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Spindle cell hemangioma

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https://www.readbyqxmd.com/read/30354275/calcifying-nested-stromal-epithelial-tumor-of-the-liver-an-update-and-literature-review
#1
Mark Benedict, Xuchen Zhang
Calcifying nested stromal epithelial tumor is a rare entity that has gone by a variety of names in the literature: ossifying malignant mixed epithelial and stromal tumor, ossifying stromal-epithelial tumor, and desmoplastic nested spindle cell tumor of the liver. To our knowledge, approximately 38 cases have been reported in the literature. The histogenesis is still largely unknown but histopathologically is characterized by nests of spindle and epithelioid cells in an organoid arrangement surrounded by a prominent dense myofibroblastic stroma with occasional psammomatous calcification and focal heterotopic ossification...
October 24, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/30288189/intramuscular-myxoma-in-the-supinator-muscle-with-transient-postoperative-posterior-interosseous-nerve-palsy-a-case-report
#2
Toshihiro Nonaka, Motoki Sonohata, Shuhei Takeshita, Yosuke Oba, Yoshimasa Fujii, Masaaki Mawatari
Background: Intramuscular myxomas are rare, benign mesenchymal tumors in the musculoskeletal system, and usually, the tumors arise in the large muscles of the thigh, buttocks, shoulder, and upper arm. However, a tumor of the forearm is very rare. Herein, we describe the case of an intramuscular myxoma in the supinator muscle of a 56-year-old female patient. Case Presentation: Magnetic resonance imaging showed a well-defined mass that was hypointense with the peritumoral fat ring sign...
2018: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/30134255/diagnostic-immunohistochemistry-for-soft-tissue-and-bone-tumors-an-update
#3
Inga-Marie Schaefer, Jason L Hornick
Although some soft tissue and bone tumors can be identified based on histologic features alone, immunohistochemistry plays a critical diagnostic role for most mesenchymal tumor types. The discovery of recurrent genomic alterations in many benign and malignant mesenchymal neoplasms has added important biologic insights and expanded the spectrum of some diagnostic subgroups. Some tumors are defined by unique genomic alterations, whereas others share abnormalities that are not tumor-specific and can be observed in a sometimes broad range of biologically unrelated neoplasms...
November 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29780644/spindle-cell-hemangioma-in-the-mucosa-of-the-upper-lip-a-case-report-and-review-of-the-literature
#4
Kazuhiro Murakami, Kazuhiko Yamamoto, Tsutomu Sugiura, Tadaaki Kirita
Spindle cell hemangioma (SCH) is a unique benign vascular lesion. We present a case of SCH in the upper lip of a 41-year-old woman. A submucosal nodular mass 30 × 20 mm in size was observed in the left upper lip. The mass developed 5 years earlier and enlarged after repeated ethanol injections. The mass was elastic firm, mobile, bluish in color, and well demarcated in magnetic resonance imaging. Under the clinical diagnosis of hemangioma, surgical excision was performed under local anesthesia. Microscopically, the lesion was composed of irregular cavernous spaces and multiple solid cellular areas...
2018: Case Reports in Dentistry
https://www.readbyqxmd.com/read/29660567/summary-of-expression-of-sparc-protein-in-cutaneous-vascular-neoplasms-and-mimickers
#5
Shakuntala H Mauzo, Denái R Milton, Victor G Prieto, Carlos A Torres-Cabala, Wei-Lien Wang, Nitin Chakravarti, Priyadharsini Nagarajan, Michael T Tetzlaff, Jonathan L Curry, Doina Ivan, Robert E Brown, Phyu P Aung
BACKGROUND: Serum protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein, which regulates cell proliferation and facilitates intracellular transport of albumin bound particles including chemotherapeutic agents such as Nab-paclitaxel/ABI-007. Therefore the presence of SPARC may achieve higher intra-tumoral drug concentration with lower dosage and thus reduce systemic side-effects. Several trials of ABI-007, in melanoma, show promising clinical activity. DESIGN: Fifty-four cases of dermal based neoplasms were retrieved including 24 angiosarcomas (AS), 10 hemangiomas, 9 nodular melanomas, 4 Kaposi sarcomas (KS), 3 leiomyosarcomas (LMS), 3 atypical fibroxanthomas (AFX) and 1 spindle cell squamous cell carcinoma (SSCC)...
June 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29445571/immunoreactivity-of-wilms-tumor-1-wt1-as-an-additional-evidence-supporting-hemangiomatous-rather-than-inflammatory-origin-in-the-etiopathogenesis-of-angiolymphoid-hyperplasia-with-eosinophilia
#6
Fatma Tokat, Julia S Lehman, Engin Sezer, Emel Dikicioglu Cetin, Umit Ince, Emel Ozturk Durmaz
Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammatory process. Aim: Recently, the intracytoplasmic staining pattern of Wilms tumor 1 (WT1) on immunohistochemistry has highlighted true vascular neoplasms, such as microvenular hemangioma, tufted angioma, and spindle cell hemangioma, which has made it helpful to distinguish ALHE from vascular malformations, as there is a negative staining pattern in the other entities...
