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https://www.readbyqxmd.com/read/30505581/morbidity-and-mortality-of-synchronous-hepatectomy-with-cytoreductive-surgery-hyperthermic-intraperitoneal-chemotherapy-crs-hipec
#1
Tyler J Mouw, Jennifer Lu, Meghan Woody-Fowler, John Ashcraft, Joseph Valentino, Peter DiPasco, Joshua Mammen, Mazin Al-Kasspooles
Background: Liver resection in conjunction with partial colectomy for colon cancer is considered acceptable treatment for isolated metastasis to the liver. This method is unstudied in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for carcinomatosis due to colon cancer and high grade appendiceal cancer. Methods: A retrospective chart review included patients from 2005 to 2016 undergoing CRS/HIPEC. Cancers other than colorectal adenocarcinoma and high grade appendiceal carcinoma were excluded...
October 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30382512/limax-nd-yag-laser-assisted-thoracoscopic-resection-of-pulmonary-metastases-a-single-centre-s-initial-experience
#2
Joseph B Mc Loughlin, Katie E O'Sullivan, Rachel H Brown, Donna A Eaton
INTRODUCTION: Pulmonary metastasectomy and indeed redo-pulmonary metastasectomy are now commonly performed thoracic surgical procedures. The air-sealant, haemostatic, and necrotic properties of the KLS Martin Limax Nd:YAG laser at 1.318 μm make it an ideal tool for limited lung resection such as metastasectomy. We present our initial experience of thoracoscopic laser metastasectomy. METHODS: We reviewed data from the first seven patients in our unit to undergo thoracoscopic laser metastasectomy, in particular, patient age, gender, primary malignancy, primary treatment, complications, length of stay (LOS), and final histopathology...
October 31, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/30382300/natural-history-of-percutaneous-drainage-of-postoperative-collection-following-colorectal-surgery-in-which-patients-can-follow-up-imaging-be-dispensed-with-before-drain-removal
#3
B Brac, C Sabbagh, B Robert, C Chivot, T Yzet, J M Regimbeau
INTRODUCTION: Colorectal surgery is complicated by postoperative collections in up to 25% of cases depending on local conditions. The aim of this study was to identify predictive factors of success of percutaneous drainage of collections in order to avoid follow-up imaging. PATIENTS AND METHODS: All consecutive patients between January 2009 and December 2016, who had undergone elective or emergency colorectal surgery (colorectal surgery and appendectomy) complicated by a postoperative collection treated by percutaneous drainage with follow-up imaging prior to drain removal, were included in this single-center and retrospective study...
October 31, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/30324063/the-impact-of-closed-incision-negative-pressure-therapy-on-postoperative-breast-reconstruction-outcomes
#4
Allen Gabriel, Steven Sigalove, Noemi Sigalove, Toni Storm-Dickerson, Jami Rice, Patrick Maxwell, Leah Griffin
Background: Studies report that incision management with closed incision negative pressure therapy (ciNPT) may provide clinical benefits, including protecting surgical incisions, for postsurgical closed incisions (eg, orthopedic, sternotomy, and colorectal). This retrospective analysis compared postoperative outcomes in patients who received ciNPT versus standard of care (SOC) for incision management after breast reconstruction postmastectomy. Methods: Patient demographics, chemotherapy exposure, surgical technique, ciNPT use, number of drains, time to drain removal, and 90-day postoperative complication rates were analyzed from records of 356 patients (ciNPT = 177, SOC = 179) with 665 closed breast incisions (ciNPT = 331, SOC = 334)...
August 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/30308424/successful-treatment-for-severe-pancreatitis-with-colonic-perforation-using-video-assisted-retroperitoneal-debridement-a-case-report
#5
Yuto Hozaka, Hiroshi Kurahara, Yuko Mataki, Yota Kawasaki, Satoshi Iino, Masahiko Sakoda, Shinichiro Mori, Kosei Maemura, Hiroyuki Shinchi, Shoji Natsugoe
INTRODUCTION: Colorectal complications including penetration and perforation in acute pancreatitis often become severe and fatal. Effective drainage is pivotal for successful treatment. We present a case of large retroperitoneal abscess with colonic necrotizing perforation due to severe acute pancreatitis treated with video-assisted retroperitoneal debridement (VARD) in a step-up approach. PRESENTATION OF CASE: A 31-year-old man was admitted to a general hospital with a diagnosis of severe acute pancreatitis...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30304509/guidelines-for-enhanced-recovery-after-lung-surgery-recommendations-of-the-enhanced-recovery-after-surgery-eras%C3%A2-society-and-the-european-society-of-thoracic-surgeons-ests
#6
Timothy J P Batchelor, Neil J Rasburn, Etienne Abdelnour-Berchtold, Alessandro Brunelli, Robert J Cerfolio, Michel Gonzalez, Olle Ljungqvist, René H Petersen, Wanda M Popescu, Peter D Slinger, Babu Naidu
Enhanced recovery after surgery is well established in specialties such as colorectal surgery. It is achieved through the introduction of multiple evidence-based perioperative measures that aim to diminish postoperative organ dysfunction while facilitating recovery. This review aims to present consensus recommendations for the optimal perioperative management of patients undergoing thoracic surgery (principally lung resection). A systematic review of meta-analyses, randomized controlled trials, large non-randomized studies and reviews was conducted for each protocol element...
