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Constance M Smith, Terry F Hayamizu, Jacqueline H Finger, Susan M Bello, Ingeborg J McCright, Jingxia Xu, Richard M Baldarelli, Jonathan S Beal, Jeffrey Campbell, Lori E Corbani, Pete J Frost, Jill R Lewis, Sharon C Giannatto, Dave Miers, David R Shaw, James A Kadin, Joel E Richardson, Cynthia L Smith, Martin Ringwald
The mouse Gene Expression Database (GXD) is an extensive, well-curated community resource freely available at Covering all developmental stages, GXD includes data from RNA in situ hybridization, immunohistochemistry, RT-PCR, northern blot and western blot experiments in wild-type and mutant mice. GXD's gene expression information is integrated with the other data in Mouse Genome Informatics and interconnected with other databases, placing these data in the larger biological and biomedical context...
October 17, 2018: Nucleic Acids Research
Wim M van Rees, Elisabetta A Matsumoto, A Sydney Gladman, Jennifer A Lewis, L Mahadevan
Recent progress in additive manufacturing and materials engineering has led to a surge of interest in shape-changing plate and shell-like structures. Such structures are typically printed in a planar configuration and, when exposed to an ambient stimulus such as heat or humidity, swell into a desired three-dimensional geometry. Viewed through the lens of differential geometry and elasticity, the application of the physical stimulus can be understood as a local change in the metric of a two dimensional surface embedded in three dimensions...
October 18, 2018: Soft Matter
J M Bayne, V Fasano, K M Szkop, M J Ingleson, D W Stephan
The water/base intolerance of the previously reported electrophilic phosphonium cations has been overcome by replacing the labile electron-withdrawing groups generally attached to phosphorus (e.g. -F, -OAr, -CF3) with methyl groups. Tri-phosphorus(v) tricationic species, accessible in one-pot from commercially available materials, are air and water/base tolerant, yet are sufficiently Lewis acidic for catalysis.
October 18, 2018: Chemical Communications: Chem Comm
Tamorah Lewis, J Steven Leeder
No abstract text is available yet for this article.
October 18, 2018: Pharmacogenomics
Shahram Oveisgharan, Zoe Arvanitakis, Lei Yu, Jose Farfel, Julie A Schneider, David A Bennett
Alzheimer's dementia is significantly more common in women than in men. However, few pathological studies have addressed sex difference in Alzheimer's disease (AD) and other brain pathologies. We leveraged postmortem data from 1453 persons who participated in one of two longitudinal community-based studies of older adults, the Religious Orders Study and the Rush Memory and Aging Project. Postmortem examination identified AD pathologies, neocortical Lewy bodies, DNA-binding protein 43 (TDP-43), hippocampal sclerosis, gross and micro infarcts, atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy...
October 17, 2018: Acta Neuropathologica
Daniel J Mason, Richard T Eastman, Richard P I Lewis, Ian P Stott, Rajarshi Guha, Andreas Bender
The parasite Plasmodium falciparum is the most lethal species of Plasmodium to cause serious malaria infection in humans, and with resistance developing rapidly novel treatment modalities are currently being sought, one of which being combinations of existing compounds. The discovery of combinations of antimalarial drugs that act synergistically with one another is hence of great importance; however an exhaustive experimental screen of large drug space in a pairwise manner is not an option. In this study we apply our machine learning approach, Combination Synergy Estimation (CoSynE), which can predict novel synergistic drug interactions using only prior experimental combination screening data and knowledge of compound molecular structures, to a dataset of 1,540 antimalarial drug combinations in which 22...
2018: Frontiers in Pharmacology
Mi Deng, Xun Gui, Jaehyup Kim, Li Xie, Weina Chen, Zunling Li, Licai He, Yuanzhi Chen, Heyu Chen, Weiguang Luo, Zhigang Lu, Jingjing Xie, Hywyn Churchill, Yixiang Xu, Zhan Zhou, Guojin Wu, Chenyi Yu, Samuel John, Kouyuki Hirayasu, Nam Nguyen, Xiaoye Liu, Fangfang Huang, Leike Li, Hui Deng, Haidong Tang, Ali H Sadek, Lingbo Zhang, Tao Huang, Yizhou Zou, Benjamin Chen, Hong Zhu, Hisashi Arase, Ningshao Xia, Youxing Jiang, Robert Collins, M James You, Jade Homsi, Nisha Unni, Cheryl Lewis, Guo-Qiang Chen, Yang-Xin Fu, X Charlene Liao, Zhiqiang An, Junke Zheng, Ningyan Zhang, Cheng Cheng Zhang
Immune checkpoint blockade therapy has been successful in treating some types of cancer but has not shown clinical benefits for treating leukaemia1 . This result suggests that leukaemia uses unique mechanisms to evade this therapy. Certain immune inhibitory receptors that are expressed by normal immune cells are also present on leukaemia cells. Whether these receptors can initiate immune-related primary signalling in tumour cells remains unknown. Here we use mouse models and human cells to show that LILRB4, an immunoreceptor tyrosine-based inhibition motif-containing receptor and a marker of monocytic leukaemia, supports tumour cell infiltration into tissues and suppresses T cell activity via a signalling pathway that involves APOE, LILRB4, SHP-2, uPAR and ARG1 in acute myeloid leukaemia (AML) cells...
