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Collagen and gut

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https://www.readbyqxmd.com/read/29997506/gut-sourced-vasoactive-intestinal-polypeptide-induced-by-the-activation-of-%C3%AE-7-nicotinic-acetylcholine-receptor-substantially-contributes-to-the-anti-inflammatory-effect-of-sinomenine-in-collagen-induced-arthritis
#1
MengFan Yue, XinYu Zhang, YanNong Dou, ZhiFeng Wei, Yu Tao, YuFeng Xia, Yue Dai
Sinomenine has long been used for the treatment of rheumatoid arthritis in China. However, its anti-inflammatory mechanism is still debatable because the in vitro minimal effective concentration (≥250 μM) is hardly reached in either synovium or serum after oral administration at a therapeutic dose. Recent findings suggest that the α7 nicotinic acetylcholine receptor (α7nAChR) might mediate the inhibitory effect of sinomenine on macrophage activation, which attracts us to explore the anti-arthritis mechanism of sinomenine by taking neuroendocrine-inflammation axis into consideration...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29988118/inflammation-independent-tl1a-mediated-intestinal-fibrosis-is-dependent-on-the-gut-microbiome
#2
Noam Jacob, Jonathan P Jacobs, Kotaro Kumagai, Connie W Y Ha, Yoshitake Kanazawa, Venu Lagishetty, Katherine Altmayer, Ariel M Hamill, Aimee Von Arx, R Balfour Sartor, Suzanne Devkota, Jonathan Braun, Kathrin S Michelsen, Stephan R Targan, David Q Shih
Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease (IBD), modulating the location and severity of intestinal inflammation and fibrosis. TL1A expression is increased in inflamed gut mucosa and associated with fibrostenosing Crohn's disease. Tl1a-overexpression in mice lead to spontaneous ileitis, and exacerbated induced proximal colitis and fibrosis. IBD is associated with shifts in the gut microbiome, but the effect of differing microbial populations and their interaction with TL1A on fibrosis has not been investigated...
July 9, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29951875/clindamycin-administration-increases-the-incidence-of-collagen-induced-arthritis-in-mice-through-the-prolonged-impact-of-gut-immunity
#3
Shukai Yang, Huijuan Chen, Bo Wei, Min Xiang, Zibing Hu, Zhiheng Peng, Hao Lin, Jiecong Sun
The profound influence of gut flora on host immune system and its link with autoimmune disorders have been established. However, the role of certain antibiotic in progression of autoimmune disorder is still confusing. Here, we employed a collagen-induced arthritis (CIA) model to explore the role of clindamycin administration in different scenarios. In the first scenario, mice treated with antibiotics for 4 weeks were performed with the induction of CIA immediately. The results showed that clindamycin administration promoted the incidence and severity of CIA, while the recipients of vancomycin showed completed tolerance...
June 27, 2018: Inflammation
https://www.readbyqxmd.com/read/29946138/comparative-genomics-of-campylobacter-concisus-analysis-of-clinical-strains-reveals-genome-diversity-and-pathogenic-potential
#4
Matthew R Gemmell, Susan Berry, Indrani Mukhopadhya, Richard Hansen, Hans L Nielsen, Mona Bajaj-Elliott, Henrik Nielsen, Georgina L Hold
In recent years, an increasing number of Campylobacter species have been associated with human gastrointestinal (GI) diseases including gastroenteritis, inflammatory bowel disease, and colorectal cancer. Campylobacter concisus, an oral commensal historically linked to gingivitis and periodontitis, has been increasingly detected in the lower GI tract. In the present study, we generated robust genome sequence data from C. concisus strains and undertook a comprehensive pangenome assessment to identify C. concisus virulence properties and to explain potential adaptations acquired while residing in specific ecological niche(s) of the GI tract...
June 26, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29873579/impact-of-collagen-induced-arthritis-on-the-pharmacokinetic-disposition-of-voriconazole-a-widely-used-antifungal-agent-in-vitro-and-in-vivo-investigations-in-dba-1j-mice
#5
Poonam Giri, Prashant Delvadia, Lakshmikant Gupta, Priyal Trivedi, Nirmal Patel, Manoranjan Sharma, Jaideep Singh, Abhijit Chatterjee, Shekhar Kadam, Nuggehally R Srinivas
1. Pharmacokinetics of voriconazole, an anti-fungal agent, was determined in collagen-induced arthritic (CIA) and healthy DBA/1J mice. CIA was confirmed in DBA/1J mice by clinical scoring and histological analysis. 2. In vivo oral pharmacokinetic study (3 mg/kg) and in vitro stability assessment in liver microsomes were performed in CIA vs. healthy DBA/1J mice. Additionally, hepatic portal vein cannulated (HPVC) CIA and healthy mice were used to clarify the role of gut first-pass effect. Voriconazole/N-oxide metabolite was measured in plasma and in vitro samples using LC-MS/MS method...
