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coagulation ,coagulate

Jing Jia, Huijuan Wang, Miaomiao Wu, Feilong Zhang, Xuelin Liu, Wenming Chen, Aijun Liu
A 62-year-old female presenting with anemia and extensive hemorrhages is reported. Coagulation tests showed significantly prolonged prothrombin time (PT) and activated partial thromboplastin time. Decreased levels of clotting factor X activity were determined (5.4%). Bone marrow biopsy revealed neoplastic plasma cells. Serum and urine protein electrophoresis were both negative for monoclonal gammopathy, and both bone marrow and abdominal fat biopsies were negative for amyloid deposition. The patient was diagnosed as suffering from nonsecretory multiple myeloma (MM) complicated by acquired factor X deficiency...
August 16, 2018: Acta Haematologica
Sidali Kourdali, Abdelmalek Badis, Ahmed Boucherit, Kamel Boudjema, Ali Saiba
The present work undertakes an examination and comparison of electro-Fenton (EF), electro-peroxi-coagulation (EPC) and electrocoagulation (EC) applied to the E. coli inactivation in batch reactor. Indeed, platinum (Pt (anode), EF), stainless steel (SS (cathode), EF, EPC) and ordinary steel (Fe (anode), EPC) and aluminum (Al, EC) were used respectively. The current intensity, nature of electrolytic support, bacterial density and hydrogen peroxide (H2 O2 ) concentration are the most influenced study parameters...
August 13, 2018: Journal of Environmental Management
Jun Wang, Feng Xu
This video demonstrates bilateral posterior communicating artery (PCoA) aneurysms that were treated through a unilateral supraorbital approach. A 53-year-old woman presented with a Hunt-Hess grade I subarachnoid hemorrhage (SAH). Computed tomography scan showed SAH in the left sylvian fissure and basal cistern. Angiography demonstrated bilateral aneurysms of the PCoA. Considering posteromedial projection of the contralateral aneurysm, unilateral approach from the side of the ruptured aneurysm was chosen to clip bilateral aneurysms...
August 13, 2018: World Neurosurgery
Joachim Kuhn, Tatjana Gripp, Tobias Flieder, Andreas Hammerschmidt, Doris Hendig, Isabel Faust, Cornelius Knabbe, Ingvild Birschmann
BACKGROUND: Measurement of direct oral anticoagulants (DOACs) concentration in patient blood is essential in special clinical circumstances. METHODS: We developed a fast, selective and sensitive method for simultaneous measurement of DOACs in human plasma consisting of an automated online solid-phase extraction method coupled with ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry (online SPE-UPLC-MS/MS). RESULTS: The calibration curves of all DOACs were linear over the working range (apixaban: 0...
August 13, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
R E Kalinin, I A Suchkov, N D Mzhavanadze, V G Demikhov, O N Zhurina, E A Klimentova
AIM: To assess intrinsic coagulation pathway factors activity and hemostatic markers of endothelial dysfunction in patients with peripheral artery disease (PAD) before and after lower extremity bypass surgery. MATERIAL AND METHODS: 80 patients with PAD Fontaine grade IIB-III were enrolled. 40 patients underwent open aorto-femoral-popliteal repair (group A) and 40 patients - medication (group B). Before and in 3 months after surgery peripheral venous blood samples were collected to assess the activity of factors VIII, IX, XI, von Willebrand factor (VWF), protein C (PrC), and metabolites of nitric oxide II (NO)...
2018: Khirurgiia
Jordana Goldman, Moreshwar S Desai, Kenneth L McClain, M Hossein Tcharmtchi, Curtis E Kennedy, Kathleen Thompson, Fong Lam, Dalia A Bashir, Ivan K Chinn, Baruch R Goldberg, Carl E Allen, Trung C Nguyen
OBJECTIVES: Hemophagocytic lymphohistiocytosis poses significant challenges due to limited tools to guide clinical decisions in a population at high risk of death. We sought to assess whether disseminated intravascular coagulation and hepatobiliary dysfunction, significant comorbidities seen in critical care settings, would identify hemophagocytic lymphohistiocytosis patients with increased risk of mortality. DESIGN: Retrospective chart review. SETTING: Single-center PICU...
