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Physical Activity + Cancer

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https://www.readbyqxmd.com/read/30544985/perceived-facilitators-and-barriers-in-response-to-a-walking-intervention-in-rural-cancer-survivors-a-qualitative-exploration
#1
Lauren J Frensham, Gaynor Parfitt, Rebecca Stanley, James Dollman
Physical activity has numerous associated benefits for cancer survivors. Compared to their urban counterparts, rural and remote Australians experience a health disadvantage, including poorer survival rate after the diagnosis of cancer. The purpose of this qualitative study was to (a) investigate factors that motivated or inhibited walking in rural participants during a 12-week intervention and (b) to investigate factors that motivated or inhibited physical activity behavior change three months post-intervention...
December 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30544267/einschr%C3%A3-nkungen-in-der-gehf%C3%A3-higkeit-und-der-sprunggelenksdorsalflexion-bei-kindern-nach-intensiver-krebsbehandlung
#2
Vanessa Oschwald, Aram Prokop, Jonas Boehme, Nadja Gressler, Felicitas Harscheidt, Volker Maas, Wilhelm Bloch, Freerk T Baumann, Julia Daeggelmann
BACKGROUND: With improved survival rates in pediatric oncology, the detection of adverse side- and late-effects is gaining increased interest. This cross-sectional study investigated walking abilities and ankle dorsiflexion function in children with cancer. PATIENTS: Study participants included 16 children with various cancers (4-20 years, patient group) after completion of the intense treatment and 16 age- and gender-matched healthy peers (comparison group). METHOD: Walking speed (10-meter-walking-test, treadmill test assessing preferred transition speed), walking capacity (2-minute-walk-test), walking balance (Timed-Up-And-Go-Test), active/passive ankle dorsiflexion range of motion (ROM) (goniometer) and ankle dorsiflexion strength (hand-held dynamometer) were comprehensively assessed...
December 13, 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/30543571/relationships-among-fatigue-anxiety-depression-and-pain-and-health-promoting-lifestyle-behaviors-in-women-with-early-stage-breast-cancer
#3
Debra Lynch Kelly, Gee Su Yang, Angela R Starkweather, Uma Siangphoe, Paula Alexander-Delpech, Debra E Lyon
BACKGROUND: With a nearly 89% 5-year survival rate for women with early-stage breast cancer, symptoms are a priority. Healthy lifestyle behaviors may be temporally associated with symptoms; however, evidence is lacking. OBJECTIVE: This research examined temporal relationships among healthy lifestyle behaviors and symptoms in women diagnosed with breast cancer receiving chemotherapy. METHODS: This research was part of a study (R01NR012667) approved by the institutional review board...
December 12, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/30543049/determinants-of-changes-in-physical-activity-from-pre-diagnosis-to-post-diagnosis-in-a-cohort-of-prostate-cancer-survivors
#4
Chelsea R Stone, Kerry S Courneya, S Elizabeth McGregor, Haocheng Li, Christine M Friedenreich
PURPOSE: Physical activity (PA) has been shown to improve quality of life and survival in cancer survivors; however, a cancer diagnosis may change PA patterns. We examine determinants of changes in meeting the PA guidelines (150 min/week of moderate aerobic PA) before and after a prostate cancer diagnosis. METHODS: Eight hundred and thirty prostate cancer survivors who participated in a population-based case-control study between 1997 and 2000 in Alberta, Canada, enrolled in a prospective cohort study...
December 12, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30543017/health-related-quality-of-life-predicted-subsequent-health-care-resource-utilization-in-patients-with-active-cancer
#5
Regina Rendas-Baum, Denise D'Alessio, Jakob Bue Bjorner
PURPOSE: The objective of this study was to estimate the association between SF-12v2® Health Survey (SF-12v2) scores and subsequent health care resource utilization (HCRU) among patients with cancer. METHODS: We analyzed 18+ year participants in the Medical Expenditure Panel Survey, diagnosed with active cancer or malignancy (n = 647). HCRU was measured by total medical expenditures (MEs) and number of medical events (EVs) in the 6 months following the SF-12v2 assessment...
