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nitrofurazone

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https://www.readbyqxmd.com/read/30030578/nanocarbon-material-supported-conducting-poly-melamine-nanoparticle-modified-screen-printed-carbon-electrodes-for-highly-sensitive-determination-of-nitrofuran-drugs-by-adsorptive-stripping-voltammetry
#1
Shao-Hua Chiu, Ya-Ling Su, Anh V T Le, Shu-Hua Cheng
The toxicity of nitrofuran drugs has attracted great attention, and the reported electroanalytical methods suffered limited sensitivity. In this work, a sensitive electrochemical assay in the cathodic region is developed to determine four nitrofuran derivatives, including nitrofurantoin (NFT), nitrofurazone (NFZ), furaltadone (FTD), and furazolidone (FZD). The screen-printed carbon electrode (SPCE) was used as the electrode substrate, and the sensing surface was composed of multi-walled carbon nanotube (MWCNT) and conducting poly(melamine) (PME)...
July 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/30006065/n-acylhydrazones-as-drugs
#2
REVIEW
Sreekanth Thota, Daniel A Rodrigues, Pedro de Sena Murteira Pinheiro, Lídia M Lima, Carlos A M Fraga, Eliezer J Barreiro
Over the last two decades, N-acylhydrazone (NAH) has been proven to be a very versatile and promising motif in drug design and medicinal chemistry. Herein, we discuss the current and future challenges in the emergence of bioactive NAH-based scaffolds and to developing strategies to overcome the failures in drug discovery. The NAH-related approved drugs nitrofurazone, nitrofurantoin, carbazochrome, testosterone 17-enanthate 3-benzilic acid hydrazine, nifuroxazide, dantrolene, and azumolene are already used as therapeutics in various countries...
July 9, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29991951/evaluation-of-the-wound-healing-activity-of-the-crude-extract-of-leaves-of-acanthus-polystachyus-delile-acanthaceae
#3
Wubante Demilew, Getnet Mequanint Adinew, Seyfe Asrade
Background: Medicinal plants play indispensable roles to treat various ailments. Acanthus polystachyus is one of the medicinal plants used traditionally for treatment of wounds. However, there were no scientific reports documented so far on the wound healing activities of this plant. Thus, the present study provides a scientific evaluation for the wound healing potential of the crude extract of A. polystachyus leaves. Methods: The crude extraction was carried out using 80% methanol...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29902621/pharmaceuticals-residues-in-selected-tropical-surface-water-bodies-from-selangor-malaysia-occurrence-and-potential-risk-assessments
#4
Sarva Mangala Praveena, Siti Norashikin Mohamad Shaifuddin, Syazwani Sukiman, Fauzan Adzima Mohd Nasir, Zanjabila Hanafi, Norizah Kamarudin, Tengku Hanidza Tengku Ismail, Ahmad Zaharin Aris
This study investigated the occurrence of nine pharmaceuticals (amoxicillin, caffeine, chloramphenicol, ciprofloxacin, dexamethasone, diclofenac, nitrofurazone, sulfamethoxazole, and triclosan) and to evaluate potential risks (human health and ecotoxicological) in Lui, Gombak and Selangor (Malaysia) rivers using commercial competitive Enzyme-Linked Immunosorbent Assay (ELISA) kit assays. Physicochemical properties of these rivers showed the surface samples belong to Class II of Malaysian National Water Quality Standards which requires conventional treatment before consumption...
November 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29749544/repair-of-urethral-defects-by-an-adipose-mesenchymal-stem-cell%C3%A2-porous-silk-fibroin-material
#5
Binqiang Tian, Lujie Song, Tao Liang, Zuowei Li, Xuxiao Ye, Qiang Fu, Yonghui Li
The aim of the present study was to determine whether it was possible to repair urethral defects with a material of adipose mesenchymal stem cells (ADMSCs)‑porous silk fibroin (SF). A total of 39 male New Zealand white rabbits were randomly divided into a control group, an SF group and a bromodeoxyuridine (BrdU)‑labeled ADMSCs‑SF group (SSF group; n=13/group). Defects were made by resecting the posterior urethral wall. The defects in the SF and SSF groups were repaired using SF and BrdU‑labeled ADMSCs‑SF materials respectively...
