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https://www.readbyqxmd.com/read/30103275/quercetin-in-food-possible-mechanisms-of-its-effect-on-memory
#1
REVIEW
Fatemeh Babaei, Mohammadreza Mirzababaei, Marjan Nassiri-Asl
Quercetin (3,3',4',5,7-pentahydroxyflavone) is found in vegetables and fruits. It is one of the major flavonoids that is part of human diets. Quercetin has several pharmacological effects in the nervous system as a neuroprotective agent. In this review, we summarize the research on quercetin and its role in memory in both animals and humans. Articles were chosen from the Scopus, PubMed, and Web of Science databases. In this review, we describe and summarize the importance of quercetin's presence in the body, particularly in the brain; its kinetics, including its absorption, metabolism, distribution, and excretion; its behavioral effects; and some of the possible mechanisms of action of quercetin on memory in different animal models...
August 13, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/30103194/circular-rna-alterations-in-the-bombyx-mori-midgut-following-b-mori-nucleopolyhedrovirus-infection
#2
Xiaolong Hu, Min Zhu, Bo Liu, Zi Liang, Lixu Huang, Jian Xu, Lei Yu, Kun Li, Mengsheng Jiang, Renyu Xue, Guangli Cao, Chengliang Gong
Thus far, no systematic studies have examined circRNA expression profiles in the silkworm following B.mori nucleopolyhedrovirus (BmNPV) infection. To explore the expression patterns of circRNAs in the silkworm midgut following BmNPV infection, circRNAs in normal midguts and BmNPV-infected midguts were analyzed by high-throughput sequencing. A total of 353 circRNAs were significantly differentially expressed, of which 241 were upregulated and 112 were downregulated following infection. GO annotation and KEGG pathways analyses of these circRNAs showed that many key immunity pathways and metabolism pathways were enriched in the BmNPV-infected midguts...
August 10, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/30103010/integrated-analysis-of-mrna-and-mirna-expression-profiles-reveals-muscle-growth-differences-between-adult-female-and-male-chinese-concave-eared-frogs-odorrana-tormota
#3
Yilin Shu, Jinquan Xia, Qiang Yu, Gang Wang, Jihui Zhang, Jun He, Huan Wang, Ling Zhang, Hailong Wu
The Chinese concave-eared torrent frog (Odorrana tormota) is the first known non-mammalian vertebrate that can communicate using ultrasound. In this species, females are approximately four times as large as males, in which the female growth rate is obviously higher than that of male. Until now, the molecular mechanisms underlying muscle growth development differences between male and female frogs have not been reported. Here, we integrated mRNA and miRNA expression profiles to reveal growth differences in the hindlimb muscles of 2-year-old frogs...
August 10, 2018: Gene
https://www.readbyqxmd.com/read/30102971/engineering-an-in-vivo-ep-bifido-pathway-in-escherichia-coli-for-high-yield-acetyl-coa-generation-with-low-co-2-emission
#4
Qian Wang, Jiasheng Xu, Zhijie Sun, Yaqi Luan, Ying Li, Junshu Wang, Quanfeng Liang, Qingsheng Qi
The low carbon yield from native metabolic machinery produces unfavorable process economics during the biological conversion of substrates to desirable bioproducts. To obtain higher carbon yields, we constructed a carbon conservation pathway named EP-bifido pathway in Escherichia coli by combining Embden-Meyerhof-Parnas Pathway, Pentose Phosphate Pathway and "bifid shunt", to generate high yield acetyl-CoA from glucose. 13 C-Metabolic flux analysis confirmed the successful and appropriate employment of the EP-bifido pathway...
August 10, 2018: Metabolic Engineering
https://www.readbyqxmd.com/read/30102953/fatty-acid-oxidation-an-emerging-facet-of-metabolic-transformation-in-cancer
#5
Yibao Ma, Sarah M Temkin, Adam M Hawkridge, Chunqing Guo, Wei Wang, Xiang-Yang Wang, Xianjun Fang
Cancer cells undergo metabolic reprogramming such as enhanced aerobic glycolysis, mutations in the tricarboxylic acid cycle enzymes, and upregulation of de novo lipid synthesis and glutaminolysis. These alterations are pivotal to the development and maintenance of the malignant phenotype of cancer cells in unfavorable tumor microenvironment or metastatic sites. Although mitochondrial fatty acid β-oxidation (FAO) is a primary bioenergetic source, it has not been generally recognized as part of the metabolic landscape of cancer...