December 12, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/30541550/trib2-functions-as-novel-oncogene-in-colorectal-cancer-by-blocking-cellular-senescence-through-ap4-p21-signaling
#6
Zhenlin Hou, Kaixuan Guo, Xuling Sun, Fuqing Hu, Qianzhi Chen, Xuelai Luo, Guihua Wang, Junbo Hu, Li Sun
BACKGROUND: Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular senescence might be a novel therapy for cancer cells. TRIB2 has been reported to participate in regulating proliferation and drug resistance of various cancer cells. However, the role of TRIB2 in cellular senescence of colorectal cancer (CRC) and its molecular mechanism remains unclear. METHODS: The expression of TRIB2 in colorectal cancer tissues and adjacent tissues was detected by immunohistochemistry and RT-PCR...
December 12, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/30533987/mondor-s-disease-after-aesthetic-breast-surgery-a-case-series-and-literature-review
#7
Alberto Goldman, Uwe Wollina
Background: Mondor's disease of the subcutaneous veins of the breast is an uncommon disorder. The etiology of Mondor's disease remains unclear. Usually, it is a self-limited disease. This condition has been associated with trauma, surgical biopsies, breast surgery (including silicone breast implant), physical activity, and a manifestation of breast cancer. Materials and Methods: This is a retrospective analysis of 652 female patients who underwent aesthetic breast surgery in the last 10 years...
July 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/30530177/basic-principles-of-drug-delivery-systems-the-case-of-paclitaxel
#8
REVIEW
S Ezrahi, A Aserin, N Garti
Cancer is the second cause of death worldwide, exceeded only by cardiovascular diseases. The prevalent treatment currently used against metastatic cancer is chemotherapy. Among the most studied drugs that inhibit neoplastic cells from acquiring unlimited replicative ability (a hallmark of cancer) are the taxanes. They operate via a unique molecular mechanism affecting mitosis. In this review, we show this mechanism for one of them, paclitaxel, and for other (non-taxanes) anti-mitotic drugs. However, the use of paclitaxel is seriously limited (its bioavailability is <10%) due to several long-standing challenges: its poor water solubility (0...
November 17, 2018: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/30528266/zinc-and-p53-disrupt-mitochondrial-binding-of-hk2-by-phosphorylating-vdac1
#9
Ya-Nan Xue, Bing-Bing Yu, Jiu-Ling Li, Rui Guo, Li-Chao Zhang, Lian-Kun Sun, Ya-Nan Liu, Yang Li
Many cell death regulators physically or functionally interact with metabolic enzymes. These interactions provide insights into mechanisms of anticancer treatments from the perspective of tumor cell metabolism and apoptosis. Recent studies have shown that zinc and p53 not only induce tumor cell apoptosis, but also regulate tumor cell metabolism. However, the underlying mechanism is complex and remains unclear, making further research imperative to provide clues for future cancer treatments. In this study, we found that hexokinase 2 (HK2), which has dual metabolic and apoptotic functions, is downstream of zinc and p53 in both prostate cancer patient tissue and prostate cancer cell lines...
December 4, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/30523074/behind-the-wheel-safety-in-palliative-care-a-literature-review
#10
Mark Howard, Christina Ramsenthaler
BACKGROUND: Driving is a complex activity that requires physical abilities and adequate executive and cognitive functioning. There is concern among specialist palliative care services about patients continuing to drive despite having progressive incurable illnesses, comorbidities and medications to manage their symptoms. OBJECTIVES: To determine the quality of literature available about driving that would apply to palliative care patients, specifically in relation to road test or simulated driving scores and neurocognitive testing...
December 6, 2018: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/30523039/the-colocare-study-a-paradigm-of-transdisciplinary-science-in-colorectal-cancer-outcomes
#11
Cornelia M Ulrich, Biljana Gigic, Jürgen Böhm, Jennifer Ose, Richard Viskochil, Martin Schneider, Graham A Colditz, Jane C Figueiredo, William M Grady, Christopher I Li, David Shibata, Erin M Siegel, Adetunji T Toriola, Alexis Ulrich
BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer death. Biomarkers to predict treatment outcomes are needed, as is evidence whether post-diagnosis diet and lifestyle can affect well-being and clinical outcomes. The international ColoCare Consortium aims to identify new biologic markers (e.g., metabolomic, transcriptomic, metagenomic, genetic, epigenetic, proteomic) that predict clinical outcomes, and to characterize associations between modifiable risk factors (e.g., diet, supplement use, physical activity) with short-term and long-term patient-reported and clinical outcomes among CRC patients...
