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Priyanka S Rana, Brandon A Gibbons, Alexey A Vereninov, Valentina E Yurinskaya, Robert J Clements, Timothy A Model, Michael A Model
The response of fluorescent ion probes to ions is affected by intracellular environment. To properly calibrate them, intracellular and extracellular concentrations of the measured ion must be made equal. In the first, computational, part of this work, we show, using the example of potassium, that the two requirements for ion equilibration are complete dissipation of membrane potential and high membrane permeability for both potassium and sodium. In the second part, we tested the ability of various ionophores to achieve potassium equilibration in Jurkat and U937 cells and found a combination of valinomycin, nigericin, gramicidin and ouabain to be the most effective...
November 29, 2018: Analytical Biochemistry
Zide Chen, Jiehua Chen, Hongyan Liu, Wei Dong, Xuan Huang, Dajun Yang, Jinlin Hou, Xiaoyong Zhang
The inhibitor of apoptosis protein ( IAP ) genes are frequently overexpressed in malignancies. Second mitochondria-derived activator of caspase (SMAC) mimetics, which target IAPs, have potential to trigger cancer cell death and sensitize tumor cells to cytotoxic therapy. The aim of this study was to investigate the anti-tumor potential of a novel bivalent SMAC mimetic, APG-1387, in hepatocellular carcinoma (HCC). The mRNA and protein expressions of IAPs, including cellular IAPs (cIAP1 and cIAP2) and X chromosome-linked IAP (XIAP), were increased in HCC tumors compared with normal liver tissue...
2018: Frontiers in Pharmacology
Jingyang Luo, Lijuan Wu, Yinguang Chen, Leiyu Feng, Jiashun Cao
The biodegradation of benz[α]anthracene (BaA), which was a high-molecule-weight PAH, was enhanced via a combination of alkaline and alkyl polyglucosides (APG) treatment during waste activated sludge (WAS) anaerobic fermentation. The biodegradation efficiency of BaA was increased from 14.1% in the control to 30.2 and 47.8% in pH 10 and pH 10 & APG reactors, respectively. Mechanism investigations found that the alkaline and APG treatments stimulated the processes of BaA desorption from sludge and transfer/entry into microorganisms, and ultimately improved the BaA bioavailability...
November 6, 2018: Journal of Hazardous Materials
R Arathy, P M Nabeel, Jayaraj Joseph, Mohanasankar Sivaprakasam
In this work, we demonstrate an accelerometric patch probe with two microelectromechanical accelerometer sensors for local pulse wave velocity (PWV) measurement from the carotid artery. Dual acceleration plethysmogram (APG) signals were acquired from a small section of the artery by keeping the sensors at 32 mm apart. A custom analog front-end circuit (inter-channel delay $< 0.15$ ms) was used for reliable signal acquisition. Simultaneously acquired dual APG signals were processed in real-time and local PWV was evaluated in a beat-by-beat manner...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Xiaoqiang Gong, Suyan Li, Scott X Chang, Qian Wu, Linlin Cai, Xiangyang Sun
Managing municipal green waste is a challenge to municipalities, partly because of the slow rate of decomposition of green waste during composting due to its high lignin and cellulose contents. Hence, this study evaluated the effect of alkyl polyglycoside (APG), a biosurfactant, and the earthworm Eisenia fetida on the composting process. Addition of APG and E. fetida significantly increased total bacteria, cellulolytic fungi, phosphate solubilizing bacteria and nitrogen fixing bacteria populations, and the activities of cellulase, urease and alkaline phosphatase in composts as compared with the control...
October 24, 2018: Ecotoxicology and Environmental Safety
Marcia Regina Cabral Oliveira, Pedro Henrique Cabral Oliveira, Luiz Henrique Cabral Oliveira, Anna Carolina Ratto Tempestini Horliana, Paulo Francisco César, Sandra Kiss Moura, Sandra Kalil Bussadori
The aim of the present study was to evaluate microhardness, mineral recovery and the enamel surface after the application of topical fluoride to artificial dental caries. Twenty-five bovine enamel blocks were prepared for artificial caries-like lesions and randomly divided into five groups (n=5): untreated (C control), 1.23% acidulated phosphate fluoride gel (APG), 2% neutral fluoride gel (NFG), 1.23% acidulated fluoride mousse (AFM) and fluoride varnish (5% Duraphat, DFV). Knoop microhardness (KHN) was evaluated after 7 and 14 days of treatment as well as 1 week after 28 days of treatment...
