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Ephedrine

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https://www.readbyqxmd.com/read/29151054/effect-of-ephedrine-and-phenylephrine-on-brain-oxygenation-and-microcirculation-in-anaesthetised-patients-with-cerebral-tumours-study-protocol-for-a-randomised-controlled-trial
#1
Klaus Ulrik Koch, Anna Tietze, Joel Aanerud, Gorm von Öettingen, Niels Juul, Jens Christian Hedemann Sørensen, Lone Nikolajsen, Leif Østergaard, Mads Rasmussen
INTRODUCTION: During brain tumour surgery, vasopressor drugs are commonly administered to increase mean arterial blood pressure with the aim of maintaining sufficient cerebral perfusion pressure. Studies of the commonly used vasopressors show that brain oxygen saturation is reduced after phenylephrine administration, but unaltered by ephedrine administration. These findings may be explained by different effects of phenylephrine and ephedrine on the cerebral microcirculation, in particular the capillary transit-time heterogeneity, which determines oxygen extraction efficacy...
November 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/29131996/development-and-application-of-the-diffusive-gradients-in-thin-films-technique-for-simultaneous-measurement-of-methcathinone-and-ephedrine-in-surface-river-water
#2
Yan Zhang, Tingting Zhang, Changsheng Guo, Song Hou, Zhendong Hua, Jiapei Lv, Yuan Zhang, Jian Xu
In this study, a passive sampling technique, diffusive gradients in thin films (DGT) was developed to simultaneously measure two drugs, methcathinone (MC) and ephedrine (EPH) in surface water. Four types of binding gels and four types of filter membranes were tested for the optimal configuration. XAD18 agarose binding gel and agarose diffusive gel, together with polyethersulfone filter membrane were used for measuring MC and EPH in the DGT device. 5% NH3 in acetonitrile was used as the elution solvent, with the elution efficiency for MC and EPH higher than 71%...
November 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29130542/safety-evaluation-of-p-synephrine-following-15%C3%A2-days-of-oral-administration-to-healthy-subjects-a-clinical-study
#3
Mohd Shara, Sidney J Stohs, Mahmoud M Smadi
Extracts of bitter orange (BOE, Citrus aurantium L.) and its primary protoalkaloid p-synephrine are extensively consumed as dietary supplements. p-Synephrine is also present in foods and juices prepared from various Citrus species. The safety of p-synephrine has been questioned as a result of structural similarities with ephedrine. This study assessed the cardiovascular (stimulant) and hemodynamic effects of BOE (49 mg p-synephrine) daily given to 16 healthy subjects for 15 days in a placebo-controlled, cross-over, double-blinded study...
November 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29127057/quantitative-analysis-of-clonidine-and-ephedrine-by-a-microfluidic-system-on-chip-electromembrane-extraction-followed-by-high-performance-liquid-chromatography
#4
Mahroo Baharfar, Yadollah Yamini, Shahram Seidi, Monireh Karami
In this work, a microfluidic device was developed for on-chip electromembrane extraction of trace amounts of ephedrine (EPH) and clonidine (CLO) in human urine and plasma samples followed by HPLC-UV analysis. Two polymethylmethacrylate plates were used as substrates and a microchannel was carved in each plate. The microchannel channel on the underneath plate provided the flow pass of the sample solution and the one on the upper plate dedicated to a compartment for the stagnant acceptor phase. A piece of polypropylene sheet was impregnated by an organic solvent and mounted between the two parts of the chip device...
November 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29113981/acupressure-for-respiratory-allergic-diseases-a-systematic-review-of-randomised-controlled-trials
#5
Yaqun Liang, George Binh Lenon, Angela Wei Hong Yang
OBJECTIVE: To evaluate the effects and safety of acupressure for the management of respiratory allergic diseases by systematically reviewing randomised controlled trials (RCTs). METHODS: A total of 13 electronic English and Chinese databases were searched until July 2017. Two authors extracted data and evaluated risk of bias independently. Review Manager V.5.3 was employed for data analysis. RESULTS: The literature search identified 186 papers, of which only four of met the inclusion criteria: two for allergic rhinitis (AR) and two for asthma...