December 6, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/30521882/body-composition-and-sarcopenia-the-next-generation-of-personalized-oncology-and-pharmacology
#12
REVIEW
Marc Hilmi, Anne Jouinot, Robert Burns, Frédéric Pigneur, Rémi Mounier, Julien Gondin, Cindy Neuzillet, François Goldwasser
Body composition has gained increasing attention in oncology in recent years due to fact that sarcopenia has been revealed to be a strong prognostic indicator for survival across multiple stages and cancer types and a predictive factor for toxicity and surgery complications. Accumulating evidence over the last decade has unraveled the "pharmacology" of sarcopenia. Lean body mass may be more relevant to define drug dosing than the "classical" body surface area or flat-fixed dosing in patients with cancer...
December 3, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/30521881/new-insights-on-the-regulation-of-cancer-cachexia-by-n-3-polyunsaturated-fatty-acids
#13
REVIEW
Renata Gorjao, Cesar Miguel Momesso Dos Santos, Tamires Duarte Afonso Serdan, Vinicius Leonardo Sousa Diniz, Tatiana Carolina Alba-Loureiro, Maria Fernanda Cury-Boaventura, Elaine Hatanaka, Adriana Cristina Levada-Pires, Fábio Takeo Sato, Tania Cristina Pithon-Curi, Luiz Claudio Fernandes, Rui Curi, Sandro Massao Hirabara
Cancer cachexia is a multifactorial syndrome that develops during malignant tumor growth. Changes in plasma levels of several hormones and inflammatory factors result in an intense catabolic state, decreased activity of anabolic pathways, anorexia, and marked weight loss, leading to cachexia development and/or accentuation. Inflammatory mediators appear to be related to the control of a highly regulated process of muscle protein degradation that accelerates the process of cachexia. Several mediators have been postulated to participate in this process, including TNF-α, myostatin, and activated protein degradation pathways...
December 3, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/30521505/uterine-cancer-incidence-and-mortality-united-states-1999-2016
#14
S Jane Henley, Jacqueline W Miller, Nicole F Dowling, Vicki B Benard, Lisa C Richardson
Uterine cancer is one of the few cancers with increasing incidence and mortality in the United States, reflecting, in part, increases in the prevalence of overweight and obesity since the 1980s (1). It is the fourth most common cancer diagnosed and the seventh most common cause of cancer death among U.S. women (1). To assess recent trends in uterine cancer incidence and mortality by race and ethnicity, CDC analyzed incidence data from CDC's National Program of Cancer Registries (NPCR) and the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program and mortality data from the National Vital Statistics System (2)...
December 7, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/30516839/levels-and-patterns-of-self-reported-and-objectively-measured-free-living-physical-activity-among-prostate-cancer-survivors-a-prospective-cohort-study
#15
Lee Smith, Jung Ae Lee, Junbae Mun, Ratna Pakpahan, Kellie R Imm, Sonya Izadi, Adam S Kibel, Graham A Colditz, Robert L Grubb Iii, Kathleen Y Wolin, Siobhan Sutcliffe, Lin Yang
BACKGROUND: No prior study has measured or compared self-reported and objectively measured physical activity trajectories in prostate cancer survivors before and after treatment. METHODS: Clinically localized prostate cancer patients treated with radical prostatectomy were recruited between 2011 and 2014. Of the 350 participants enrolled at the main site, 310 provided self-reported physical activity at baseline before radical prostatectomy, and 5 weeks, 6 months, and 12 months after radical prostatectomy...
