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JOURNAL ARTICLE
Dominik Linz, Jason G Andrade, Elena Arbelo, Giuseppe Boriani, Guenter Breithardt, A John Camm, Valeria Caso, Jens Cosedis Nielsen, Mirko De Melis, Tom De Potter, Wolfgang Dichtl, Søren Zoega Diederichsen, Dobromir Dobrev, Nicolas Doll, David Duncker, Elke Dworatzek, Lars Eckardt, Christoph Eisert, Larissa Fabritz, Michal Farkowski, David Filgueiras-Rama, Andreas Goette, Eduard Guasch, Guido Hack, Stéphane Hatem, Karl Georg Haeusler, Jeff S Healey, Hein Heidbuechel, Ziad Hijazi, Lucas H Hofmeister, Leif Hove-Madsen, Thomas Huebner, Stefan Kääb, Dipak Kotecha, Katarzyna Malaczynska-Rajpold, José Luis Merino, Andreas Metzner, Lluís Mont, Ghulam Andre Ng, Michael Oeff, Abdul Shokor Parwani, Helmut Puererfellner, Ursula Ravens, Michiel Rienstra, Prashanthan Sanders, Daniel Scherr, Renate Schnabel, Ulrich Schotten, Christian Sohns, Gerhard Steinbeck, Daniel Steven, Tobias Toennis, Stylianos Tzeis, Isabelle C van Gelder, Roderick H van Leerdam, Kevin Vernooy, Manish Wadhwa, Reza Wakili, Stephan Willems, Henning Witt, Stef Zeemering, Paulus Kirchhof
AIMS: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). METHODS AND RESULTS: Eighty-three international experts met in Münster for 2 days in September 2023...
March 30, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#22
JOURNAL ARTICLE
Takashi Amano, Yuane Jia, Audrey Redding
OBJECTIVES: This study, based on socioemotional selectivity theory and cognitive theory, investigates the dynamic and reciprocal relationship between perceived discrimination and cognitive function in later life. METHODS: Data were drawn from four waves of the Health and Retirement Study (HRS 2006, 2010, 2014, and 2018). A total of 4,125 people who were 51 and older were included. Cognitive function was measured by the telephone interview for cognitive status (TICS-27)...
April 9, 2024: Aging & Mental Health
#23
JOURNAL ARTICLE
Ning Hsieh, Hui Liu, Zhenmei Zhang
OBJECTIVES: Recent studies have found that perceived discrimination as a chronic stressor predicts poorer cognitive health. However, little research has investigated how social relationships as potential intervening mechanisms may mitigate or exacerbate this association. Using a nationally representative sample of U.S. older adults, this study examined how the existence and quality of four types of relationships-with a partner, children, other family members, and friends-may modify the impact of perceived discrimination on incident dementia...
April 8, 2024: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
#24
JOURNAL ARTICLE
SIRT4 promotes neuronal apoptosis in models of Alzheimer's disease via the STAT2-SIRT4-mTOR pathway.
Dianxia Xing, Wenjin Zhang, Wei Cui, Xiuya Yao, Yaping Xiao, Lihua Chen, Shiyun Yuan, Yanyan Duan, Weihua Yu, Pengfei Pan, Yang Lü
Alzheimer's disease (AD) is the leading cause of dementia and presents a considerable disease burden. Its pathology involves substantial neuronal loss, primarily attributed to neuronal apoptosis. Although sirtuin 4 (SIRT4) has been implicated in regulating apoptosis in various diseases, the role of SIRT4 in AD pathology remains unclear. The study employed APP/PS1 mice as an animal model of AD and amyloid-β (Aβ)1-42-treated HT-22 cells as an AD cell model. SIRT4 expression was determined by quantitative real-time polymerase chain reaction, western blot, and immunofluorescence...
April 8, 2024: American Journal of Physiology. Cell Physiology
#25
Dan Vitale, Mathew Koretsky, Nicole Kuznetsov, Samantha Hong, Jessica Martin, Mikayla James, Mary B Makarious, Hampton Leonard, Hirotaka Iwaki, Faraz Faghri, Cornelis Blauwendraat, Andrew B Singleton, Yeajin Song, Kristin Levine, Ashwin Ashok Kumar Sreelatha, Zih-Hua Fang, Mike Nalls
GenoTools, a Python package, streamlines population genetics research by integrating ancestry estimation, quality control (QC), and genome-wide association studies (GWAS) capabilities into efficient pipelines. By tracking samples, variants, and quality-specific measures throughout fully customizable pipelines, users can easily manage genetics data for large and small studies. GenoTools' "Ancestry" module renders highly accurate predictions, allowing for high-quality ancestry-specific studies, and enables custom ancestry model training and serialization, specified to the user's genotyping or sequencing platform...
