Emily A Sloan, Jason Chiang, Javier E Villanueva-Meyer, Sanda Alexandrescu, Jennifer M Eschbacher, Wesley Wang, Manuela Mafra, Nasir Ud Din, Emily Carr-Boyd, Michael Watson, Michael Punsoni, Angelica Oviedo, Ahmed Gilani, Bette K Kleinschmidt-DeMasters, Dylan J Coss, M Beatriz Lopes, Corey Raffel, Mitchel S Berger, Susan M Chang, Alyssa Reddy, Biswarathan Ramani, Sean P Ferris, Julieann C Lee, Jeffrey W Hofmann, Soo-Jin Cho, Andrew E Horvai, Melike Pekmezci, Tarik Tihan, Andrew W Bollen, Fausto J Rodriguez, David W Ellison, Arie Perry, David A Solomon
Intracranial mesenchymal tumors with FET-CREB fusions are a recently described group of neoplasms in children and young adults characterized by fusion of a FET family gene (usually EWSR1, but rarely FUS) to a CREB family transcription factor (ATF1, CREB1, or CREM), and have been variously termed intracranial angiomatoid fibrous histiocytoma or intracranial myxoid mesenchymal tumor. The clinical outcomes, histologic features, and genomic landscape are not well defined. Here, we studied 20 patients with intracranial mesenchymal tumors proven to harbor FET-CREB fusion by next-generation sequencing (NGS)...
July 2021: Brain Pathology