December 5, 2018: Cancer
https://www.readbyqxmd.com/read/30514263/physical-activity-patterns-and-the-risk-of-colorectal-cancer-in-the-norwegian-women-and-cancer-study-a-population-based-prospective-study
#16
Sunday Oluwafemi Oyeyemi, Tonje Braaten, Idlir Licaj, Eiliv Lund, Kristin Benjaminsen Borch
INTRODUCTION: Colorectal cancer (CRC) remains the second most common cancer in women worldwide. Physical activity (PA) has been associated with reduced risk of CRC; however, this has been demonstrated more consistently in men, while results of studies in women have been largely equivocal. We aimed to further examine the relationship between PA patterns and the risk of CRC in women, using repeated measurements. METHODS: We followed participants of the Norwegian Women and Cancer (NOWAC) Study - a nationally representative cohort...
December 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30514193/malignant-pleural-effusion-still-a-long-way-to-go
#17
Fausto Meriggi
BACKGROUND: Malignant pleural effusion, which is a common clinical problem in patients with cancer, may be due to both primary thoracic tumours or to a metastatic spread in the chest and constitutes the first sign of disease in approximately 10% of patients. Almost all cancers can potentially produce a pleural effusion. The presence of malignant tumour cells in the pleural fluid is generally indicative of advanced disease and is associated with high morbidity and mortality with reduced therapeutic options...
December 3, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/30514109/understanding-physical-activity-behavior-in-patients-with-bladder-cancer-before-and-after-radical-cystectomy-a-qualitative-interview-study
#18
Elke Rammant, Valérie Fonteyne, Karel Decaestecker, Renée Bultijnck, Benedicte Deforche, Ronny Pieters, Piet Ost, Sofie Verhaeghe, Ann Van Hecke
OBJECTIVE: To explore the determinants of physical activity in patients with bladder cancer before and after radical cystectomy. DESIGN: A qualitative research design using semi-structured face-to-face interviews. SETTING AND SUBJECTS: A total of 30 interviews were conducted with people diagnosed with bladder cancer and treated with radical cystectomy at Ghent University Hospital. MAIN MEASURES: The interviews were audiotaped and transcribed verbatim...
December 4, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/30509735/physical-activity-functional-ability-and-quality-of-life-after-breast-cancer-surgery
#19
K P Fontes, D F Veiga, A C Naldoni, M Sabino-Neto, L M Ferreira
This cross-sectional study aimed to assess the influence of different surgical treatment modalities on the level of physical activity, functional capacity, and quality of life of breast cancer survivors. One hundred eighty women aged 30-60 years old were selected and allocated to control group (CG, women without breast cancer, n = 45), breast-conserving surgery group (BCG, n = 45), mastectomy group (MG, n = 45), and breast reconstruction group (BRG, n = 45). Physical activity, functional capacity, and quality of life were assessed, respectively, using the following self-report questionnaires validated for use in Brazil: International Physical Activity Questionnaire (IPAQ), Stanford Health Assessment Questionnaire (HAQ-20), and Medical Outcomes Study 36-item Short-Form Health Survey (SF-36)...
November 13, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/30508641/quality-of-life-in-non-small-cell-lung-cancer-survivors-a-multicenter-cross-sectional-study
#20
Marlene Hechtner, Martin Eichler, Beatrice Wehler, Roland Buhl, Martin Sebastian, Jan Stratmann, Heinz Schmidberger, Bernhard Gohrbandt, Jessica Peuser, Cornelius Kortsik, Ursula Nestle, Sebastian Wiesemann, Hubert Wirtz, Thomas Wehler, Robert Bals, Maria Blettner, Susanne Singer
INTRODUCTION: The objective was to assess quality of life (QoL) in lung cancer survivors, compare it to the general population, and identify factors associated with global QoL, physical functioning, emotional functioning, fatigue, pain, and dyspnea. METHODS: Data from non-small-cell lung cancer (NSCLC) patients who had survived ≥1 year after diagnosis were collected cross-sectionally in a multicenter study. QoL was assessed with the EORTC QLQ-C30 and the lung cancer module QLQ-LC13 across different clinical subgroups and compared to age- and gender-standardized general population reference values...
November 30, 2018: Journal of Thoracic Oncology
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