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Egg allergens

A A Eapen, K M Kloepfer, F E Leickly, J E Slaven, G Vitalpur
BACKGROUND: Recent studies have suggested that removing foods from the diet to manage atopic dermatitis (AD), based on positive allergy tests, may lead to immediate allergic reactions on reintroduction of that food. OBJECTIVE: The purpose of this study was to examine the frequency of oral food challenge (OFC) failures among foods removed from the diet as suspected AD triggers, focusing on the five major food allergens in the US. METHODS: OFCs to egg, milk, peanut, soy, and wheat, performed from 2008-14, at a children's hospital's allergy clinics, were reviewed...
October 13, 2018: Annals of Allergy, Asthma & Immunology
Natasha Purington, R Sharon Chinthrajah, Andrew Long, Sayantani Sindher, Sandra Andorf, Katherine O'Laughlin, Margaret A Woch, Alexandra Scheiber, Amal Assa'ad, Jacqueline Pongracic, Jonathan M Spergel, Jonathan Tam, Stephen Tilles, Julie Wang, Stephen J Galli, Manisha Desai, Kari C Nadeau
Background: Food allergy prevalence has continued to rise over the past decade. While studies have reported threshold doses for multiple foods, large-scale multi-food allergen studies are lacking. Our goal was to identify threshold dose distributions and predictors of severe reactions during blinded oral food challenges (OFCs) in multi-food allergic patients. Methods: A retrospective chart review was performed on all Stanford-initiated clinical protocols involving standardized screening OFCs to any of 11 food allergens at 7 sites...
2018: Frontiers in Immunology
Manuel Jorge Rial, Marcela Valverde-Monge, Aida Gómez-Cardeñosa, Rosialzhira Vera-Berríos, Carlos Pastor-Vargas, Javier Cuesta-Herranz
No abstract text is available yet for this article.
October 5, 2018: Journal of Allergy and Clinical Immunology in Practice
Michael S Benninger, Thomas Daly, Kevin Graffmiller
Rates of allergy-test positivity vary by country and by regions within countries. Several studies have looked at allergy test results to determine the most common allergens. Many of these studies have been based on surveys or on studies of small numbers of tests. Positivity rates for allergy tests are poorly defined in the northern midwestern region of the United States. We conducted a study to identify the rates of positive allergy tests for both inhalant/respiratory allergens and food allergens in the upper Midwest...
September 2018: Ear, Nose, & Throat Journal
Runar Almaas, Svanhildur Haflidadottir, Runa Helen Kaldestad, Iren Lindbak Matthews
OBJECTIVES: To describe the prevalence and the relationship between asthma, eczema, food allergy, and rhinitis in children after liver transplantation. STUDY DESIGN: Children who were liver transplant recipients were investigated to assess whether the high prevalence of food allergies was accompanied by eczema, rhinitis, and asthma. Furthermore, we included 56 children with chronic liver disease to explore the risk of allergy, eczema, and asthma in this group. RESULTS: After liver transplantation, children had higher prevalence of allergic reactions to food as compared with children with chronic liver disease (P < ...
September 27, 2018: Journal of Pediatrics
Susan Waserman, Philippe Bégin, Wade Watson
Food allergy is defined as an adverse immunologic response to a food protein. Food-related reactions are associated with a broad range of signs and symptoms that may involve any body system, including the skin, gastrointestinal and respiratory tracts, and cardiovascular system. Immunoglobulin E (IgE)-mediated food allergy is a leading cause of anaphylaxis and, therefore, referral to an allergist for timely and appropriate diagnosis and treatment is imperative. Diagnosis entails a careful history and diagnostic tests, such as skin prick tests, serum-specific IgE and, if indicated, an oral food challenge...
2018: Allergy, Asthma, and Clinical Immunology
Zi-Wei Liao, Yun-Hua Ye, Hui Wang, Yang Chen, Xiao-Mei Sha, Lu Zhang, Tao Huang, Yue-Ming Hu, Zong-Cai Tu
Ovalbumin is one of the most important sensitizing ingredients in allergens of egg albumin, which restricts the application of egg in the field of food processing. Previous research has indicated that glycation could cause the protein to partially expand, which may bring about the destruction of the structural IgG and IgE epitopes and induce the decline of the IgG- and IgE-binding ability of ovalbumin. In this research, the effect of a preheating treatment integrated with glycation on the IgG- and IgE-binding capability and the conformation changes of ovalbumin was studied by detecting the glycated sites and the values of degree of substitution per peptide (DSP) by liquid chromatography and high-resolution mass spectrometry (LC-HRMS)...
