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https://www.readbyqxmd.com/read/30552972/sustained-release-of-recombinant-thrombomodulin-from-cross-linked-gelatin-hyaluronic-acid-hydrogels-potentiate-wound-healing-in-diabetic-mice
#1
Yun-Yan Hsu, Kuan-Lin Liu, Hsun-Hua Yeh, Hong-Ru Lin, Hua-Lin Wu, Jui-Chen Tsai
Thrombomodulin (TM) is a type-I transmembrane glycoprotein expressed on the surfaces of endothelial cells and epidermal keratinocytes. It is known to regulate blood coagulation, inflammation, and cell-cell adhesion. A recombinant TM, which contains an epidermal growth factor - like domain and serine/threonine-riches domain, has been demonstrated to stimulate cell proliferation and migration of keratinocytes and wound healing. In this study, we developed the biodegradable hydrogels and evaluated the efficacy of sustained release of rhTM from the hydrogel for the treatment of diabetic wounds...
December 12, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/30551739/pancreatic-carcinoma-underlying-a-complex-presentation-in-late-pregnancy-a-case-report
#2
Ai-Wu Shi, Xiao-Feng Shen, Hong-Juan Ding, Yao-Qiu Liu, Li Meng, Bill Kalionis
BACKGROUND: Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Pancreatic adenocarcinoma is one of the most common malignancies associated with thromboembolic events. A clinical study showed that thromboembolic events were detected in 36% of patients diagnosed as having pancreatic cancer...
December 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/30551547/resistin-impairs-activation-of-protein-c-by-suppressing-epcr-and-increasing-sp1-expression
#3
Pei Zhang, Yu Liu, Jiangli Su, Jie Bai, Shikai Zhao, Shouguo Zhao
Endothelial cells are vital to blood coagulation and maintain whole body hemostasis. Binding of endothelial cells to endothelial protein C receptor (EPCR) and thrombomodulin (TM) is essential to the formation of activated protein C (APC), one of the key factors regulating blood coagulation. In our study, we showed that resistin, an adipocyte hormone, suppresses thrombin-induced protein C activation in endothelial cells. Resistin treatment results in a reduction in EPCR expression, but not TM. Mechanistically, we demonstrate that resistin induces expression of the nuclear transcription factor SP-1, which could lead to downregulation of EPCR...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30550035/-the-pathway-of-vasopressin-as-a-pharmacological-target-in-nephrology-a-narrative-review
#4
Michi Recupero, Pierluigi Fulignati, Alessandro Naticchia, Silvia D'Alonzo, Francesca D'Ascenzo, Stefano Costanzi
ADH is a hormone secreted by neurohypophysis that plays different roles based on the target organ. At the renal level, this peptide is capable of causing electrolyte-free water absorption, thus playing a key role in the hydro-electrolytic balance. There are pathologies and disorders that jeopardize this balance and, in this field, ADH receptor inhibitors such as Vaptans could play a key role. By inhibiting the activation pathway of vasopressin, they are potentially useful in euvolemic and hypervolemic hypotonic hyponatremia...
December 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/30548773/impact-of-erythrocytapheresis-on-natural-anticoagulant-levels-in-children-with-sickle-cell-disease-a-pilot-study
#5
Ruchika Sharma, Gary M Woods, Susan Creary, Sarah O'Brien, Joseph Stanek, Kan Hor, Christina Gallagher, Amy L Dunn, Riten Kumar
Venous thromboembolism (VTE) is being increasingly recognized in children with sickle cell disease (SCD). In a retrospective cohort study, we identified bilateral central venous catheter (CVC) placement as an independent risk factor for VTE. At our institution, the only indication for bilateral CVC placement in children with SCD is erythrocytapheresis. To investigate the impact of erythrocytapheresis on coagulation, we measured levels of natural anticoagulants in 11 patients with SCD on chronic erythrocytapheresis, immediately before and after apheresis...
