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Arterial hypertension and age

Helen Triantafyllidi, Dimitris Benas, Stefanos Vlachos, Dimitris Vlastos, George Pavlidis, Antonios Schoinas, Mary Varoudi, Dionysia Birmpa, Paraskevi Moutsatsou, John Lekakis, Ignatios Ikonomidis
Endothelial dysfunction indicates target organ damage in hypertensive patients. The integrity of endothelial glycocalyx (EG) plays a vital role in vascular permeability, inflammation and elasticity, and finally to cardiovascular disease. The authors aimed to investigate the role of increased HDL cholesterol (HDL-C) levels, which usually are considered protective against cardiovascular disease, in EG integrity in older hypertensive patients. The authors studied 120 treated hypertensive patients older than 50 years were divided regarding HDL-C tertiles in group HDLH (HDL-C ≥ 71 mg/dL, upper HDL-C tertile) and group HDLL (HDL-C < 71 mg/dL, two lower HDL-C tertiles)...
October 13, 2018: Journal of Clinical Hypertension
Mohammed Al-Jarallah, Rajesh Rajan, Ibrahim Al-Zakwani, Raja Dashti, Bassam Bulbanat, Kadhim Sulaiman, Alawi A Alsheikh-Ali, Prashanth Panduranga, Khalid F AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al-Motarreb, Mustafa Ridha, Nooshin Bazargani, Nidal Asaad, Haitham Amin
AIMS: This study aims to evaluate the incidence and impact of cardiorenal anaemia syndrome (CRAS) on all-cause mortality in acute heart failure (AHF) patients stratified by left ventricular ejection fraction (LVEF) status in the Middle East. METHODS AND RESULTS: Data were analysed from 4934 consecutive patients admitted to 47 hospitals in seven Middle Eastern countries (Saudi Arabia, Oman, Yemen, Kuwait, United Arab Emirates, Qatar, and Bahrain) with AHF from February to November 2012...
October 12, 2018: ESC Heart Failure
Manu M Mysore, Kenneth C Bilchick, Priscilla Ababio, Benjamin K Ruth, William C Harding, Khadijah Breathett, Kimberley Chadwell, Brandy Patterson, Hunter Mwansa, Christiana M Jeukeng, Younghoon Kwon, Jamie L W Kennedy, Andrew D Mihalek, Sula Mazimba
BACKGROUND: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance leading to right heart failure. Elevated right atrial (RA) pressure reflects right ventricular (RV) pressure overload and is an established risk factor for mortality in PH. We hypothesized that PH patients with an increased ratio of RA to LA volume index (RAVI/LAVI), would have increased mortality. METHODS: We evaluated the association of RAVI/LAVI with mortality in 124 patients seen at a single academic center's PH clinic after adjusting for the REVEAL risk score, an established risk score in PH...
October 12, 2018: Echocardiography
A A Zarudsky, E P Kulakova, A E Markovskaya, E A Perutskaya, D N Perutskiy
Arterial hypertension (AH) is the most prevalent cardiac risk factor in old patients. Falls-related complications includes increased disability and mortality, decreased activity levels, quality of life, and overall health status. So falls are an important health problem. The aim of our study was to study falls in patients with AH 56+ years old finding fall risk factors in this population. METHODS: We examined 146 patients. 50 patients with AH had a fall during last 6 month. 96 patients with AH had no falls during this period...
2018: Kardiologiia
Sahrai Saeed, Eva Gerdts
Hypertension is highly prevalent in aortic stenosis (AS) patients as the prevalence of both disorders increases with age. Hypertension and associated stiffening of the large arteries increase afterload and thereby influence both the transvalvular flow and the remodelling of the aortic root and the left ventricle during AS progression. Area covered: The present review gives an overview on complications of hypertension in AS, how these can be diagnosed, and potentially may be managed. Expert commentary: Hypertension-mediated cardiovascular damage in AS is associated with increased morbidity and a 2-fold higher mortality even in asymptomatic patients, and also limits the symptomatic and survival benefit from valve replacement...
October 12, 2018: Expert Review of Cardiovascular Therapy
Mo-Li Zhu, Rui-Li Sun, He-Yun Zhang, Fan-Rong Zhao, Guo-Pin Pan, Chong Zhang, Ping Song, Peng Li, Jian Xu, Shuangxi Wang, Ya-Ling Yin
BACKGROUNDS AND AIMS: Increased arterial stiffness may increase cardiovascular morbidity and mortality. Angiotensin II type 1 receptor blockers (ARBs) are potentially useful in controlling the central blood pressure and arterial stiffness in mild to moderate essential hypertension, while the effects of ARBs in aged patients with essential hypertension are not entirely investigated. METHODS: The carotid-femoral arterial pulse wave velocity (PWV) was measured in aged patients with essential hypertension...
