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https://www.readbyqxmd.com/read/30107039/isolated-schistosoma-mansoni-eggs-prevent-allergic-airway-inflammation
#1
Katja Obieglo, Martijn J Schuijs, Arifa Ozir-Fazalalikhan, Frank Otto, Yolanda van Wijck, Louis Boon, Bart N Lambrecht, Christian Taube, Hermelijn H Smits
Chronic helminth infection with Schistosoma (S.) mansoni protects against allergic airway inflammation (AAI) in mice and is associated with reduced Th2 responses to inhaled allergens in humans, despite the presence of schistosome-specific Th2 immunity. Schistosome eggs strongly induce type 2 immunity and allow to study the dynamics of Th2 versus regulatory responses in the absence of worms. Treatment with isolated S. mansoni eggs by i.p. injection prior to induction of AAI to ovalbumin (OVA)/alum led to significantly reduced AAI as assessed by less BAL and lung eosinophilia, less cellular influx into lung tissue, less OVA-specific Th2 cytokines in lungs and lung-draining mediastinal lymph nodes, and less circulating allergen-specific IgG1 and IgE antibodies...
August 14, 2018: Parasite Immunology
https://www.readbyqxmd.com/read/30035811/egg-allergen-specific-ige-diversity-predicts-resolution-of-egg-allergy-in-the-population-cohort-healthnuts
#2
Thanh D Dang, Rachel L Peters, Jennifer J Koplin, Shyamali C Dharmage, Lyle C Gurrin, Anne-Louise Ponsonby, David J Martino, Melanie Neeland, Mimi L K Tang, Katrina J Allen
BACKGROUND: IgE-mediated egg allergy presents as one of the most common food allergies in children. Measurement of egg white-specific IgE levels in serum or skin prick test has been shown to be a poor predictor of clinical allergy to raw egg white, and also to baked or cooked egg. Recent developments in component resolved diagnostic (CRD) technology have enabled us to improve the way in which we diagnose and predict peanut allergy through examining IgE specificity to individual peptides...
July 23, 2018: Allergy
https://www.readbyqxmd.com/read/30033989/-development-of-a-method-for-simultaneous-analysis-of-egg-and-milk-major-allergens-in-beverage-products-using-high-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#3
Azusa Yamashita, Yasuhisa Miyamoto, Koichi Harayama, Koji Suzuki
A method for simultaneous analysis of egg and milk allergens using LC-QTOF-MS was developed. The proteins measured were α-casein, β-lactoglobulin, and ovalbumin, which are the main protein allergens in milk and eggs. The proteins were digested using trypsin, and the digests were analyzed by LC-QTOF-MS. Sixteen peaks were detected that confirmed the amino acid sequences of the digests, and a MRM method with high resolution (MRM-HR) using product ions of these peaks was applied for quantification. Next, validation studies were performed using beverage products to which milk and egg standard protein solutions had been added...
2018: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/30024817/bifidobacterium-animalis-subspecies-lactis-modulates-the-local-immune-response-and-glucose-uptake-in-the-small-intestine-of-juvenile-pigs-infected-with-the-parasitic-nematode-ascaris-suum
#4
Gloria Solano-Aguilar, Terez Shea-Donohue, Kathleen B Madden, Alejandro Quinoñes, Ethiopia Beshah, Sukla Lakshman, Yue Xie, Harry Dawson, Joseph F Urban
An evaluation of a localized intestinal allergic type-2 response concomitant with consumption of probiotic bacteria is not well documented. This study investigated the effect of feeding probiotic Bifidobacterium animalis subspecies lactis (Bb12) or a placebo in weaned pigs that were also inoculated with Ascaris suum (A. suum) eggs to induce a strong Th2-dependent allergic type 2 immune response. Sections of jejunal mucosa were mounted in Ussing chambers to determine changes in permeability and glucose absorption, intestine and liver samples were collected for analysis of type-2 related gene expression, jejunum examined histologically, and sera and intestinal fluid were assayed for parasite antigen specific antibody...
