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Khalid Hussain Janbaz, Tashfeen Akhtar, Fatima Saqib, Imran Imran, Muhammad Zia-Ul-Haq, Chaweeewan Jansakul, Vincenzo De Feo, Marius Moga
BACKGROUND: Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. METHODS: The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system...
2015: Journal of Translational Medicine
Tae Sung Lim, Ji Man Hong, Jin Soo Lee, Dong Hoon Shin, Jun Young Choi, Kyoon Huh
BACKGROUND: Although an early neurological deterioration after lacunar infarction is not rare, its therapeutic options are still undetermined. We investigated the effect of induced-hypertension in lacunar infarction with motor progression. METHODS: We reviewed 82 lacunar infarction patients who experienced motor progression [≥ 1-point increase of NIH stroke scale (NIHSS) during hospitalization]. Induced-hypertension using phenylephrine was applied to 52 patients and the others received conventional treatment...
September 15, 2011: Journal of the Neurological Sciences
Paul Fidelis, Leticia Wilson, Kayama Thomas, Mayra Villalobos, Adebayo O Oyekan
The production of 20-hydroxyeicosatetraenoic acid (20-HETE) in the kidney is thought to be involved in the control of renal vascular tone and tubular sodium and chloride reabsorption. Cytochrome (Cyp) P-450 enzymes of the Cyp4a family in the mouse, namely 4a10, -12 and 14, are involved in 20-HETE synthesis. Recent advances in the molecular genetics of the mouse have produced mice in which Cyp4a isoforms have been disrupted and the consequence of such an approach is examined. This study evaluated the effect of deletion of the Cyp4a14 gene on blood pressure, renal vascular responses and tubular function...
November 2010: Experimental Biology and Medicine
Omar Z Ameer, Ibrahim M Salman, Mohammad Jamshed A Siddiqui, Mun F Yam, Raghava N Sriramaneni, Ali J Mohamed, Amirin Sadikun, Zhari Ismail, Amin M Shah, Mohd Z Asmawi
AIM OF THE STUDY: The present study was aimed to investigate the pharmacological basis for the use of Loranthus ferrugineus in hypertension. MATERIALS AND METHODS: Loranthus ferrugineus methanol extract (LFME) was obtained using Soxhelt extractor and then successively fractionated using chloroform, ethyl acetate and n-butanol. The n-butanol fraction of LFME (NBF-LFME) was studied using isolated rat thoracic aorta. RESULTS: NBF-LFME (1.0 x 10(-5) to 3...
January 8, 2010: Journal of Ethnopharmacology
Cristina Morales-Carpi, Carolina Torres-Chazarra, Empar Lurbe, Isabel Torró, Francisco J Morales-Olivas
A 5-year-old girl presented hypertension [24-h blood pressure (BP) average 135/80 mmHg, above the 99th BP percentile], as confirmed by ambulatory BP monitoring, following the use of a cold preparation (2.5 ml every 8 h for 4 days) containing phenyephrine (1 mg/ml). There was a clear relationship between the administration of the medication and hypertension, and between normalized BP values (24-h BP average 109/66 mmHg, 90th percentile) and the withdrawal of the medication. Alternative causes of hypertension could not be found...
August 2008: European Journal of Pediatrics
Tohru Yamamori, Anthony R White, Ilwola Mattagajasingh, Firdous A Khanday, Azeb Haile, Bing Qi, Byeong Hwa Jeon, Artem Bugayenko, Kenji Kasuno, Dan E Berkowitz, Kaikobad Irani
The p66shc adaptor protein mediates age-associated oxidative stress. We examined the role of p66shc in endothelial nitric oxide synthase (eNOS) signaling. Overexpression of p66shc inhibited eNOS-dependent NO production. RNAi-mediated down-regulation of endogenous p66shc led to activation of the proto-oncogene ras, and Akt kinase, with a corresponding increase in phosphorylation of eNOS at S1177 (S1179 on bovine eNOS). In rat aortic rings, down-regulation of p66shc suppressed the vasoconstrictor response to phenyephrine that was abrogated by treatment with the NOS inhibitor l-NAME, and enhanced vasodilation induced by sub-maximal doses of acetylcholine...
December 2005: Journal of Molecular and Cellular Cardiology
Ihsan Bagcivan, Gökhan Gökçe, Semih Ayan, Sahin Yildirim, Bülent Saraç, Hakan Kiliçarslan, Yusuf Sarioglu
BACKGROUND: To determine the relaxant effect of omeprazole and lansaprazole, hydrogen-potassium (H+-K+) ATPase inhibitors, on rabbit prostatic tissue in vitro. METHODS: Male New Zealand white rabbits were sacrificed and their prostatic tissues were removed. The prostatic stromal strips were mounted in organ baths and relaxation responses were obtained in precontracted tissues with phenylephrine, carbachol and potassium chloride (KCl). Relaxation responses were controlled in the presence of various antagonists to explain the mechanism for relaxation exerted by omeprazole and lansaprazole...
November 2002: International Journal of Urology: Official Journal of the Japanese Urological Association
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