required for the action of N-BPs in mammalian cells...
May 10, 2018: ELife
https://www.readbyqxmd.com/read/29727683/fasting-activates-fatty-acid-oxidation-to-enhance-intestinal-stem-cell-function-during-homeostasis-and-aging
#17
Maria M Mihaylova, Chia-Wei Cheng, Amanda Q Cao, Surya Tripathi, Miyeko D Mana, Khristian E Bauer-Rowe, Monther Abu-Remaileh, Laura Clavain, Aysegul Erdemir, Caroline A Lewis, Elizaveta Freinkman, Audrey S Dickey, Albert R La Spada, Yanmei Huang, George W Bell, Vikram Deshpande, Peter Carmeliet, Pekka Katajisto, David M Sabatini, Ömer H Yilmaz
Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting...
May 3, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29700228/nufip1-is-a-ribosome-receptor-for-starvation-induced-ribophagy
#18
Gregory A Wyant, Monther Abu-Remaileh, Evgeni M Frenkel, Nouf N Laqtom, Vimisha Dharamdasani, Caroline A Lewis, Sze Ham Chan, Ivonne Heinze, Alessandro Ori, David M Sabatini
The lysosome degrades and recycles macromolecules, signals to the master growth regulator mTORC1 [mechanistic target of rapamycin (mTOR) complex 1], and is associated with human disease. We performed quantitative proteomic analyses of rapidly isolated lysosomes and found that nutrient levels and mTOR dynamically modulate the lysosomal proteome. Upon mTORC1 inhibition, NUFIP1 (nuclear fragile X mental retardation-interacting protein 1) redistributes from the nucleus to autophagosomes and lysosomes. Upon these conditions, NUFIP1 interacts with ribosomes and delivers them to autophagosomes by directly binding to microtubule-associated proteins 1A/1B light chain 3B (LC3B)...
May 18, 2018: Science
https://www.readbyqxmd.com/read/29590090/architecture-of-the-human-gator1-and-gator1-rag-gtpases-complexes
#19
Kuang Shen, Rick K Huang, Edward J Brignole, Kendall J Condon, Max L Valenstein, Lynne Chantranupong, Aimaiti Bomaliyamu, Abigail Choe, Chuan Hong, Zhiheng Yu, David M Sabatini
Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate mTORC1. The GATOR1 protein complex-comprising DEPDC5, NPRL2 and NPRL3-regulates the Rag GTPases as a GTPase-activating protein (GAP) for RAGA; loss of GATOR1 desensitizes mTORC1 signalling to nutrient starvation. GATOR1 components have no sequence homology to other proteins, so the function of GATOR1 at the molecular level is currently unknown. Here we used cryo-electron microscopy to solve structures of GATOR1 and GATOR1-Rag GTPases complexes...
April 5, 2018: Nature
https://www.readbyqxmd.com/read/29555419/discovery-and-optimization-of-piperazine-1-thiourea-based-human-phosphoglycerate-dehydrogenase-inhibitors
#20
Jason M Rohde, Kyle R Brimacombe, Li Liu, Michael E Pacold, Adam Yasgar, Dorian M Cheff, Tobie D Lee, Ganesha Rai, Bolormaa Baljinnyam, Zhuyin Li, Anton Simeonov, Matthew D Hall, Min Shen, David M Sabatini, Matthew B Boxer
Proliferating cells, including cancer cells, obtain serine both exogenously and via the metabolism of glucose. By catalyzing the first, rate-limiting step in the synthesis of serine from glucose, phosphoglycerate dehydrogenase (PHGDH) controls flux through the biosynthetic pathway for this important amino acid and represents a putative target in oncology. To discover inhibitors of PHGDH, a coupled biochemical assay was developed and optimized to enable high-throughput screening for inhibitors of human PHGDH...
May 1, 2018: Bioorganic & Medicinal Chemistry
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