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Geetika Garg, Sandeep Singh, Abhishek Singh, Syed Ibrahim Rizvi
N-acetyl-L-cysteine (NAC) is a precursor of cysteine which is known to increase the level of GSH in brain. Several neurodegenerative changes linked to oxidative stress take place in aging brain. This study is aimed to assess the neuroprotective effect of NAC supplementation on age- dependent neurodegeneration in the rat brain. Wistar rats: young (4 months) and old (24 months) age were supplemented with NAC (100 mg/kg b.w. orally) for 14 days. Enzymatic and non-enzymatic antioxidants such as SOD, catalase, GSH and total thiol (T-SH), prooxidants such as protein carbonyl (PC), advanced oxidation protein products (AOPP), reactive oxygen species (ROS) and malondialdehyde (MDA) were assessed in the brain homogenates...
August 14, 2018: Canadian Journal of Physiology and Pharmacology
Sartaj S Sandhu, Sandeep S Dhindsa, Nitesh D Kuhadiya, Paresh Dandona
No abstract text is available yet for this article.
August 14, 2018: Endocrine Practice
Arun H Patil, Keshava K Datta, Santosh Kumar Behera, Sandeep Kasaragod, Sneha M Pinto, Shashanka G Koyangana, Premendu P Mathur, Harsha Gowda, Akhilesh Pandey, Thottethodi Subrahmanya Keshava Prasad
Candida tropicalis belongs to the non-albicans group of Candida, and causes epidermal, mucosal, or systemic candidiasis in immunocompromised individuals. Although the prevalence of candidiasis has increased worldwide and non-albicans Candida (NAC) are becoming more significant, there are very few studies that focus on the NAC biology. Proteins and their post-translational modifications (PTMs) are an integral aspect in the pathobiology of such medically important fungi. Previously, we had reported the largest proteomic catalog of C...
August 2018: Omics: a Journal of Integrative Biology
Joshua Payne, Samuel Aznaurov, Sandeep Gautam
BACKGROUND: Figure-of-Eight sutures (F8S) have emerged as an alternative to the standard practice of manual compression to achieve venous hemostasis after catheter ablation for atrial fibrillation (AF). In lieu of a knot to secure the sutures in place, a three-way stopcock can be used that can be loosened or tightened as needed to achieve hemostasis and is easier to remove. The safety and effectiveness of this technique when compared to traditional F8S is unknown. In this case series, we sought to describe this stopcock closure technique (SC) and compare procedural characteristics and outcomes to traditional F8S...
August 14, 2018: Journal of Cardiovascular Electrophysiology
Natesan Anand Vijai, Palanisamy Senthilnathan, Vikram Annamaneni, Sandeep C Sabnis, Arvinder Singh Soin, Chinnusamy Palanivelu
Liver transplantation is a ray of hope for thousands of patients with end-stage liver disease but is currently challenged by the scarcity of donor organs worldwide. Unlike kidney transplantation where minimally invasive donor organ procurement has almost become a norm, laparoscopic procurement of hemi-liver from a living donor is still in the infancy of development, at least in the Indian sub-continent. Minimally invasive surgery has made its way into different procedures of hepatobiliary and pancreatic surgery, but only a few centres in the world are performing pure laparoscopic donor hepatectomy...
August 7, 2018: Journal of Minimal Access Surgery
Vishwas Malik, Usha Kiran, Sandeep Chauhan, Neeti Makhija
Background and Aims: In patients undergoing open heart surgery, chest tubes are removed postoperatively when patients are well awake and stable. Pain during chest tube removal can be moderate to severe and can be the worst experience of hospitalization. Various modalities of pain relief during chest tube removal have been tried with variable results. We sought to examine the effect of transcutaneous electrical nerve stimulation (TENS) as an intervention for pain relief during chest tube removal after cardiac surgery...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Tapas Kumar Singh, Sandeep Sahu, Anil Agarwal, Devendra Gupta, Prabhaker Mishra
Background and Aims: Catheter-related bladder discomfort (CRBD) has started to gain recognition as a problem in early postoperative care. Dexmedetomidine reduces bladder contractility via M3 muscarinic receptor antagonism and α-2 receptor agonism, apart from its concomitant therapeutic benefits, such as sedation and sympatholysis, in a postoperative period. We, therefore, evaluated the efficacy of dexmedetomidine in reducing incidence and severity of CRBD. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial done on 110 voluntary kidney donors for live related kidney transplantations were planned for laparoscopic donor nephrectomy...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Anju Manuja, Balvinder Kumar, Rajender Kumar, Meenu Chopra, Neeraj Dilbaghi, Sandeep Kumar, Suresh C Yadav
Quinapyramine sulfate (QS) produces trypanocidal effect against the parasite Trypanosoma evansi , but often poorly tolerated and causes serious local reactions in animals. The encapsulation of QS in chitosan/mannitol to provide the sustained release would improve both the therapeutic effect of QS and the quality of life of animals treated with this formulation. QS was encapsulated into nanoformulation prepared from chitosan, tripolyphosphate and mannitol nanomatrix (ChQS-NPs). ChQS-NPs were well-ordered in shape with nanoparticle size as determined by transmission electron microscopy and atomic force microscopy...