March 29, 2024: bioRxiv
#26
Chonghua Xue, Sahana S Kowshik, Diala Lteif, Shreyas Puducheri, Varuna H Jasodanand, Olivia T Zhou, Anika S Walia, Osman B Guney, J Diana Zhang, Serena T Pham, Artem Kaliaev, V Carlota Andreu-Arasa, Brigid C Dwyer, Chad W Farris, Honglin Hao, Sachin Kedar, Asim Z Mian, Daniel L Murman, Sarah A O'Shea, Aaron B Paul, Saurabh Rohatgi, Marie-Helene Saint-Hilaire, Emmett A Sartor, Bindu N Setty, Juan E Small, Arun Swaminathan, Olga Taraschenko, Jing Yuan, Yan Zhou, Shuhan Zhu, Cody Karjadi, Ting Fang Alvin Ang, Sarah A Bargal, Bryan A Plummer, Kathleen L Poston, Meysam Ahangaran, Rhoda Au, Vijaya B Kolachalama
Differential diagnosis of dementia remains a challenge in neurology due to symptom overlap across etiologies, yet it is crucial for formulating early, personalized management strategies. Here, we present an AI model that harnesses a broad array of data, including demographics, individual and family medical history, medication use, neuropsychological assessments, functional evaluations, and multimodal neuroimaging, to identify the etiologies contributing to dementia in individuals. The study, drawing on 51, 269 participants across 9 independent, geographically diverse datasets, facilitated the identification of 10 distinct dementia etiologies...
March 26, 2024: medRxiv
#27
JOURNAL ARTICLE
Min Young Chun, Taein Lee, Su Hong Kim, Hye Sun Lee, Yun Joong Kim, Phil Hyu Lee, Young H Sohn, Yong Jeong, Seok Jong Chung
PURPOSE OF THE REPORT: Although early detection of individuals at risk of dementia conversion is important in patients with Parkinson's disease (PD), there is still no consensus on neuroimaging biomarkers for predicting future cognitive decline. We aimed to investigate whether cerebral perfusion patterns on early-phase 18F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (18F-FP-CIT) PET have the potential to serve as a neuroimaging predictor for early dementia conversion in patients with PD...
April 8, 2024: Clinical Nuclear Medicine
#28
JOURNAL ARTICLE
Yanqing Wang, Zimei Wu, Yuyang He, Xiaoying Zeng, Zijuan Gu, Xianxi Zhou, Wenwen Si, Dongfeng Chen
RNA methylation can epigenetically regulate learning and memory. However, it is unclear whether RNA methylation plays a critical role in the pathophysiology of Vascular dementia (VD). Here, we report that expression of the fat mass and obesity associated gene (FTO), an RNA demethylase, is downregulated in the hippocampus in models of VD. Through prediction and dual-luciferase reporters validation studies, we observed that miRNA-711 was upregulated after VD and could bind to the 3'-untranslated region of FTO mRNA and regulate its expression in vitro...
April 3, 2024: Neuropeptides
#29
JOURNAL ARTICLE
Begashaw Melaku Gebresillassie, John Richard Attia, Amanual Getnet Mersha, Melissa L Harris
BACKGROUND: Precise prognostic information, if available, is very helpful for guiding treatment decisions and resource allocation in patients with non-cancer non-communicable chronic diseases (NCDs). This study aimed to systematically review the existing evidence, examining prognostic models and factors for identifying end-of-life non-cancer NCD patients. METHODS: Electronic databases, including Medline, Embase, CINAHL, Cochrane Library, PsychINFO and other sources, were searched from the inception of these databases up until June 2023...
April 5, 2024: BMJ Supportive & Palliative Care
#30
JOURNAL ARTICLE
Alexander Tobias Ysbæk-Nielsen
INTRODUCTION: The progressive nature of Parkinson's disease (PD) affords emphasis on accurate early-stage individual-level assessment of risk and intervention appropriateness. In PD, cognitive impairment (CI) may follow or precede motor symptoms but are generally underdetected. In addition to impeding daily functioning and quality of life, CIs increase the risk for later conversion to dementia, providing a pressing need to develop novel tools to detect and interpret them. Connectome-based predictive modelling (CPM) is an emerging machine-learning approach to individual prediction that holds translational promise due to its noninvasiveness and simple implementation...
