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coagulation ,coagulate

Ramesh Kumar, Divendu Bhushan, Mukesh Kumar
A 24-year-old male who presented to our emergency department with the history of having ingested mercury due to accidental breakage of the tip of mercury thermometer. He had 3 bouts of vomiting following ingestion; however, mercury beads were not seen in the vomitus. On admission, the patient was clinically stable, and his physical and systemic examinations were unremarkable. His routine investigations which included complete blood count, liver function test, kidney function tests, coagulation profiles, blood glucose, and electrocardiogram were normal...
January 2018: Journal of the Association of Physicians of India
Yu Lu, Makoto Harada, Yuji Kamijo, Takero Nakajima, Naoki Tanaka, Eiko Sugiyama, Mamoru Kyogashima, Frank J Gonzalez, Toshifumi Aoyama
Peroxisome proliferator-activated receptor α (PPARα) is involved in the regulation of fatty acid and cholesterol metabolism. A high-cholesterol (HC) diet increases the risk of developing cardiovascular diseases (CVD); however, it is unclear whether the toxic effects of cholesterol involve changes in thrombotic factor expression, and whether PPARα is necessary for such effects. To investigate this possibility, we fed a HC diet to wild-type (WT) and Ppara-null mice and measured cholesterol and triglyceride contents, liver histology, serum/plasma levels of coagulation factors, hepatic expression of the coagulation factors, liver/serum sulfatide levels, hepatic sulfatide metabolism, hepatic expression of lipid transporters, and hepatic oxidative stress and its relating enzymes...
October 19, 2018: Archives of Toxicology
Xueren Gao, Xixi Wang, Shulong Zhang
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. Up to date, HCC pathogenesis has not been fully understood. The aim of the present study was to identify crucial genes and pathways associated with HCC by bioinformatics methods. The differentially expressed genes (DEGs) between 14 HCC tissues and corresponding non-cancerous tissues were identified using limma package. Gene Ontology (GO) and KEGG pathway enrichment analysis of DEGs were performed by clusterProfiler package...
October 19, 2018: Bioscience Reports
Moxi Xue, Baoyu Gao, Ruihua Li, Jianzhang Sun
Aluminum formate (AF), a degradable and non-corrosive coagulant, was synthesized from aluminum hydroxide and formic acid. Polyamidine (PA), as a coagulation aid, was combined with AF for dye wastewater treatment. AF was characterized by XPS, FT-IR, viscosity, zeta potential, mass spectrum and XRD, and the flocculation properties of the dual-coagulation system were characterized by FT-IR and SEM. The results showed that COOH, Al2 O3 -Al and O2 -Al bonds were formed in the AF synthesis process, and AF had a higher molecular weight and higher charge neutralization ability than PAC...
December 2018: Journal of Environmental Sciences (China)
Xinxin Guo, Xu Qian, Yili Wang, Huaili Zheng
In this study, a magnetic micro-particle conditioning-pressurized vertical electro-osmotic dewatering (MPEOD) process with magnetic micro-particle conditioning-drainage under gravity-mechanical compression-electrical compression (MMPC-DG-MC-EC) stages was established to study the distribution and migration of water, extracellular polymeric substances (EPS), and other organic matter in the activated sludge (AS) matrix at each stage. Results showed that the MPEOD process could attain 53.52% water content (WC) in dewatered AS with bound water (BW) and free water (FW) reduction rates of 82...
December 2018: Journal of Environmental Sciences (China)
Raissa L Davis, Geunho Choi, Thijs Kuiken, Pascale Quéré, Sascha Trapp, Kirsty R Short, Mathilde Richard
BACKGROUND: Endothelial cells play a major role in highly pathogenic avian influenza (HPAI) virus pathogenesis in gallinaceous poultry species (e.g. chicken, turkey and quail). Upon infection of gallinaceous poultry with HPAI viruses, endothelial cells throughout the body become rapidly infected, leading to systemic dissemination of the virus, disseminated intravascular coagulation, oedema and haemorrhaging. In contrast, the pathogenesis of HPAI viruses in most wild bird species (e.g...
October 19, 2018: BMC Microbiology
Zhujian Huang, Beini Gong, Chin-Pao Huang, Shu-Yuan Pan, Pingxiao Wu, Zhi Dang, Pen-Chi Chiang
Emerging pollutants introduced into surface water pose potential hazards to the safety of drinking water. In this study, the removal performance of three emerging compounds (exemplified by caffeine, diclofenac and octylphenol, with different physico-chemical properties) from synthetic water and source water by combining activated carbon (AC) adsorption and nanofiltration (NF) membrane processes was evaluated and analyzed. Results from synthetic water showed that the adsorption isotherms modeled well with the Langmuir equation...