July 19, 2018: Gut Microbes
https://www.readbyqxmd.com/read/30024695/frequency-of-food-hypersensitivity-in-patients-with-functional-gastrointestinal-disorders
#5
F W Ismail, S Abid, S Awan, F Lubna
BACKGROUND AND STUDY AIMS: Food hypersensitivity (FH), irritable bowel syndrome (IBS) and functional dyspepsia (FD) have many overlapping symptoms, including abdominal discomfort, bloating, and altered bowel habits. We aimed to determine the frequency of FH in patients with IBS and functional FD. PATIENTS AND METHODS: Adult patients of either gender diagnosed with IBS and/or FD as per the Rome III criteria were recruited. Patients underwent serological testing against 6 food allergens: beef, shrimp, egg white, milk, peanut, and soy-bean...
April 2018: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29977439/debates-in-allergy-medicine-oral-immunotherapy-shortens-the-duration-of-milk-and-egg-allergy-the-con-argument
#6
Wenyin Loh, Mimi L K Tang
Oral immunotherapy (OIT) has been shown to be effective for inducing desensitization in children with cow's milk and egg allergy. In contrast, there is limited evidence that OIT can induce tolerance or sustained unresponsiveness in food allergic patients. Sustained unresponsiveness, determined by a food challenge following a period of secondary avoidance, has been suggested to reflect a more enduring state of tolerance and is pertinent when considering the ability of OIT to shorten the duration of food allergy...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29977438/debates-in-allergy-medicine-does-oral-immunotherapy-shorten-the-duration-of-milk-and-egg-allergy-the-pro-argument
#7
REVIEW
Valentina Pecora, Rocco Luigi Valluzzi, Maurizio Mennini, Vincenzo Fierro, Lamia Dahdah
The development of oral tolerance or food allergy is an active process, related to dynamic interactions between host immune cells, microbiome, dietary factors, and food allergens. Oral tolerance is the default immune response in the gut. A food allergy occurs when this process fails and a pathologic Th2 response is activated. Oral food immunotherapy (OIT) aims to restore immune tolerance in food-allergic individuals. The stimulation of Tregs production seems to represent a crucial step in inducing long-term tolerance, but other mechanisms (e...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29977437/prenatal-omega-3-lcpufa-and-symptoms-of-allergic-disease-and-sensitization-throughout-early-childhood-a-longitudinal-analysis-of-long-term-follow-up-of-a-randomized-controlled-trial
#8
K P Best, T R Sullivan, D J Palmer, M Gold, J Martin, D Kennedy, M Makrides
Background: Randomized controlled trials of prenatal omega (ω-3) long chain polyunsaturated fatty acid (LCPUFA) supplementation are suggestive of some protective effects on allergic sensitization and symptoms of allergic disease in childhood. Due to the nature of the atopic march, investigation of any effects of this prenatal intervention may be most informative when consistently assessed longitudinally during childhood. Methods: Follow-up of children ( n  = 706) with familial risk of allergy from the Docosahexaenoic Acid to Optimize Mother Infant Outcome (DOMInO) trial...
2018: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29974523/gal-d-1-specific-ige-predicts-allergy-to-heated-egg-in-finnish-children
#9
Kati Palosuo, Anna Kaarina Kukkonen, Anna Susanna Pelkonen, Mika Juhani Mäkelä
BACKGROUND: Allergen-specific IgE levels can be useful in predicting outcomes of oral food challenges, but optimal cutoff levels vary in different populations. The aim was to determine cutoff values for egg white and Gal d 1,2,3, and 4 -specific IgE (sIgE) predicting positive oral heated egg challenges in 185 Finnish children and adolescents. METHODS: 185 egg-sensitized patients (age 1-19 years, median 6.3, mean 7.0 years) with suspected egg allergy underwent double-blind, placebo-controlled (n=78) or open (n=107) oral food challenges with heated egg white...