October 5, 2018: Dental Materials Journal
Xiaoxue Han, Xifeng Zhang, Yuqin Gao, Pai Pang, Fayu Liu, Changfu Sun
Objective This study was performed to analyze the clinical management of accessory parotid gland (APG) cancer and possible risk factors for disease-related death. Methods Patients diagnosed with primary APG cancers in the largest medical center in Northeast China were enrolled from January 1990 to December 2016. Results All 43 patients underwent resection of the tumors and superficial parotid gland by a standard Blair incision. Seven (16.3%) patients also required selective neck dissection. The most common lesion was mucoepidermoid carcinoma...
October 5, 2018: Journal of International Medical Research
Xianming Liu, Gene Cheung, Xiangyang Ji, Debin Zhao, Wen Gao
JPEG images captured in poor lighting conditions suffer from both low luminance contrast and coarse quantization artifacts due to lossy compression. Performing dequantization and contrast enhancement in separate back-to-back steps would amplify the residual compression artifacts, resulting in low visual quality. Leveraging on recent development in graph signal processing (GSP), we propose to jointly dequantize and contrast-enhance such images in a single graph-signal restoration framework. Specifically, we separate each observed pixel patch into illumination and reflectance via Retinex theory, where we define generalized smoothness prior and signed graph smoothness prior according to their respective unique signal characteristics...
March 2019: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Anna Räsch, Mauricio Hunsche, Matthias Mail, Jürgen Burkhardt, Georg Noga, Shyam Pariyar
Adjuvants such as surfactants are commonly incorporated into agrochemical formulations to enhance the biological efficiency of foliar sprays by improving the wetting behavior of the spray and/or the penetration of the active ingredients into the leaf tissues. Penetration accelerating adjuvants are known to increase the cuticular permeability and may alter the cuticular barrier to water loss. However, none or very little emphasis has been given to the impacts of adjuvants on crop water balance or drought tolerance, a very important factor affecting crop performance under water scarcity...
November 2018: Plant Physiology and Biochemistry: PPB
Qinan Wu, Xiaotian Lei, Liu Chen, Yanling Zheng, Hongmei Huang, Cheng Qian, Ziwen Liang
The diabetic foot ulcer (DFU) is the leading cause of the high mortality and morbidity rates of diabetes patients, and the DFU accounts for approximately 15% of all diagnosed diabetes cases in China. Traditional treatment is typically ineffective for DFUs. Here, we present a case of DFU that was successfully treated with an autologous platelet-rich gel (APG) and in vitro amplification of bone marrow mesenchymal stem cell (BMMSC) transplantation. A 54-year-old woman initially presented with a right foot diabetic ulcer at the hospital...
August 2018: Annals of Translational Medicine
Yan Li, Yunyi Gao, Yun Gao, Dawei Chen, Chun Wang, Guanjian Liu, Xin Yang, Xingwu Ran
BACKGROUND: Recent years, many studies have reported that autologous platelet-rich gel (APG) is an effective adjunctive method to promote chronic cutaneous ulcers in diabetics. The aim of the present study was to explore the efficacy and safety of APG for the topical treatment of diabetic chronic cutaneous ulcers. METHODS: The Chinese CBM, CNKI, VIP, Wanfang databases, Cochrane Library databases, EBSCOhost, Embase and PubMed on October 18, 2017 were systematically searched...
September 5, 2018: Journal of Diabetes
Danyi Wei, Hailong Zhang, Lu Cai, Jian Guo, Yaning Wang, Lili Ji, Wendong Song
Biomass is known to efficiently adsorb pollutants from wastewater. In this paper, we demonstrated that a new antistatic oil-cleaning material can be prepared and assembled by using two surfactants, alkyl polyglucosides (APG) and dimethyl octadecyl hydroxy ethyl ammonium nitrate (SN), to modify calcined mussel shell powder (CMSP) through a two-step hydrotherm-assisted adsorption. The pore size and structure of CMSP was measured by BET and a contact angle meter was used to characterize the surface wetting ability...
August 11, 2018: Materials
Xiaoyan Liu, Liya Cao, Xinying Zhang, Jing Chen, Zhuhao Huo, Ying Mao
At present, the remediation for organic pollutants and heavy metals co-contaminated soils is a challenge which needs to be broken through. In this study, alkyl polyglucoside (APG), citric acid (CA), and nitrilotriacetic acid (NTA) were chosen to enhance the phytoremediation of pyrene and Pb co-contaminated soils by perennial ryegrass. Through the comparison of the results with different applications, it could be found that the application of NTA was beneficial to the growth of perennial ryegrass, the underground and aboveground biomass were increased by 172...