August 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/30102932/a-chronic-lps-induced-low-grade-inflammation-fails-to-reproduce-in-lean-mice-the-impairment-of-preference-for-oily-solution-found-in-diet-induced-obese-mice
#6
Arnaud Bernard, Déborah Ancel, Patricia Passilly-Degrace, Jean-François Landrier, Laurent Lagrost, Philippe Besnard
Diet-induced obesity (DIO) is associated with a decreased oral fat detection in rodents. This alteration has been explained by an impairment of the lipid-mediated signaling in taste bud cells (TBC). However, factors responsible for this defect remain elusive. Diet rich in saturated fatty acids is known to elicit a metabolic inflammation by promoting intestinal permeation to lipopolysaccharides (LPS), Gram-negative bacteria-derived endotoxins. To determine whether a local inflammation of the gustatory tissue might explain the obese-induced impairment of the oro-sensory detection of lipids, mice were subjected to a DIO protocol...
August 10, 2018: Biochimie
https://www.readbyqxmd.com/read/30102929/microrna-in-lung-cancer-role-mechanisms-pathways-and-therapeutic-relevance
#7
REVIEW
Mohammad Askandar Iqbal, Shweta Arora, Gopinath Prakasam, George A Calin, Mansoor Ali Syed
Lung cancer is the cardinal cause of cancer-related deaths with restricted recourse of therapy throughout the world. Clinical success of therapies is not very promising due to - late diagnosis, limited therapeutic tools, relapse and the development of drug resistance. Recently, small ∼20-24 nucleotides molecules called microRNAs (miRNAs) have come into the limelight as they play outstanding role in the process of tumorigenesis by regulating cell cycle, metastasis, angiogenesis, metabolism and apoptosis. miRNAs essentially regulate gene expression via post-transcriptional regulation of mRNA...
August 10, 2018: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/30102849/identification-of-metabolites-of-evobrutinib-in-rat-and-human-hepatocytes-by-using-ultra-high-performance-liquid-chromatography-coupled-with-diode-array-detector-and-q-exactive-orbitrap-tandem-mass-spectrometry
#8
Zeyun Li, Lizhen Zhang, Yongliang Yuan, Zhiheng Yang
Evobrutinib is a highly selective inhibitor of Bruton's tyrosine kinase (BTK) which may be clinically effective in treating certain autoimmune diseases. The purpose of the present study was to investigate the metabolism of evobrutinib in rat and human hepatocytes. Evobrutinib was incubated with rat and human hepatocytes at 37 o C for 2 h after which the samples were analyzed by ultra-high performance liquid chromatography with diode array detection and Q Exactive Orbitrap tandem mass spectrometry (UPLC-DAD-Q Exactive Orbitrap-MS)...
August 13, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/30102829/transcriptome-analysis-of-papillary-thyroid-cancer-harboring-telomerase-reverse-transcriptase-promoter-mutation
#9
Ming-Nan Chien, Po-Sheng Yang, Yi-Chiung Hsu, Tsang-Pai Liu, Jie-Jen Lee, Shih-Ping Cheng
BACKGROUND: Telomerase reverse transcriptase (TERT) promoter mutations have recently been identified as an important prognostic factor in thyroid cancer. Studies suggest that TERT may have noncanonical functions beyond telomere maintenance. METHODS: Clinicopathological information and transcriptome data for papillary thyroid carcinoma (PTC) samples were obtained from The Cancer Genome Atlas (TCGA). Propensity score matching was performed to adjust for potential confounding variables between the TERT promoter wild-type group and the mutant group...
August 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/30102814/the-myo-inositol-converting-pathway-via-glucuronic-acid-does-not-contribute-to-ascorbic-acid-synthesis-in-arabidopsis
#10
Eva Ivanov Kavkova, Constantin Blöchl, Raimund Tenhaken
Ascorbic acid (AsA) biosynthesis in plants predominantly occurs via a pathway with D-mannose and L-galactose as intermediates. One alternative pathway for AsA synthesis, which is similar to the biosynthesis route in mammals, is controversially discussed for plants. Here, myo-inositol is cleaved to glucuronic acid and then converted via L-gulonate to AsA. In contrast to animals, plants have an effective recycling pathway for glucuronic acid being a competitor for the metabolic rate. Recycling involves a phosphorylation at C1 by the enzyme glucuronokinase...