January 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29242801/spindle-cell-hemangioma-of-the-midfoot-a-case-report
#7
Tanawat Vaseenon, Jirawat Saengsin, Nuttaya Pattamapaspong, Jongkolnee Settakorn, Dumnoensun Pruksakorn
Introduction: Spindle cell hemangioma (SCH) of the bone (midfoot) is a rare disease, but it can cause symptomatic pain and invade surrounding tissues lead to limb deformities and functional loss. Case Report: We report the case of a 35-year-old woman who experienced a firm mass over the left midfoot for 5 years causing pain and numbness in the foot. Radiographs showed a geographic osteolytic lesion involving calcification of the base of the 2nd and 3rd metatarsals, cuneiforms bones and surrounding soft tissue...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28845532/mutational-analysis-using-sanger-and-next-generation-sequencing-in-sporadic-spindle-cell-hemangiomas-a-study-of-19-cases
#8
Roel W Ten Broek, Elise M Bekers, Wendy W J de Leng, Eric Strengman, Bastiaan B J Tops, Heinz Kutzner, Jan Willem Leeuwis, Joost M van Gorp, David H Creytens, Thomas Mentzel, Paul J van Diest, Astrid Eijkelenboom, Uta Flucke
Spindle cell hemangioma (SCH) is a distinct vascular soft-tissue lesion characterized by cavernous blood vessels and a spindle cell component mainly occurring in the distal extremities of young adults. The majority of cases harbor heterozygous mutations in IDH1/2 sporadically or rarely in association with Maffucci syndrome. However, based on mosaicism and accordingly a low percentage of lesional cells harboring a mutant allele, detection can be challenging. We tested 19 sporadic SCHs by Sanger sequencing, multiplex ligation-dependent probe amplification (MLPA), conventional next generation sequencing (NGS), and NGS using a single molecule molecular inversion probes (smMIP)-based library preparation to compare their diagnostic value...
December 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28591992/-spindle-cell-hemangioma-a-clinicopathologic-analysis-of-3-cases
#9
W Zhang, Z Wang, Z H Zhang, Q H Fan, H Li
No abstract text is available yet for this article.
June 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28577557/unusual-neoplasm-on-the-hard-palate-of-a-child-a-case-report
#10
Mathangi Kumar, Shruthi Acharya, Kanthilatha Pai, Vijay Kumar, Sundeep P Thotan
BACKGROUND: Myoepitheliomas account for less than 1% of salivary gland tumors. They mostly affect the parotid glands of adults during the third to fifth decades. CASE PRESENTATION: A 10-year-old Indian boy reported a small swelling in the roof of his mouth of 10 days' duration. History revealed that the lesion was painless and not associated with bleeding or pus discharge. On examination, a purplish well-circumscribed growth was noted on his posterior hard palate...
June 2, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28477885/histopathology-of-spindle-cell-vascular-tumors
#11
REVIEW
Zlatko Marušić, Steven D Billings
Vascular tumors with a spindled morphology represent a diagnostic challenge in soft tissue pathology. It may be difficult to distinguish certain benign entities in this category from spindled vascular tumors of intermediate malignancy or even spindled variants of angiosarcoma. This article focuses on vascular tumors characterized by a predominantly spindled morphology, including spindle cell hemangioma, acquired tufted angioma (angioblastoma of Nakagawa), kaposiform hemangioendothelioma, Kaposi sarcoma, and spindle cell variants of angiosarcoma...
June 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/28413654/hepatic-perivascular-epithelioid-cell-neoplasm-a-clinical-and-pathological-experience-in-diagnosis-and-treatment
#12
Wenying Chen, Yeqing Liu, Yanyan Zhuang, Juanfei Peng, Fengting Huang, Shineng Zhang
Hepatic perivascular epithelioid cell neoplasm (PEComa) is a rare type of neoplasm derived from mesenchymal tumors that is often misdiagnosed as hepatocellular carcinoma (HCC), hepatic hemangioma or other liver malignancies. The clinical and histological characteristics of PEComa have yet to be fully documented. To optimize the diagnosis and treatment of the disease, a retrospective analysis was performed to investigate the clinicopathological characteristics of 7 patients diagnosed with hepatic PEComa in the Sun Yat-Sen Memorial Hospital between January 2004 and December 2015...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28009608/fosb-is-a-useful-diagnostic-marker-for-pseudomyogenic-hemangioendothelioma
#13
Yin P Hung, Christopher D M Fletcher, Jason L Hornick
Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a distinctive vascular neoplasm of intermediate biological potential with a predilection for young adults and frequent multifocal presentation. Pseudomyogenic hemangioendothelioma is characterized by loose fascicles of plump spindled and epithelioid cells with abundant eosinophilic cytoplasm and coexpression of keratins and endothelial markers. Recently, a SERPINE1-FOSB fusion has been identified as a consistent genetic alteration in pseudomyogenic hemangioendothelioma...
