keyword
MENU ▼
Read by QxMD icon Read
search

"steroid induce", "osteoporosis"

keyword
https://www.readbyqxmd.com/read/30276424/dose-dependent-bradycardia-as-a-rare-side-effect-of-corticosteroids-a-case-report-and-review-of-the-literature
#1
REVIEW
Döndü Üsküdar Cansu, Erdal Bodakçi, Cengiz Korkmaz
Corticosteroids rank at the first place among the most commonly used immunosuppressive agents in the rheumatology practice. Although their conventional adverse effects including hyperglycemia, hypertension, hyperlipidemia, and osteoporosis are well-recognized and managed, steroid-induced cardiac arrhythmias are known to a lesser extent. In this regard, steroid-associated bradycardia is rarely expected and not very well known. Reported cases of steroid-associated bradycardias in the literature predominantly have emerged during the course of intravenous high-dose (pulse) methylprednisolone (MP) administrations...
October 1, 2018: Rheumatology International
https://www.readbyqxmd.com/read/30045610/effects-of-epidural-steroid-injections-on-bone-mineral-density-and-bone-turnover-markers-in-patients-taking-anti-osteoporotic-medications
#2
Seon Yoon Nah, Jae Hyup Lee, Ji-Ho Lee
BACKGROUND: Glucocorticoids adversely affect bone mineral density (BMD) and increase the risk of fracture. Yet, the cause-and-effect relationship between epidural steroid injection (ESI) and BMD has not been thoroughly investigated, and available results are inconsistent. This is probably a consequence of differences in the dose of steroids and follow-up duration. OBJECTIVE: This study aimed to evaluate changes in BMD and the risk of fracture according to duration of the follow-up and amount of steroids used for ESI...
July 2018: Pain Physician
https://www.readbyqxmd.com/read/30019224/denosumab-in-the-treatment-of-glucocorticoid-induced-osteoporosis
#3
REVIEW
Ilke Coskun Benlidayi
Glucocorticoid therapy is the number one cause of secondary osteoporosis particularly effecting young individuals. Possessing an increased risk for fractures, glucocorticoid-induced osteoporosis might interfere with patients' well-being and quality of life. Therefore, proper treatment of bone loss and prevention from fractures are of great importance. There are a limited number of therapeutic and preventative options for glucocorticoid-induced osteoporosis. Denosumab, with its high anti-resorptive potential, has been studied several times among patients on glucocorticoid therapy...
July 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29902593/bone-matrix-development-in-steroid-induced-osteoporosis-is-associated-with-a-consistently-reduced-fibrillar-stiffness-linked-to-altered-bone-mineral-quality
#4
L Xi, P De Falco, E Barbieri, A Karunaratne, L Bentley, C T Esapa, N J Terrill, S D M Brown, R D Cox, G R Davis, N M Pugno, R V Thakker, H S Gupta
Glucocorticoid-induced osteoporosis (GIOP) is a major secondary form of osteoporosis, with the fracture risk significantly elevated - at similar levels of bone mineral density - in patients taking glucocorticoids compared with non-users. The adverse bone structural changes at multiple hierarchical levels in GIOP, and their mechanistic consequences leading to reduced load-bearing capacity, are not clearly understood. Here we combine experimental X-ray nanoscale mechanical imaging with analytical modelling of the bone matrix mechanics to determine mechanisms causing bone material quality deterioration during development of GIOP...
August 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29705870/animal-models-of-steroid-induced-osteonecrosis-of-the-femoral-head-a-comprehensive-research-review-up-to-2018
#5
REVIEW
Jianzhong Xu, Hanpu Gong, Shitao Lu, Matthey J Deasey, Quanjun Cui
Osteonecrosis of the femoral head (ONFH) is a significant cause of both pain and disability that often affects young adults during what ought to be their most productive age. Two broad categories of ONFH exist: traumatic and non-traumatic. Traumatic ONFH results from acute mechanical disruption of the femoral head's blood supply. Many factors that increase the risk of non-traumatic osteonecrosis have been identified. Steroid-induced osteonecrosis of the femoral head (SONFH) is the most common form of non-traumatic ONFH...