June 6, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29845272/therapeutic-effect-of-the-natural-compounds-baicalein-and-baicalin-on-autoimmune-diseases
#6
Jian Xu, Jinlong Liu, Guolin Yue, Mingqiang Sun, Jinliang Li, Xia Xiu, Zhenzhong Gao
A series of natural compounds have been implicated to be useful in regulating the pathogenesis of various autoimmune diseases. The present study demonstrated that the Scutellariae radix compounds baicalein and baicalin may serve as drugs for the treatment of autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease. Following the administration of baicalein and baicalin in vivo, T cell‑mediated autoimmune diseases in the mouse model were profoundly ameliorated: In the collagen‑induced arthritis model (CIA), the severity of the disease was reduced by baicalein and, consistently, baicalein was demonstrated to suppress T cell proliferation in CIA mice...
July 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29678817/collagen-18-and-agrin-are-secreted-by-neural-crest-cells-to-remodel-their-microenvironment-and-regulate-their-migration-during-enteric-nervous-system-development
#7
Nandor Nagy, Csilla Barad, Ryo Hotta, Sukhada Bhave, Emily Arciero, David Dora, Allan M Goldstein
The enteric nervous system (ENS) arises from neural crest cells that migrate, proliferate, and differentiate into enteric neurons and glia within the intestinal wall. Many extracellular matrix (ECM) components are present in the embryonic gut, but their role in regulating ENS development is largely unknown. Here, we identify heparan sulfate proteoglycan proteins, including collagen XVIII (Col18) and agrin, as important regulators of enteric neural crest-derived cell (ENCDC) development. In developing avian hindgut, Col18 is expressed at the ENCDC wavefront, while agrin expression occurs later...
May 8, 2018: Development
https://www.readbyqxmd.com/read/29619419/tumor-necrosis-factor-%C3%AE-mediated-hepatocyte-apoptosis-stimulates-fibrosis-in-the-steatotic-liver-in-mice
#8
Yosuke Osawa, Ekumi Kojika, Yukiko Hayashi, Masamichi Kimura, Koji Nishikawa, Sachiyo Yoshio, Hiroyoshi Doi, Tatsuya Kanto, Kiminori Kimura
Hepatocyte apoptosis has been implicated in the progression of nonalcoholic steatohepatitis. However, it is unclear whether the induction of tumor necrosis factor (TNF)-α-mediated hepatocyte apoptosis in the simple fatty liver triggers liver fibrosis. To address this question, high-fat diet-fed mice were repeatedly administered D-galactosamine, which increases the sensitivity of hepatocytes to TNF-α-mediated apoptosis. In mice treated with a high-fat diet plus D-galactosamine, hepatocyte apoptosis and liver fibrosis were induced, whereas both apoptosis and fibrosis were inhibited in these mice following gut sterilization with antimicrobials or knockout of TNF-α...
April 2018: Hepatology communications
https://www.readbyqxmd.com/read/29603368/oral-budesonide-in-gastrointestinal-and-liver-disease-a-practical-guide-for-the-clinician
#9
REVIEW
Stephan Miehlke, Manuel Barreiro-de Acosta, Gerd Bouma, Daniel Carpio, Fernando Magro, Tom Moreels, Chris Probert
Oral budesonide is a second-generation steroid that allows local, selective treatment of the gastrointestinal tract and the liver, minimizing systemic exposure. The results of randomized trials comparing budesonide versus placebo or active comparators have led to expert recommendations that budesonide be used to treat mild or moderate active ileocecal Crohn's disease, microscopic colitis (including both collagenous and lymphocytic colitis), ulcerative colitis, and non-cirrhotic autoimmune hepatitis. The mechanism of budesonide action obviates the need for dose tapering due to safety reasons after induction therapy...
March 30, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29567573/-1-h-nmr-based-metabolomics-approach-to-investigate-the-urine-samples-of-collagen-induced-arthritis-rats-and-the-intervention-of-tetrandrine
#10
Xinming Yun, Shu Dong, Qiaoqiao Hu, Yue Dai, Yufeng Xia
Tetrandrine is an effective ingredient isolated from the roots of a frequently used medicinal plant Stephania tetrandra S. Moore. It has been used for the management of arthritis in China, but the precise mechanism remains unclear. In the present study, a metabolomics method based on the 1 H NMR was constituted to quantify the alterations of the endogenous metabolites in the urines of collagen-induced arthritis (CIA) rats treated with tetrandrine. Data showed that tetrandrine treatment could alleviate the ankle joint swelling and ameliorate histopathological changes in rats...
