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Dementia prediction

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https://www.readbyqxmd.com/read/29147949/physical-activity-across-adulthood-and-subjective-cognitive-function-in-older-men
#1
Elinor Fondell, Mary Kay Townsend, Leslie Diane Unger, Olivia Ifeoma Okereke, Francine Grodstein, Alberto Ascherio, Walter Churchill Willett
Low subjective cognitive function (SCF), which is associated with APOE4 genotype, adversely impacts quality of life and has predicted clinical dementia. We examined whether physical activity during early adulthood or mid-to-late life is associated with late-life SCF. We followed 28,481 US male health professionals aged 40-75 years who reported their physical activity in 1986 and biennially thereafter. SCF was reported in 2008 and 2012. The SCF score was averaged for the 2008 and 2012 assessments and categorized as "good", "moderate", and "poor"...
November 17, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29146050/progranulin-plasma-levels-predict-the-presence-of-grn-mutations-in-asymptomatic-subjects-and-do-not-correlate-with-brain-atrophy-results-from-the-genfi-study
#2
Daniela Galimberti, Giorgio G Fumagalli, Chiara Fenoglio, Sara M G Cioffi, Andrea Arighi, Maria Serpente, Barbara Borroni, Alessandro Padovani, Fabrizio Tagliavini, Mario Masellis, Maria Carmela Tartaglia, John van Swieten, Lieke Meeter, Caroline Graff, Alexandre de Mendonça, Martina Bocchetta, Jonathan D Rohrer, Elio Scarpini
We investigated whether progranulin plasma levels are predictors of the presence of progranulin gene (GRN) null mutations or of the development of symptoms in asymptomatic at risk members participating in the Genetic Frontotemporal Dementia Initiative, including 19 patients, 64 asymptomatic carriers, and 77 noncarriers. In addition, we evaluated a possible role of TMEM106B rs1990622 as a genetic modifier and correlated progranulin plasma levels and gray-matter atrophy. Plasma progranulin mean ± SD plasma levels in patients and asymptomatic carriers were significantly decreased compared with noncarriers (30...
November 13, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29143722/relationship-between-the-number-of-behavioral-symptoms-in-dementia-and-caregiver-distress-what-is-the-tipping-point
#3
Paul B Arthur, Laura N Gitlin, John A Kairalla, William C Mann
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are a primary manifestation of brain dysfunction in dementia and a great challenge in caregiving. While BPSD are historically associated with caregiver distress, it is unclear whether there is an identifiable point where BPSD number is associated with heightened caregiver distress. The purpose of this study was to determine if such a tipping point exists to assist clinicians in identifying caregiver compromise. METHODS: Analyses were performed with three datasets totaling 569 community-dwelling persons with dementia and their caregivers...
November 16, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29135998/multivariate-regression-analysis-of-structural-mri-connectivity-matrices-in-alzheimer-s-disease
#4
Javier Rasero, Nicola Amoroso, Marianna La Rocca, Sabina Tangaro, Roberto Bellotti, Sebastiano Stramaglia
Alzheimer's disease (AD) is the most common form of dementia among older people and increasing longevity ensures its prevalence will rise even further. Whether AD originates by disconnecting a localized brain area and propagates to the rest of the brain across disease-severity progression is a question with an unknown answer. An important related challenge is to predict whether a given subject, with a mild cognitive impairment (MCI), will convert or not to AD. Here, our aim is to characterize the structural connectivity pattern of MCI and AD subjects using the multivariate distance matrix regression (MDMR) analysis, and to compare it to those of healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/29130521/a-variant-in-ppp4r3a-protects-against-alzheimer-related-metabolic-decline
#5
Leigh Christopher, Valerio Napolioni, Raiyan R Khan, Summer S Han, Michael D Greicius
OBJECTIVES: A reduction in glucose metabolism in the posterior cingulate cortex (PCC) predicts conversion to Alzheimer's disease (AD) and tracks disease progression, signifying its importance in AD. We aimed to use decline in PCC glucose metabolism as a proxy for the development and progression of AD to discover common genetic variants associated with disease vulnerability. METHODS: We performed a genome-wide association study (GWAS) of decline in PCC [(18) F] FDG PET measured in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (n=606)...