July 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29652557/skeletal-response-to-treatment-with-teriparatide-tpd-after-bisphosphonate-in-post-menopausal-women-with-osteoporosis-and-a-high-prevalence-of-secondary-risk-factors-in-real-life-setting-of-a-metabolic-bone-clinic-effect-of-age-and-vitamin-d-status
#6
J Mok, C Brown, A E B Moore, S S Min, G Hampson
PURPOSE: Teriparatide (TPD) is a skeletal anabolic agent used in patients with severe post-menopausal osteoporosis (PMO) and steroid-induced osteoporosis who are at hish risk of fracture. Predictors of therapeutic response to teriparatide in real-life setting are not well characterised. We investigated potential factors associated with teriparatide response in post-menopausal women with established osteoporosis. METHODS: We carried out a retrospective survey of 48 women, aged 73...
August 2018: Endocrine Research
https://www.readbyqxmd.com/read/29404179/a-prospective-review-of-the-results-of-patients-treated-and-followed-up-for-a-diagnosis-of-sarcoidosis
#7
Levent Özdemir, Burcu Özdemir
OBJECTIVES: The present study reports the treatment and follow-up results of patients prospectively diagnosed and treated in a public hospital. MATERIAL AND METHODS: The present study reports the prospective follow-up data of 21 sarcoidosis cases followed up and treated in the Department of Chest Diseases of Dörtyol State Hospital from January 2010 to December 2014. RESULTS: The 21 cases had a mean age of 44±10 years and a mean follow-up period of 38±13 months...
January 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29084466/elevated-expression-of-dkk-1-by-glucocorticoid-treatment-impairs-bone-regenerative-capacity-of-adipose-tissue-derived-mesenchymal-stem-cells
#8
Toshiki Kato, Vuong Cat Khanh, Kazutoshi Sato, Kenichi Kimura, Toshiharu Yamashita, Hisashi Sugaya, Tomokazu Yoshioka, Hajime Mishima, Osamu Ohneda
Glucocorticoids are steroid hormones used as anti-inflammatory treatments. However, this strong immunomodulation causes undesirable side effects that impair bones, such as osteoporosis. Glucocorticoid therapy is a major risk factor for developing steroid-induced osteonecrosis of the femur head (ONFH). Since ONFH is incurable, therapy with mesenchymal stem cells (MSCs) that can differentiate into osteoblasts are a first-line choice. Bone marrow-derived MSCs (BM-MSCs) are often used as a source of stem cell therapy for ONFH, but their proliferative activity is impaired after steroid treatment...
January 15, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/28492609/the-risk-of-osteoporosis-in-oral-steroid-treatment-for-nasal-polyposis-a-systematic-review
#9
L Winblad, C G Larsen, K Håkansson, B Abrahamsen, C von Buchwald
BACKGROUND: Systemic glucocorticoids are often used in the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP), and osteoporosis is a well-known complication to steroid treatment, associated with significant morbidity. Nevertheless, the burden of steroid induced osteoporosis is unknown in patients with CRSwNP. We aimed to assess the risk of acquiring osteoporosis caused by oral steroids in patients with CRSwNP, and provide recommendations on future research and guidelines. METHODOLOGY: Cochrane Review Database, EMBASE, Ovid Medline, and PubMed were searched for studies including adult patients with CRSwNP treated with oral steroids...