July 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29705505/development-of-biosynthesized-silver-nanoparticles-based-formulation-for-treating-wounds-during-nursing-care-in-hospitals
#6
Cui-Ping Gong, Shou-Cun Li, Rong-Ye Wang
Silver nanoparticles (AgNPs) have been emerged as significant wound healing agents because of their improved mechanical properties. However, the green synthesized silver nanoparticleshave reported significant wound healing action in Albino rats which was validated by the measurement of wound closure rate. Silver nanoparticles were efficiently synthesized using Euphorbia milii leaf extract. The UV-visible spectra recorded the effect of the reaction time on AgNPs synthesis and was indentified that the peak became shaper with an increase in time, which corresponds to increase in the number of nanoparticles formed from the reduction of silver ions present in the aqueous solution...
June 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29297225/interpenetration-dependent-luminescent-probe-in-indium-organic-frameworks-for-selectively-detecting-nitrofurazone-in-water
#7
Sheng-Li Hou, Jie Dong, Xiao-Lei Jiang, Zhuo-Hao Jiao, Chu-Ming Wang, Bin Zhao
Two novel anionic In-MOFs V101 and V102 were synthesized and structurally characterized. The structrual transformation from 2-fold interpenetration to noninterpenetration was completed by changing solvent from DMF to DEF. Luminescence investigations reveal that only V102 not V101 can sensitively and selectively detect traces of antibiotics nitrofurazone in water solution via an environmentally friendly manner, and the detection limit can reach to 0.2 ppm. The luminescent difference between V101 and V102 mainly originates from the divergence of interpenetration structures...
February 6, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29215338/evaluation-of-antimicrobial-durability-and-anti-biofilm-effects-in-urinary-catheters-against-enterococcus-faecalis-clinical-isolates-and-reference-strains
#8
Didem Kart, Ayşe Semra Kustimur, Meral Sağıroğlu, Ayşe Kalkancı
BACKGROUND: Enterococcus faecalis, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa and Candida albicans biofilms are major causes of catheter-associated urinary tract infections. Antimicrobial-coated or impregnated urinary catheters are seen as a possible way to prevent these infections. AIMS: To determine the biofilm-forming ability of 89 E. faecalis isolates from urinary tract infections and to compare several urinary catheters for antimicrobial durability and the inhibitory effects on biofilm formation of different laboratory strains and clinical isolates of E...
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29193145/polyethylene-glycol-as-marker-for-nitrofurazone-allergy-20-years-of-experience-from-turkey
#9
Esen Özkaya, Sıla Kılıç
BACKGROUND: Polyethylene glycols (PEGs) and propylene glycol (PG) are used as vehicles in various medicinal and cosmetic products. They are potential contact sensitizers, including low molecular weight PEGs in nitrofurazone preparations that are still widely used in Turkey. OBJECTIVES: To investigate the prevalence of allergic contact dermatitis caused by PEG and PG in a relatively large group of patients in Turkey. METHODS: In this retrospective, cross-sectional, single-centre study, 836 patients patch tested with PEG and PG between 1996 and 2015 were reviewed...