August 13, 2018: Plant Biology
https://www.readbyqxmd.com/read/30102772/macrophage-specific-hif-1%C3%AE-contributes-to-impaired-autophagic-flux-in-non-alcoholic-steatohepatitis
#11
Xiaojing Wang, Marcelle Ribeiro, Arvin Iracheta-Vellve, Patrick Lowe, Aditya Ambade, Abhishek Satishchandran, Terence Bukong, Donna Catalano, Karen Kodys, Gyongyi Szabo
Inflammatory cell activation drives diverse cellular programming during hepatic diseases. Hypoxia-inducible factors (HIFs) have recently been identified as important regulators of immunity and inflammation. In non-alcoholic steatohepatitis (NASH), HIF-1α is upregulated in hepatocytes where it induces steatosis; however, the role of HIF-1α in macrophages under metabolic stress has not been explored. In this study, we found increased HIF-1α levels in hepatic macrophages in methionine-choline-deficient (MCD) diet-fed mice and in macrophages of NASH patients compared to controls...
August 13, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30102770/reconstruction-of-tca-cycle-in-corynebacterium-glutamicum-with-a-genome-scale-metabolic-network-model-for-trans-4-hydroxyproline-production
#12
Yu Zhang, Yun Zhang, Xiuling Shang, Bo Wang, Qitiao Hu, Shuwen Liu, Tingyi Wen
trans-4-Hydroxy-l-proline (Hyp) is an abundant component of mammalian collagen, and functions as a chiral synthon for the syntheses of anti-inflammatory drugs in the pharmaceutical industry. Proline 4-hydroxylase (P4H) can catalyze the conversion of l-proline to Hyp, however, it is still challenging for the fermentative production of Hyp from glucose using P4H due to the low yield and productivity. Here, we report the metabolic engineering of Corynebacterium glutamicum for the fermentative production of Hyp by reconstructing tricarboxylic acid (TCA) cycle together with heterologously expressing the p4h gene from Dactylosporangium sp...
August 13, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/30102358/virescent-albino-leaf-1-regulates-leaf-colour-development-and-cell-division-in-rice
#13
Ting Zhang, Ping Feng, Yunfeng Li, Peng Yu, Guoling Yu, Xianchun Sang, Yinghua Ling, Xiaoqin Zeng, Yidan Li, Junyang Huang, Tianquan Zhang, Fangming Zhao, Nan Wang, Changwei Zhang, Zhenglin Yang, Renhong Wu, Guanghua He
The de novo synthesis of purine nucleotides is crucial to all living organisms, but limited information is available for plants. In this study, we isolated a virescent-albino leaf 1 (val1) mutant of rice (Oryza sativa) that produces dynamic green-revertible albino and narrow-leaf phenotypes. In albino leaves, chloroplast development was defective, pigment contents were reduced, and cell division was impaired compared with the wild-type. Map-based cloning revealed that VAL1 encodes a phosphoribosylamine-glycine ligase (PurD), the second enzyme in the de novo purine biosynthesis pathway...
August 8, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/30102349/on-entropy-and-information-in-gene-interaction-networks
#14
Z S Wallace, S B Rosenthal, K M Fisch, T Ideker, R Sasik
Motivation: Modern biological experiments often produce candidate lists of genes presumably related to the studied phenotype. One can ask if the gene list as a whole makes sense in the context of existing knowledge: Are the genes in the list reasonably related to each other or do they look like a random assembly? There are also situations when one wants to know if two or more gene sets are closely related. Gene enrichment tests based on counting the number of genes two sets have in common are adequate if we presume that two genes are related only when they are in fact identical...
August 9, 2018: Bioinformatics
https://www.readbyqxmd.com/read/30101382/transcriptome-analysis-in-malus-halliana-roots-in-response-to-iron-deficiency-reveals-insight-into-sugar-regulation
#15
Ya Hu, Yan-Fang Zhu, Ai-Xia Guo, Xu-Mei Jia, Li Cheng, Tong Zhao, Yan-Xiu Wang
Iron (Fe) deficiency is a frequent nutritional problem limiting apple production in calcareous soils. The utilization of rootstock that is resistant to Fe deficiency is an effective way to solve this problem. Malus halliana is an Fe deficiency-tolerant rootstock; however, few molecular studies have been conducted on M. halliana. In the present work, a transcriptome analysis was combined with qRT-PCR and sugar measurements to investigate Fe deficiency responses in M. halliana roots at 0 h (T1), 12 h (T2) and 72 h (T3) after Fe deficiency stress...