May 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27867327/unusual-glomus-tumor-of-the-penis
#14
REVIEW
Gautam Dagur, Kelly Warren, Yimei Miao, Navjot Singh, Yiji Suh, Sardar A Khan
INTRODUCTION: Glomus tumors are benign neoplasms commonly found in subungual regions of the extremities and rarely located in the penis. Misdiagnosis of glomus tumors is common; therefore, symptoms and clinical presentations should be reviewed. OBJECTIVE: The primary objective of this review article is to emphasize the pathogenesis, pathology, clinical presentation, symptoms, diagnosis, and treatment methods of glomus tumors in order to better identify and manage the condition...
October 2016: Current Urology
https://www.readbyqxmd.com/read/27756995/cytological-diagnosis-of-deep-seated-cellular-hemangioma-of-the-parotid-gland-by-using-cell-button-technique
#15
Sonam Sharma, Rahul Mannan, Tejinder Bhasin
Intraparotid hemangioma of the children is a rare neoplasm, posing diagnostic dilemma to the diagnosticians as well as treating clinicians. A 2-month-old male infant presented with a diffuse swelling in the parotid region since birth that was gradually increasing in size. The ultrasonography (USG) report was suggestive of a right intraparotid mass of uncertain etiology; whereas magnetic resonance imaging (MRI) report inclined toward a mass associated with chronic inflammatory pathology. Fine-needle aspiration cytology (FNAC) suggested two differentials - a vascular neoplasm of the parotid gland and a spindle cell neoplasm with increased vascularity...
July 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27642429/-spindle-shaped-hemangioma-an-unusual-location
#16
Fatima Zahra Nasreddine, Bouchra Baghad, Soumiya Chiheb
Spindle cell hemangioma, formerly known as spindle cell hemangioendothelioma, was described by Weiss and Enzinger in 1986. Since the advent of immunohistochemical studies it is no longer considered as low grade angiosarcoma. It is a benign vascular tumor It almost exclusively affects the dermis at the distal ends. We report the first case of a patient with spindle cell hemangioma located in the scapular, breast, thighs and mandibular area. According to the literature, only 9 cases located in the head and neck were reported...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27617527/infantile-myofibroma-a-firm-round-plaque-in-an-infant
#17
REVIEW
Shinya Amano, Mark Halsey, Mariko Yasuda, Patrick O'Donnell, Courtney Csikesz
Infantile myofibroma is a rare fibromatous tumor that is variable in presentation and is frequently mistaken for hemangioma or rhabdomyosarcoma. We describe a 14-month-old boy who presented with multiple, enlarging, firm lesions on the shoulder. Biopsy revealed a proliferation of small spindle cells with myxoid and hyalinized stroma infiltrating into the superficial adipose tissue. We provide a brief review of the clinical presentation, histopathologic features, management, and recent advances in our understanding of this rare condition...
May 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27445035/spindle-cell-haemangioma-of-the-tongue
#18
Kathryn E M French, Andrew M Felstead, Norman Haacke, Jeffrey Theaker, Peter A Brennan, Serryth D Colbert
BACKGROUND: Spindle cell hemangioma (SCH) is an uncommon benign vascular tumor that rarely occurs in the mouth. METHODS AND RESULTS: We present an SCH arising in the tongue of a 52-year-old otherwise healthy woman. SCH should be considered in the differential diagnosis of vascular tumors in the oral cavity and not misinterpreted as a more aggressive vascular tumor. We describe the clinical presentation, investigation, differential diagnosis and management of this condition and a literature search showing published case reports...
November 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27318413/contributions-of-dr-juan-rosai-to-the-pathology-of-cutaneous-vascular-proliferations-a-review-of-selected-lesions
#19
REVIEW
Mark R Wick
Vascular proliferations in the skin have been thoroughly studied over the past 35 years, and a great deal of knowledge has been accrued regarding their pathobiological features. Dr. Juan Rosai has been a consistent contributor to the literature on this topic throughout most of his career, and this article reviews selected cutaneous endothelial lesions that he helped to characterize. They include histiocytoid-epithelioid hemangioma, targetoid-hobnail hemangioma, acquired tufted hemangioma, glomeruloid hemangioma, spindle cell hemangioma, retiform hemangioendothelioma, and angiosarcoma...
September 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27234547/neck-kaposiform-haemangioendothelioma-in-a-fischer-s-lovebird-agapornis-fischeri
#20
Giacomo Rossi, Livio Galosi, Sara Berardi, Maria Assunta Piano, Patrizia Robino, Timothy Rose, Maria Luisa Calabrò
A six-year-old female Fischer's lovebird (Agapornis fischeri) presented at necropsy with a cutaneous mass on the neck, 3.5cm in diameter, yielding and with blood content. Histopathological findings showed a neoplasm characterized by proliferation of vascular endothelial cells. The histology of the mass revealed a multinodular, focally infiltrating tumor. Deeper dermal nodules were made of spindle cells forming vascular slits reminiscent of the histology seen in Kaposi's sarcoma (KS). More superficially located dermal nodules consisted of small blood vessels, with histology resembling capillary hemangioma...
June 2016: Research in Veterinary Science
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