October 9, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/30294427/bilirubin-urobilinogen-pancreas-elastase-and-bile-acid-in-drain-fluid-the-gbup-study-analysis-of-biomarkers-for-a-colorectal-anastomotic-leakage
#7
Christoph Paasch, Silke Rink, Marcus Steinbach, Sören Kneif, Dirk Peetz, Andre Klötzler, Ulrich Gauger, Klaus Mohnike, Michael Hünerbein
Purpose: A colorectal anastomotic leakage (CAL) is a major complication after colorectal surgery and leads to high rates of morbidity and prolonged hospital stay. The study aims to evaluate the benefit of using bilirubin, urobilinogen, pancreas elastase and bile acid in the drain fluid (DF) as a predictive marker for the CAL. Methods: From June 2015 to October 2017 100 patients, who underwent left hemicolectomy (LH), sigma resection (SR), high anterior resection (HAR), low anterior resection (LAR) or reversal of Hartmann's Procedure (ROHP) were included in this monocentric non-randomized prospective clinical trial...
November 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/30217305/inhibition-of-tnf%C3%AE-in-peritoneal-fluids-of-patients-following-colorectal-resection-attenuates-the-postoperative-stress-related-increase-in-colon-cancer-cell-migration-a-prospective-in-vitro-study
#8
Liron Berkovich, Ronen Ghinea, Itzhak Greemland, Salem Majdop, Baruch Shpitz, Moshe Mishaeli, Shmuel Avital
BACKGROUND AND OBJECTIVES: Surgical trauma in patients undergoing colorectal cancer resection generates local and systemic inflammatory responses that can affect oncological outcomes. Post-operative peritoneal fluids of patients undergoing colorectal surgery increase the pro-malignant effect of cancer cells in vitro with correlation to elevated TNFα in these fluids. This study evaluated whether inhibiting TNFα in patients' postoperative fluid biopsies would attenuate this effect. METHODS: Peritoneal fluids from 53 patients undergoing colorectal surgery were sampled before and daily after surgery via intra-abdominal drains...
September 2018: Surgical Oncology
https://www.readbyqxmd.com/read/30171179/urologic-surgery-with-multisystem-comorbidities-a-case-report
#9
Upendra Maddineni, Eric F Worrall, Erik A Baker, Madhavi Earasi, Francis Mathieu, Georgi Guruli
BACKGROUND Originally implemented for colorectal surgery, enhanced perioperative protocols have been incorporated into many surgical fields in an effort to improve outcomes. The cornerstone of many strategies includes patient education, liberalized oral intake on the day of surgery, no routine bowel prep, targeted multimodal analgesia, cautious use of IV hydration, early extubation, avoidance of NG tubes and/or surgical drains, and encouraging early postoperative ambulation. CASE REPORT We report on the successful outcome of a single patient with a rare autosomal dominant disorder (hereditary hemorrhagic telangiectasia) with multisystem involvement including pulmonary, cardiac, hematologic, gastrointestinal, renal, oncologic, and hepatic comorbidities, scheduled for open nephrectomy...
September 1, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/30166125/immunological-environment-in-colorectal-cancer-a-computer-aided-morphometric-study-of-whole-slide-digital-images-derived-from-tissue-microarray
#10
Daniel Eyraud, Benjamin Granger, Armelle Bardier, Yann Loncar, GaËlle Gottrand, Gilles Le Naour, Jean-Michel Siksik, Jean-Christophe Vaillant, David Klatzmann, Louis Puybasset, Frederic Charlotte, Jeremy Augustin
Cancer research has moved from investigating tumour cells to including analysis of the tumour microenvironment as well. The aim of this study was to assess the cellular infiltrate of colorectal cancer (CRC) using computer-aided analysis of whole slide digital image derived from tissue microarray (TMA). TMA slides from 31 CRC patients were immunostained for forkhead box protein 3 (FOXP3) and immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) at four sites: centre (C) and invasive front (F) of the tumour, proximal non-metastatic draining lymph node (N-), tumour-draining lymph node with metastasis (N+) and healthy mucosa at 10 cm from the cancer (M)...