February 1, 2024: Parkinsonism & related Disorders
#31
JOURNAL ARTICLE
Martina Wiwie Setiawan Nasrun, Profitasari Kusumaningrum, Khamelia Malik, Widjajalaksmi Kusumaningsih, Kuntjoro Harimurti, Pukovisa Prawiroharjo, Fithriani Salma Mardhiyah, Richard Holman Matanta, Leonardo Alfonsius Paulus Lalenoh, Saarah Khansa Kiasati
In Indonesia, the number of People Living with Dementia (PLWD) is predicted to be rising continuously. PLWD need help operating cell phones for their daily needs. Numerous mobile health applications have been innovated to deliver better dementia care. The objective of this study is to identify the technological acceptance and features needed by PLWD and caregivers in Indonesia. This study started with questionnaire development through focused-group discussion with experts, caregivers and PLWD. It was followed by item development involving experts in geriatrics (psychiatry, internal medicine, medical rehabilitation and neurology) to prepare an online questionnaire...
April 5, 2024: Informatics for Health & Social Care
#32
JOURNAL ARTICLE
Amina H McDiarmid, Katerina O Gospodinova, Richard J R Elliott, John C Dawson, Rebecca E Graham, Marie-Therese El-Daher, Susan M Anderson, Sophie C Glen, Simon Glerup, Neil O Carragher, Kathryn L Evans
Alzheimer's disease accounts for 60-70% of dementia cases. Current treatments are inadequate and there is a need to develop new approaches to drug discovery. Recently, in cancer, morphological profiling has been used in combination with high-throughput screening of small-molecule libraries in human cells in vitro . To test feasibility of this approach for Alzheimer's disease, we developed a cell morphology-based drug screen centred on the risk gene, SORL1 (which encodes the protein SORLA). Increased Alzheimer's disease risk has been repeatedly linked to variants in SORL1 , particularly those conferring loss or decreased expression of SORLA, and lower SORL1 levels are observed in post-mortem brain samples from individuals with Alzheimer's disease...
2024: Brain communications
#33
REVIEW
Sharada Kadaba Sridhar, Jen Dysterheft Robb, Rishabh Gupta, Scarlett Cheong, Rui Kuang, Uzma Samadani
INTRODUCTION: Normal Pressure Hydrocephalus (NPH) is a prominent type of reversible dementia that may be treated with shunt surgery, and it is crucial to differentiate it from irreversible degeneration caused by its symptomatic mimics like Alzheimer's Dementia (AD) and Parkinson's Disease (PD). Similarly, it is important to distinguish between (normal pressure) hydrocephalus and irreversible atrophy/degeneration which are among the chronic effects of Traumatic Brain Injury (cTBI), as the former may be reversed through shunt placement...
2024: Frontiers in Neurology
#34
EDITORIAL
Sudesh Prajapathi, Akshyaya Pradhan
Several anatomical, demographic, clinical, electrocardiographic, procedural, and valve-related variables can be used to predict the probability of developing conduction abnormalities after transcatheter aortic valve replacement (TAVR) that necessitate permanent pacemaker (PPM) implantation. These variables include calcifications around the device landing zone and in the mitral annulus; pre-existing electrocardiographic abnormalities such as left and right bundle branch blocks (BBB), first- and second-degree atrioventricular blocks, as well as bifascicular and trifascicular blocks; male sex; diabetes mellitus (DM); hypertension; history of atrial fibrillation; renal failure; dementia; and use of self-expanding valves...
March 26, 2024: World Journal of Cardiology
#35
JOURNAL ARTICLE
Margherita Grasso, Annamaria Fidilio, Francesca L'Episcopo, Marilena Recupero, Concetta Barone, Maria Giulia Bacalini, Cristina Benatti, Maria Concetta Giambirtone, Giuseppe Caruso, Donatella Greco, Santo Di Nuovo, Corrado Romano, Raffaele Ferri, Serafino Buono, A Claudio Cuello, Johanna M C Blom, Fabio Tascedda, Pier Vincenzo Piazza, Rafael De La Torre, Filippo Caraci
Almost all individuals with Down's syndrome (DS) show the characteristic neuropathological features of Alzheimer's disease (AD) by the age of 40, yet not every individual with DS experiences symptoms of AD later in life. Similar to neurotypical developing subjects, AD in people with DS lasts for a long preclinical phase in which biomarkers follow a predictable order of changes. Hence, a prolonged asymptomatic period precedes the onset of dementia, underscoring the importance of identifying new biomarkers for the early detection and monitoring of cognitive decline in individuals with DS...