October 17, 2018: Nature
Jacqueline Estevez, Ju Dong Yang, Jennifer Leong, Pauline Nguyen, Nasra H Giama, Ning Zhang, Hamdi A Ali, Mei-Hsuan Lee, Ramsey Cheung, Lewis Roberts, Myron Schwartz, Mindie H Nguyen
BACKGROUND: African-Americans (AA) have a higher incidence of hepatocellular carcinoma (HCC) and lower survival. We characterized survival rates and clinical features associated with survival in AA vs. Caucasians with HCC over the past two decades. METHODS: HCC patients from three US medical centers were matched by year of diagnosis (1991-2016): AA (n = 578)/Caucasian (n = 578) and placed in one of two groups-HCC diagnosed prior to 2010 or 2010 and after...
October 17, 2018: American Journal of Gastroenterology
Ying Qian, Mohan Song, Xi Jiang, Ming Xia, Jarek Meller, Ming Tan, Yutao Chen, Xuemei Li, Zihe Rao
Human noroviruses (huNoVs) that cause epidemic acute gastroenteritis recognize histo-blood group antigens (HBGAs) as host attachment factors affecting host susceptibility. HuNoVs are genetically diverse, containing at least 31 genotypes in the two major genogroups (GI and GII). Three GII genotypes, GII.17/13/21, form a unique genetic lineage, in which GII.17 genotype retains the conventional GII HBGA binding site (HBS), while GII.13/21 genotypes acquire a completely new HBS. To understand the molecular bases behind these evolutionary changes, we solved the crystal structures of the HBGA-binding protruding domains of 1) an early GII...
October 17, 2018: Journal of Virology
Marc Lewis
New England Journal of Medicine, Volume 379, Issue 16, Page 1551-1560, October 2018.
October 18, 2018: New England Journal of Medicine
Sarah E Dumas, Dale Lewis, Alexander J Travis
Animal source foods can efficiently enhance dietary quality, but they remain inaccessible and unaffordable for many women and young children in remote, low-income communities. We piloted an intervention in which 20 groups established egg production centres (EPCs) in their rural Zambian communities to increase the availability of eggs in the local food system. In a repeated cross-sectional design over 1 year (midline [4 months after the start of egg production] and endline [11 months]), we evaluated programme impact on household egg acquisition within those communities and on egg consumption and height-for-age z score (HAZ) among young children (6-36 months) using multilevel linear, logistic, and truncated negative binomial regression techniques...
October 2018: Maternal & Child Nutrition
Conchín Simó-Sanz, M ª Luisa Ballestar-Tarín, Antonio Martínez-Sabater
The wide functionality and the vast range of attributes offered by smartphones has led to a substantial increase in the average amount of time these devices are used per day. An excessive use of these tools has been shown to result in symptomatology similar to psychological disorders caused by substance addiction. In Spain, smartphone use has risen exponentially but the effects of this increase remain unclear. Therefore, an instrument is required to help determine the extent of smartphone addiction in the Spanish population...
2018: PloS One
Mehmet A Bilen, Dylan J Martini, Yuan Liu, Colleen Lewis, Hannah H Collins, Julie M Shabto, Mehmet Akce, Haydn T Kissick, Bradley C Carthon, Walid L Shaib, Olatunji B Alese, Rathi N Pillai, Conor E Steuer, Christina S Wu, David H Lawson, Ragini R Kudchadkar, Bassel F El-Rayes, Viraj A Master, Suresh S Ramalingam, Taofeek K Owonikoko, R Donald Harvey
BACKGROUND: Optimal prognostic and predictive biomarkers for patients with advanced-stage cancer patients who received immunotherapy (IO) are lacking. Inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), the monocyte-to-lymphocyte ratio (MLR), and the platelet-to-lymphocyte ratio (PLR), are readily available. The authors investigated the association between these markers and clinical outcomes of patients with advanced-stage cancer who received IO. METHODS: A retrospective review was conducted of 90 patients with advanced cancer who received treatment on phase 1 clinical trials of IO-based treatment regimens...
October 17, 2018: Cancer
Ethan Moitra, Yovanska Duarte-Velez, Roberto Lewis-Fernández, Risa B Weisberg, Martin B Keller
BACKGROUND: Ataque de nervios (ataque) represents a cultural syndrome of paroxysmic symptoms that is described as an expression of distress among Latinx (gender-inclusive term for people of Latin-American descent). Some ataques are symptomatically similar to DSM-5-defined panic attacks, but also may include acute anger, grief, suicidal/violent behavior, or dissociation, and can last for hours or even days. Ataques usually occur after stressors and can trigger the mobilization of social support networks...
