Read by QxMD icon Read

Arterial hypertension and age

Doron Aronson, Varda Shalev, Rachel Katz, Gabriel Chodick, Diab Mutlak
PURPOSE:  We used a large real-world data from community settings to develop and validate a 10-year risk score for new-onset atrial fibrillation (AF) and calculate its net benefit performance. METHODS:  Multivariable Cox proportional hazards model was used to estimate effects of risk factors in the derivation cohort ( n  = 96,778) and to derive a risk equation. Measures of calibration and discrimination were calculated in the validation cohort ( n  = 48,404)...
August 13, 2018: Thrombosis and Haemostasis
Florence A Aeschlimann, Lillian Barra, Roaa Alsolaimani, Susanne M Benseler, Diane Hebert, Nader Khalidi, Ronald M Laxer, Damien Noone, Christian Pagnoux, Marinka Twilt, Rae Sm Yeung
OBJECTIVE: To compare the clinical features, efficacy and safety of treatment regimens, and outcomes of childhood- and adult-onset Takayasu Arteritis (TAK). METHODS: This is a retrospective cohort study comparing patients with childhood-onset TAK since 1986 and adult-onset TAK since 1988 followed at four centers in Ontario, Canada until 2015. Demographic, clinical, laboratory and angiographic features, treatment regimens and outcomes were recorded throughout the course of disease...
August 12, 2018: Arthritis & Rheumatology
Ulrike M M Bauer, Marc-André Körten, Gerhard-Paul Diller, Paul Helm, Helmut Baumgartner, Peter Ewert, Oktay Tutarel
BACKGROUND: As adult congenital heart disease (ACHD) patients are aging, a high prevalence of cardiovascular risk factors is encountered similar to the general population. Currently, data regarding the primary and secondary prevention of acquired cardiovascular disease in ACHD is lacking. METHODS: The German National Register of Congenital Heart Defects was systematically screened for ACHD patients with established cardiovascular risk factors or documented acquired cardiovascular conditions...
August 4, 2018: International Journal of Cardiology
C S A Monção, L N Martins, M P S Penteado, R C P Reis, F M M Santos, C C D Lanna, A L Ribeiro, R W Telles
Objectives To evaluate the incidence and variability of traditional coronary artery disease (CAD) risk factors in a cohort of lupus patients and to investigate if prednisone use predicts an increase in the number of risk factors. Methods A total of 151 women, 37.8 ± 11.1 (mean ± SD) years old at baseline, were reevaluated after a median period of 39 (interquartile range 36.5-42.0) months. The cumulative incidence of traditional risk factors, the incidence rate (with 95% confidence interval) of hypertension, diabetes, dyslipidemia and hypertriglyceridemia, and the frequency of the risk factors' disappearance were calculated...
August 12, 2018: Lupus
Jun-Jun Yeh, Cheng-Li Lin, Chia-Hung Kao
AIMS: To evaluate the relationship between cardiovascular diseases (CVDs) and pneumonia in the general population. METHODS: This retrospective observational study included two cohorts, namely CVD (n = 28,363) and non-CVD (n = 28,363) cohorts, which were matched by propensity score and examined for cases of pneumonia. Data were obtained from 2000 to 2011. In both cohorts, pneumonia risk was measured using multivariable Cox proportional hazard models. RESULTS: With the non-CVD cohort as reference, the corresponding adjusted hazard ratios (aHRs) [95% confidence intervals (CIs)] of pneumonia were 2...
August 8, 2018: European Journal of Internal Medicine
Sridhara Sastry Yaddanapudi, Maria Carissa Pineda, David W Boorman, Richard E Bryne, Krista Lim Hing, Sunil Sharma
INTRODUCTION: Obstructive sleep apnea (OSA) is a well-known risk factor for stroke. This is attributed to multiple mechanisms such as endothelial dysfunction, atrial fibrillation, hypertension, and comorbid obesity. STOP questionnaire alone is unreliable to diagnose OSA and in-hospital sleep study is costly and can be technically challenging. We used high-resolution pulse oximetry (HRPO) to test the feasibility of screening for OSA and predicting outcome. METHODS: Data from 115 stroke patients who underwent HRPO was collected including Oxygen desaturation index (ODI) <4%, pulse rate, arterial oxygen saturation (SaO2 ), and time spent at SaO2 saturation <88%...
August 7, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Zach Rozenbaum, Yan Topilsky, Shafik Khoury, David Pereg, Michal Laufer-Perl
BACKGROUND: Small scale cohorts demonstrated an association between body mass index (BMI) and diastolic function in a metabolically healthy population. We aimed to characterize the relation between BMI and diastolic function in a relatively large cohort of metabolically healthy obese with preserved ejection fraction. METHODS AND RESULTS: Echocardiograms of metabolically healthy patients between 2011 and 2016, who had no significant valvulopathies or atrial fibrillation, and had preserved ejection fraction, were retrospectively identified and analyzed...