September 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28425086/the-clinical-benefits-of-denosumab-for-prophylaxis-of-steroid-induced-osteoporosis-in-patients-with-pulmonary-disease
#10
Shigeo Ishiguro, Kentaro Ito, Shigenori Nakagawa, Osamu Hataji, Akihiro Sudo
Previous reports demonstrated that bone density decreased rapidly during the initial few months of steroid therapy and continued decreasing at a rate of 2 to 4% annually. Our data indicates that denosumab can also play a role in the treatment of osteoporosis in the steroid-taking population. INTRODUCTION: Respiratory physicians are often faced with the dilemma that long-term steroid use will deteriorate bone mineral density and quality. Previous reports demonstrated that bone density decreased 8 to 12% during the initial few months of steroid therapy then continued decreasing at a rate of 2 to 4% annually...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/27918081/st1926-attenuates-steroid-induced-osteoporosis-in-rats-by-inhibiting-inflammation-response
#11
Hong-Xing Zhao, Yuan-Xia Huang, Jin-Gang Tao
Steroid, also known as glucocorticoid, induced osteonecrosis of the femoral head in young adults, which has been a challenging disorder for the frequent incidence of collapse of femoral head, leading to dysfunction of hip joint and impairing life quality of human. Bioavailable and less toxic synthetic retinoids, such as the atypical adamantyl retinoid ST1926, have been developed and investigated in clinical trials for many diseases. Serum lipid-related indicators were assessed to elucidate the role of ST1926 in regulating lipid metabolism...
August 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27908909/dtb-select-12-december-2016
#12
(no author information available yet)
Azithromycin of no benefit for asthma attacks ● Risk of heart failure with NSAIDs ● Bisphosphonates and steroid-induced osteoporosis ● Triple therapy for moderate-to-severe COPD: marginal benefits ● Much data on adverse events remains unpublished ● Rising placebo response rates in antidepressant trials a 'myth' ● Prenatal fetal RhD testing recommended.
December 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27706804/bisphosphonates-for-steroid-induced-osteoporosis
#13
REVIEW
Claire S Allen, James Hs Yeung, Ben Vandermeer, Joanne Homik
BACKGROUND: This is an update of a Cochrane Review first published in 1999. Corticosteroids are widely used in inflammatory conditions as an immunosuppressive agent. Bone loss is a serious side effect of this therapy. Several studies have examined the use of bisphosphonates in the prevention and treatment of glucocorticosteroid-induced osteoporosis (GIOP) and have reported varying magnitudes of effect. OBJECTIVES: To assess the benefits and harms of bisphosphonates for the prevention and treatment of GIOP in adults...
October 5, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27666694/-steroids-induced-osteoporosis-due-to-the-treatment-for-pulmonary-diseases
#14
REVIEW
Nobuyuki Horita, Takeshi Kaneko
Corticosteroids are key medications to treat pulmonary diseases. A variety of medications, doses, administration route, and duration of corticosteroids were chosen for each of pulmonary diseases. Although corticosteroids are potent medications, they often cause serious adverse effects such as osteoporosis, diabetes, and immunosuppression. Thus, physicians have to properly assess the risk of adverse effects to prevent them. In this review, we discuss the risk of osteoporosis by corticosteroids that are prescribed for pulmonary diseases...
2016: Clinical Calcium
https://www.readbyqxmd.com/read/27355337/sex-steroid-induced-apoptosis-as-a-rational-strategy-to-treat-anti-hormone-resistant-breast-and-prostate-cancer
#15
V Craig Jordan, Ping Fan, Balkees Abderrahman, Philipp Y Maximov, Yousef M Hawsawi, Poulomi Bhattacharya, Niranjana Pokharel
The combined incidence and the extended disease course of breast and prostate cancer is a major challenge for health care systems. The solution for society requires an economically viable treatment strategy to maintain individuals disease free and productive, so as to avoid the fracture of the family unit. Forty years ago, translational research using the antiestrogen tamoxifen was targeted to estrogen receptor (ER) positive micrometastatic tumor cells and established the long-term antihormone adjuvant treatment strategy used universally today...
May 2016: Discovery Medicine
https://www.readbyqxmd.com/read/27298501/an-experimental-study-to-evaluate-the-antiosteoporotic-effect-of-panchatikta-ghrita-in-a-steroid-induced-osteoporosis-rat-model
#16
Renuka Munshi, Tanvi Patil, Chetan Garuda, Dushyant Kothari
OBJECTIVE: The study was conducted to develop the glucocorticoid-induced osteoporosis (GIO) model in Sprague-Dawley weanling rats using different doses of methylprednisolone (MP) and evaluate the antiosteoporotic effect of a classical ayurvedic formulation, Panchatikta Ghrita (PG), in this model. MATERIALS AND METHODS: Institutional Animal Ethics Committee approval was obtained. Development of model was done by subcutaneous injection of 2 doses of MP (14 and 28 mg/kg/week) for 4 weeks in 21-day old weanlings...