October 17, 2018: Depression and Anxiety
Amgad H Hanna, Davinder Ramsingh, Whitney Sullivan-Lewis, Sarah Cano, Patrick Leiter, Desiree Wallace, Gerald Andrews, Briahnna Austin, Richard L Applegate
BACKGROUND: Anxiety associated with pediatric surgery can be stressful. Midazolam is a well-accepted anxiolytic in this setting. However, there are cases in which this medication is not effective. Zolpidem is a short-acting nonbenzodiazepine hypnotic drug that is administered orally and has quick onset of action (~15 minutes), and 2-3 hour duration. AIMS: Based on the theory that impaired perception following oral zolpidem administration would suppress the development of anxiety, we sought to compare zolpidem to midazolam for pediatric preoperative anxiety...
October 17, 2018: Paediatric Anaesthesia
Yuji Yamazaki, Yukiko Nambu, Masashi Ohmae, Manabu Sugai, Shunsaku Kimura
Immune responses against Lewis y (LY) displayed on nanocarriers at different surface densities were studied. The high surface density of LY was obtained by the A2B-type amphiphilic polypeptides having LY at the two terminals [LY-poly(sarcosine)2-b-(l- or d-Leu-Aib)6]. The equimolar mixture of these two amphiphilic polypeptides formed interdigitated planar sheet-like molecular assemblies densely displaying LY (G4). G4 seemed to induce the anti-LY IgM upon immunization to BALB/c mice by only a single administration...
October 17, 2018: Organic & Biomolecular Chemistry
Heena Panchal, Christopher Clarke, Charles Bell, Somnath Narayan Karad, William Lewis, Hon Wai Lam
Nickel-catalyzed, highly diastereoselective annulations between activated allenes and 2-acetylarylboronic acid or 2-formylarylboronic acids are reported. No ligand for nickel is required, and the reactions proceed efficiently at room temperature to give a broad range of substituted 3-methyleneindan-1-ols. Preliminary results of an enantioselective variant are also described.
October 17, 2018: Chemical Communications: Chem Comm
Jacob L Brown, David E Lee, Megan E Rosa-Caldwell, Lemuel A Brown, Richard A Perry, Wesley S Haynie, Kendra Huseman, Kavithalakshmi Sataranatarajan, Holly Van Remmen, Tyrone A Washington, Michael P Wiggs, Nicholas P Greene
BACKGROUND: Cancer cachexia occurs in approximately 80% of cancer patients and is a key contributor to cancer-related death. The mechanisms controlling development of tumour-induced muscle wasting are not fully elucidated. Specifically, the progression and development of cancer cachexia are underexplored. Therefore, we examined skeletal muscle protein turnover throughout the development of cancer cachexia in tumour-bearing mice. METHODS: Lewis lung carcinoma (LLC) was injected into the hind flank of C57BL6/J mice at 8 weeks age with tumour allowed to develop for 1, 2, 3, or 4 weeks and compared with PBS injected control...
October 16, 2018: Journal of Cachexia, Sarcopenia and Muscle
Kenny Yat Hong Kwan, Cora Bow, Dino Samartzis, Lawrence G Lenke, Christopher I Shaffrey, Leah Y Carreon, Benny T Dahl, Michael G Fehlings, Christopher P Ames, Oheneba Boachie-Adjei, Mark B Dekutoski, Khaled M Kebaish, Stephen J Lewis, Yukihiro Matsuyama, Hossein Mehdian, Ferran Pellisé, Yong Qiu, Frank J Schwab, Kenneth Man Chee Cheung
PURPOSE: Accurate information regarding the expected complications of complex adult spinal deformity (ASD) is important for shared decision making and informed consent. The purpose of the present study was to investigate the rate and types of non-neurologic adverse events after complex ASD surgeries, and to identify risk factors that affect their occurrence. METHODS: The details and occurrence of all non-neurologic adverse events were reviewed in a prospective cohort of 272 patients after complex ASD surgical correction in a mulitcentre database of the Scoli-RISK-1 study with a planned follow-up of 2 years...
October 16, 2018: European Spine Journal
Virginie Courchet, Amanda J Roberts, Géraldine Meyer-Dilhet, Peggy Del Carmine, Tommy L Lewis, Franck Polleux, Julien Courchet
Recently, numerous rare de novo mutations have been identified in patients diagnosed with autism spectrum disorders (ASD). However, despite the predicted loss-of-function nature of some of these de novo mutations, the affected individuals are heterozygous carriers, which would suggest that most of these candidate genes are haploinsufficient and/or lead to expression of dominant-negative forms of the protein. Here, we tested this hypothesis with the candidate ASD gene Nuak1 that we previously identified for its role in the development of cortical connectivity...
October 16, 2018: Nature Communications
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