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Physical Activity + Cancer

Heide Götze, Sabine Taubenheim, Andreas Dietz, Florian Lordick, Anja Mehnert
PURPOSE: Our study provides a detailed overview of comorbid conditions and health-related quality of life of long-term cancer survivors and analyses the impact of demographic, disease- and treatment-related characteristics. METHODS: We present data obtained from 1000 survivors across mixed tumour entities 5 and 10 years after cancer diagnosis in a cross-sectional study. We analyse the prevalence of physical symptoms and health conditions via self-report and health-related quality of life using the EORTC QLQ-C30 in comparison to gender- and age-matched reference values of the general population...
August 10, 2018: Journal of Cancer Survivorship: Research and Practice
Ruth Elisa Eyl, Lena Koch-Gallenkamp, Lina Jansen, Viola Walter, Prudence Carr, Michael Hoffmeister, Jenny Chang-Claude, Hermann Brenner, Volker Arndt
PURPOSE: Since physical activity (PA) has been shown to be associated with better prognosis and quality of life (QOL) in colorectal cancer (CRC) patients, this study focuses on the barriers of PA among CRC survivors. METHODS: This study is based on a population-based study from Germany of 1343 women and men, diagnosed with CRC between 2003 and 2008 and being alive five years later. Multivariable logistic regression was used to explore associations between baseline as well as five-year follow-up (5YFU) characteristics and physical inactivity (PIA) at 5YFU...
August 10, 2018: Journal of Cancer Survivorship: Research and Practice
Rajeswara Rao Arasada, Konstantin Shilo, Tadaaki Yamada, Jianying Zhang, Seiji Yano, Rashelle Ghanem, Walter Wang, Shinji Takeuchi, Koji Fukuda, Nobuyuki Katakami, Keisuke Tomii, Fumitaka Ogushi, Yasuhiko Nishioka, Tiffany Talabere, Shrilekha Misra, Wenrui Duan, Paolo Fadda, Mohammad A Rahman, Patrick Nana-Sinkam, Jason Evans, Joseph Amann, Elena E Tchekneva, Mikhail M Dikov, David P Carbone
EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin in EGFR TKI resistance has been previously reported, however, the precise mechanism by which β-catenin activation contributes to EGFR TKI resistance is not clear. Here, we show that EGFR inhibition results in the activation of β-catenin signaling in a Notch3-dependent manner, which facilitates the survival of a subset of cells that we call "adaptive persisters"...
August 10, 2018: Nature Communications
Ann Blair Kennedy, Sarah B Hales
An epidemic of physical inactivity has given rise to a population struggling with early mortality and an increase in chronic non-communicable diseases such as cardiovascular disease, diabetes, and cancer. Primary care providers as well as other clinicians are in a position to help overcome this epidemic of physical inactivity. The goal of this commentary is to provide clinicians with resources and recommendations from the recent literature to help overcome barriers to physical activity counseling and help patients become physically active...
August 2018: Current Sports Medicine Reports
Bernat-Carles Serdà I Ferrer, Eline van Roekel, Brigid M Lynch
PURPOSE OF REVIEW: This review provides an up-to-date overview of the evidence relating to how physical inactivity ameliorates cancer-related fatigue. A summary of the postulated biological mechanisms underpinning the relationship is presented. RECENT FINDINGS: Systematic reviews and meta-analyses synthesising the results of randomised controlled trials of physical activity interventions to reduce fatigue broadly conclude that aerobic and combination exercise may be the most helpful, while resistance training alone is less efficacious...
August 9, 2018: Current Nutrition Reports
Synne-Kristin Hoffart Bøhn, Sophie Dorothea Fosså, Torbjørn Wisløff, Lene Thorsen
PURPOSE: The present study aimed to determine the level of physical activity (PA) among prostate cancer (PCa) patients across treatment modalities and explore the association between PA and treatment-induced adverse effects (AEs). METHODS: The present study was based on a cross-sectional postal survey among members of the Norwegian Prostate Cancer Association. Patients were eligible for the present study if they had either (1) completed radical prostatectomy, (2) completed radiotherapy and (neo)-adjuvant androgen deprivation therapy (ADT), or (3) were undergoing lifelong ADT...