May 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29552620/activation-of-myofibroblast-trpa1-by-steroids-and-pirfenidone-ameliorates-fibrosis-in-experimental-crohn-s-disease
#11
Lin Hai Kurahara, Keizo Hiraishi, Yaopeng Hu, Kaori Koga, Miki Onitsuka, Mayumi Doi, Kunihiko Aoyagi, Hidetoshi Takedatsu, Daibo Kojima, Yoshitaka Fujihara, Yuwen Jian, Ryuji Inoue
Background & Aims: The transient receptor potential ankyrin 1 (TRPA1) channel is highly expressed in the intestinal lamina propria, but its contribution to gut physiology/pathophysiology is unclear. Here, we evaluated the function of myofibroblast TRPA1 channels in intestinal remodeling. Methods: An intestinal myofibroblast cell line (InMyoFibs) was stimulated by transforming growth factor-β1 to induce in vitro fibrosis. Trpa1 knockout mice were generated using the Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system...
March 2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29534332/modulation-of-inflammatory-arthritis-in-mice-by-gut-microbiota-through-mucosal-inflammation-and-autoantibody-generation
#12
Widian K Jubair, Jason D Hendrickson, Erin L Severs, Hanna M Schulz, Sumitra Adhikari, Diana Ir, Jose D Pagan, Robert M Anthony, Charles E Robertson, Daniel N Frank, Nirmal K Banda, Kristine A Kuhn
OBJECTIVE: Observations of microbial dysbiosis in patients with rheumatoid arthritis (RA) have raised interest in studying microbial-mucosal interactions as a potential trigger of RA. Using the murine collagen-induced arthritis (CIA) model, we undertook this study to test our hypothesis that microbiota modulate immune responses leading to autoimmune arthritis. METHODS: CIA was induced by immunization of mice with type II collagen (CII) in adjuvant on days 0 and 21, with arthritis appearing on days 23 and 24...
March 13, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29510760/cysteine-peptidases-of-eudiplozoon-nipponicum-a-broad-repertoire-of-structurally-assorted-cathepsins-l-in-contrast-to-the-scarcity-of-cathepsins-b-in-an-invasive-species-of-haematophagous-monogenean-of-common-carp
#13
Lucie Jedličková, Hana Dvořáková, Jan Dvořák, Martin Kašný, Lenka Ulrychová, Jiří Vorel, Vojtěch Žárský, Libor Mikeš
BACKGROUND: Cysteine peptidases of clan CA, family C1 account for a major part of proteolytic activity in the haematophagous monogenean Eudiplozoon nipponicum. The full spectrum of cysteine cathepsins is, however, unknown and their particular biochemical properties, tissue localisation, and involvement in parasite-host relationships are yet to be explored. METHODS: Sequences of cathepsins L and B (EnCL and EnCB) were mined from E. nipponicum transcriptome and analysed bioinformatically...
March 6, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29507905/pyrroloquinoline-quinone-prevents-developmental-programming-of-microbial-dysbiosis-and-macrophage-polarization-to-attenuate-liver-fibrosis-in-offspring-of-obese-mice
#14
Jacob E Friedman, Evgenia Dobrinskikh, Alba Alfonso-Garcia, Alexander Fast, Rachel C Janssen, Taylor K Soderborg, Aimee L Anderson, Julie A Reisz, Angelo D'Alessandro, Daniel N Frank, Charles E Robertson, Becky A de la Houssaye, Linda K Johnson, David J Orlicky, Xiaoxin X Wang, Moshe Levi, Eric O Potma, Karim C El Kasmi, Karen R Jonscher
Increasingly, evidence suggests that exposure to maternal obesity creates an inflammatory environment in utero , exerting long-lasting postnatal signatures on the juvenile innate immune system and microbiome that may predispose offspring to development of fatty liver disease. We found that exposure to a maternal Western-style diet (WD) accelerated fibrogenesis in the liver of offspring and was associated with early recruitment of proinflammatory macrophages at 8-12 weeks and microbial dysbiosis as early as 3 weeks of age...