October 12, 2018: Clinical and Experimental Hypertension: CHE
Michael Inouye, Gad Abraham, Christopher P Nelson, Angela M Wood, Michael J Sweeting, Frank Dudbridge, Florence Y Lai, Stephen Kaptoge, Marta Brozynska, Tingting Wang, Shu Ye, Thomas R Webb, Martin K Rutter, Ioanna Tzoulaki, Riyaz S Patel, Ruth J F Loos, Bernard Keavney, Harry Hemingway, John Thompson, Hugh Watkins, Panos Deloukas, Emanuele Di Angelantonio, Adam S Butterworth, John Danesh, Nilesh J Samani
BACKGROUND: Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes has not been evaluated comprehensively, because available studies have involved limited genomic scope and limited sample sizes. OBJECTIVES: This study sought to construct a genomic risk score for CAD and to estimate its potential as a screening tool for primary prevention. METHODS: Using a meta-analytic approach to combine large-scale, genome-wide, and targeted genetic association data, we developed a new genomic risk score for CAD (metaGRS) consisting of 1...
October 16, 2018: Journal of the American College of Cardiology
Pierre-Yves Courand, Michael Serraille, Adrien Grandjean, Caroline Tilikete, Hugues Milon, Brahim Harbaoui, Pierre Lantelme
OBJECTIVE: Dizziness is associated with hypertension but there are numerous other causes. The aims of the present study were to describe the characteristics and the clinical correlates of dizziness in a large cohort of hypertensive patients, and to test its prognostic value for all-cause, cardiovascular, and stroke mortality. METHODS: A total of 1716 individuals from the OLD-HTA Lyon's cohort of hypertensive patients recruited in the 1970s were categorized according to the absence or the presence of dizziness...
October 10, 2018: Journal of Hypertension
András Jánosi, Tamás Ferenci, Péter Ofner, Géza Lupkovics, Dávid Becker, József Faluközy, Péter Polgár, Zsolt Kőszegi, Iván Horváth, Zoltán Jambrik, Veronika Szentes, Béla Merkely, Csaba András Dézsi
BACKGROUND: The authors analyzed data from the Hungarian Myocardial Infarction Registry (HUMIR) to examine the potential impact of gender on the treatment and 30-day and 1-year mortality of patients with myocardial infarction (MI). MATERIALS AND METHODS: The National Registry of Myocardial Infarction included 42,953 patients between January 1, 2013 and December 31, 2016; 19,875 of whom were diagnosed with ST-elevation myocardial infarction (STEMI) and 23,078 with non-ST-elevation myocardial infarction (NSTEMI)...
October 10, 2018: Journal of Women's Health
C Kruppa, C Maier, P Zahn, T A Schildhauer
BACKGROUND: Due to the demographic development the proportion of older patients has increased. These show at least a higher rate of comorbidities, which affects the length of inpatient hospital stay. Until now no uniform recording exists for such comorbidities within the occupational insurance association system even if the clinical relevance is beyond dispute. Adaptations within the system with increased interdisciplinary treatment are necessary. OBJECTIVE: The aim of this study was to analyze changes in the age distribution and the frequency of comorbidities in patients in the occupational insurance association system...
October 10, 2018: Der Unfallchirurg
Alejandro Javier Torres
Atrial septal defect (ASD) is one of the most common congenital cardiac anomalies. ASD can present as an isolated lesion in an otherwise normal heart or in association with other congenital heart conditions. Regardless of the type of ASD, the direction and degree of shunting across the communication is mainly determined by the difference in compliance between the right and left ventricle. Hemodynamics in children is characterized by left-to-right shunting, dilated right heart structures and normal pulmonary artery pressures (PAP)...
September 2018: Journal of Thoracic Disease
Chiu-Huang Kuo, Yu-Li Lin, Chih-Hsien Wang, Yu-Hsien Lai, Ru-Jiang Syu, Bang-Gee Hsu
Objective: Central arterial stiffness predicts cardiovascular (CV) mortality in hemodialysis (HD) patients. The aging process transforms lipid distribution and thus alters adipokine secretion. The harmful effects of leptin on CV events may change in the elderly. The purpose of this study was to investigate the relationship between leptin and central arterial stiffness markers through carotid-femoral pulse wave velocity (cfPWV) in geriatric HD patients. Materials and Methods: Patients over 65 years old on chronic HD were recruited...
October 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
Yoshihiro Nozaki, Kasumi Nakayama-Inaba, Tomoko Ishizu, Noriko Iida, Yoshiaki Kato, Yuji Hiramatsu, Hitoshi Horigome
Adult patients with repaired coarctation of the aorta (r-CoA) show high prevalence of late hypertension, but the exact mechanisms of this phenomenon are unknown. Endothelial dysfunction has been implicated in this paradoxical hypertension. We evaluated the endothelial function of both conduit and resistance arteries by using flow-mediated dilation (FMD) and digital peripheral artery tonometry (PAT).Seventeen patients with r-CoA and one patient with repaired interrupted aortic arch (r-CoA group) aged 22.0 ± 6...