November 7, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29059613/capillary-electrophoresis-separation-of-phenethylamine-enantiomers-using-amino-acid-based-ionic-liquids
#6
Joachim Wahl, Ulrike Holzgrabe
In recent years increasing interest was drawn towards ionic liquids in analytical separation science, such as capillary electrophoresis. Ionic liquids combining tetrabutylammonium cations with chiral amino acid based anions were prepared and investigated as capillary electrophoresis background electrolyte additives for the enantioseparation of ephedrine, pseudoephedrine, and methylephedrine isomers. For the optimization of buffer pH and ionic liquid concentration a design of experiments approach was performed...
October 17, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29058089/evidence-based-treatment-of-neurogenic-orthostatic-hypotension-and-related-symptoms
#7
REVIEW
Sabine Eschlböck, Gregor Wenning, Alessandra Fanciulli
Neurogenic orthostatic hypotension, postprandial hypotension and exercise-induced hypotension are common features of cardiovascular autonomic failure. Despite the serious impact on patient's quality of life, evidence-based guidelines for non-pharmacological and pharmacological management are lacking at present. Here, we provide a systematic review of the literature on therapeutic options for neurogenic orthostatic hypotension and related symptoms with evidence-based recommendations according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE)...
October 22, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29048834/-preparation-and-performance-characterization-of-gold-nanoparticles-modified-chiral-capillary-electrochromatography-stationary-phase
#8
Lele Xiong, Ruijun Li, Yibing Ji
Gold nanoparticles (GNPs, 15 nm) were prepared and introduced to amino groups derived silica monolithic column. Bovine serum albumin (BSA) was immobilized via covalent modification method onto the carboxylic functionalized GNPs to afford chiral stationary phase (CSP) for enantioseparation. GNPs were well dispersed and successfully incorporated onto the columns with the contents as high as 17.18% by characterization method such as transmission electron microscopy (TEM), ultraviolet (UV)-visible absorption spectra and scanning electron microscopy (SEM)...
July 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29044483/hyperbaric-vs-isobaric-bupivacaine-for-spinal-anaesthesia-for-elective-caesarean-section-a-cochrane-systematic-review
#9
REVIEW
B L Sng, N L R Han, W L Leong, R Sultana, F J Siddiqui, P N Assam, E S Chan, K H Tan, A T Sia
Both isobaric and hyperbaric bupivacaine have been used for spinal anaesthesia for elective caesarean section, but it is not clear if one is better than the other. The primary objective of this systematic review was to determine the effectiveness and safety of hyperbaric bupivacaine compared with isobaric bupivacaine administered during spinal anaesthesia for elective caesarean section. We included 10 studies with 614 subjects in the analysis. There was no evidence of differences either in the risk of conversion to general anaesthesia, with a relative risk (95%CI) of 0...
October 17, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29039329/synthesis-characterization-antioxidant-and-brine-shrimp-cytotoxic-activity-of-novel-3-benzothioyl-1-3-hydroxy-3-phenyl-3-propyl-1-methylthiourea
#10
Mohammad Shoaib, Abid Ullah, Syed Wadood Ali Shah, Muhammad Nawaz Tahir
In the present research work novel ephedrine based thiourea derivative, 3-benzothioyl-1-(3-hydroxy-3-phenyl -3-propyl)-1-methylthiourea 4is synthesized and then characterized elemental analyzed via various techniques i.e., Proton NMR, carbon13 NMR and fatherly confirmed via X-ray crystallography. Compound 4 was then screened for their possible antioxidant and cytotoxic potentials. Benzoyl chloride was treated with an equimolar potassium thiocyanate in acetone to achieve benzoyl isothiocyantes. It was then treated with an equimolar (1R, 2S)-(-)-Ephedrine to obtain the 3-benzothioyl-1-(3-hydroxy-3-phenyl-3-propyl)-1-methyl thiourea4...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29034983/pleth-variability-index-can-predict-spinal-anaesthesia-induced-hypotension-in-patients-undergoing-caesarean-delivery
#11
S Kuwata, K Suehiro, T Juri, S Tsujimoto, A Mukai, K Tanaka, T Yamada, T Mori, K Nishikawa
BACKGROUND: Spinal anaesthesia carries a risk of hypotension. We hypothesized that pleth variability index and perfusion index would assess maternal volume status, and thus, allow identification of patients at higher risk of developing hypotension after spinal anaesthesia for caesarean delivery. METHODS: Fifty patients undergoing elective caesarean delivery were enrolled. All patients received spinal anaesthesia with 0.5% hyperbaric bupivacaine (10 mg) and fentanyl (10 mcg)...
