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Vaishnavi Potluri, Preethi Sangeetha Kathiresan, Hemanth Kandula, Prudhvi Thirumalaraju, Manoj Kumar Kanakasabapathy, Sandeep Kota Sai Pavan, Divyank Yarravarapu, Anand Soundararajan, Karthik Baskar, Raghav Gupta, Neeraj Gudipati, John C Petrozza, Hadi Shafiee
The ability to accurately predict ovulation at-home using low-cost point-of-care diagnostics can be of significant help for couples who prefer natural family planning. Detecting ovulation-specific hormones in urine samples and monitoring basal body temperature are the current commonly home-based methods used for ovulation detection; however, these methods, relatively, are expensive for prolonged use and the results are difficult to comprehend. Here, we report a smartphone-based point-of-care device for automated ovulation testing using artificial intelligence (AI) by detecting fern patterns in a small volume (<100 μL) of saliva that is air-dried on a microfluidic device...
December 11, 2018: Lab on a Chip
Bheemsain Tekkalaki, Veerappa Y Patil, Sandeep Patil, Sameeran S Chate, Ramling Dhabale, Nanasaheb M Patil
No abstract text is available yet for this article.
November 2018: Indian Journal of Psychological Medicine
Sandeep Grover, Swapnajeet Sahoo, Subho Chakrabarti, Debashish Basu, Shubh M Singh, Ajit Avasthi
Objective: To evaluate the clinical profile and effectiveness of ECT in females with postpartum onset psychiatric syndromes or worsening of psychiatric disorder during the postpartum period. Materials and Methods: A retrospective chart review was carried out to identify females who had received ECT during their postpartum period from January2004 to April 2017. Results: During the study period, 13 females in their postpartum period received ECT, which accounted for 2...
November 2018: Indian Journal of Psychological Medicine
Sandeep Kumar Vishwakarma, Chandrakala Lakkireddy, Avinash Bardia, Syed Ameer Basha Paspala, Chaturvedula Tripura, Md Aejaz Habeeb, Aleem Ahmed Khan
End stage liver diseases (ESLD) represent a major, neglected global public health crisis which requires an urgent action towards finding a proper cure. Orthotropic liver transplantation has been the only definitive treatment modality for ESLD. However, shortage of donor organs, timely unavailability, post-surgery related complications and financial burden on the patients limits the number of patients receiving the transplants. Since last two decades cell-based therapies have revolutionized the field of organ/tissue regeneration...
November 27, 2018: World Journal of Hepatology
Sudhakar P Awandkar, Prabhakar A Tembhurne, Jeevan A Kesharkar, Nitin V Kurkure, Sandeep P Chaudhari, Sachin W Bonde, Vijay C Ingle
Aim: The study was undertaken to isolate infectious bursal disease virus (IBDV) from clinical cases in broiler and cockerel flocks of Maharashtra state, India, and its molecular epidemiological investigation. Materials and Methods: The morbid bursal tissues were collected from flocks suspected for IBD. The samples were subjected for virus adaptation in primary chicken embryo fibroblast (CEF) cells followed by confirmation by reverse transcription polymerase chain reaction (RT-PCR) for partial VP2 sequence and phylogenetic analysis...
November 2018: Veterinary World
James Fowler, Sandeep Dhaliwal, Lorne S Parnes
No abstract text is available yet for this article.
January 2019: Otology & Neurotology
Sandeep Batra
No abstract text is available yet for this article.
December 7, 2018: Journal of Pediatric Hematology/oncology
Sandeep Grover, Swapnajeet Sahoo, Ashish Bhalla, Ajit Avasthi
BACKGROUND: Problematic Internet use/ Internet addiction (IA) has gained the attention of mental health professionals recently and studies have found that medical professionals are not immune to IA with prevalence rate ranging from 2.8 to 8%. Few studies from India have also reported high rates of IA among medical students. The term 'Problematic internet use' is being increasing used nowadays in place of IA as it signifies a better terminology than the word 'addiction' per se. However, there is lack of information among resident doctors...
