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Physical Activity + Cancer

Tateaki Naito, Shuichi Mitsunaga, Satoru Miura, Noriatsu Tatematsu, Toshimi Inano, Takako Mouri, Tetsuya Tsuji, Takashi Higashiguchi, Akio Inui, Taro Okayama, Teiko Yamaguchi, Ayumu Morikawa, Naoharu Mori, Toshiaki Takahashi, Florian Strasser, Katsuhiro Omae, Keita Mori, Koichi Takayama
BACKGROUND: Combinations of exercise and nutritional interventions might improve the functional prognosis for cachectic cancer patients. However, high attrition and poor compliance with interventions limit their efficacy. We aimed to test the feasibility of the early induction of new multimodal interventions specific for elderly patients with advanced cancer Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) programme. METHODS: This was a multicentre prospective single-arm study...
October 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
Nathan H Parker, An Ngo-Huang, Rebecca E Lee, Daniel P O'Connor, Karen M Basen-Engquist, Maria Q B Petzel, Xuemei Wang, Lianchun Xiao, David R Fogelman, Keri L Schadler, Richard J Simpson, Jason B Fleming, Jeffrey E Lee, Gauri R Varadhachary, Sunil K Sahai, Matthew H G Katz
PURPOSE: Guidelines recommend exercise to cancer survivors, but limited data exists regarding exercise among patients undergoing preoperative cancer treatment. We examined differences in weekly self-reported exercise and accelerometer-measured physical activity among participants in a home-based exercise program administered during preoperative treatment for pancreatic cancer. METHODS: Participants were encouraged to perform at least 60 min/week of moderate-intensity aerobic exercise and at least 60 min/week of full-body strengthening exercises concurrent with chemotherapy, chemoradiation therapy or both sequentially and received resistance equipment, program instruction, and biweekly follow-up calls to encourage adherence...
October 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Nicole M Niehoff, Hazel B Nichols, Shanshan Zhao, Alexandra J White, Dale P Sandler
BACKGROUND: Recreational physical activity has been consistently associated with reduced breast cancer risk. Less is known about how family history of breast cancer impacts the association, and whether it varies by menopausal status. METHODS: The Sister Study is a cohort of 50,884 women who had a sister with breast cancer, but no prior breast cancer themselves. Women reported all recreational sport/exercise activities they participated in over the past 12 months...
October 17, 2018: Cancer Epidemiology, Biomarkers & Prevention
Justin C Brown, Andrew D Rhim, Sara L Manning, Luke Brennan, Alexandra I Mansour, Anil K Rustgi, Nevena Damjanov, Andrea B Troxel, Michael R Rickels, Bonnie Ky, Babette S Zemel, Kerry S Courneya, Kathryn H Schmitz
BACKGROUND: Physical activity is associated with a lower risk of disease recurrence among colon cancer patients. Circulating tumor cells (CTC) are prognostic of disease recurrence among stage I-III colon cancer patients. The pathways through which physical activity may alter disease outcomes are unknown, but may be mediated by changes in CTCs. METHODS: Participants included 23 stage I-III colon cancer patients randomized into one of three groups: usual-care control, 150 min∙wk-1 of aerobic exercise (low-dose), and 300 min∙wk-1 of aerobic exercise (high-dose) for six months...
2018: PloS One
Su Yon Jung, Nick Mancuso, Herbert Yu, Jeanette Papp, Eric M Sobel, Zuo-Feng Zhang
Insulin-resistance (IR)-related genetic variants are possibly associated with breast cancer, and the gene-phenotype-cancer association could be modified by lifestyle factors including obesity, physical inactivity, and high-fat diet. Using data from postmenopausal women, a population highly susceptible to obesity, IR, and increased risk of breast cancer, we implemented a genome-wide association study (GWAS) in 2 steps: 1) GWAS meta-analysis of gene-environmental (i.e., behavioral) interaction (G*E) for IR phenotypes (hyperglycemia, hyperinsulinemia, and homeostatic model assessment-insulin resistance); and 2) after the G*E GWAS meta-analysis, the identified single-nucleotide polymorphisms (SNPs) were tested for their associations with breast cancer risk in overall or subgroup population, where the SNPs were identified at genome-wide significance...