October 5, 2018: Journal of Agricultural and Food Chemistry
Wenyin Loh, Mimi L K Tang
There is a lack of high-quality evidence based on the gold standard of oral food challenges to determine food allergy prevalence. Nevertheless, studies using surrogate measures of food allergy, such as health service utilization and clinical history, together with allergen-specific immunoglobulin E (sIgE), provide compelling data that the prevalence of food allergy is increasing in both Western and developing countries. In Western countries, challenge-diagnosed food allergy has been reported to be as high as 10%, with the greatest prevalence noted among younger children...
September 18, 2018: International Journal of Environmental Research and Public Health
Akihiro Maeta, Risako Katahira, Marin Matsushima, Haruka Onishi, Yu Nakamura, Kyoko Takahashi
We examined whether the stepwise oral immunotherapy (OIT) for 10 days ameliorates the severity of allergy and the biomarkers in an allergy mouse model. The OIT could not protect anaphylaxis symptoms after allergen challenges but promote the production of antibodies, especially allergen-specific IgA. It was suggested that this OIT influenced the function of immuno response against the allergen. ABBREVIATIONS: EW: egg white; IFC: intraperitoneal food challenge; IFN-γ: interferon-γ; IL: interleukin; OVA: ovalbumin; OM: ovomucoid; OFC: oral food challenge; OIT: oral immunotherapy...
September 19, 2018: Bioscience, Biotechnology, and Biochemistry
Diana Aguilar-Jasso, Francisco Valdez-López, Jaime Guadalupe Valle-Leal, Juan Aguilar-Jasso, Julio César Del Hierro-Yepo, Natalia Lizola-Arvizu
BACKGROUND: Food allergy is an adverse reaction secondary to a specific immune response after exposure to a food. Knowing the natural course of food allergies is essential for opportune diagnosis and treatment. OBJECTIVE: To know the clinical profile of children diagnosed with food allergy attended to at the pediatric allergology department of a secondary care hospital. METHODS: Cross-sectional study of medical records of children with a confirmed diagnosis of food allergy...
July 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
Yuqin Lu, Shuiming Li, Haoxie Xu, Tingting Zhang, Xiao Lin, Xuli Wu
Ovalbumin (OVA) is a major allergen in avian egg white. Here, we investigated the conjugation of OVA and chlorogenic acid (CHA) to reduce the allergenic capacity of OVA. OVA-CHA conjugate was characterized by SDS-PAGE, MALDI-TOF-MS, differential scanning calorimetry, and multispectroscopic methods. Sites of the OVA-CHA conjugate were identified by LC-MS/MS. CHA possibly conjugated with Lys20 and Lys17 in OVA, which resulted in the unfolding of OVA. ELISA and Western blot assay indicated that the OVA-CHA conjugate reduced the IgE binding capacity of OVA...
September 19, 2018: Journal of Agricultural and Food Chemistry
Steven L Staal, Sarika K L Hogendoorn, Sophie A Voets, Rebecca C Tepper, Mirte Veenstra, Ivo I de Vos, Koen C van Son, Jari K Gool, Antonia C Paramitha, Kevin Aristyo, Ardy Wildan, Chici Pratiwi, Ronald van Ree, Maria Yazdanbakhsh, Taniawati Supali, Yenny Djuardi, Lucja A Labuda, Dicky L Tahapary, Erliyani Sartono
BACKGROUND: In many rural areas of tropical countries such as Indonesia, the prevalence of soil-transmitted helminths (STH) infections remains high. At the same time, the burden of allergic disorders in such rural areas is reported to be low and inversely associated with helminth infections. To reduce the morbidity and transmission of helminth infections, the world health organization recommends preventive treatment of school children by providing mass drug administration (MDA) with albendazole...
August 21, 2018: International Archives of Allergy and Immunology
Katja Obieglo, Martijn J Schuijs, Arifa Ozir-Fazalalikhan, Frank Otto, Yolanda van Wijck, Louis Boon, Bart N Lambrecht, Christian Taube, Hermelijn H Smits
Chronic helminth infection with Schistosoma (S.) mansoni protects against allergic airway inflammation (AAI) in mice and is associated with reduced Th2 responses to inhaled allergens in humans, despite the presence of schistosome-specific Th2 immunity. Schistosome eggs strongly induce type 2 immunity and allow to study the dynamics of Th2 versus regulatory responses in the absence of worms. Treatment with isolated S. mansoni eggs by i.p. injection prior to induction of AAI to ovalbumin (OVA)/alum led to significantly reduced AAI as assessed by less BAL and lung eosinophilia, less cellular influx into lung tissue, less OVA-specific Th2 cytokines in lungs and lung-draining mediastinal lymph nodes and less circulating allergen-specific IgG1 and IgE antibodies...