November 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29129622/personalized-long-term-prediction-of-cognitive-function-using-sequential-assessments-to-improve-model-performance
#6
Chih-Lin Chi, Wenjun Zeng, Wonsuk Oh, Soo Borson, Tatiana Lenskaia, Xinpeng Shen, Peter J Tonellato
Prediction of onset and progression of cognitive decline and dementia is important both for understanding the underlying disease processes and for planning health care for populations at risk. Predictors identified in research studies are typically accessed at one point in time. In this manuscript, we argue that an accurate model for predicting cognitive status over relatively long periods requires inclusion of time-varying components that are sequentially assessed at multiple time points (e.g., in multiple follow-up visits)...
November 9, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29129545/predicting-progression-of-amnesic-mci-the-integration-of-episodic-memory-impairment-with-perfusion-spect
#7
Davide Quaranta, Guido Gainotti, Daniela Di Giuda, Maria Gabriella Vita, Fabrizio Cocciolillo, Giordano Lacidogna, Valeria Guglielmi, Carlo Masullo, Alessandro Giordano, Camillo Marra
The present study aimed at assessing if the ability to predict progression from amnesic Mild Cognitive Impairment (aMCI) to dementia is improved by considering the presence at the baseline of Single Photon Emission Computed Tomography (SPECT) perfusion abnormalities in addition to a defect of long term memory. The Episodic Memory Score (EMS), a global index which integrates results obtained in subtests of the Rey's Verbal Learning Test and the Rey-Osterrieth Figure recall, were taken into account to evaluate defects of long term memory...
October 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29128685/unravelling-positive-aspects-of-caregiving-in-dementia-an-integrative-review-of-research-literature
#8
REVIEW
Doris S F Yu, Sheung-Tak Cheng, Jungfang Wang
BACKGROUND: Family caregiving is the crucial informal care resource to lessen the burdens associated with dementia. Research in this field has focused on reducing the caregiver's burden, but little attention has been given to promoting the positive aspects of caregiving. OBJECTIVES: To conduct a systematic critical review of research on the nature of positive aspects of caregiving, and the factors predicting this phenomenon among family caregivers of dementia patients, with the ultimate purpose of gaining insights to explain how and why it emerges...
October 16, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29128327/clinical-predictors-of-stroke-mimics-in-patients-treated-with-recombinant-tissue-plasminogen-activator-according-to-a-normal-multimodal-computed-tomography-imaging
#9
Stephane Olindo, Martin Chardonnet, Pauline Renou, Cyrielle Coignion, Sabrina Debruxelles, Mathilde Poli, Sharmila Sagnier, François Rouanet, Igor Sibon
BACKGROUND: Multimodal computed tomography imaging (MCTI) is increasingly used for rapid assessment of acute stroke. We investigated characteristics and final diagnoses of patients treated with recombinant tissue plasminogen activator (rt-PA) while admission imaging was unremarkable. METHODS: From our prospectively collected stroke database (2013-2016), we identified consecutive patients treated with rt-PA on the basis of an unremarkable brain MCTI and assessed with a 24-hour follow-up brain magnetic resonance imaging (MRI)...
November 8, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29126762/association-between-abnormal-nocturnal-blood-pressure-profile-and-dementia-in-parkinson-s-disease
#10
Ryota Tanaka, Yasushi Shimo, Kazuo Yamashiro, Takashi Ogawa, Kenya Nishioka, Genko Oyama, Atsushi Umemura, Nobutaka Hattori
BACKGROUND: Circadian blood pressure alterations are frequently observed in Parkinson's disease, but the association between these changes and dementia in the condition remains unclear. Here, we assess the relationship between abnormal nocturnal blood pressure profiles and dementia in Parkinson's disease. METHODS: We enrolled 137 patients with Parkinson's disease, who underwent 24 h ambulatory blood pressure monitoring, following cognitive and clinical assessment...