March 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29158722/synthesis-and-investigation-of-antimicrobial-activities-of-nitrofurazone-analogues-containing-hydrazide-hydrazone-moiety
#10
Łukasz Popiołek, Anna Biernasiuk
In this research we synthesized and tested for in vitro antimicrobial activity 21 nitrofurazone analogues. The compounds we obtained were identified on the basis of1 H NMR and13 C NMR spectroscopy. The in vitro screening of antimicrobial properties of synthesized compounds revealed a wide spectrum of antimicrobial activity. Compounds 28 , 29 , 32 - 43 , and 45 - 48 showed very high bactericidal effect towards Staphylococcus spp. ATTC and Bacillus spp. ATTC (MIC = 0.002-7.81 µg/ml and MBC = 0.002-31.25 µg/ml)...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29126469/high-reliable-and-robust-ultrathin-layer-gold-coating-porous-silver-substrate-via-galvanic-free-deposition-for-solid-phase-microextraction-coupled-with-surface-enhanced-raman-spectroscopy
#11
Weiwei Bian, Zhen Liu, Gang Lian, Le Wang, Qilong Wang, Jinhua Zhan
That intense demand for both high sensitivity and high reliability has been a key factor strengthening the surface enhanced Raman spectroscopy (SERS) in the analytical application, particular in the hyphenation with pre-concentration technique. Credible data acquisition and processing is very dependent on the stable and uniform performance of SERS-active substrate. Here, a reliable and uniform ultrathin-layer Au was proposed for protecting the porous Ag fiber (porous Ag@Au) and applied in the solid phase microextraction coupled with SERS...
November 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28922723/protective-effects-of-mirtazapine-and-chrysin-on-experimentally-induced-testicular-damage-in-rats
#12
Alaa E El-Sisi, Magda E El-Sayad, Nermine M Abdelsalam
Mirtazapine is an antidepressant with prominent antioxidant effects. Chrysin, a natural flavone, exhibits multiple pharmacological actions. This study was designed to investigate the potential protective effects of chrysin and mirtazapine against nitrofurazone-induced testicular damage in rats. Possible underlying mechanisms such as oxidative stress, inflammation and apoptosis were also investigated. Testicular damage was induced by oral administration of nitrofurazone (50mg/kg/day) for two weeks. Chrysin (25 and 50mg/kg/day, p...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738638/mixed-matrix-membranes-incorporated-with-ln-mof-for-selective-and-sensitive-detection-of-nitrofuran-antibiotics-based-on-inner-filter-effect
#13
Feng Zhang, Hua Yao, Yifan Zhao, Xing Li, Gaowei Zhang, Yangyi Yang
The detection of antibiotics is critical and challenging due to the pervasive use of antibiotics had inevitably brought some negative impacts on ecosystem and human health. Herein, we reported an anti-interfere ability enhanced luminescent sensor of lanthanide metal-organic framework (Ln-MOF) filled mixed matrix membranes (MMMs), which combining the processibility of poly(methyl methacrylate) (PMMA) polymer with Ln-MOF of {[Tb2 (AIP)2 (H2 O)10 ]·(AIP)·4H2 O}n (Tb-AIP, where AIP is 5-aminoisophthalate) fillers...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28713723/the-effect-of-aloe-vera-gel-and-nitrofurazone-on-dressing-related-pain-of-superficial-burn-wounds
#14
Shokoh Varaei, Fatemeh Mohaddes Ardabili, Parichehr Sabaghzadeh Irani, Hadi Ranjbar
No abstract text is available yet for this article.
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28688356/evaluation-of-biomarkers-for-ecotoxicity-assessment-by-dose-response-dynamic-models-effects-of-nitrofurazone-on-antioxidant-enzymes-in-the-model-ciliated-protozoan-euplotes-vannus
#15
Yazhen Hong, Yalin Tan, Yang Meng, Hao Yang, Yu Zhang, Alan Warren, Jiqiu Li, Xiaofeng Lin
Understanding dose-responses is crucial for determining the utility of biomarkers in ecotoxicity assessment. Nitrofurazone is a broad-spectrum antibiotic that is widely used in the aquaculture industry in China despite its detrimental effects on ecosystems. Potential dose-response models were examined for the effect of nitrofurazone on two antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPx), in the ciliated protozoan Euplotes vannus. This was achieved by measuring enzyme activity and gene expression profiling of SOD and GPx in ciliate cells exposed to nitrofurazone at doses ranging from 0 to 180mgl-1 for 6h, 12h, 18h and 24h...