October 2018: Pathology
https://www.readbyqxmd.com/read/30097970/laparoscopic-lavage-and-drainage-for-hinchey-iii-diverticulitis-review-of-technical-aspects
#11
Matteo Gregori, Diletta Cassini, Norma Depalma, Michelangelo Miccini, Farshad Manoochehri, Gianandrea A Baldazzi
The surgical treatment for patients with generalized peritonitis complicating sigmoid diverticulitis is currently debated; particularly in case of diffuse purulent contamination (Hinchey 3). Laparoscopic lavage and drainage (LLD) has been proposed by some authors as a safe and effective alternative to single- or multi-stage resective surgery. However, among all the different studies on LLD, there is no uniformity in terms of surgical technique adopted and data show significant differences in postoperative outcomes...
August 10, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/30097434/a-phase-i-trial-of-a-guadecitabine-sgi-110-and-irinotecan-in-metastatic-colorectal-cancer-patients-previously-exposed-to-irinotecan
#12
Valerie Lee, Judy S Wang, Marianna L Zahurak, Elske C Gootjes, Henk M W Verheul, Rose M Parkinson, Zachary Kerner, Anup Sharma, Gary L Rosner, Ana De Jesus-Acosta, Daniel A Laheru, Dung T Le, Aram Oganesian, Ellen Lilly-Foreman, Thomas Brown, Peter A Jones, Stephen B Baylin, Nita Ahuja, Nilofer A Azad
PURPOSE: Chemotherapeutic resistance eventually develops in all patients with metastatic colorectal cancer (mCRC). Gene silencing through promoter demethylation is one potential reversible mechanism of resistance with administration of hypomethylating agents. We evaluated the safety and tolerability of guadecitabine and irinotecan in mCRC patients previously treated with irinotecan. EXPERIMENTAL DESIGN: In this 3+3 dose-escalation study, mCRC patients previously exposed to irinotecan received guadecitabine days 1-5 of a 28 day cycle and irinotecan 125mg/m2 days 8 and 15 [dose level (DL) 1, guadecitabine 45mg/m2; DL -1: guadecitabine 30mg/m2; DL -1G: guadecitabine 30mg/m2 with growth factor support (GFS); DL 1G: guadecitabine 45mg/m2 with GFS...
August 10, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30031749/surgical-technical-evidence-review-for-gynecologic-surgery-conducted-for-the-agency-for-healthcare-research-and-quality-safety-program-for-improving-surgical-care-and-recovery
#13
REVIEW
Eleftheria Kalogera, Gregg Nelson, Jessica Liu, Q Lina Hu, Clifford Y Ko, Elizabeth Wick, Sean C Dowdy
BACKGROUND: The Agency for Healthcare Research and Quality, in partnership with the American College of Surgeons and the Armstrong Institute at Johns Hopkins, developed the Safety Program for Improving Surgical Care and Recovery, which integrates principles of implementation science into adoption of enhanced recovery pathways and promotes evidence-based perioperative care. OBJECTIVE: The objective of this study is to review the enhanced recovery pathways literature in gynecologic surgery and provide the framework for an Improving Surgical Care and Recovery pathway for gynecologic surgery...
December 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30004033/laparoscopic-surgery-with-total-mesocolic-excision-in-colon-cancer-a-systematic-review-of-the-literature
#14
Rosario Vecchio, Eva Intagliata, Salvatore Marchese, Renato Catalano
PURPOSE: Nowadays, there is no standardization in surgical procedures for treatment of colon cancer. Since its introduction, laparoscopic surgery has gained increasing interest in colorectal surgery and it is now performed worldwide for treatment of colon cancer. Following the concept of total mesocolic excision introduced by Heald in 1988 in order to reduce local recurrence after surgical treatment of mid/low rectal tumors, the idea of complete removal of the mesocolon mesocolic envelope has been developed also for colon cancer, has evolved longtime and complete mesocolic excision has been recently adopted as the optimal approach for colon cancer...
June 26, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29915483/anastomotic-failure-in-colorectal-surgery-where-are-we-at
#15
REVIEW
Vinna An, Raaj Chandra, Matthew Lawrence
Anastomotic leak (AL) can be a devastating complication in colorectal surgery. While it is less frequent in the modern era, it still results in significant morbidity and mortality, prolonged hospital stays and increases the costs and demands on health services. There is inevitable interplay between patient physiology and technical factors that predispose a patient to AL. Obesity, preoperative total proteins, male gender, ongoing anticoagulant treatment, intraoperative complication and number of hospital beds have been identified as independent risk factors...