October 16, 2018: Cancer Prevention Research
Ena Huseinovic, Anna Winkvist, Heinz Freisling, Nadia Slimani, Heiner Boeing, Genevieve Buckland, Lukas Schwingshackl, Anja Olsen, Anne Tjønneland, Magdalena Stepien, Marie-Christine Boutron-Ruault, Francesca Mancini, Fanny Artaud, Tilman Kühn, Verena Katzke, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Rosario Tumino, Giovanna Masala, Vittorio Krogh, Maria Santucci de Magistris, Marga C Ocké, Magritt Brustad, Torill Enget Jensen, Guri Skeie, Miguel Rodríguez-Barranco, José María Huerta, Eva Ardanaz, José Ramón Quirós, Paula Jakszyn, Emily Sonestedt, Ulrika Ericson, Maria Wennberg, Timothy J Key, Dagfinn Aune, Elio Riboli, Elisabete Weiderpass, Heléne Bertéus Forslund
OBJECTIVE: To examine timing of eating across ten European countries. DESIGN: Cross-sectional analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study using standardized 24 h diet recalls collected during 1995-2000. Eleven predefined food consumption occasions were assessed during the recall interview. We present time of consumption of meals and snacks as well as the later:earlier energy intake ratio, with earlier and later intakes defined as 06...
October 17, 2018: Public Health Nutrition
Edward J Calabrese, James J Giordano, Walter J Kozumbo, Rehana K Leak, Tarun N Bhatia
The activation or polarization of macrophages to pro- or anti-inflammatory states evolved as an adaptation to protect against a spectrum of biological threats. Such an adaptation engages pro-oxidative mechanisms and enables macrophages to neutralize and kill threatening organisms (e.g., viruses, bacteria, mold), limit cancerous growths, and enhance recovery and repair processes. The present study demonstrates that (1) many diverse pharmacological, chemical and physical agents can mediate a dose/concentration-dependent shift between pro- and anti-inflammatory activation states, and (2) these shifts in activation states display biphasic dose-response relationships that are characteristic of hormesis...
October 13, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Tang Gao, Anyao Bi, Shuiqi Yang, Yi Liu, Xiangqi Kong, Wenbin Zeng
Prostate cancer (PCa) is the most common type of cancer in men with high morbidity and mortality. However, the current treatment with drugs often leads to chemotherapy resistance. It is known that the multi-disciplines research on molecular imaging is very helpful for early diagnosing, staging, restaging and precise treatment of PCa. In the past decades, the tumor-specific targeted drugs were developed for the clinic to treat prostate cancer. Among them, the emerging nanotechnology has brought about many exciting novel diagnosis and treatments systems for PCa...
2018: Advances in Experimental Medicine and Biology
Xiaoyun Sun, Ji Chen, Yanyong Zhang, Mumingjiang Munisha, Scott Dougan, Yuhua Sun
MAX giant associated protein (MGA) is a dual transcriptional factor containing both T-box and bHLHzip DNA binding domains. In vitro studies have shown that MGA functions as a transcriptional repressor or activator to regulate transcription of promotors containing either E-box or T-box binding sites. BS69 (ZMYND11), a multidomain-containing (i.e., PHD, BROMO, PWWP, and MYND) protein, has been shown to selectively recognizes histone variant H3.3 lysine 36 trimethylation (H3.3K36me3), modulates RNA Polymerase II elongation, and functions as RNA splicing regulator...
2018: Frontiers in Cell and Developmental Biology
Moses Koobotse, Jeff Holly, Claire Perks
Within populations carrying the same genetic predisposition, the penetrance of BRCA1 mutations has increased over time. Although linked to changes in lifestyle factors associated with energy metabolism, these observations cannot be explained by the established role of BRCA1 in DNA repair alone. We manipulated BRCA1 expression using tetracycline in the UBR60-bcl2 cell line (which has an inducible, tetracycline-regulated BRCA1 expression) and siRNA in oestrogen receptor(ER)-positive MCF7 and T47D breast cancer cells...
September 11, 2018: Oncotarget
Engle Angela Chan, Shirley Ching, Michael Li
PURPOSE: The aim of this study was to explore how the provision of community care in a cancer support center can help cancer patients and survivors cope with the demands of cancer and its treatment. METHODS: A focused ethnographic approach was adopted. Data were collected through participant observations and focus groups with various stakeholders. The data from the focus groups were transcribed verbatim and analyzed using constant comparative analysis. RESULTS: Four main themes emerged: 1...
October 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Steven S Coughlin, Valerie Williams, Nicole Moore, Deborah Bowen, Judith Anglin, Nadine Mansur, Gianluca De Leo
Introduction: Several studies have provided important information about health conditions and other challenges faced by women diagnosed with breast cancer and how they can improve their quality of life and reduce their risk of cancer recurrence. Although African American and Hispanic breast cancer patients have a poorer survival than their white counterparts, few studies have compared the experiences of African American, Hispanic, and non-Hispanic white breast cancer survivors. Objectives: To facilitate collaborative studies on breast cancer survivorship in a multicultural population, including future intervention research on nutrition, and physical activity, and clinical substudies...