October 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28651570/methanol-leaves-extract-hibiscus-micranthus-linn-exhibited-antibacterial-and-wound-healing-activities
#16
Berhan Begashaw, Bharat Mishra, Asegedech Tsegaw, Zewdneh Shewamene
BACKGROUND: Infectious diseases are the most common causes of morbidity and mortality in developing countries. Wound and wound infections are also major health problem. Nowadays, medicinal plants play a major role in treatment of infectious diseases and wound healing and they are easily available and more affordable as compared to synthetic compounds. The aim of this study is therefore, to investigate the antibacterial and wound healing activities of 80% methanol extract of Hibiscus micranthus leaves using disc diffusion methods and rat excision model respectively...
June 26, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28637162/response-of-antimicrobial-nitrofurazone-degrading-biocathode-communities-to-different-cathode-potentials
#17
Deyong Kong, Hui Yun, Dan Cui, Mengyuan Qi, Chunyan Shao, Dichen Cui, Nanqi Ren, Bin Liang, Aijie Wang
Bioelectrodegradation of various organic pollutants has been extensively studied. However, whether different cathode potentials could alter the antimicrobial-degrading biocathode community structure and composition remain poorly understood. Here, the microbial community structure and composition of the nitrofurans nitrofurazone (NFZ) degrading biocathode in response to different cathode potentials (-0.45±0.01, -0.65±0.01 and -0.86±0.05V vs standard hydrogen electrode, with applied cell voltages of 0.2, 0...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28514366/-applicability-of-antibacterial-agents-in-chronic-tonsillitis-treatment
#18
T Yu Vladimirova, L A Barishevskaya, A V Lyamin, O V Kondratenko, A K Velikanov
The purpose of the present study was to evaluate the effectiveness of nitrofuranes applied for the treatment of chronic tonsillitis. A total of 92 subjects divided into three cohorts were involved in this study. Cohort 1 included 43 patients presenting with decompensated chronic tonsillitis and having pathogens in palatine tonsil lacunae. Cohort 2 was comprised of 13 patients with compensated chronic tonsillitis having pathogenic microflora of the same localization, while Cohort 3 was composed of 36 patients resembling those of cohort 1 in terms of clinical presentation, pathogen composition, and microbial spectrum...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28273215/comparative-analysis-of-the-effects-of-copaifera-multijuga-oil-resin-and-nitrofurazona-in-the-cutaneous-wound-healing-process
#19
Carlos Augusto Nunes Martini, João Guilherme Seifert Scapini, Luiz Martins Collaço, Anderson Matsubara, Valdir Florêncio DA Veiga Júnior
OBJECTIVES: to evaluate, histologically and macroscopically, the influence of Copaifera multijuga (Copaíba) oil-resin on the healing process of cutaneous wounds, comparing it with nitrofurazone. METHODS: we divided 36 rats into three groups of 12 animals, according to the treatment to be administered. Group SL (control) received saline on the lesion; the Group OIL received topical treatment with Copaíba oil; and the Group NITRO was treated with Nitrofurazone. We inflicted a circular wound of 8mm in diameter on the back of each animal...
December 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28244190/rapid-determination-of-trace-semicarbazide-in-flour-products-by-high-performance-liquid-chromatography-based-on-a-nucleophilic-substitution-reaction
#20
Tianfu Wei, Gongke Li, Zhuomin Zhang
Semicarbazide, a toxic food contaminant, widely exists in food products and it originates from the thermal degradation of a food additive of azodicarbonamide or a metabolite of nitrofurazone abused in meat specimens. Many previous methods for semicarbazide determination usually required expensive instruments, difficult-to-prepare monoclonal antibodies, and a long operation time. In this study, a high-performance liquid chromatography method was developed for the rapid determination of trace semicarbazide coupling with a nucleophilic substitution reaction firstly using 4-nitrobenzoyl chloride as derivatization reagent...
May 2017: Journal of Separation Science
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