April 2018: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29861865/peritumoral-endothelial-indoleamine-2-3-dioxygenase-expression-is-an-early-independent-marker-of-disease-relapse-in-colorectal-cancer-and-is-influenced-by-dna-mismatch-repair-profile
#16
Annabel Meireson, Inès Chevolet, Eva Hulstaert, Liesbeth Ferdinande, Piet Ost, Karen Geboes, Marc De Man, Dirk Van de Putte, Laurine Verset, Vibeke Kruse, Pieter Demetter, Lieve Brochez
Targeting immune checkpoint molecules has become a major new strategy in the treatment of several cancers. Indoleamine 2,3-dioxygenase (IDO)-inhibitors are a potential next-generation immunotherapy, currently investigated in multiple phase I-III trials. IDO is an intracellular immunosuppressive enzyme and its expression/activity has been associated with worse prognosis in several cancers. The aim of this study was to investigate the expression pattern of IDO in colorectal cancer (CRC). In a cohort of 94 CRC patients, primary tumors (PTs) with corresponding tumor-draining lymph nodes (TDLNs, n = 93) and extranodal/distant metastases ( n = 27) were retrospectively analyzed by immunohistochemical staining for IDO, CD8 and Foxp3...
May 18, 2018: Oncotarget
https://www.readbyqxmd.com/read/29766654/prospective-short-term-feasibility-study-of-perioperative-suprapubic-catheters-in-laparoscopic-colectomy
#17
Sayaka Nagao, Yoshihisa Saida, Toshiyuki Enomoto, Asako Takahashi, Tadashi Higuchi, Hodaka Moriyama, Toru Niituma, Manabu Watanabe, Koji Asai, Shinya Kusachi
INTRODUCTION: Here we report a prospective study on whether a temporary suprapubic catheter (SPC) can be safely inserted as a substitute for transurethral balloon catheterization during laparoscopy-assisted colectomy. METHODS: Our subjects included 52 cases who gave informed consent to have an SPC inserted. These subjects were selected from cases who underwent laparoscopy-assisted surgery for primary colorectal cancer from October 2014 to August 2015. RESULTS: An SPC was inserted into 45 of the original 52 cases...
May 16, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29717372/combined-repeat-laparoscopy-and-transanal-endolumenal-repair-hybrid-approach-in-the-early-management-of-postoperative-colorectal-anastomotic-leaks-technique-and-outcomes
#18
William Tzu-Liang Chen, Saurabh Bansal, Tao-Wei Ke, Sheng-Chi Chang, Yu-Chun Huang, Takashi Kato, Hwei-Ming Wang, Abe Fingerhut
BACKGROUND: Few clear recommendations exist for the management of colorectal anastomotic leaks, often based on surgeon preferences or institutional protocols. The primary goal was to evaluate the feasibility and safety of the combined laparoscopic and transanal (hybrid) approach to treat postoperative colorectal anastomotic leaks. The secondary goals included comparison of outcomes following early (< 5 days after initial resection) versus late (≥ 5 days) detection of leaks...
November 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29682710/-surgical-skills-in-the-prevention-of-anastomotic-leakage-after-rectal-neoplasm-surgery
#19
Qianqian Shao, Guole Lin
For colorectal surgeons, how to reduce anastomotic leakage after laparoscopic rectal cancer surgery remains to be challenging. We provide a brief discussion regarding the surgical skills required to prevent anastomotic leakage after rectal cancer surgery, such as the following: 1) Low ligation of inferior mesenteric vessel during laparoscopic total mesorectal excision can improve anastomotic tension and blood supply, thus reducing the risk of anastomotic leakage. While high ligation of inferior mesenteric artery results in poor blood supply and high tension in atastomotic site, thus increasing the risk of anastomotic leakage...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29666000/how-does-the-application-of-surgical-components-in-enhanced-recovery-programs-for-colorectal-surgery-change-over-time
#20
Julie Veziant, Daniel Leonard, Bruno Pereira, Karem Slim
BACKGROUND: Enhanced recovery programs (ERP) improve post-operative outcomes in proportion to how fully they are implemented. Maintaining an optimal level of application of all the ER components is thus essential. Our aim was to assess the sustainability of ER surgical components 2 years after their first implementation. METHOD: Patients undergoing elective colorectal resections were included in a prospective database. To retrospectively analyze compliance with ERP over a period of 24 months, the following components were considered: colonic preparation, surgical approach, nasogastric tube omission and absence of abdominal drainage...
December 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
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