August 13, 2018: Antimicrobial Agents and Chemotherapy
Lindsay Johnston, Taylor Sawyer, Akira Nishisaki, Travis Whtifill, Anne Ades, Heather French, Kristen Glass, Rita Dadiz, Christie Bruno, Orly Levit, Sandeep Gangadharan, Daniel Scherzer, Ahmed Moussa, Marc Auerbach
BACKGROUND: Neonatal tracheal intubation (NTI) is an important clinical skill. Suboptimal performance is associated with patient harm. Simulation training can improve NTI performance. Improving performance requires an objective assessment of competency. Competency assessment tools need strong evidence of validity. We hypothesized that a NTI competency assessment tool with multi-source validity evidence could be developed, and could be used for formative and summative assessment during simulation-based training...
August 10, 2018: Academic Pediatrics
Paul J Converse, Deepak V Almeida, Rokeya Tasneen, Vikram Saini, Sandeep Tyagi, Nicole C Ammerman, Si-Yang Li, Nicole M Anders, Michelle A Rudek, Jacques H Grosset, Eric L Nuermberger NCT03474198, NCT01659437.
August 13, 2018: PLoS Neglected Tropical Diseases
Venkatesh Teja Banala, Shweta Sharma, Puja Barnwal, Sandeep Urandur, Ravi P Shukla, Naseer Ahmad, Naresh Mittapelly, Gitu Pandey, Monika Dwivedi, Navodayam Kalleti, Kalyan Mitra, Srikanta Kumar Rath, Ritu Trivedi, Prabhat Ranjan Mishra
The combination of metabolic modulators with chemotherapy holds vast promise for effective inhibition of tumor progression and invasion. Herein, a ratiometric codelivery platform is developed for metformin (MET), a known metabolic modulator and topotecan (TPT), a chemotherapeutic drug, by engineering lipid bilayer-camouflaged mesoporous silica nanoparticles (LB-MSNs). In an attempt to deliver and maintain high tumor site concentrations of MET and TPT, a novel ion pairing-assisted loading procedure is developed using pamoic acid (PA) as an in situ trapping agent...
August 13, 2018: Advanced Healthcare Materials
Parikshaa Gupta, Gurwinder Kaur, Arvind Rajwanshi, Sandeep Bansal, Rajeev Kamble, R Ranjini
16-year-old male child. Presented with bilateral proptosis (more on right than left) over the last 8 years, which was painless and gradually increasing in size. He had slight blurring of vision in right eye with restriction of eye movements. In addition, he had difficulty in breathing from nose. There was no history of fever, fatigue, weight loss, night sweats or joint pains. The clinical suspicion was of a lymphoma or an invasive fungal infection. On examination, there was no significant cervical, axillary or inguinal lymphadenopathy or hepatosplenomegaly...
August 12, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Dennis D Black, Sandeep K Gupta
No abstract text is available yet for this article.
August 9, 2018: Gastroenterology
Biplab Giri, Sananda Dey, Tanaya Das, Mrinmoy Sarkar, Jhimli Banerjee, Sandeep Kumar Dash
Chronic exposure of glucose rich environment creates several physiological and pathophysiological changes. There are several pathways by which hyperglycemia exacerbate its toxic effect on cells, tissues and organ systems. Hyperglycemia can induce oxidative stress, upsurge polyol pathway, activate protein kinase C (PKC), enhance hexosamine biosynthetic pathway (HBP), promote the formation of advanced glycation end-products (AGEs) and finally alters gene expressions. Prolonged hyperglycemic condition leads to severe diabetic condition by damaging the pancreatic β-cell and inducing insulin resistance...
