Jiatai Yin, Yiheng Gou, Yiheng Wang, Qingyuan Ma, Rui Wang, Jing Yu, Yajun Zhang, Jing Wang, Qian Li, Xinfeng Zhao
Epimer separation is crucial in the field of analytical chemistry, separation science, and the pharmaceutical industry. No reported methods could separate simultaneously epimers or even isomers and remove other unwanted, co-existing, interfering substances from complex systems like herbal extracts. Herein, we prepared a heptapeptide-modified stationary phase for the separation of 1R,2S-(-)-ephedrine [(-)-Ephe] and 1S,2S-(+)-pseudoephedrine [(+)-Pse] epimers from Ephedra sinica Stapf extract and blood samples...
March 30, 2024: Journal of Chromatography. A