July 3, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29946340/prevalence-of-food-allergens-sensitization-and-food-allergies-in-a-group-of-allergic-honduran-children
#10
Victoria Alejandra Gonzales-González, Adolfo Martin Díaz, Karla Fernández, María Félix Rivera
Background: Food allergy is a public health problem that has increased in the last decade. Despite the increasing rates in children, quality data on the burden of these diseases is lacking particularly in developing countries. Honduras has no studies in pediatric patients. Objectives: The objective of this research was to identify the most common sensitization patterns to food through epicutaneous skin testing and food allergy rates in children and their correlation with common allergic diseases in a group of patients from Hospital of Pediatrics Maria...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29936683/the-role-of-dust-mites-in-allergy
#11
REVIEW
Jeffrey D Miller
House dust mites are an unsurpassed cause of atopic sensitization and allergic illness throughout the world. The major allergenic dust mites Dermatophagoides pteronyssinus, Dermatophagoides farinae, Euroglyphus maynei, and Blomia tropicalis are eight-legged members of the Arachnid class. Their approximately 3-month lifespan comprises egg, larval, protonymph, tritonymph, and adult stages, with adults, about one fourth to one third of a millimeter in size, being at the threshold of visibility. The geographic and seasonal distributions of dust mites are determined by their need for adequate humidity, while their distribution within substrates is further determined by their avoidance of light...
June 23, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29895783/immunological-comparison-of-native-and-recombinant-hen-s-egg-yolk-allergen-chicken-serum-albumin-gal-d-5-produced-in-kluveromyces-lactis
#12
Chamika De Silva, Pathum Dhanapala, Samuel King, Timothy Doran, Mimi Tang, Cenk Suphioglu
Chicken serum albumin (CSA) is a hen's egg yolk allergen causing IgE-mediated allergy. The objective of this study was to produce a recombinant version of CSA and compare its IgE reactivity to natural CSA (nCSA). CSA was cloned and expressed as a soluble fraction in the yeast Kluyveromyces lactis ( K. lactis ) protein expression system. The gene encoding CSA was amplified with a C -terminal hemagglutinin epitope tag by polymerase chain reaction (PCR) and cloned into the pKLAC2 expression vector prior to transforming into K...
June 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29894999/grass-allergic-children-frequently-show-asymptomatic-low-level-ige-co-sensitization-and-cross-reactivity-to-wheat
#13
Nora Nilsson, Caroline Nilsson, Helena Ekoff, Sandra Wieser-Pahr, Magnus P Borres, Rudolf Valenta, Gunilla Hedlin, Sigrid Sjölander
BACKGROUND: Specific immunoglobulin E (IgE) sensitization to wheat is more common than a doctor's confirmed wheat allergy and is also frequently observed in grass pollen-allergic patients (pollinosis patients). Thus, the objective of this study was to investigate the level and feature of serological IgE cross-reactivity between grass pollen and wheat in a cohort of pollinosis subjects with no diagnosis of wheat allergy. METHODS: Seventy-two children, aged 5-17 years, with a doctor's diagnosis of pollinosis, IgE towards grass pollen, and currently eating wheat were recruited...
June 12, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29876624/eosinophilic-esophagitis-an-underdiagnosed-cause-of-dysphagia-and-food-impaction-to-be-recognized-by-otolaryngologists
#14
REVIEW
C Górriz Gil, V Matallana Royo, Ó Álvarez Montero, A Rodríguez Valiente, C Fernández Manzano, B Conde García, J R García-Berrocal
Eosinophilic esophagitis (EoE) is a recently recognised pathologic entity whose prevalence has risen significantly since first being described in 1993. Defined as a chronic, local immune-mediated disease with predominant eosinophil infiltration, it is nowadays the leading cause of dysphagia and food bolus impaction in children and young adults. Genetic and environmental risk factors, and especially food antigens, trigger the disease and are in the focus of investigation as avoidance can cure three quarters of patients...
June 6, 2018: HNO
https://www.readbyqxmd.com/read/29847815/diets-supplemented-with-1-egg-white-induce-oral-desensitization-and-immune-tolerance-in-an-egg-white-specific-allergic-mouse-model
#15
Akihiro Maeta, Marin Matsushima, Risako Katahira, Natsumi Sakamoto, Kyoko Takahashi
BACKGROUND: The objective of this study was to determine the required concentration of egg white (EW) in the diet to induce oral desensitization and/or immune tolerance within 4 weeks of oral immunotherapy (OIT) in an EW allergic mouse model. METHODS: Female BALB/c mice were systemically sensitized to EW by intraperitoneal injections and subsequently subjected to oral allergen gavage. Sensitized mice were provided 4 weeks of OIT by supplementing with 0 (non-OIT), 0...