October 16, 2018: Journal of Environmental Management
Annukka S Vahtera, Eija K Junttila, L Ville Jalkanen, Heini S Huhtala, Ksenia V Katanandova, Pauli T Hélen, Anne H Kuitunen
OBJECTIVES: Aneurysmal subarachnoid haemorrhage (aSAH) is reported to actuate blood coagulation. Rotational thromboelastometry (ROTEM®) is a dynamic haemostatic test that can differentiate various coagulation abnormalities, for example, increased coagulation activity can be detected as a wider amplitude of tracing (maximal clot firmness [MCF]). Previously, ROTEM® has not been used to evaluate coagulation changes after aSAH. The aim of this prospective, observational study was to evaluate the on-going coagulation process in patients with aSAH by comparing their ROTEM assay results to the control values obtained from patients undergoing clipping of non-ruptured aneurysms...
October 16, 2018: World Neurosurgery
Jeffrey W Shupp, Kathleen E Brummel-Ziedins, Mitchell J Cohen, Kalev Freeman, Rasha Hammamieh, Uma S Mudunuri, Thomas Orfeo, Lauren T Moffatt, Bernard H Brownstein, Kenneth G Mann, Marti Jett, Anthony E Pusateri
INTRODUCTION: Provisioning care for traumatically injured patients makes conducting research very proximal to injury difficult. These studies also inherently have regulatory barriers to overcome. Here we outline a protocol for acute-phase enrollment of traumatically injured patients into a prospective observational clinical trial with precise and comprehensive sample acquisition in support of a systems biology approach to a research study. METHODS: Experts in trauma, burn, blood coagulation, computational biology, and integrative systems biology developed a prospective study that would capture the natural history of coagulation pathology after traumatic injury...
October 18, 2018: Shock
Jinghui Zhang, Hong Yang, Wei Li, Yang Wen, Xingmin Fu, Jing Chang
Anaerobic digestion with thermal hydrolysis pretreatment (THP), also called advanced anaerobic digestion (AAD), is a mainstream technology for sludge treatment. AAD changes sludge, it can degrade extracellular polymeric substances (EPS), release EPS from the sludge, and alter the particle size distribution. We synthesized PFS-PDMDAAC from the inorganic coagulant polyferric sulfate (PFS) and the organic coagulant polymer polydimethyldiallylammonium chloride (PDMDAAC) in various PFS:PDMDAAC weight ratios. We investigated the effects of PFS-PDMDAAC pretreatment on AAD sludge dewaterability, and developed an explanation for them...
October 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Joseph S Biedermann, Willem M Lijfering
No abstract text is available yet for this article.
October 18, 2018: European Heart Journal
Francesco Paciullo, Paolo Gresele
No abstract text is available yet for this article.
October 18, 2018: European Heart Journal
Yang Gao, Ke Chen, Xue Mei Ren, Ahmed Alsaedi, Tasawar Hayat, Changlun Chen
In this study, the aggregation kinetics, aggregate morphology and aggregation mechanisms of graphene oxide (GO) in the presence of Cs¬+, Sr2+, UO22+, Eu3+, or Th4+ were characterized by using time-resolved dynamic light scattering, transmission electron microscopy-element mapping, re-dispersion of GO aggregate, and the density functional theory calculations. The destabilization capability of Cs¬+, Sr2+, UO22+, Eu3+, and Th4+ and the corresponding critical coagulation concentrations values were obtained for the first time...
October 19, 2018: Environmental Science & Technology
Mark Crowther, Adam Cuker
The direct oral anticoagulants (DOACs), or non-vitamin K antagonist oral anticoagulants (NOACs), including dabigatran, which inhibits thrombin, and rivaroxaban, apixaban, edoxaban, and betrixaban, which inhibit coagulation factor Xa, are associated with similar or lower risk of bleeding compared with warfarin. The need for reversal of their anticoagulant effect may occur in patients with life-threatening bleeding or those requiring urgent surgery. Currently, the only specific reversal agent for dabigatran, idarucizumab is widely available, while andexanet alfa, which reverses factor Xa inhibitors, was approved in the US in May 2018...