October 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29126099/clinical-utility-of-select-neuropsychological-assessment-battery-tests-in-predicting-functional-abilities-in-dementia
#11
Lee Ashendorf, Michael L Alosco, Hanaan Bing-Canar, Kimberly R Chapman, Brett Martin, Christine E Chaisson, Diane Dixon, Eric G Steinberg, Yorghos Tripodis, Neil W Kowall, Robert A Stern
Objective: Neuropsychological test performance can provide insight into functional abilities in patients with dementia, particularly in the absence of an informant. The relationship between neuropsychological measures and instrumental activities of daily living (IADLs) is unclear due to hetereogeneity in cognitive domains assessed and neuropsychological tests administered. Practical and ecologically valid performance-based measures of IADLs are also limited. The Neuropsychological Assessment Battery (NAB) is uniquely positioned to provide a dual-purpose assessment of cognitive and IADL function, as it includes Daily Living tests that simulate real-world functional tasks...
November 8, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29125486/putative-dementia-cases-fluctuate-as-a-function-of-mini-mental-state-examination-cut-off-points
#12
Ilka M Rosa, Ana G Henriques, Jens Wiltfang, Odete A B da Cruz E Silva
As the population ages, there is a growing need to quickly and accurately identify putative dementia cases. Many cognitive tests are available; among those commonly used are the Cognitive Dementia Rating (CDR) and the Mini-Mental Status Examination (MMSE). The aim of this work was to compare the validity and reliability of these cognitive tests in a primary care based cohort (pcb-Cohort). The MMSE and the CDR were applied to 568 volunteers in the pcb-Cohort. Distinct cut-off points for the MMSE were considered, namely MMSE 27, MMSE 24, and MMSE PT (adapted for the Portuguese population)...
November 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29125073/erythrocyte-associated-amyloid-%C3%AE-as-potential-biomarker-to-diagnose-dementia
#13
Michele Lauriola, Giulia Paroni, Filomena Ciccone, Grazia D Onofrio, Leandro Cascavilla, Francesco Paris, Carolina Gravina, Maria Urbano, Davide Seripa, Antonio Greco
BACKGROUND: Although it is well known that Alzheimer's disease (AD) is associated with the progressive accumulation of amyloid β-peptide (Aβ) in the human brain, its pathogenic role has yet to be completely clarified. Aβ moves from the blood-brain barrier to the plasma and an increased Aβ production in brain could be associated with higher Aβ concentrations in blood. A recent study has evaluated Aβ-40 and Aβ-42 levels in human red blood cells (RBCs) with evidence of age-dependent higher Aβ concentration in RBCs...
November 10, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29124116/toward-common-mechanisms-for-risk-factors-in-alzheimer-s-syndrome
#14
REVIEW
Miguel Medina, Zaven S Khachaturian, Martin Rossor, Jesús Avila, Angel Cedazo-Minguez
The global strategic goal of reducing health care cost, especially the prospects for massive increases due to expanding markets for health care services demanded by aging populations and/or people with a wide range of chronic disorders-disabilities, is a complex and formidable challenge with many facets. Current projections predict marked increases in the demand for health driven by both the exponential climb in the prevalence of chronic disabilities and the increases in the absolute numbers of people in need of some form of health care...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29122049/predictive-factors-associated-with-psychological-distress-of-caregivers-of-people-with-dementia-in-japan-a-cross-sectional-study
#15
Ryo Shikimoto, Mitsuhiro Sado, Akira Ninomiya, Kimio Yoshimura, Baku Ikeda, Toshiaki Baba, Masaru Mimura
BACKGROUND: Caregivers of people with dementia are likely to have psychological distress that sometimes results in mental health problems, such as depression. The objective of this study was to examine some predictive factors that are thought to be associated with psychological distress of caregivers of people with dementia in Japan. METHODS: Design: A cross-sectional study. SAMPLE: As part of a study to estimate the cost of dementia in Japan, 1,437 people with dementia-caregiver dyads were enrolled in the current informal care time study...