October 16, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29033722/effect-of-intravenous-phenylephrine-infusion-on-dose-requirement-of-intrathecal-plain-levobupivacaine-for-cesarean-section-a-placebo-controlled-preliminary-study
#12
Asha Tyagi, Aanchal Kakkar, Namrata Niwal, Medha Mohta, Ashok Kumar Sethi
BACKGROUND: Phenylephrine infusion has been shown to decrease rostral spread of plain and hyperbaric local anesthetic (LA) when compared to ephedrine infusion. However, it does not result in higher dose requirement of hyperbaric LA for cesarean section. There is no trial evaluating the effect of phenylephrine infusion on ED50 of a plain intrathecal LA. METHODS: Pregnant patients with term uncomplicated singleton pregnancy undergoing elective cesarean section were given combined spinal-epidural anesthesia...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29033720/reducing-by-50-the-incidence-of-maternal-hypotension-during-elective-caesarean-delivery-under-spinal-anesthesia-effect-of-prophylactic-ondansetron-and-or-continuous-infusion-of-phenylephrine-a-double-blind-randomized-placebo-controlled-trial
#13
Jose Ramon Ortiz-Gómez, Francisco Javier Palacio-Abizanda, Francisco Morillas-Ramirez, Inocencia Fornet-Ruiz, Ana Lorenzo-Jiménez, Maria Lourdes Bermejo-Albares
BACKGROUND: Prophylactic administrations of ondansetron or phenylephrine have been reported to provide a protective effect against hypotension in women undergoing cesarean delivery under spinal anesthesia (SA). The main hypothesis is that ondansetron improves the hemodynamic response, especially combined with phenylephrine infusion. METHODS: This prospective, double-blind, randomized, placebo-controlled study included 265 healthy pregnant women scheduled for elective cesarean delivery under SA...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29016527/acute-macular-neuroretinopathy-and-peripheral-retinal-vascular-abnormalities-in-a-patient-born-hiv-seropositive
#14
Chiara Giuffrè, Alessandro Rabiolo, Eleonora Corbelli, Adriano Carnevali, Riccardo Sacconi, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To describe the case of a born HIV seropositive woman who developed outer retinal alterations secondary to vascular abnormalities in the perimacular region and in the periphery of both eyes. METHODS: Case report. RESULTS: A 21-year-old woman born HIV seropositive was referred for a routinary visit. Her best-corrected visual acuity was 20/20 in both eyes, and during the visit, only mild superotemporal metamorphopsia in the left eye was reported...
October 9, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28994520/-establish-quality-evaluation-system-for-standard-ephedrae-herba-decoction
#15
Jia-Yu Tong, Jung Chao, Yun-Tao Dai, Zi-Quan Fan, Dan-Dan Wang, Xue-Mei Qin, Shi-Lin Chen
To establish the quality control methods for the standard decoction of Ephedrae Herba, and provide the reference for quality evaluation method of all Chinese herbal medicine decoction.Standard decoction of Ephedrae Herba was prepared, and UPLC-UV fingerprint was established to determine the total contents of ephedrine and pseudoephedrine. Then UPLC-QTOF/MS was used to confirm the major common peaks in the fingerprint to clarify the main chemical constituents in the decoction. In addition, the stability of the process was evaluated by calculating the parameters such as the extraction ratio, transfer rate of the index components and the pH values...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28992846/-idiopathic-oedema-may-cause-many-different-clinical-visits
#16
Hanne Kalleklev Velure, Emiliya Vatsko, Anette Bygum
Two patients with idiopathic oedema are presented describing their chronic tendency to accumulate fluid in the body and associated clinical features. One patient also tended to develop spontaneous purpura, which has been described in this condition. The other patient had an Odyssey in the healthcare system, before a final diagnosis of idiopathic oedema was reached and explained her different symptoms. Non-pharmacological interventions and various diuretics worked insufficiently, while ephedrine had an excellent efficacy in the second patient...