November 26, 2018: Asian Journal of Psychiatry
Guilherme F Attizzani, Sandeep M Patel, George D Dangas, Wilson Y Szeto, Paul Sorajja, Michael J Reardon, Jeffrey J Popma, Susheel Kodali, Sharla Chenoweth, Marco A Costa
Transfemoral transcatheter aortic valve replacement (TF-TAVR) is mostly performed under general anesthesia (GA) in most US centers. We examined in-hospital and 30-day outcomes in patients who underwent TF-TAVR with a self-expanding bioprosthesis using local anesthesia (LA) or GA. Patients from the Transcatheter Valve Therapeutics Registry who underwent TF-TAVR from January 2014 to June 2016 with LA or GA were evaluated. Propensity matching was performed and procedural and clinical outcomes compared up to 30 days...
November 6, 2018: American Journal of Cardiology
Alexander Light, Maria Dadabhoy, Abigail Burrows, Madura Nandakumar, Tanya Gupta, Sandeep Karthikeyan, Allen Daniel
BACKGROUND: The gold standard for research is publication within a peer-reviewed journal. There is a discrepancy between the number of abstracts presented at scientific meetings and the number published as full articles. We identified publication rates for the 2012 meetings of four British surgical societies. These were the Association of Surgeons of Great Britain & Ireland (ASGBI), the Vascular Society of Great Britain and Ireland, the British Transplantation Society (BTS), and the Association of Coloproctology of Great Britain and Ireland (ACPGBI)...
February 2019: Journal of Surgical Research
Junhao Li, Matthew Otten, Adam A Holmes, Sandeep Sharma, C J Umrigar
This paper presents in detail our fast semistochastic heat-bath configuration interaction (SHCI) method for solving the many-body Schrödinger equation. We identify and eliminate computational bottlenecks in both the variational and perturbative steps of the SHCI algorithm. We also describe the parallelization and the key data structures in our implementation, such as the distributed hash table. The improved SHCI algorithm enables us to include in our variational wavefunction two orders of magnitude more determinants than has been reported previously with other selected configuration interaction methods...
December 7, 2018: Journal of Chemical Physics
Tamar Wolf, Sandeep Kumar, Harishchandra Singh, Tanmoy Chakrabarty, Fabien Aussenac, Anatoly I Frenkel, Dan Thomas Major, Michal Leskes
In recent years magic angle spinning - dynamic nuclear polarization (MAS-DNP) developed as an excellent approach for boosting the sensitivity of solid state NMR (ssNMR) spectroscopy, thereby enabling the characterization of challenging systems in biology and chemistry. Most commonly, MAS-DNP is based on the use of nitroxide biradicals as polarizing agents. In materials science, since the use of nitroxides often limits the signal enhancement to the materials' surface and subsurface layers, there is need for hyperpolarization approaches which will provide sensitivity in the bulk of micron sized particles...
December 11, 2018: Journal of the American Chemical Society
Sandeep Kumar Dey, Mohammad Al Kobaisi, Sheshanath V Bhosale
This Review article provides a comprehensive analysis of recent examples reported in the field of quinoxaline-based chromogenic and fluorogenic chemosensors for inorganic anions such as fluoride, cyanide, acetate, and phosphate, as well as their utility in biomolecular science. It commences with a discussion of the various structural motifs such as quinoxaline-based oligopyrroles, polymers, sulfonamides, cationic receptors, and miscellaneous receptors bearing mixed recognition sites in the same receptor. Advances are discussed in depth, where the focus of this review is to tackle mainly solution state anion sensing utilizing quinoxaline-based receptors using different spectroscopic techniques with reference to anion selectivity by colorimetric and fluorescence response...
December 2018: ChemistryOpen
Priyanka Gaur, Sandeep Bhattacharya, Surya Kant, R A S Kushwaha, Gaurav Singh, Sarika Pandey
Background: Lung cancer is the most common type of cancer worldwide with an estimation of 1.82 million new cancer cases diagnosed; and it is the leading cause of cancer-related deaths. Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase identified as being highly expressed in cancer cells including lung cancers. The aim of the study is to determine the EGFR mutation status in non-small cell lung cancer (NSCLC) patients to investigate the association between the EGFR mutation status and clinicopathological characters of patients...