August 9, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Kari Johansson, Johan Askling, Lars Alfredsson, Daniela Di Giuseppe
BACKGROUND: The Mediterranean diet has been associated with lower mortality and lower risk of cardiovascular diseases and cancer. Although its components have been analysed in several studies, only one study has specifically investigated the association between Mediterranean diet and risk of rheumatoid arthritis (RA), and reported no association. METHODS: Data on 1721 patients with incident RA (cases) and 3667 controls, matched on age, gender and residential area, from the Swedish epidemiological investigation of RA (EIRA), a population-based case-control study, were analysed using conditional logistic regression...
August 9, 2018: Arthritis Research & Therapy
Crystal L Park, Emily Waddington, Rachel Abraham
OBJECTIVE: Religiousness/spirituality (R/S) may influence cancer survivors' health through multiple pathways. We aimed to examine one potentially key pathway that has seldom been examined: relationships between survivors' R/S and their health behaviors. METHODS: The present study investigated links between four core dimensions of R/S (beliefs, behaviors, identity, coping) and three health behaviors (fruit/vegetable consumption, physical activity, maintenance of a healthy weight) in 172 breast cancer survivors...
August 9, 2018: Psycho-oncology
Muhammad Hassan Majeed, Ali Ahsan Ali, Donna M Sudak
Background Long-term use of opioids to treat chronic pain incurs serious risks for the individual-including misuse, abuse, addiction, overdose and death-as well as creating economic, social, and cultural impacts on society as a whole. Chronic pain and substance use disorders are often co-morbid with other medical problems and at the present time, primary care clinicians serve most of this population. Primary care clinicians would benefit from having alternatives to opioids to employ in treating such patients...
August 9, 2018: International Journal of Psychiatry in Medicine
Robert W Motl, Dorothy Pekmezi, Brooks C Wingo
There is an obvious disconnect between evidence of benefits and rates of participation in exercise and physical activity among people living with multiple sclerosis (MS). We propose that the problem with exercise behavior in MS (i.e. lack of broad or increasing participation by people with MS despite evidence of meaningful benefits) might be ameliorated through the inclusion of behavior change theory in the design of exercise programs and promotion efforts, as has been undertaken in other populations such as breast cancer survivors...
July 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Erika A Waters, Emily Hawkins
INTRODUCTION: Little is known about people's awareness of the link between insufficient physical activity and increased risk for multiple health outcomes. METHODS: Of 1161 respondents to an online cross-sectional survey of the US population, we randomly selected 361 and used content analysis to code up to three responses to an open-ended question asking what illnesses are caused by insufficient physical activity. Chi-square and Fisher's exact tests examined relations between disease codes and socio-demographics; t-tests and Mann-Whitney U tests examined relations between codes and physical activity intentions and behavior...
August 9, 2018: Journal of Health Communication
Pasquale F Innominato, Sandra Komarzynski, Oxana G Palesh, Robert Dallmann, Georg A Bjarnason, Sylvie Giacchetti, Ayhan Ulusakarya, Mohamed Bouchahda, Mazen Haydar, Annabelle Ballesta, Abdoulaye Karaboué, Nicholas I Wreglesworth, David Spiegel, Francis A Lévi
BACKGROUND: Psychosocial symptoms often cluster together, are refractory to treatment, and impair health-related quality of life (HR-QoL) in cancer patients. The contribution of circadian rhythm alterations to systemic symptoms has been overlooked in cancer, despite a causal link shown under jet lag and shift work conditions. We investigated whether the circadian rest-activity rhythm provides a reliable and objective estimate of the most frequent patient-reported outcome measures (PROMs)...
August 7, 2018: Cancer Medicine
Neilane Bertoni, Mirian Carvalho de Souza, Susanne Crocamo, Moyses Szklo, Liz Maria de Almeida
Families share behavioral risk factors that can increase the risk of cancer development. We examined whether having a positive family breast cancer history is associated with health behaviors/screening practices. Analyses were based on a cross-sectional sample of 545 Brazilian National Cancer Institute Hospital patients with newly diagnosed breast cancer in 2013/2014. Women were categorized according to their breast cancer family history. Age-adjusted Poisson regressions with robust variance were performed to estimate the association between breast cancer family history and selected health-related behaviors and screening practices...
August 7, 2018: International Journal of Behavioral Medicine
Yuzhou Shen, Wentao Li
Background: Aim of this study was to prepare the hyaluronic acid and human serum albumin modified erlotinib nanoparticles (ERT-HSA-HA NPs) delivery system by a precipitation method. Methods: ERT-HSA-HA NPs were characterized for physical properties, such as morphology and particle size, and in vitro drug release. Moreover, the cytotoxicity, cellular uptake, in vivo studies of ERT-HSA-HA nanoparticle were investigated and compared in A549 cells. Results: The ERT-HSA-HA NPs showed spherical morphology, and their hydrodynamic diameter was 112...