October 2, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28989908/the-effects-of-hydroxyethyl-starch-6-and-crystalloid-on-volume-preloading-changes-following-spinal-anesthesia
#17
Masoud Saghafinia, Alireza Jalali, Mahnaz Eskandari, Nahid Eskandari, Marzieh Lak
BACKGROUND: Hypotension is one of the most common complications after spinal anesthesia for cesarean delivery. Normally, preloading with fluids, especially crystalloids, is used to prevention of hypotension. METHODS: In the present randomized clinical trial study, 120 parturients presenting for elective cesarean section with the American Society of Anesthesiologists Class I and II received either 15 cc normal saline or 7 cc/kg hydroxyethyl starch 6% (Voluven) fluid...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28976555/techniques-for-preventing-hypotension-during-spinal-anaesthesia-for-caesarean-section
#18
REVIEW
Cheryl Chooi, Julia J Cox, Richard S Lumb, Philippa Middleton, Mark Chemali, Richard S Emmett, Scott W Simmons, Allan M Cyna
BACKGROUND: Maternal hypotension is the most frequent complication of spinal anaesthesia for caesarean section. It can be associated with nausea or vomiting and may pose serious risks to the mother (unconsciousness, pulmonary aspiration) and baby (hypoxia, acidosis, neurological injury). OBJECTIVES: To assess the effects of prophylactic interventions for hypotension following spinal anaesthesia for caesarean section. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register (9 August 2016) and reference lists of retrieved studies...
August 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28974849/comparison-of-hemodynamic-changes-in-unilateral-spinal-anesthesia-versus-epidural-anesthesia-below-the-t10-sensory-level-in-unilateral-surgeries-a-double-blind-randomized-clinical-trial
#19
Alieh Zamani Kiasari, Anahita Babaei, Abbas Alipour, Shima Motevalli, Afshin Gholipour Baradari
BACKGROUND: Unilateral spinal anesthesia is used to limit the spread of block. The aim of the present study was to compare hemodynamic changes and complications in unilateral spinal anesthesia and epidural anesthesia below the T10 sensory level in unilateral surgeries. MATERIALS AND METHODS: In this double-blind randomized clinical trial in total 120 patients were randomly divided into a unilateral spinal anesthesia group (Group S) and an epidural anesthesia group (Group E)...
August 2017: Medical Archives
https://www.readbyqxmd.com/read/28972499/impact-of-pharmacy-reform-on-the-dynamics-of-the-use-of-drugs-and-psychoactive-substances-according-to-the-2013-2016-clinical-data-from-the-center-for-mental-health-and-prevention-of-addiction
#20
L Kiladze, Kh Todadze, T Balkhamishvili, E Gadelia, G Lezhava
Use of medications without doctor's prescription widely established in Georgia had negative impact on the health of the population and on the whole social situation. The use of home-made drugs "Krokodil", "Jeff" and "Vint" produced from the preparations bought without prescriptions (Codeine, Ephedrine), became a special matter of concern. Psychoactive substances became available for teenagers causing damage to their central nervous system and formation of drug-addiction in them. Due to the situation Georgian Government took a number of legislative measures, particularly, it set Criminal Liability for illegal circulation of pharmaceutical products containing Codeine and Ephedrine and Administrative Measures for issuing the psychoactive substances without prescription...
September 2017: Georgian Medical News
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