November 2018: World Journal of Oncology
Hugh C Welles, Madeleine F Jennewein, Rosemarie D Mason, Sandeep Narpala, Lingshu Wang, Cheng Cheng, Yi Zhang, John-Paul Todd, Jeffrey D Lifson, Alejandro B Balazs, Galit Alter, Adrian B McDermott, John R Mascola, Mario Roederer
Gene based delivery of immunoglobulins promises to safely and durably provide protective immunity to individuals at risk of acquiring infectious diseases such as HIV. We used a rhesus macaque animal model to optimize delivery of naturally-arising, autologous anti-SIV neutralizing antibodies expressed by Adeno-Associated Virus 8 (AAV8) vectors. Vectored transgene expression was confirmed by quantitation of target antibody abundance in serum and mucosal surfaces. We tested the expression achieved at varying doses and numbers of injections...
December 5, 2018: PLoS Pathogens
Sandeep Dhindsa, Rama Chemitiganti, Husam Ghanim, Evangelina Santiago, Adnan Haider, Natalia Chaar, Mary Mok, Alexis McKee, Paresh Dandona
A quarter of men with obesity or type 2 diabetes have hypogonadotropic hypogonadism. Animal studies and in vitro data have shown that insulin action and insulin responsiveness in the brain are necessary for the maintenance of the functional integrity of the hypothalamo-hypophyseal-gonadal axis. We conducted a randomized, placebo-controlled trial to evaluate the effect of one dose of intranasal insulin (40 IU of regular insulin) or saline on LH concentrations in 14 men (8 with type 2 diabetes and 6 healthy lean men)...
2018: International Journal of Endocrinology
Sandeep Jha, Rickard Zeijlon, Aaron Shekka Espinosa, Jessica Alkhoury, Jonatan Oras, Elmir Omerovic, Björn Redfors
Takotsubo syndrome (TS) is an increasingly recognized acute heart failure syndrome which is self-limiting in most cases but can result in life-threatening complications. TS is difficult to distinguish from acute myocardial infarction (AMI) early in the disease course and currently lacks evidence-based treatment recommendations. Areas covered: Based on the available literature this systematic review discusses the clinical management of patients with TS during (i) the diagnostic workup; (ii) acutely after establishing the TS diagnosis; and (iii) after recovery of cardiac function...
December 4, 2018: Expert Review of Cardiovascular Therapy
Toni M Brand, Mari Iida, Andrew P Stein, Kelsey L Corrigan, Cara M Braverman, John P Coan, Hannah E Pearson, Harsh Bahrar, Tyler L Fowler, Bryan P Bednarz, Sandeep Saha, David Yang, Parkash S Gill, Mark W Lingen, Vassiliki Saloura, Victoria M Villaflor, Ravi Salgia, Randall J Kimple, Deric L Wheeler
No abstract text is available yet for this article.
December 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Jennifer R Shingleton, Sandeep S Dave
TET2 is a well-established tumor suppressor in the context of myeloid malignancies, but its role in lymphoma development has been less clear. In this issue of Cancer Discovery , Dominguez and colleagues report that TET2 function is critical for germinal center exit and plasma cell differentiation, and its deficiency can lead to B-cell lymphoma phenotypes. See related article by Dominguez et al., p. 1632 .
December 2018: Cancer Discovery
Sandeep Bodduluri, Abhilash S Kizhakke Puliyakote, Sarah E Gerard, Joseph M Reinhardt, Eric A Hoffman, John D Newell, Hrudaya P Nath, MeiLan K Han, George R Washko, Raúl San José Estépar, Mark T Dransfield, Surya P Bhatt, COPDGene Investigators
No abstract text is available yet for this article.
December 3, 2018: Journal of Clinical Investigation
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