October 2018: Parasite Immunology
Thanh D Dang, Rachel L Peters, Jennifer J Koplin, Shyamali C Dharmage, Lyle C Gurrin, Anne-Louise Ponsonby, David J Martino, Melanie Neeland, Mimi L K Tang, Katrina J Allen
BACKGROUND: IgE-mediated egg allergy presents as one of the most common food allergies in children. Measurement of egg white-specific IgE levels in serum or skin prick test has been shown to be a poor predictor of clinical allergy to raw egg white, and also to baked or cooked egg. Recent developments in component resolved diagnostic (CRD) technology have enabled us to improve the way in which we diagnose and predict peanut allergy through examining IgE specificity to individual peptides...
July 23, 2018: Allergy
Azusa Yamashita, Yasuhisa Miyamoto, Koichi Harayama, Koji Suzuki
A method for simultaneous analysis of egg and milk allergens using LC-QTOF-MS was developed. The proteins measured were α-casein, β-lactoglobulin, and ovalbumin, which are the main protein allergens in milk and eggs. The proteins were digested using trypsin, and the digests were analyzed by LC-QTOF-MS. Sixteen peaks were detected that confirmed the amino acid sequences of the digests, and a MRM method with high resolution (MRM-HR) using product ions of these peaks was applied for quantification. Next, validation studies were performed using beverage products to which milk and egg standard protein solutions had been added...
2018: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
Gloria Solano-Aguilar, Terez Shea-Donohue, Kathleen B Madden, Alejandro Quinoñes, Ethiopia Beshah, Sukla Lakshman, Yue Xie, Harry Dawson, Joseph F Urban
An evaluation of a localized intestinal allergic type-2 response concomitant with consumption of probiotic bacteria is not well documented. This study investigated the effect of feeding probiotic Bifidobacterium animalis subspecies lactis (Bb12) or a placebo in weaned pigs that were also inoculated with Ascaris suum (A. suum) eggs to induce a strong Th2-dependent allergic type 2 immune response. Sections of jejunal mucosa were mounted in Ussing chambers to determine changes in permeability and glucose absorption, intestine and liver samples were collected for analysis of type-2 related gene expression, jejunum examined histologically, and sera and intestinal fluid were assayed for parasite antigen specific antibody...
July 19, 2018: Gut Microbes
F W Ismail, S Abid, S Awan, F Lubna
BACKGROUND AND STUDY AIMS: Food hypersensitivity (FH), irritable bowel syndrome (IBS) and functional dyspepsia (FD) have many overlapping symptoms, including abdominal discomfort, bloating, and altered bowel habits. We aimed to determine the frequency of FH in patients with IBS and functional FD. PATIENTS AND METHODS: Adult patients of either gender diagnosed with IBS and/or FD as per the Rome III criteria were recruited. Patients underwent serological testing against 6 food allergens: beef, shrimp, egg white, milk, peanut, and soy-bean...
April 2018: Acta Gastro-enterologica Belgica
Wenyin Loh, Mimi L K Tang
Oral immunotherapy (OIT) has been shown to be effective for inducing desensitization in children with cow's milk and egg allergy. In contrast, there is limited evidence that OIT can induce tolerance or sustained unresponsiveness in food allergic patients. Sustained unresponsiveness, determined by a food challenge following a period of secondary avoidance, has been suggested to reflect a more enduring state of tolerance and is pertinent when considering the ability of OIT to shorten the duration of food allergy...
2018: World Allergy Organization Journal
Valentina Pecora, Rocco Luigi Valluzzi, Maurizio Mennini, Vincenzo Fierro, Lamia Dahdah
The development of oral tolerance or food allergy is an active process, related to dynamic interactions between host immune cells, microbiome, dietary factors, and food allergens. Oral tolerance is the default immune response in the gut. A food allergy occurs when this process fails and a pathologic Th2 response is activated. Oral food immunotherapy (OIT) aims to restore immune tolerance in food-allergic individuals. The stimulation of Tregs production seems to represent a crucial step in inducing long-term tolerance, but other mechanisms (e...
2018: World Allergy Organization Journal
K P Best, T R Sullivan, D J Palmer, M Gold, J Martin, D Kennedy, M Makrides
Background: Randomized controlled trials of prenatal omega (ω-3) long chain polyunsaturated fatty acid (LCPUFA) supplementation are suggestive of some protective effects on allergic sensitization and symptoms of allergic disease in childhood. Due to the nature of the atopic march, investigation of any effects of this prenatal intervention may be most informative when consistently assessed longitudinally during childhood. Methods: Follow-up of children ( n  = 706) with familial risk of allergy from the Docosahexaenoic Acid to Optimize Mother Infant Outcome (DOMInO) trial...
2018: World Allergy Organization Journal
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