August 14, 2018: Pediatric Critical Care Medicine
Dong Hun Lee, Byung Kook Lee, Kyung Woon Jeung, Jung Soo Park, Yong Deok Lim, Yong Hun Jung, Sung Min Lee, Yong Soo Cho
The present study aimed to analyze and compare the prognostic performances of the Japanese Ministry of Health and Welfare (JMHW) score, the Korean Society on Thrombosis and Hemostasis (KSTH) score, the International Society on Thrombosis and Haemostasis (ISTH) score, the Japanese Association for Acute Medicine (JAAM) score, and the revised JAAM (rJAAM) score, for 28-day mortality in severe trauma.This retrospective observational study included patients admitted for severe trauma between 2012 and 2015. Receiver operating characteristics analysis was performed to examine the prognostic performance of the 5 different DIC score systems...
August 2018: Medicine (Baltimore)
Yuan-Yuan Yang, Yi-Hua Fang, Xue Wang, Ying Zhang, Xiao-Jun Liu, Zong-Zhi Yin
This study aims to investigate major complications or symptoms of pregnant women, causes of maternal near-miss, and issues that are relevant to severe maternal disease.A retrospective analysis was performed in the "maternal individual investigation form," which included all critical maternity patients admitted to the First Affiliated Hospital of Anhui Medical University from January 1, 2012 to September 31, 2015.A total of 14,014 pregnant patients who delivered at 28 to 42 weeks of gestation were included...
August 2018: Medicine (Baltimore)
Xiaolin Ai, Zengpanpan Ye, Weijing Li, Jun Zheng, Chao You, Jianguo Xu
RATIONALE: Tetralogy of Fallot (TOF) accounts for approximately 5% of all congenital heart disease. However, only 1% of patients with TOF survive to the age of 40 years without undergoing surgery. Additionally, the relationship between intracerebral hemorrhage and unrepaired TOF remains unknown. We report a rare case of unrepaired TOF in a patient who presented with intracerebral hemorrhage, and we also present a literature review. PATIENT CONCERNS: A 40-year-old man presented with headache and right-sided limb weakness...
August 2018: Medicine (Baltimore)
Nathalie I Caversaccio, Maria D Reina Caro, Raja Prince, Martin Müller, Clayton S Lewis, Vladimir Y Bogdanov, Jean-François Dufour, Anne Angelillo-Scherrer
OBJECTIVES: In patients with chronic liver diseases, hypercoagulability can contribute to the progression of fibrosis and complications of cirrhosis. Tissue factor (TF) is a transmembrane glycoprotein that initiates the extrinsic pathway of blood coagulation. Recent investigations have established that TF is elevated in patients with pancreatic cancer, blood disorders, diabetes, and cardiovascular disease. Alternatively spliced tissue factor (asTF), a secreted form of TF, induces angiogenesis and exhibits low-level procoagulant activity...
August 14, 2018: European Journal of Gastroenterology & Hepatology
Ornella Spagnolello, Federica Letteri, Anne Falcou, Lorena Cipollone, Manuela De Michele, Giuliano Bertazzoni, Danilo Toni
The widespread use of direct oral anticoagulants (DOACs) has been increasing the conditions in which emergency physicians are forced to rapidly reverse anticoagulation in case of life-threatening bleeding or need of urgent surgery or invasive procedures. Recent approval of Idarucizumab, a humanized monoclonal antibody fragment (Fab), offered the opportunity to rapidly and safely neutralize the anticoagulant effect of Dabigatran. However, real world experience of its effective use in different emergency setting is now required...
August 16, 2018: Current Drug Safety
Marco Ranucci, Alessandro Giamberti, Ekaterina Baryshnikova
Surgical correction or palliation of complex congenital heart defects in newborns and small infants is often accompanied by severe perioperative bleeding, almost invariably requires the use of blood components (fresh frozen plasma and platelets) and often of other pro-coagulant interventions, including fibrinogen concentrate, prothrombin complex concentrate, factor XIII, and even recombinant activated factor VII [1,2]. The nature of perioperative bleeding in this segment of the cardiac surgery population is certainly multifactorial...
August 15, 2018: Journal of Thrombosis and Haemostasis: JTH
Hugo Maas, Savion Gropper, Fenglei Huang, Joachim Stangier, Igor Tartakovsky, Martina Brueckmann, Jacqueline M L Halton, Lesley G Mitchell
BACKGROUND:  Physiological age-related changes in the haemostatic and coagulation systems result in differing anticoagulant assay responses to standard anticoagulants. Therefore, we investigated the response of anticoagulant assays to dabigatran etexilate (DE) in children compared with adults. OBJECTIVE:  This article assesses the relationship between plasma dabigatran concentration and coagulation assay results across age groups in children and adults. PATIENTS AND METHODS:  Data from three clinical trials in which children received DE following standard of care for venous thromboembolism were compared with data from adult clinical trials...