November 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29113534/the-relationship-between-neuropsychological-tests-of-visuospatial-function-and-lobar-cortical-thickness
#16
Davor N Zink, Justin B Miller, Jessica Z K Caldwell, Christopher Bird, Sarah J Banks
INTRODUCTION: Tests of visuospatial function are often administered in comprehensive neuropsychological evaluations. These tests are generally considered assays of parietal lobe function; however, the neural correlates of these tests, using modern imaging techniques, are not well understood. In the current study we investigated the relationship between three commonly used tests of visuospatial function and lobar cortical thickness in each hemisphere. METHOD: Data from 374 patients who underwent a neuropsychological evaluation and MRI scans in an outpatient dementia clinic were included in the analysis...
November 7, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29112909/potential-diagnostic-value-of-131-i-mibg-myocardial-scintigraphy-in-discrimination-between-alzheimer-disease-and-dementia-with-lewy-bodies
#17
Mehrshad Abbasi, Nafise Ghalandari, Saeed Farzanefar, Vajiheh Aghamollaii, Mona Ahmadi, Morsaleh Ganji, Mohsen Afarideh, Sogol Loloee, Maryam Naseri, Abbas Tafakhori
OBJECTIVES: Clinical difficulty to discriminate between the Alzheimer disease (AD) and dementia with Lewy bodies (DLB) has led researchers to focus on highly sensitive functional imaging modalities. The aim of the present study was to assess (131)I-MIBG cardiac imaging to distinguish between AD and DLB. PATIENTS AND METHODS: Seventeen patients who were known cases of dementia underwent (131)I-MIBG myocardial scintigraphy to differentiate AD from DLB. Planar and (131)I-MIBG SPECT were obtained 2h after the injection of 1mCi (131)I-MIBG on a dual head gamma camera...
October 25, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29110782/biomarkers-in-cerebrospinal-fluid-for-synucleinopathies-tauopathies-and-other-neurodegenerative-disorders
#18
Tainá M Marques, Anouke Van Rumund, H Bea Kuiperij, Marcel M Verbeek
The incidence of neurodegenerative disorders is increasing due to worldwide population aging. In general, sporadic forms account for 90% of total cases with neurodegenerative disorders and the reasons underlying initiation or progression of these diseases remain unknown for almost all disorders. To date, diagnosis is mainly based on clinical symptoms and neuroimaging, which is in many cases insufficient due to overlap in clinical symptoms among several neurodegenerative disorders. Therefore, postmortem neuropathologic confirmation remains the gold-standard diagnostic technique for many disorders...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29109949/the-impact-of-frailty-on-the-risk-of-conversion-from-mild-cognitive-impairment-to-alzheimer-s-disease-evidences-from-a-5-year-observational-study
#19
Alessandro Trebbastoni, Marco Canevelli, Fabrizia D'Antonio, Letizia Imbriano, Livia Podda, Lidia Rendace, Alessandra Campanelli, Valentina Celano, Giuseppe Bruno, Carlo de Lena
The frailty construct has increasingly been adopted in the field of cognitive disorders. The aim of the present study was to measure frailty in a cohort of individuals with mild cognitive impairment (MCI) and to explore whether frailty measures may consent to predict the risk of conversion to dementia. We retrospectively reviewed the clinical charts of outpatients with amnesic MCI (aMCI) consecutively recruited at our Department, and followed-up for 5 years. Individual frailty status was measured by means of a frailty index (FI) consisting of 39 deficits (including signs, symptoms, diagnoses, and disabilities)...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29106531/medicaid-savings-from-the-new-york-university-caregiver-intervention-for-families-with-dementia
#20
Steven S Foldes, James P Moriarty, Paul H Farseth, Mary S Mittelman, Kirsten Hall Long
Purpose of the study: The economic burden of dementia is substantially borne by state Medicaid programs. We estimated savings, from the state payer perspective, from offering the New York University Caregiver Intervention (NYUCI), a well-studied caregiver support and counseling program, to eligible Minnesota Medicaid enrollees. Design and Methods: A population-based microsimulation Markov model predicted and compared costs over 15 years with and without implementation of the NYUCI for family caregivers of community-based Medicaid eligibles with dementia...
July 5, 2017: Gerontologist
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