2024: Frontiers in Pharmacology
#36
JOURNAL ARTICLE
Seth Sanders, Lynne Steuerle Schofield, L Philip Schumm, Linda Waite
OBJECTIVES: Scholarly, clinical, and policy interest in cognitive function has grown over the last several decades in part due to large increases in Alzheimer's Disease and related dementias as populations age. However, adequate measures of cognitive function have not been available in many research data sets. We argue that a wealth of previously unexploited survey data exists to model cognition and cognitive decline. METHODS: We use metadata of the time it takes older respondents in the National Social Life, Health and Aging Survey, which we label response times (RT), to answer questions in a standard cognitive assessment...
April 5, 2024: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
#37
JOURNAL ARTICLE
Emily C Edmonds, Kelsey R Thomas, Steven Z Rapcsak, Shannon L Lindemer, Lisa Delano-Wood, David P Salmon, Mark W Bondi
INTRODUCTION: Data-driven neuropsychological methods can identify mild cognitive impairment (MCI) subtypes with stronger associations to dementia risk factors than conventional diagnostic methods. METHODS: Cluster analysis used neuropsychological data from participants without dementia (mean age = 71.6 years) in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (n = 26,255) and the "normal cognition" subsample (n = 16,005)...
April 4, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#38
JOURNAL ARTICLE
Ariane Bollack, Lyduine E Collij, David Vállez García, Mahnaz Shekari, Daniele Altomare, Pierre Payoux, Bruno Dubois, Oriol Grau-Rivera, Mercè Boada, Marta Marquié, Agneta Nordberg, Zuzana Walker, Philip Scheltens, Michael Schöll, Robin Wolz, Jonathan M Schott, Rossella Gismondi, Andrew Stephens, Christopher Buckley, Giovanni B Frisoni, Bernard Hanseeuw, Pieter Jelle Visser, Rik Vandenberghe, Alexander Drzezga, Maqsood Yaqub, Ronald Boellaard, Juan Domingo Gispert, Pawel Markiewicz, David M Cash, Gill Farrar, Frederik Barkhof
INTRODUCTION: To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations. METHODS: A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [18 F]flutemetamol, [18 F]florbetaben or [18 F]florbetapir amyloid-PET were included...
April 4, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#39
JOURNAL ARTICLE
Kira Trares, Manuel Wiesenfarth, Hannah Stocker, Laura Perna, Agnese Petrera, Stefanie M Hauck, Konrad Beyreuther, Hermann Brenner, Ben Schöttker
BACKGROUND: It is of interest whether inflammatory biomarkers can improve dementia prediction models, such as the widely used Cardiovascular Risk Factors, Aging and Dementia (CAIDE) model. METHODS: The Olink Target 96 Inflammation panel was assessed in a nested case-cohort design within a large, population-based German cohort study (n = 9940; age-range: 50-75 years). All study participants who developed dementia over 20 years of follow-up and had complete CAIDE variable data (n = 562, including 173 Alzheimer's disease (AD) and 199 vascular dementia (VD) cases) as well as n = 1,356 controls were selected for measurements...
April 3, 2024: Immunity & Ageing: I & A
#40
JOURNAL ARTICLE
Sigrid Breinholt Vestergaard, Andreas Gammelgaard Damsbo, Niels Lech Pedersen, Katrine Zachariassen, Kim Ryun Drasbek, Leif Østergaard, Grethe Andersen, Rikke Beese Dalby, Janne Kærgård Mortensen
BACKGROUND: Post-stroke cognitive impairment (PSCI) is common. However, the underlying pathophysiology remains largely unknown. Understanding the role of microvascular changes and finding markers that can predict PSCI, could be a first step towards better screening and management of PSCI. Capillary dysfunction is a pathological feature of cerebral small vessel disease and may play a role in the mechanisms underlying PSCI. Extracellular vesicles (EVs) are secreted from cells and may act as disease biomarkers...
April 3, 2024: BMC Neurology
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