August 15, 2018: Thrombosis and Haemostasis
Kjersti Tunströmer, Lars Faxälv, Niklas Boknäs, Tomas L Lindahl
Imaging methods based on time-lapse microscopy are important tools for studying the dynamic events that shape thrombus formation upon vascular injury. However, there is a lack of methods to translate the vast amount of visual data generated in such experiments into quantitative variables describing platelet movements that can be subjected to systematic analysis. In this study, we developed experimental and computational protocols allowing for a detailed mathematical analysis of platelet movements within a developing thrombus...
August 15, 2018: Thrombosis and Haemostasis
Michael Guarnieri, Cory Brayton, Betty M Tyler
Animal models to study opiates are of growing interest. We have examined the short-term safety of buprenorphine implants in Fischer F344/NTac rats treated with excess doses of a cholesterol-triglyceride suspension of buprenorphine. A single injection of 0.65 mg/kg afforded clinically significant blood levels of analgesia for 3 days. Chemistry, hematology, coagulation, and urinalysis values with 2- to 10-fold excess doses of the drug-lipid suspension were within normal limits. Histopathology findings were unremarkable...
2018: Journal of Veterinary Medicine
Ali Alhousseini, Sunil Jaiman, Edgar Hernandez-Andrade, Salam Zeineddine, Faisal Qureshi, Suzanne M Jacques
Background: Thrombosis of one of the umbilical arteries can be associated with adverse pregnancy outcomes such as stillbirth and severe intrauterine growth restriction (IUGR). Case: A 21-year-old gravida 1 patient, with a history of 3-vessel cord at 20 weeks, presented at 29 weeks with a single umbilical artery. The estimated fetal weight measurements at 26 weeks, 29 weeks, and 31 weeks were at the 27th percentile, the 26th percentile, and less than the 5th percentile, respectively...
2018: Case Reports in Obstetrics and Gynecology
Xin-Fang Zhu, Yu-Bo Wu, Li-Hui Yang, Rong Xia, Jing-Han Liu, Jiong-Cai Lan
OBJECTIVE: Through researching preoperative coagulation function in the case of ABO-identical blood insufficient for emergency rescue transfusion according to recommended programs of special emergency rescue transfusion was carried out, the relationship between volume of blood products and coagulation function was analyzed. METHODS: The surgical cases of blood transfusion more than 1 600 ml during operation were collected in our hospitals from Aug 2015 to Dec 2016(n=218), these cases were divided into the normal coagulation group(Group A) and abnormal coagulation group(Group B), and the patients of emergency rescue transfusion O type blood group(Group C)...
August 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
Michael Caspers, Nadine Schäfer, Matthias Fröhlich, Ursula Bauerfeind, Bertil Bouillon, Manuel Mutschler, Marc Maegele
BACKGROUND: External factors following trauma and iatrogenic intervention influence blood coagulation and particularly clot formation. In particular, three external factors (in detail dilution via uncritical volume replacement, acidosis and hypothermia), in combination, referred to as the "lethal triad", substantially aggravate the hypocoagulative state after trauma. Contribution of these external factors to the resulting hypocoagulative state in trauma and especially their influence on primary haemostasis has still not been investigated systematically...
August 15, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Yifeng Huang, Alec Mackenzie, Laura Meteer, Ron Hofmann
The impact of drinking water treatment plants on phosphorous in a lake has never been previously reported. In this mass balance study, phosphorus removal by a conventional plant and a membrane plant on Lake Simcoe was monitored. Approximately 16 kg of phosphorus per year were removed from the lake by the membrane plant, representing 72% of the influent phosphorous load to the plant. The membrane plant did not practice coagulation, so approximately two-thirds of the removal was via circulation of the treated water to the municipal wastewater treatment plant where phosphorous was removed...
August 16, 2018: Environmental Technology
Y N Prashantha, P N Suman Rao, Saudamini Nesargi, B S Chandrakala, Kalyan Chakravarthy Balla, A Shashidhar
BACKGROUND: Different methods have been used for therapeutic hypothermia for neonates with moderate-to-severe hypoxic ischaemic encephalopathy (HIE). As standard cooling devices are expensive, there is a need to establish the safety and efficacy of low-cost devices such as ice packs (IP) and phase changing material (PCM). AIM: To assess the efficacy and safety of therapeutic hypothermia (TH) and the clinico-laboratory profile of neonates who underwent cooling with IP or PCM...
August 15, 2018: Paediatrics and International Child Health
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