August 4, 2018: International Journal of Cardiology
F M M Meijer, P Kies, M R M Jongbloed, S E van Wijngaarden, C A Swenne, S Man, M J Schalij, J K de Vries-Bouwstra, H W Vliegen
BACKGROUND: Patients with systemic sclerosis (SSc) are at risk for developing pulmonary hypertension (PH) which is a major cause of death in this population. Echocardiographic (TTE) derived pulmonary arterial pressure (PAP) can be unreliable for the early detection of PH. Previous studies demonstrate that the ECG derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO) can detect PH in a heterogeneous population suspected of PH. The aim of this study is to assess the use of the VG-RVPO as a screening and monitoring instrument of early PH in SSc patients...
July 24, 2018: International Journal of Cardiology
Julia Ruhe, Christoph Waldeyer, Francisco Ojeda, Alev Altay, Renate B Schnabel, Sarina Schäfer, Karl J Lackner, Stefan Blankenberg, Tanja Zeller, Mahir Karakas
Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR). In a cohort of 811 patients with angiographically documented CAD levels of hepcidin and sTfR were measured at baseline. Systemic body iron release was defined as low levels of hepcidin (<24 ng/mL) and high levels of sTfR (≥2 mg/L)...
August 9, 2018: Biomolecules
Charles Marcus, Prasanna Santhanam, Matthew J Kruse, Mehrbod S Javadi, Lilja B Solnes, Steven P Rowe
The aim of the present study was to evaluate the incidence of undiagnosed pulmonary arterial dilatation using the gated computed tomography (CT) images acquired in patients with an otherwise normal Tc-sestamibi single-photon-emission CT (SPECT)/CT myocardial perfusion study.This was a retrospective review of 200 consecutive patients (100 men, mean age 58.7 years) who underwent a myocardial perfusion Tc-sestamibi SPECT/CT study with normal perfusion and with gated CT images acquired for coronary calcium scoring...
August 2018: Medicine (Baltimore)
B Saka, A E Abilogoun-Chokki, S Akakpo, J Teclessou, G W Soga, G Mahamadou, W Gnassingbe, A Mouhari-Toure, K Kombate, E D Dosseh, V P Pitche
The aim of this study was to document the profile and causes of chronic leg ulcers (CLU) in patients hospitalized in Lomé, Togo. This retrospective study reviewed records from the dermatology departments (CHU Sylvanus Olympio and Campus, and the dermatology center of Gbossimé) from 2000 to 2017 and from the general surgery department of CHU Sylvanus Olympio from 2013 to 2017 to identify cases. In all, 125 cases of CLU were identified during the study period. The patients' mean age was 56.6 years and the sex ratio (M/F) was 0...
August 8, 2018: Médecine et Santé Tropicales
Luciana Neves Cosenso-Martin, Luiz Tadeu Giollo-Júnior, Letícia Aparecida Barufi Fernandes, Cláudia Bernardi Cesarino, Marcelo Arruda Nakazone, Maurício de Nassau Machado, Juan Carlos Yugar-Toledo, José Fernando Vilela-Martin
AIMS: Several trials have reported that dipeptidyl peptidase-4 (DPP-4) inhibitors, used to treat type 2 diabetes (T2DM), improve endothelial function. The current study investigated the effects of vildagliptin, a DPP-4 inhibitor, compared to glibenclamide on endothelial function, arterial stiffness, and blood pressure in patients with T2DM and hypertension. METHODS: Patients aged over 35 years with T2DM and hypertension, but without cardiovascular disease, were randomly allocated to treatment with vildagliptin (n = 25) or glibenclamide (n = 25)...
August 9, 2018: Acta Diabetologica
Keith Gillis, Kathryn K Stevens, Elizabeth Bell, Rajan K Patel, Alan G Jardine, Scott T W Morris, Markus P Schneider, Christian Delles, Patrick B Mark
Background: Premature cardiovascular disease in patients with chronic kidney disease (CKD) is not explained by traditional risk factors and oxidative stress may contribute via endothelial and vascular dysfunction. We investigated the effect of ascorbic acid on oxidative stress and vascular function in CKD patients compared with controls with hypertension (HTN). Methods: A crossover study of intravenous saline and ascorbic acid was conducted. Biomarkers of oxidative stress were measured, while pulse wave analysis and brachial flow - mediated dilatation were performed to assess large artery and endothelial function...
August 2018: Clinical Kidney Journal
Ali H Eid, Ahmed F El-Yazbi, Fouad Zouein, Abdelilah Arredouani, Allal Ouhtit, Md M Rahman, Hatem Zayed, Gianfranco Pintus, Haissam Abou-Saleh
Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. Evidence supports a role for vascular aging in the development of hypertension involving an impairment in endothelial function together with an alteration in vascular smooth muscle cells (VSMCs) calcium homeostasis leading to increased myogenic tone. Changes in free intracellular calcium levels ([Ca2+ ] i ) are mediated either by the influx of Ca2+ from the extracellular space or release of Ca2+ from intracellular stores, mainly the sarcoplasmic reticulum (SR)...