August 24, 2018: International Journal of Phytoremediation
Winesh Ramphal, Marnix Mus, Hans K S Nuytinck, Marianne J van Heerde, Cees M Verduin, Paul D Gobardhan
We present a case of 45-year-old male with acute phlegmonous gastritis (APG) based on a hemolytic group A Streptococcus. APG is a rare and often a potentially fatal disease, which is characterized by a severe bacterial infection of the gastric wall. Because APG is a rapidly progressive disease, it comes with high mortality rates. Patients with an early diagnosis may undergo successful treatment and have a survival benefit. As soon as the diagnosis of APG is suspected, aggressive and adequate antibiotic treatment in combination with surgical intervention should be considered...
August 2018: Journal of Surgical Case Reports
Deqing Wang, Yongjie Zhu, Tapani Ristaniemi, Fengyu Cong
BACKGROUND: Preprocessed Event-related potential (ERP) data are usually organized in multi-way tensor, in which tensor decomposition serves as a powerful tool for data processing. Due to the limitation of computation burden for multi-way data and the low algorithm performance of stability and efficiency, multi-way ERP data are conventionally reorganized into low-order tensor or matrix before further analysis. However, the reorganization may hamper mode specification and spoil the interaction information among different modes...
August 2, 2018: Journal of Neuroscience Methods
Adriano L Schünemann, Pedro Henrique A Almeida, André Thomazini, Elpídio I Fernandes Filho, Márcio R Francelino, Carlos E G R Schaefer, Antonio Batista Pereira
High resolution topography (HRT) surveys is an important tool to model landscapes, especially in zones subjected to strong environmental changes, such as Antarctica, where landform is highly influenced by cryoclasty and permafrost melting. The aim of this work was to obtain a high accurate DTM for Keller Peninsula, Maritime Antarctica. The survey study was assessed in the 2014/2015 and 2015/2016 during the austral summer, by using Terrestrial Laser Scanner (TLS). In order to cover 8 km² of the Peninsula, the TLS equipment was installed in 81 different points...
August 2018: Anais da Academia Brasileira de Ciências
Hanyang Peng, Cheng-Lin Liu
A wide variety of sparsity-inducing feature selection methods have been developed in recent years. Most of the loss functions of these approaches are built upon regression since it is general and easy to optimize, but regression is not well suitable for classification. In contrast, the hinge loss (HL) of support vector machines has proved to be powerful to handle classification tasks, but a model with existing multiclass HL and sparsity regularization is difficult to optimize. In view of that, we propose a new loss, called smooth and robust HL, which gathers the merits of regression and HL but overcome their drawbacks, and apply it to our sparsity regularized feature selection model...
July 26, 2018: IEEE Transactions on Neural Networks and Learning Systems
Xiaoming Yang, Yulong Ren, Yue Cai, Mei Niu, Zhiming Feng, Ruonan Jing, Changling Mou, Xi Liu, Lianjie Xiao, Xin Zhang, Fuqing Wu, Xiuping Guo, Ling Jiang, Jianmin Wan
BACKGROUND: Grain size, which is determined by grain length, grain width, and grain thickness, is an important determinant for grain yield in rice. Identification and characterization of new genes that are associated with grain size will be helpful for the improvement of grain yield in rice. RESULTS: We characterized the grain size mutant, larger grain size 1 (lgs1), derived from rice activation-tagged T-DNA insertion lines. Histological analysis showed that increased cell numbers in the longitudinal direction of spikelet hulls was responsible for the grain mutant phenotype in lgs1...
July 20, 2018: Rice
Inkyu Park, Sungyu Yang, Wook J Kim, Pureum Noh, Hyun O Lee, Byeong C Moon
Ipomoea L. is the largest genus within the Convolvulaceae and contains 600-700 species. Ipomoea species (morning glories) are economically valuable as horticultural species and scientifically valuable as ecological model plants to investigate mating systems, molecular evolution, and both plant-herbivore and plant-parasite interactions. Furthermore, the dried seeds of I. nil or I. purpurea are used in Korean traditional herbal medicines. In this study, chloroplast (cp) genomes were sequenced from six Ipomoea species, namely, I...
2018: Frontiers in Plant Science
Erica L Morley, Daniel Robert
When one thinks of airborne organisms, spiders do not usually come to mind. However, these wingless arthropods have been found 4 km up in the sky [1], dispersing hundreds of kilometers [2]. To disperse, spiders "balloon," whereby they climb to the top of a prominence, let out silk, and float away. The prevailing view is that drag forces from light wind allow spiders to become airborne [3], yet ballooning mechanisms are not fully explained by current aerodynamic models [4, 5]. The global atmospheric electric circuit and the resulting atmospheric potential gradient (APG) [6] provide an additional force that has been proposed to explain ballooning [7]...
July 23, 2018: Current Biology: CB
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