October 10, 2018: International Heart Journal
Sandra Kutkiene, Zaneta Petrulioniene, Aleksandras Laucevicius, Pranas Serpytis, Vytautas Kasiulevicius, Justina Staigyte, Akvile Saulyte, Emilija Petrulionyte, Urte Gargalskaite, Egle Skiauteryte, Gabija Matuzeviciene, Milda Kovaite, Egidija Rinkuniene
BACKGROUND: Cardiovascular mortality in Lithuania is extremely high and abnormal lipid levels are very common among Lithuanian adults. Dyslipidemia is one of the main independent risk factors for cardiovascular diseases (CVD) leading to high absolute CVD risk. The aim of this study was to assess CVD risk in dyslipidemic middle-aged subjects. METHODS: During the period of 2009-2016 a total of 92,373 people (58.4% women and 41.6% men) were evaluated. This study included men aged 40-54 and women aged 50-64 without overt CVD...
October 11, 2018: Lipids in Health and Disease
Pedro D Ortolani, João H Romaldini, Ricardo A Guerra, Evandro S Portes, George C X Meireles, João Pimenta
OBJECTIVE: The association between coronary artery disease (CAD) and thyroid function remains controversial. We evaluated the thyroid function and graduated well-defined CAD as confirmed by quantitative coronary angiography (CA). SUBJECTS AND METHODS: We evaluated the serum TSH, free thyroxine, free triiodothyronine and thyroid antibody levels in 300 consecutive patients (age 61.6 ± 9.9 years and 54% were male) undergoing CAD diagnosis as confirmed by CA. Plaques with ≥ 50% stenosis being indicative of obstructive CAD, and patients were divided into groups according to main epicardial coronary arteries with plaques (0, 1, 2, 3)...
August 2018: Archives of Endocrinology and Metabolism
Minke C Kortekaas, Marit H N van Velzen, Frank Grüne, Sjoerd P Niehof, Robert J Stolker, Frank J P M Huygen
BACKGROUND: Vascular transit time (VTT) is the propagation time of a pulse wave through an artery; it is a measure for arterial stiffness. Because reliable non-invasive VTT measurements are difficult, as an alternative we measure pulse transit time (PTT). PTT is defined as the time between the R-wave on electrocardiogram and arrival of the resulting pulse wave in a distal location measured with photoplethysmography (PPG). The time between electrical activation of the ventricles and the resulting pulse wave after opening of the aortic valve is called the pre-ejection period (PEP), a component of PTT...
2018: PloS One
M Spacek, K Kunze, J Mehrholz
This study describes the course of renal recovery after dialysis in a specific population of chronically critically ill patients with a history of prolonged and complicated treatment in an intensive care unit. This study shows that, in a specialized center, patients can be successfully weaned from dialysis even months after acute kidney injury (AKI). Of the patients who could be recompensated (33%), approximately 20% achieved renal recovery more than 3 months after the start of dialysis. The duration of renal recovery after AKI did not differ between those patients with pre-existing chronic kidney disease (CKD) and those without...
October 9, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Leszek Bryniarski, Łukasz Klima, Sławomir Surowiec, Krzysztof L Bryniarski, Michał Terlecki, Dariusz Dudek
Introduction: In past studies, it has been questioned whether success of recanalization of chronic total occlusion (CTO) depends on the location of the occlusion - the circumflex artery (Cx) was considered as the most difficult to open. Aim: To determine whether the effectiveness of recanalization of CTO depends on the location of the obstruction. Material and methods: From January 2011 to January 2016, a single operator dedicated to chronic total occlusions performed in our center 357 procedures on 337 patients...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Ivana Horvat, Ana Boban, Renata Zadro, Margareta Radic Antolic, Ranka Serventi-Seiwerth, Pavle Roncevic, Ivo Radman, Dubravka Sertic, Marijo Vodanovic, Drazen Pulanic, Sandra Basic-Kinda, Nadira Durakovic, Silva Zupancic-Salek, Radovan Vrhovac, Igor Aurer, Damir Nemet, Boris Labar
INTRODUCTION: Thrombosis is the most common complication in Philadelphia chromosome negative (Ph-) myeloproliferative neoplasms patients. PATIENTS AND METHODS: In a cohort of 258 Ph- myeloproliferative neoplasm patients, the difference between patients with and without thrombosis was analyzed according to genetic thrombophilia factors, JAK2 V617F status and burden allele, blood count, cardiovascular risk factors and age. Patients were also divided in polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) subgroups as well as by the type of thrombosis...
September 10, 2018: Clinical Lymphoma, Myeloma & Leukemia
Hui Wang, Qian Wang, Zhuang Tian, Xiaoxiao Guo, Jinzhi Lai, Mengtao Li, Jiuliang Zhao, Yongtai Liu, Xiaofeng Zeng, Quan Fang
BACKGROUND: Right ventricular (RV) function has been identified as an important determinant of outcome in patients with pulmonary hypertension. We aimed to investigate the relationship between echocardiographic-derived RV function and health-related quality of life (HRQOL) in patients with systemic lupus erythematosus associated pulmonary arterial hypertension (SLE-APAH), and to identify the best echocardiographic parameter for evaluating RV function in these patients. METHODS: Sixty consecutive patients with SLE-APAH (all female, mean age 33...
September 27, 2018: Heart, Lung & Circulation
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