March 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29506157/bone-turnover-markers-in-patients-with-nonalcoholic-fatty-liver-disease-and-or-type-2-diabetes-during-oral-glucose-and-isoglycemic-intravenous-glucose
#15
Henrik Maagensen, Anders E Junker, Niklas R Jørgensen, Lise L Gluud, Filip K Knop, Tina Vilsbøll
Context: Nonalcoholic fatty liver disease (NAFLD) is associated with type 2 diabetes (T2D) and vice versa, and both conditions are associated with an increased risk of fractures and altered bone turnover. Although patients with NAFLD typically suffer from decreased bone mineral density (BMD), T2D is associated with normal to high BMD. The pathophysiology is uncertain but may involve the gut-bone axis. Objective: We investigated the influence of the gut on glucose-induced changes in plasma bone turnover markers in healthy controls and patients with T2D and/or biopsy-verified NAFLD...
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29466999/a-probiotic-complex-rosavin-zinc-and-prebiotics-ameliorate-intestinal-inflammation-in-an-acute-colitis-mouse-model
#16
Jin-Sil Park, JeongWon Choi, Ji Ye Kwon, Kyung-Ah Jung, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho
BACKGROUND: An altered gut microbiota balance is involved in the pathogenesis of inflammatory bowel disease (IBD), and several probiotic strains are used as dietary supplements to improve intestinal health. We evaluated the therapeutic effect of 12 probiotics in combination with prebiotics, rosavin, and zinc in the dextran sodium sulfate (DSS)-induced colitis mouse model. METHODS: The probiotic complex or the combination drug was administered orally to mice with DSS-induced colitis, and the body weight, disease activity index, colon length, and histopathological parameters were evaluated...
February 21, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29444734/growth-performance-carcass-and-noncarcass-traits-and-meat-quality-of-barbarine-lambs-fed-rosemary-distillation-residues
#17
Y Yagoubi, H Hajji, S Smeti, M Mahouachi, M Kamoun, N Atti
The aim of this experiment was to study the effect of total replacement of oat hay by rosemary distillation residues (RR) on growth, carcass characteristics and meat quality of Barbarine lambs. A total of 21 lambs were divided into three groups. The control group (C) was offered 600 g of oat hay; the RR87 and RR60 groups received 600 g of pellets containing 87% and 60% of RR, respectively. The CP content was 9% and 14% for RR87 and RR60, respectively. All animals were supplemented by 600 g of concentrate. After 77 days of fattening, lambs were slaughtered...
February 15, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29384322/the-effects-of-green-kiwifruit-combined-with-isoflavones-on-equol-production-bone-turnover-and-gut-microflora-in-healthy-postmenopausal-women
#18
Marlena C Kruger, Catherine Middlemiss, Shinichi Katsumata, Yuko Tousen, Yoshiko Ishimi
BACKGROUND AND OBJECTIVES: Isoflavone (daidzein and genistein) interventions in postmenopausal women have produced inconsistent skeletal benefits, partly due to population heterogeneity in daidzein metabolism to equol by enteric bacteria. This study assessed changes in microflora and bone turnover in response to isoflavone and ki-wifruit supplementation in New Zealand postmenopausal women. METHODS AND STUDY DESIGN: Healthy women 1-10 years post-menopause were randomly allocated to group A (n=16) or B (n=17) for a 16-week crossover trial...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29336663/lactobacillus-acidophilus-improves-intestinal-inflammation-in-an-acute-colitis-mouse-model-by-regulation-of-th17-and-treg-cell-balance-and-fibrosis-development
#19
Jin-Sil Park, Jeong Won Choi, JooYeon Jhun, Ji Ye Kwon, Bo-In Lee, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho
Disruption of the balance among the microbiota, epithelial cells, and resident immune cells in the intestine is involved in the pathogenesis of inflammatory bowel disease (IBD). Probiotics exert protective effects against IBD, and probiotic commensal Lactobacillus species are common inhabitants of the natural microbiota, especially in the gut. To investigate the effects of Lactobacillus acidophilus on the development of IBD, L. acidophilus was administered orally in mice with dextran sodium sulfate (DSS)-induced colitis...
March 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29306322/curcumin-attenuates-collagen-induced-inflammatory-response-through-the-gut-brain-axis
#20
Yannong Dou, Jinque Luo, Xin Wu, Zhifeng Wei, Bei Tong, Juntao Yu, Ting Wang, Xinyu Zhang, Yan Yang, Xusheng Yuan, Peng Zhao, Yufeng Xia, Huijuan Hu, Yue Dai
BACKGROUND: Previous studies have demonstrated that oral administration of curcumin exhibited an anti-arthritic effect despite its poor bioavailability. The present study aimed to explore whether the gut-brain axis is involved in the therapeutic effect of curcumin. METHODS: The collagen-induced arthritis (CIA) rat model was induced by immunization with an emulsion of collagen II and complete Freund's adjuvant. Sympathetic and parasympathetic tones were measured by electrocardiographic recordings...
January 6, 2018: Journal of Neuroinflammation
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