August 12, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/30101334/a-metagenomic-window-into-the-2-km-deep-terrestrial-subsurface-aquifer-revealed-multiple-pathways-of-organic-matter-decomposition
#16
Vitaly V Kadnikov, Andrey V Mardanov, Alexey V Beletsky, David Banks, Nikolay V Pimenov, Yulia A Frank, Olga V Karnachuk, Nikolai V Ravin
We have sequenced metagenome of the microbial community of a deep subsurface thermal aquifer in the Tomsk Region of the Western Siberia, Russia. Our goal was the recovery of near-complete genomes of the community members to enable accurate reconstruction of metabolism and ecological roles of the microbial majority, including previously unstudied lineages. The water, obtained via a 2.6 km deep borehole 1-R, was anoxic, with a slightly alkaline pH, and a temperature around 45°C. Microbial community, as revealed by 16S rRNA gene profiling over 2 years, mostly consisted of sulfate-reducing Firmicutes and Deltaproteobacteria, and uncultured lineages if the phyla Chlorofexi, Ignavibacteriae and Aminicenantes (OP8)...
August 7, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/30101328/trajectories-of-body-fatness-from-age-5-to-60-y-and-plasma-biomarker-concentrations-of-the-insulin-insulin-like-growth-factor-system
#17
Ane S Kværner, Dong Hang, Edward L Giovannucci, Walter C Willett, Andrew T Chan, Mingyang Song
Background: A major pathway through which obesity increases the risk of cardiometabolic diseases and cancer is by inducing hormonal and metabolic abnormalities, including hyperinsulinemia and altered insulin-like growth factor (IGF) signaling. However, little is known about the influence of lifetime adiposity on the relevant biomarkers. Objective: The aim of this study was to examine associations of trajectories of body fatness with plasma biomarker concentrations of the insulin-IGF system in 2 large prospective cohorts of US men and women...
August 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30101081/aflatoxin-b-1-residues-in-human-livers-and-their-relationship-with-markers-of-hepatic-carcinogenesis-in-s%C3%A3-o-paulo-brazil
#18
Leandra N Z Ramalho, Livia D Porta, Roice E Rosim, Tânia Petta, Marlei J Augusto, Deisy M Silva, Fernando S Ramalho, Carlos A F Oliveira
In this study, hepatic biopsies from autopsy cases in São Paulo, Brazil, showing hepatocellular carcinoma (HCC, n  = 8), cirrhosis associated with viral hepatitis (VC, n  = 20), cirrhosis associated with alcoholism (AC, n  = 20), and normal livers (NL or controls, n  = 10) were subjected to determination of aflatoxin B1 (AFB1 ) and its main metabolites, and of markers of hepatic carcinogenesis Only non-metabolized AFB1 was detected in 13 samples (27.1%, N  = 48) of liver disorders (HCC, VC and AC), at levels between 10...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/30100477/srebp1-pparg-and-ampk-pathways-mediated-the-cu-induced-change-in-intestinal-lipogenesis-and-lipid-transport-of-yellow-catfish-pelteobagrus-fulvidraco
#19
Guang-Hui Chen, Zhi Luo, Christer Hogstrand, Kun Wu, Shi-Cheng Ling
Cu could act as a modifier and influence lipid metabolism, but the potential mechanism was not explored. Juvenile yellow catfish were fed diet containing 0.71 (low Cu), 3.93 (intermediate Cu) and 88.81 (high Cu) mg Cu kg-1 , for 8 weeks to explore the modulation of intestinal lipid metabolism following dietary Cu addition. Using specific pathway inhibitors (Fatostatin for SREBP1, T0070907 for PPARG and Compound C for AMPK), primary enterocytes of yellow catfish were used to explore the molecular mechanisms of Cu reducing intestinal lipid deposition...
December 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/30100473/nmr-based-global-metabolomics-approach-to-decipher-the-metabolic-effects-of-three-plant-growth-regulators-on-strawberry-maturation
#20
Li An, Jingwei Ma, Hong Wang, Fugen Li, Dongmei Qin, Jiakai Wu, Guangyan Zhu, Junfeng Zhang, Yongliang Yuan, Ling Zhou, Xujin Wu
Plant growth regulators (PGRs) are commonly used to regulate maturation in strawberry. Despite this, comprehensive assessments of the metabolomic effects of PGRs on strawberry maturation are lacking. In this study, a nuclear magnetic resonance-based approach, combined with multivariate and pathway analysis, was used to evaluate the regulatory effects of gibberellin, forchlorfenuron, and brassinolide, applied at two different maturation stages, on the expression of metabolites in strawberry. The results demonstrated that the PGRs differentially influenced metabolism, whether applied at the same or different maturation stages...
December 15, 2018: Food Chemistry
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