December 13, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/30548173/an-evaluation-of-variation-in-pathology-investigations-and-associated-factors-for-adult-patients-presenting-to-emergency-departments-with-chest-pain-an-observational-study
#6
Nasir Wabe, Maria R Dahm, Ling Li, Robert Lindeman, Alex Eigenstetter, Johanna I Westbrook, Andrew Georgiou
OBJECTIVE: To determine variation in pathology test ordering practices and identify associated factors for adult patients presenting to emergency departments (ED) with chest pain and subsequently admitted with ischemic heart disease. METHODS: A retrospective study across six hospital EDs in New South Wales, Australia. A total of 6,769 patient presentations between January 2014 and December 2017 met the inclusion criteria. Ordered pathology tests were grouped into three categories based on Australasian College for Emergency Medicine and the Royal College of Pathologists of Australasia recommendations: category I (no restriction in ordering), category II (can be ordered after consulting a supervisor) and category III (not for routine ordering in ED)...
December 10, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/30547189/role-of-platelets-in-thrombin-generation-amongst-patients-with-non-transfusion-dependent-thalassaemia
#7
Chuen Wen Tan, Wan Hui Wong, Roserahayu Idros, Yiong Huak Chan, Hartirathpal Kaur, Alvin Ren Kwang Tng, Lai Heng Lee, Heng Joo Ng, Ai Leen Ang
Non-transfusion-dependent thalassaemia (NTDT) is associated with a hypercoagulable state with thrombotic risk highest after splenectomy. Various mechanisms have been proposed. Although an antiplatelet agent is commonly recommended as thromboprophylaxis in NTDT, the role of platelets contributing to this hypercoagulable state is not well-defined. This study aims to evaluate the role of platelets contributing to hypercoagulability in NTDT patients using thrombin generation (TG). Platelet-rich (PRP) and platelet-poor plasma (PPP) were collected from NTDT patients (n = 30) and normal controls (n = 20) for TG measurement and compared...
December 13, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/30547143/successful-treatment-of-disseminated-intravascular-coagulation-associated-with-aortic-dissection
#8
Masahiko Fujii, Hiroyuki Watanabe, Masayoshi Otsu, Yuta Sugahara
Disseminated intravascular coagulation (DIC) is an infrequent aortic dissection complication, and its optimal treatment remains controversial. A 55-year-old woman developed DIC associated with Stanford type B aortic dissection, which improved by administration of low-molecular-weight heparin combined with tranexamic acid, but the dissecting aneurysm of the descending aorta was dilated. After thoracic endovascular aortic repair for occlusion of entry tears detected by transesophageal echocardiography, DIC improved without anticoagulant therapy...
December 2018: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/30546368/non-coding-rnas-function-as-immune-regulators-in-teleost-fish
#9
REVIEW
Man Wang, Shuai Jiang, Wei Wu, Fei Yu, Wenguang Chang, Peifeng Li, Kun Wang
Non-coding RNAs (ncRNAs) are functional RNA molecules that are transcribed from DNA but not translated into proteins. ncRNAs function as key regulators of gene expression and chromatin modification. Recently, the functional role of ncRNAs in teleost fish has been extensively studied. Teleost fish are a highly diverse group among the vertebrate lineage. Fish are also important in terms of aquatic ecosystem, food production and human life, being the source of animal proteins worldwide and models of biomedical research...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30546314/indoxyl-sulfate-promotes-arterial-thrombosis-in-rat-model-via-increased-levels-of-complex-tf-vii-pai-1-platelet-activation-as-well-as-decreased-contents-of-sirt1-and-sirt3
#10
Malgorzata Karbowska, Tomasz W Kaminski, Beata Znorko, Tomasz Domaniewski, Tomasz Misztal, Tomasz Rusak, Anna Pryczynicz, Katarzyna Guzinska-Ustymowicz, Krystyna Pawlak, Dariusz Pawlak
Patients suffering from chronic kidney disease (CKD) are at a 20-fold higher risk of dying due to cardiovascular diseases (CVDs), primarily thrombosis following vascular injury. CKD is connected with retention of uremic toxins, especially indoxyl sulfate (IS), which are currently considered as a non-classical CKD-specific risk factor for CVDs. The present study aimed to examine the effect of chronic exposure to IS on the hemostatic system and arterial thrombosis in a model without greater interferences from the uremic milieu consisting of additional uremic toxins...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30545924/prevention-of-the-anti-factor-viii-memory-b-cell-response-by-inhibition-of-the-bruton-s-tyrosine-kinase-in-experimental-hemophilia-a
#11
Sandrine Delignat, Jules Russick, Bagirath Gangadharan, Julie Rayes, Mathieu Ing, Jan Voorberg, Srinivas V Kaveri, Sébastien Lacroix-Desmazes
Hemophilia A is a rare hemorrhagic disorder due to the lack of functional pro-coagulant factor VIII. Factor VIII replacement therapy in patients with severe hemophilia A results in the development of inhibitory anti-factor VIII IgG in up to 30% of the cases. To date, immune tolerance induction upon daily injection of large amounts of factor VIII is the only strategy to eradicate factor VIII inhibitors. It is however efficient in only 60-80% of the patients. Here, we investigated whether blocking B-cell receptor signaling upon inhibition of the Bruton's tyrosine kinase prevents anti-factor VIII immune responses in a mouse model of severe hemophilia A...