August 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Avinash Jain, Dinesh Kumar, Anupam Guleria, Durga Prasanna Misra, Abhishek Zanwar, Smriti Chaurasia, Sandeep Kumar, Umesh Kumar, Shravan K Mishra, Ruchika Goel, Debashish Danda, Ramnath Misra
Takayasu arteritis (TA) is a large vessel vasculitis of unknown pathogenesis. Assessment of disease activity is a challenge and there is an unmet need for relevant biomarker(s). In our previous study, NMR based serum metabolomics had revealed distinctive metabolic signatures in TA patients compared with age/sex matched healthy controls and Systemic Lupus Erythematosus (SLE). In this study, we investigate whether the metabolites correlate with disease activity. Patients with TA fulfilling American College of Rheumatology (ACR) criteria were enrolled and disease activity was assessed using Indian Takayasu Clinical Activity Score using Acute Phase Reactant - Erythrocyte Sedimentation Rate [ITAS-A (ESR]...
August 10, 2018: Journal of Proteome Research
Sandeep Kumar, Amit Kumar, Bhumika Badiyani, Siddharth Kumar Singh, Anjali Gupta, Mohammed B Ismail
Background and aims: Internet addiction (IA) has negative consequences on the mental health and affects daily activities. This study was conducted with the aim to assess the prevalence of Internet addiction among dental university students and to determine if there is any relationship of excessive Internet use with depression and academic performance among students. Methods: This was a cross sectional study which included 384 dental students from different academic years...
July 2018: Clujul Medical (1957)
Irfan Ahmad, Kundan Singh Chufal, Irfan Bashir, Chandi Prasad Bhatt, Ram Bajpai, Lalit Sharma, Sandeep Rathour
Purpose: To evaluate clinical outcomes and failure patterns in patients with locally advanced cervical cancer (LACC) treated definitively using image-guided volumetric-modulated arc therapy (IG-VMAT). Methods and materials: This retrospective review included 18 consecutively treated patients with LACC. Treatment consisted of IG-VMAT and concurrent chemotherapy followed by intracavitary radiotherapy. The primary end points were overall survival (OS) and disease-free survival (DFS)...
2018: Clinical Medicine Insights. Oncology
Sandeep Arora, Neha Sodhi, Arun Kumar Harith, Umesh Kapoor
A 60-year-old female presented with a 20-year history of progressive dark bluish discoloration of skin and passage of dark colored urine, painful arthritis and a recent history of invasive ductal carcinoma of right breast. Skin biopsy revealed hyaline material which was Periodic-Acid-Schiff stain positive and Congo-red stain negative, urine analysis revealed dark urine with presence reducing substance and radio-imaging showed intervertebral ossification and joint ankyloses. The patient was managed symptomatically with physiotherapy and acetaminophen on as required basis...
July 2018: Medical Journal, Armed Forces India
Bheemsain Tekkalaki, Veerappa Y Patil, Sandeep Patil, Sameeran S Chate, Ramling Dhabale, Nanasaheb M Patil
Background: Psychiatric advance directives have been incorporated in the Mental Health Care Act 2017 despite strong concerns about their feasibility and utility in the Indian patient population. Data on its utility in India is very scarce. Aims: To determine the possible treatment options our clients make as a part of psychiatric advance directives. Materials and Methods: Fifty consecutive individuals with severe mental illness were interviewed using a self-designed semi-structured tool to find out the possible choices they make as part of advance directives and the factors affecting their choices...
July 2018: Indian Journal of Psychological Medicine
Richard J Bodnar, Tianbing Yang, Lora H Rigatti, Fang Liu, Alexander Evdokiou, Sandeep Kathju, Latha Satish
BACKGROUND: Pericytes have been shown to have mesenchymal stromal cell-like properties and play a role in tissue regeneration. The goal of this study was to determine whether the addition of a pericyte sheet to a full-thickness dermal wound would enhance the healing of an acute wound. METHODS: Human muscle-derived pericytes and human dermal fibroblasts were formed into cell sheets, then applied to full-thickness excisional wounds on the dorsum of nu/nu mice. Histology was performed to evaluate epidermal and dermal reformation, inflammation and fibrosis...
August 6, 2018: Cytotherapy
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