2018: Journal of cancer treatment & diagnosis
María Del Pilar Del Pozo, Adela Castelló, Carmen Vidal, Dolores Salas-Trejo, Carmen Sánchez-Contador, Carmen Pedraz-Pingarrón, Pilar Moreo, Carmen Santamariña, María Ederra, Rafael Llobet, Jesús Vioque, Beatriz Pérez-Gómez, Marina Pollán, Virginia Lope
OBJECTIVES: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women. STUDY DESIGN: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey...
November 2018: Maturitas
Ting Fu, Hui-Juan Guang, Xiang-Zhuan Gao
This retrospective study investigated the effectiveness of percutaneous nerve electrical stimulation (PNES) for fatigue caused by chemotherapy for cervical cancer survivors.Totally, 83 cases of fatigue caused by chemotherapy for cervical cancer survivors were analyzed. All these cases were assigned to a treatment group (n = 43), and a control group (n = 40). Patients in the treatment group received PNES, while the subjects in the control group were on waiting list. The treatment was applied once daily for a total of 6 weeks...
October 2018: Medicine (Baltimore)
Hilde Elisabeth Timenes Mikkelsen, Karianne Vassbakk-Brovold, Anne Jørstad Antonsen, Sveinung Berntsen, Christian Kersten, Liv Fegran
BACKGROUND: Lifestyle interventions seem promising with regard to cancer patients' potential for physical and psychological health benefits and as an empowerment tool. Nevertheless, there is a lack of knowledge concerning cancer patients' longer-term experiences of participating in comprehensive lifestyle interventions. OBJECTIVE: The aim of this study was to explore cancer patients' long-term experiences of participating in a 12-month individualized comprehensive lifestyle intervention study focusing on physical activity, diet, smoking cessation, and stress management while receiving curative or palliative chemotherapy...
October 12, 2018: Cancer Nursing
Lauren J Frensham, Gaynor Parfitt, James Dollman
BACKGROUND: Physical activity has numerous associated benefits for cancer survivors. Compared with their urban counterparts, rural Australians experience a health disadvantage, including poorer survival rate after diagnosis of cancer. OBJECTIVE: The aims of this study were to test the effectiveness of an online 12-week walking intervention designed for cancer survivors and explore region-specific psychological predictors of behavior change. METHODS: This was a quasi-randomized controlled trial of an online resource designed according to Social Cognitive Theory and Self-determination Theory, based on individualized goal setting...
October 12, 2018: Cancer Nursing
Casey Walsh, Jennifer Currin-McCulloch, Pamela Simon, Brad Zebrack, Barbara Jones
PURPOSE: This study was designed to identify and explore the social support needs and preferences of young adult cancer patients during the transition process from active treatment to survivorship care. METHODS: Semi-structured qualitative interviews were conducted with study participants (n = 13, ages 17-25 at the time of cancer diagnosis) within ∼6 months of completion of active treatment and again 3 months later. Participants completed a sociodemographic questionnaire at the first study visit...
October 12, 2018: Journal of Adolescent and Young Adult Oncology
I Veal, N Peat, G D Jones, V Tsianakas, J Armes
PURPOSE: Physical activity (PA) is central to self-management for people with colorectal cancer (CRC) to support health behaviour and function secondary to cancer treatment. However, there is limited evidence on how health professionals (HPs) promote PA during cancer treatment. This study aimed to investigate how and when PA is promoted throughout the chemotherapy pathway among colorectal cancer survivors. METHODS: A qualitative study was conducted with adults with CRC receiving chemotherapy at a large cancer centre...
October 11, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Gabriella Cifu, Hannah Arem
PURPOSE: Breast cancer is the most common cancer in women. Many lifestyle factors have been associated with an increased risk of breast cancer incidence and mortality. An index-based approach to analyzing adherence to American Cancer Society (ACS) guidelines as a whole may better explain associations between lifestyle variables and breast cancer incidence and mortality. METHODS: We created an index based on American Cancer Society-specific guidelines, including body mass index (BMI), physical activity, alcohol intake, tobacco use, daily time spent watching television, and certain dietary habits...
September 18, 2018: Annals of Epidemiology
Marisa da Silva, Elisabete Weiderpass, Idlir Licaj, Charlotta Rylander
AIM: To identify factors associated with high weight gain and obesity duration in a representative sample of Norwegian women. METHODS: 66,618 Norwegian women aged 34-70 years at baseline were included in the analysis. Baseline and follow-up questionnaires completed in 1991-2011 provided information on height, weight as well as sociodemographic, lifestyle and reproductive factors. We assessed the association with multivariable logistic regression. RESULTS: Women gained on average 0...
October 12, 2018: Obesity Facts
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