December 13, 2018: Haematologica
https://www.readbyqxmd.com/read/30545831/affimer-proteins-as-a-tool-to-modulate-fibrinolysis-stabilize-the-blood-clot-and-reduce-bleeding-complications
#12
Katherine J Kearney, Nikoletta Pechlivani, Rhodri King, Christian Tiede, Fladia Phoenix, Ramsah Cheah, Fraser L Macrae, Katie J Simmons, Iain W Manfield, Kerrie A Smith, Benjamin E J Spurgeon, Khalid M Naseem, Robert A S Ariens, Michael J McPherson, Darren C Tomlinson, Ramzi A Ajjan
Bleeding complications secondary to surgery, trauma, or coagulation disorders are important causes of morbidity and mortality. Although fibrin sealants are considered to minimize blood loss, this is not widely adopted due to high cost and/or risk of infection. We present a novel methodology employing non-antibody fibrinogen-binding proteins, termed Affimers, to stabilize fibrin networks with the potential to control excessive bleeding. Two fibrinogen-specific Affimer proteins, F5 and G2, were identified and characterized for their effects on clot structure/fibrinolysis using turbidimetric and permeation analyses, confocal and electron microscopy...
December 13, 2018: Blood
https://www.readbyqxmd.com/read/30543964/ferric-sludge-derived-from-the-process-of-water-purification-as-an-efficient-catalyst-and-or-support-for-the-removal-of-volatile-organic-compounds
#13
Rut Sanchis, Ana Dejoz, Isabel Vázquez, Enrique Vilarrasa-García, José Jiménez-Jiménez, Enrique Rodríguez-Castellón, José M López Nieto, Benjamín Solsona
Ferric chloride solutions are used as coagulants or flocculants in water treatment operations for human consumption. This treatment produces large amounts of clay-type solids formed mainly of montmorillonite with iron oxides and humic substances. This ferric sludge can be used as an efficient catalyst for the removal of volatile organic compounds (VOCs) by total oxidation. This waste isolated in the purification process has been activated by calcinations in air, characterized by several physicochemical techniques and employed as a catalyst for the removal by total oxidation of representative VOCs: toluene, propane and mixtures of toluene/propane with or without water...
December 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/30543791/correlation-between-active-disease-and-hypercoagulability-state-in-patients-with-systemic-lupus-erythematosus
#14
Karine Silvestre Ferreira, Walter Batista Cicarini, Luan Carlos Vieira Alves, Cristina de Mello Gomide Loures, Fernanda Magalhães Freire Campos, Luara Isabela Dos Santos, Marcos Vinícius Ferreira da Silva, Tânia Mara Dabés Guimarães, Vicente de Paulo Coelho Peixoto de Toledo, Edna Afonso Reis, Claudia Lopes Santoro Neiva, Renato Vargas Consoli, Paulo Madureira de Pádua, Maria das Graças Carvalho
OBJECTIVE: This study has investigated whether high levels of Reticulocytes-C4d (R-C4d) and Platelets-C4d (P-C4d) reflecting recent activity in SLE patients are correlated with changes in natural anticoagulation components, coagulation activation and endothelial injury markers. METHODS: This study included three groups: 1) healthy women (control, n = 30); 2) women with low activity of the disease (SLEDAI 2 K ≤ 4, n = 30); 3) women with active disease (moderate or high activity) (SLEDAI 2 K > 4, n = 30)...