October 19, 2018: Kardiologia Polska
Linxiao Wu, Adrián Magaz, Tao Wang, Chaozong Liu, Arnold Darbyshire, Marilena Loizidou, Mark Emberton, Martin Birchall, Wenhui Song
This article contains data related to the research article entitled "Stiffness memory of indirectly 3D-printed elastomer nanohybrid regulates chondrogenesis and osteogenesis of human mesenchymal stem cells" [1] (Wu et al., 2018). Cells respond to the local microenvironment in a context dependent fashion and a continuous challenge is to provide a living construct that can adapt to the viscoelasticity changes of surrounding tissues. Several materials are attractive candidates to be used in tissue engineering, but conventional manufactured scaffolds are primarily static models with well-defined and stable stiffness that lack the dynamic biological nature required to undergo changes in substrate elasticity decisive in several cellular processes key during tissue development and wound healing...
December 2018: Data in Brief
C Q Li, D X Wang, X Y Wei
Congenital fibrinogen deficiency is an autosomal recessive or dominant disorder in which quantitative (afibrinogenaemia or hypofibrinogenaemia) or qualitative (dysfibrinogenaemia) defects in the fibrinogen Aa, Bb or c protein chains that lead to reduced functional fibrinogen. We now report the perioperative management of 4 pregnant women suffering from hypofibrinogenaemia scheduled for elective caesarean section from December 2012 to October 2016 in Peking University First Hospital and review this disease with reference to classification, symptom, replacement therapy, and selection of the modes of pregnancy termination and anesthesia...
October 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Rio S Boothello, Nirmita J Patel, Chetna Sharon, Elsamani I Abdelfadiel, Shravan Morla, Donald F Brophy, H Robert Lippman, Umesh R Desai, Bhaumik B Patel
Targeting of cancer stem cells (CSCs) is expected to be a paradigm-shifting approach for the treatment of cancers. Cell surface proteoglycans bearing sulfated glycosaminoglycan (GAG) chains are known to play a critical role in the regulation of stem cell fate. Here, we show for the first time that G2.2, a sulfated non-saccharide GAG mimetic (NSGM) of heparin hexasaccharide, selectively inhibits colonic CSCs in vivo. G2.2 reduced CSCs (CD133+/CXCR4+, Dual hi) induced HT-29 and HCT 116 colon xenografts' growth in a dose-dependent fashion...
October 18, 2018: Molecular Cancer Therapeutics
Ludek Slavik, Jiri Lukes, David Friedecky, Monika Zhanelova, Marketa Nemcova, Jana Ulehlova, Jana Prochazkova, Antonin Hlusi, Miroslava Palova, Jan Vaclavik
BACKGROUND: Detection of new oral anticoagulant (NOAC) levels by screening, special and global tests, and liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) is important in clinical situations when the cause of bleeding needs to be determined. METHODS: We compared a routine coagulation test, special function test for NOACs, global coagulation test, and an LC-MS/MS method that enables simultaneous determination of apixaban, dabigatran and rivaroxaban in human plasma within one analysis to determine the optimal indication of the comparison methods, including their limitations and interferences...
October 1, 2018: Clinical Laboratory
Fatma Ersöz, Mehmet İnan
Milk-clotting enzymes used in the dairy industry can be obtained from different sources such as plants, animals, and microorganisms. Recombinant chymosin is the best alternative for the dairy industry due to the differences in physicochemical properties of coagulating enzymes and scarcity of chymosin from animal sources. In this study, glycosylated and non-glycosylated forms of yak chymosin were extracellularly produced in a methylotrophic yeast, Komagataella phaffii (Pichia pastoris). Synthetic yak prochymosin genes were cloned into the pPICZαA vector, expressed in P...
October 15, 2018: Protein Expression and Purification
Chun-Xiang Geng, Na Cao, Wei Xu, Chen He, Zi-Wen Yuan, Jin-Wei Liu, Quan Shi, Chun-Ming Xu, Si-Tong Liu, Hua-Zhang Zhao
Coagulation is an important process to remove organics from water. The molecular composition and structure of organic matter influence water quality in many ways, and the lack of information regarding the organics removed by different coagulants makes it challenging to optimize coagulation processes and ensure reclaimed water safety. In this paper, we investigated coagulation of secondary biological effluent from a municipal sewage treatment plant with different coagulants. We emphasized investigation of organics removal characteristics at the molecular level using Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR MS) coupled with electrospray ionization (ESI)...
October 18, 2018: Environmental Science & Technology
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