2018: Frontiers in Physiology
Ibrahim Sultan, Arturo Cardounel, Islam Abdelkarim, Arman Kilic, Andrew D Althouse, Michael S Sharbaugh, Aman Gupta, Jeff Xu, Miho Fukui, Marc A Simon, John T Schindler, Joon S Lee, Thomas G Gleason, João L Cavalcante
OBJECTIVES: To evaluate the prognostic value of the ratio between tricuspid annular plane systolic excursion (TAPSE)-pulmonary artery systolic pressure (PASP) as a determinant of right ventricular to pulmonary artery (RV-PA) coupling in patients undergoing transcatheter aortic valve replacement (TAVI). BACKGROUND: RV function and pulmonary hypertension (PH) are both prognostically important in patients receiving TAVI. RV-PA coupling has been shown to be prognostic important in patients with heart failure but not previously evaluated in TAVI patients...
August 9, 2018: Heart: Official Journal of the British Cardiac Society
Mohammad Arif Hossain, Takashi Miyajima, Keiko Akiyama, Yoshikatsu Eto
BACKGROUND: Pompe disease is an autosomal recessive glycogen storage disorder caused by a deficiency of the lysosomal glycogen-hydrolyzing enzyme acid α-glucosidase. The adult-onset form, late-onset Pompe disease, has been characterized by glycogen accumulation, primarily in skeletal and smooth muscles, causing weakness of the proximal limb girdle and respiratory compromises. CASE REPORT: A 59-year-old female was admitted to the hospital with acute cerebral stroke at the age of 57 years...
August 6, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Irfan Siddiqui, Sudarshan Rajagopal, Amanda Brucker, Karen Chiswell, Bridgette Christopher, Fawaz Alenezi, Aditya Mandawat, Danny Rivera, Kristine Arges, Victor Tapson, Joseph Kisslo, Eric Velazquez, Pamela S Douglas, Zainab Samad
In pulmonary hypertension (PH), measurement of various echocardiographic parameters that assess right heart function is recommended by current clinical guidelines. Limited data exists on the combined value of clinical and echocardiographic parameters in precapillary PH in the modern era of therapy. We examined the association of clinical and echocardiographic parameters with surrogate outcomes (6-minute walk distance) and hard outcomes (hospitalization or death) in patients with precapillary PH. A cohort of patients with an established diagnosis of precapillary PH who underwent transthoracic echocardiography at the Duke Echo Lab were prospectively enrolled from 2010 to 2014...
June 15, 2018: American Journal of Cardiology
Laura Palma, Rossella Gaudino, Paolo Cavarzere, Franco Antoniazzi
BACKGROUND: Gonadotropin-releasing hormone agonists (GnRH-a) are common treatment options for central precocious puberty (CPP) in childhood. GnRH-a treatment is useful and has a good safety profile, with minimal adverse effects and no severe long-term consequences. The common side effects in children are menopause-like symptoms and local adverse events at the injection site. CASE PRESENTATION: We present the case of a girl with CPP who developed arterial hypertension from treatment with GnRH-a (triptorelin)...
August 8, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Shinjan Patra, Partha Pratim Chakraborty, Sugata Narayan Biswas, Himanshu Barman
Introduction: Hypokalemia is associated with increased morbidity and at times mortality. "Hypokalemic paralysis", particularly if recurrent, has often been considered synonymous with "hypokalemic periodic paralysis (HPP)"; however, diseases such as Gitelman syndrome (GS), Bartter syndrome (BS), and renal tubular acidosis (RTA) can have identical presentation. We have tried to explore the etiological spectrum along with epidemiological and certain clinical, biochemical, and electrophysiological features in patients with hypokalemic paralysis...
May 2018: Indian Journal of Endocrinology and Metabolism
Seung Woon Rha, Seung Hyuk Choi, Doo Il Kim, Dong Woon Jeon, Jae Hwan Lee, Kyung Soon Hong, Tae Joon Cha, Jang Hyun Cho, Sang Kon Lee, Yong Hwan Park, Woo Jung Park, Hyun Joo Kim, Young Joo Kim, Juneyoung Lee, Donghoon Choi
BACKGROUND AND OBJECTIVES: We aimed to investigate the history of medical resource consumption and quality of life (QoL) in peripheral arterial disease (PAD) patients in Korea. METHODS: This was a prospective, multi-center (23 tertiary-hospitals, division of cardiology), non-interventional study. Adult patients (age ≥20 years) suffering from PAD for the last 12-month were enrolled in the study if they met with any of following; 1) ankle-brachial index (ABI) ≤0...
June 18, 2018: Korean Circulation Journal
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"