2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29805413/detection-and-allergen-analysis-of-serum-ige-in-pediatric-patients-with-chronic-urticaria
#16
Yi Zhou, Minmin Sheng, Mingyan Chen
Objective: To detect the serum IgE and allergen-specific IgE levels of pediatric patients with chronic urticaria, and to analyze the distribution characteristics of allergens. Methods: Ninety-six patients with chronic urticaria admitted in our hospital, which were not administered antihistamine 10 days before detection or glucocorticoid 20 days before detection, were selected. Their serum IgE levels were measured and 34 antigens were analyzed. Results: Ninety-two of the ninety-six patients were detected as serum IgE positive (positive rate: 95...
March 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29798078/-multiple-factor-analysis-of-serum-allergen-distribution-of-patients-with-allergic-rhinitis-and-level-of-main-allergen-ige-in-shenyang-area
#17
Y L Chu, A H Yan, X H Tai, X J Jiang, L Hui, F F Jiang, Y Hu
Objective: To discuss multiple-factor analysis of serum allergen distribution of patients with allergic rhinitis and level of main allergen IgE in Shenyang area, and to provide a scientific basis for the prevention of allergic rhinitis in this area. Method: Serum IgE was detected in 749 cases[501 cases of male (66.8%), and 248 cases of female (33.2%)], with allergic rhinitis.The age range was from 3 to 65 years old, and they were divided into 5 groups based on age. A questionnaire survey was conducted to analyze the distribution of serum allergens and to carry out a multiple-factor analysis of level of the main allergen IgE in patients...
April 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29797412/egg-proteins-fractionation-bioactive-peptides-and-allergenicity
#18
REVIEW
Chang Chang, Todd Lahti, Takuji Tanaka, Michael T Nickerson
Eggs are an important source of macro and micronutrients within the diet, comprised of proteins, lipids, vitamins, and minerals. They are constituted by a shell, the white (containing 110 g kg-1 proteins: ovalbumin, ovotransferrin, ovomucoid, lysozyme and ovomucin), and the yolk (containing 150-170 g kg-1 proteins: lipovitellins, phosvitin, livetins, and low-density lipoproteins). Owing to their nutritional value and biological characteristics, both the egg white and yolk proteins are extensively fractionated using different techniques (e...
May 23, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29790165/igg1-b-cell-immunity-predates-ige-responses-in-epicutaneous-sensitization-to-foods
#19
Rodrigo Jiménez-Saiz, Yosef Ellenbogen, Joshua Koenig, Melissa E Gordon, Tina D Walker, Domenico Rosace, Paul Spill, Kelly Bruton, Joshua Kong, Kristin Monteiro, Jianping Wen, Elaine I Tuomanen, Roland Kolbeck, Derek K Chu, Susan Waserman, Manel Jordana
BACKGROUND: The generation of IgE-mediated food allergy in humans is silent, and only diagnosed upon manifestation of clinical symptoms. While experimental models have been used to investigate some mechanisms of allergic sensitization, the generation of humoral immunity and memory remain to be elucidated. Here, we defined the evolution of allergen-specific B cell responses during epicutaneous sensitization to foods. METHODS: Wild-type and genetic knockout animals, and drug or antibody strategies for cell depletion and immunoglobulin signaling blockade were used to investigate epicutaneous sensitization and disease progression; we analyzed allergen-specific germinal centers and IgG1+ memory B cells by flow cytometry, evaluated humoral responses and determined clinical reactivity (anaphylaxis)...
May 22, 2018: Allergy
https://www.readbyqxmd.com/read/29766369/nutritional-issues-in-food-allergy
#20
REVIEW
Isabel J Skypala, Rebecca McKenzie
Diet and nutrition play an important role in the development and management of food allergy. The diet of expectant mothers can have an effect on their offspring in terms of allergic outcomes. A host of confounding factors may influence this, with a maternal diet rich in fruits and vegetables, fish, vitamin D-rich foods associated with a lower risk of allergic disease in their children. More surprisingly, the consumption of milk and butter has also been shown to have a protective effect, especially in a farm environment...
May 15, 2018: Clinical Reviews in Allergy & Immunology
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