May 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/26935513/osteoporosis-in-gastrointestinal-diseases
#17
REVIEW
Iwona Krela-Kaźmierczak, Aleksandra Szymczak, Liliana Łykowska-Szuber, Piotr Eder, Krzysztof Linke
Secondary osteoporosis occurs as an isolated pathology or co-exists with types I and II osteoporosis. The gastroenterologist may come across osteoporosis or osteopenia in a patient with a gastrointestinal disease. This is often a young patient in whom investigations should be carried out and appropriate treatment initiated, aimed at preventing bone fractures and the formation of the best peak bone mass. Osteoporosis occurs in patients with the following conditions: Crohn's disease, ulcerative colitis, celiac disease, post gastrectomy patients, patients with short bowel syndrome, chronic hepatitis and cirrhosis, treated with steroids (steroid-induced osteoporosis) and patients using proton pump inhibitors chronically (state of achlorhydria)...
January 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/26929019/efficacy-and-safety-of-minodronic-acid-hydrate-in-patients-with-steroid-induced-osteoporosis
#18
Noboru Kitamura, Hidetaka Shiraiwa, Hirotake Inomata, Takamasa Nozaki, Natsumi Ikumi, Kaita Sugiyama, Yousuke Nagasawa, Hiromi Karasawa, Mitsuhiro Iwata, Yoshihiro Matsukawa, Masami Takei
OBJECTIVES: Minodronic acid hydrate, an oral bisphosphonate, has a greater inhibitory effect on bone resorption than do other approved drugs; however, this has been studied only in patients with primary osteoporosis. Here, we administered minodronic acid hydrate to patients with steroid-induced osteoporosis who have been treated with steroids for rheumatoid arthritis or other collagen diseases, and the efficacy and safety of minodronic acid hydrate were prospectively investigated. METHODS: Twenty-five patients treated in our rheumatology clinic received minodronic acid hydrate 1 mg/day...
April 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/26657825/multiscale-alterations-in-bone-matrix-quality-increased-fragility-in-steroid-induced-osteoporosis
#19
A Karunaratne, L Xi, L Bentley, D Sykes, A Boyde, C T Esapa, N J Terrill, S D M Brown, R D Cox, R V Thakker, H S Gupta
A serious adverse clinical effect of glucocorticoid steroid treatment is secondary osteoporosis, enhancing fracture risk in bone. This rapid increase in bone fracture risk is largely independent of bone loss (quantity), and must therefore arise from degradation of the quality of the bone matrix at the micro- and nanoscale. However, we lack an understanding of both the specific alterations in bone quality n steroid-induced osteoporosis as well as the mechanistic effects of these changes. Here we demonstrate alterations in the nanostructural parameters of the mineralized fibrillar collagen matrix, which affect bone quality, and develop a model linking these to increased fracture risk in glucocorticoid induced osteoporosis...
March 2016: Bone
https://www.readbyqxmd.com/read/26163144/systemic-application-of-teriparatide-for-steroid-induced-osteonecrosis-in-a-rat-model
#20
Yulei Dong, Yulong Li, Cheng Huang, Kai Gao, Xisheng Weng
BACKGROUND: Steroid associated osteonecrosis is difficult to treat. Teriparatide, as the only one bone anabolic drug, has achieved very promising effect in osteoporosis and other bone skeletal diseases. We carried out this animal study to evaluate the effect of subcutaneous injection of teriparatide for the steroid induced femoral head necrosis in a rat model. METHODS: 24 Sprague-Dawley male adult rats were included in the study. All the rats were randomized into 4 groups: 18 rats from LPS/MPS group, LPS/MPS + PTH group and LPS/MPS + NS group were given lipopolysaccharide (20 μg/kg) and methylprednisolone (40 mg/kg) to establish the steroid induced osteonecrosis model...
July 11, 2015: BMC Musculoskeletal Disorders
keyword
keyword
167138
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"