December 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30543740/-a-case-of-refractory-hemorrhagic-cystitis-in-which-bleeding-control-was-finally-achieved-by-cystectomy
#15
Wakako Yorozuya, Atsushi Takahashi, Akio Takayanagi, Ko Okabe, Yoshio Takagi
A 60-year-old man presented at our hospital with gross hematuria. He had been treated for nephrotic syndrome with cyclophosphamide and steroids since he was in his 20s. We detected diffuse hemorrhagic cystitis on cystoscopy and diagnosed him with cyclophosphamide-induced hemorrhagic cystitis. He was hospitalized due to clot retention. We treated him with blood transfusion for severe anemia and conducted continuous bladder irrigation. We performed hyperbaric oxygen therapy and transurethral electric coagulation, and increased the steroid dose...
October 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/30542801/prevention-and-management-of-bleeding-episodes-in-patients-with-acquired-hemophilia-a
#16
Paul Knöbl
Acquired hemophilia A (AHA) is a rare autoimmune disease caused by autoantibodies inhibiting the function of coagulation factor VIII. It is characterized by spontaneous bleeding in patients with no previous family or personal history of bleeding. Although several large registries have collected clinical data on AHA, limited information is available on the optimal management of AHA because controlled clinical trials are lacking. AHA can easily be diagnosed if the problem (prolonged activated partial thromboplastin time in a bleeding patient) is recognized...
December 2018: Drugs
https://www.readbyqxmd.com/read/30542696/identifying-the-key-genes-and-micrornas-in-colorectal-cancer-liver-metastasis-by-bioinformatics-analysis-and-in-vitro-experiments
#17
Tao Zhang, Jianrong Guo, Jian Gu, Zheng Wang, Guobin Wang, Huili Li, Jiliang Wang
Colorectal cancer (CRC) is one of the principal causes of cancer‑associated mortality worldwide. The high incidence of liver metastasis is the leading risk factor of mortality in patients with CRC, and the mechanisms of CRC liver metastasis are poorly understood. In the present study, 7 datasets, including 3 gene expression profile datasets and 4 microRNA (miRNA) expression profile datasets were downloaded from the NCBI Gene Expression Omnibus (GEO) database to identify potential key genes and miRNAs, which may be candidate biomarkers for CRC liver metastasis...
November 1, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30542645/the-differences-between-childhood-and-adult-onset-antiphospholipid-syndrome
#18
REVIEW
Chris Wincup, Yiannis Ioannou
Antiphospholipid syndrome (APS) is a rare autoimmune disease of unknown etiology that represents a leading cause of acquired thromboembolism and recurrent miscarriage. It is characterized by the persistent elevated presence of pathogenic antiphospholipid auto-antibodies directed against cardiolipin, ß2-glycoprotein-I, and/or a positive lupus anticoagulant test. As with many autoimmune disorders, the pathogenesis of APS is believed to be the result of a complex interaction between environmental triggers and genetic predisposition...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/30542426/effects-of-permanent-cardiac-pacemaker-implantation-on-vascular-endothelial-function-blood-coagulation-and-cardiac-function-in-patients-with-bradycardia
#19
Xinling Zhang, Yan Li, Nan Wang, Chunxiang Zhang, Debing Zhang, Qiang Li
Changes in vascular endothelial function, blood coagulation and cardiac function indexes after the implantation of a permanent cardiac pacemaker in patients with bradycardia were investigated. A total of 53 healthy people and 117 patients with bradycardia in Jining First People's Hospital from January 2015 to August 2017 were selected. Factor VIII: coagulation (FVIII:C), von Willebr and factor (vWF), antithrombin activity (AT:A), D-dimmer (D-D), thrombomodulin (TM), tissue factor (TF), left ventricular ejection fraction (LVEF) and left ventricular end-systolic volume (LVESV) in the non-pacemaker group and the pacemaker group were significantly different from those in the control group (P<0...
December 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30542425/effect-and-clinical-value-of-coagulation-test-on-adverse-reactions-of-blood-transfusion-in-patients-with-major-bleeding-in-ectopic-pregnancy
#20
Fanjiu Kong, Yingbo Li, Xiaoxin Liu
Influence and clinical value of coagulation test on adverse reactions of blood transfusion in patients with major bleeding of ectopic pregnancy were analyzed. Six hundred and twenty-seven cases of ectopic pregnancy admitted to Zibo First Hospital from July 2014 to March 2017 were retrospectively analyzed. The 369 patients who had adverse reactions after blood transfusion were selected as the experimental group. Another 258 patients without adverse reaction after blood transfusion were selected as the control group...
December 2018: Experimental and Therapeutic Medicine
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