2018: Drug Design, Development and Therapy
Wenhao Dong, Yipeng Ren, Zhixue Bai, Yi Yang, Zihua Wang, Cong Zhang, Qiang Chen
Recently, great efforts have been made to use biosensors for the early diagnosis of cancer. Specifically, using a biomarker to detect H2 O2 in physiological conditions is of great significance for understanding the signal transduction pathways and achieving early cancer diagnosis. In this work, we report an innovative H2 O2 sensor that was fabricated by trimetallic AuPtPd nanocomposites platform on reduced graphene oxide (rGO) nanosheets with the modification of the rGO and trimetallic AuPtPd nanoparticles on a glassy carbon electrode (GCE) by physical adsorption...
November 1, 2018: Talanta
Fausto Roila, Guglielmo Fumi, Benedetta Ruggeri, Andrea Antonuzzo, Carla Ripamonti, Sonia Fatigoni, Luigi Cavanna, Stefania Gori, Alessandra Fabi, Nicola Marzano, Claudio Graiff, Vitaliana De Sanctis, Aurora Mirabile, Samantha Serpentini, Chiara Bocci, Maria Simona Pino, Giuseppina Cilenti, Claudio Verusio, Enzo Ballatori
BACKGROUND: Fatigue is one of the most distressing symptoms of cancer patients. Its characteristics and impact on quality of life have not been fully explored and treatment of cancer-related fatigue in Italian oncological centers has not been codified. METHODS: A cross-sectional study was carried out on all patients attending for any reason the 24 participating centers in two non-consecutive days. Patients with fatigue filled out the Brief Fatigue Inventory (BFI) questionnaire and reported any pharmacological or non-pharmacological treatment for fatigue...
August 6, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Carlos Nunez, Johan Clausen, Magnus Thorsten Jensen, Andreas Holtermann, Finn Gyntelberg, Adrian Bauman
Little knowledge exists about the role of cardiorespiratory fitness (CRF) or its interaction with excess adiposity determined by body mass index (BMI) in cancer prevention. A total of 5,128 middle-aged men, without a history of cancer at baseline in 1970-71, were examined for subsequent incidence and mortality of several cancer types. Participants' data were linked with cancer registration and mortality data to March 2017. During 47 years of follow-up, a total of 1,920 incident cases and 1,638 cancer-related deaths were ascertained...
August 6, 2018: Scientific Reports
Adele Idolo, Tiziana Grassi, Francesco Bagordo, Alessandra Panico, Mattia De Giorgi, Francesca Serio, Marcello Guido, Prisco Piscitelli, Giovanni De Filippis, Annamaria Raho, Antonella De Donno
During the years 2014⁻2016 the University of Salento performed the "Impact of Air Quality on Health of Residents in the Municipalities of Cutrofiano, Galatina, Sogliano Cavour, Soleto and Sternatia" (IMP.AIR) study, an epidemiological-molecular research project aiming to evaluate early DNA damage in children living in an area of Salento with high incidence of lung cancer among the male population. One hundred and twenty-two children aged 6⁻8 years attending primary school were enrolled and the frequency of micronucleated cells (MNC) in oral mucosa was evaluated...
August 5, 2018: International Journal of Environmental Research and Public Health
Jennifer L Moss, Qian Xiao, Charles E Matthews
Multiple health behaviors could have greater impact on chronic diseases than single behaviors, but correlates of behavioral clusters are relatively understudied. Using data from NIH-AARP Diet and Health Study (initiated in 1995) for 324,522 participants from the U.S. (age 50-71), we conducted exploratory factor analysis to identify clusters of adherence to eight cancer prevention behaviors. Poisson regressions examined associations between cluster scores and neighborhood socioeconomic deprivation, measured with census block group (1) poverty and (2) low education...
August 3, 2018: Preventive Medicine
M Robertson, Y Liao, J Song, E J Lyons, K Basen-Engquist
The aim of this study was to investigate associations between types of motivation for physical activity and self-reported weekly aerobic moderate-to-vigorous physical activity (MVPA) in the 2012 and 2014 waves of the nationally representative Health Information National Trends Survey 4 (n = 7307). We further explored differential associations between MVPA and types of motivation for physical activity by cancer survivor status. We found that those who were more motivated by "getting enjoyment from exercise" reported 26...
August 3, 2018: Preventive Medicine
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