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Imeshi Wijetunga, Clare Ecuyer, Sonsoles Martinez-Lopez, Muhammad Jameel, Richard J Baker, Matthew Wellberry-Smith, Chirag Patel, Michael Weston, Niaz Ahmad
Kidney transplants from young paediatric donors are uncommonly performed in the UK. Published literature of kidney transplant from donors under 5kg in weight is sparse. We present our initial experience of en bloc kidney transplantation (EKT) from donors under 20kg in weight including neonatal donors. All recipients undergoing EKT from donors under 20kg at our centre from January 2005 to October 2016 were included. Donor and recipient details were recorded from a prospective database. Electronic patient records were examined for follow-up data...
July 7, 2018: American Journal of Transplantation
Chih-Zong Deng, Yu-Jui Fan, Pei-Shan Chung, Horn-Jiunn Sheen
In this study, we developed a new immunosensor that can achieve an ultralow detection limit and high sensitivity. This new device has an electrokinetic trapping (EKT)-based nanofluidic preconcentrator, which was integrated with oscillating bubble valves, to trap concentrated antigen and immunobeads. During the immunoassay process, oscillating bubbles rapidly grew and acted as control valves and to block the microchannel. Thereafter, the trapped preconcentrated antigen plug and antibody-coated nanobeads were preserved in the region between these two valves...
July 27, 2018: ACS Sensors
Sonsoles Martinez-Lopez, Imeshi Wijetunga, Clare Ecuyer, Niaz Ahmad
EKT from neonatal donors remains rare despite successful outcome being reported. The surgical aspects of neonatal abdominal organ recovery remain unfamiliar to the vast majority of abdominal organ recovery teams and renal transplant surgeons. BAH is not uncommon in newborn babies suffering distress in the perinatal period. BAH is often also associated with RVT and will impact on utilization of kidneys for transplantation. We present a case of a neonatal kidney donor with massive BAHs discovered at the time of organ recovery...
June 2018: Pediatric Transplantation
Dan Li, Huazhen Duan, Yuhong Wang, Qinmei Zhang, Hairong Cao, Wei Deng, Dawei Li
The authors have developed a method for simultaneous quantification of several charged pesticides (as shown for amitrole, simazine, trichlorfon and bisultap). It is based on the use of a reduced graphene oxide-modified screen-printed electrode (RGO-SPE) and combines electrokinetic trapping (EKT) and surface-enhanced Raman scattering (SERS). When a 50 μL droplet containing negatively charged RGO and positively charged gold nanorods is placed on the SPE, the RGO and gold nanorods are selectively attracted on the surface of the SPE during EKT...
December 4, 2017: Mikrochimica Acta
Jan Sternby
A new formula for calculating standard Kt/V from clinical data has been derived mathematically. It is based on using the relation between eKt/V and the pre- and postdialysis concentrations in order to find the steady state concentrations. The resulting expression for standard Kt/V depends on the treatment schedule (number, length, and spacing of treatments), residual renal function, and eKt/V and relative ultrafiltration volume of each individual treatment. These results include the effects of ultrafiltration and residual renal function also in the case with unequal treatments that may be arbitrarily distributed over the week...
March 23, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Uğur Bozkaya, Aslı Ünal
The accurate computation of ionization potentials (IPs), within 0.10 eV, is one of the most challenging problems in modern computational chemistry. The extended Koopmans' theorem (EKT) provides a systematic direct approach to compute IPs from any level of theory. In this study, the EKT approach is integrated with the coupled-cluster singles and doubles with perturbative triples [CCSD(T)] method for the first time. For efficiency, the density-fitting (DF) approximation is employed for electron repulsion integrals...
May 3, 2018: Journal of Physical Chemistry. A
Samir Patel, Alice Topping, Xiaoling Ye, Hanjie Zhang, Bernard Canaud, Paola Carioni, Cristina Marelli, Adrian Guinsburg, Albert Power, Neill Duncan, Jeroen Kooman, Frank van der Sande, Len A Usvyat, Yuedong Wang, Xiaoqi Xu, Peter Kotanko, Jochen G Raimann
BACKGROUND: Tall people have improved metabolic profiles and better cardiovascular outcomes, a relationship inverted in dialysis patients. We investigated the relationship between height and outcomes in incident hemodialysis (HD) patients commencing treatment in an analysis of the international Monitoring Dialysis Outcomes (MONDO) database. METHODS: In this retrospective cohort study, we included incident HD patients commencing treatment between -January 1, 2006 and December 31, 2010 and investigated the association between height and mortality using the MONDO database...
2018: Blood Purification
Laura Pedraza-González, Jorge Charry, William Quintero, Jorge Alí-Torres, Andrés Reyes
In this work we propose schemes based on the extended Koopmans' theorem for quantum nuclei (eKT), in the framework of the any particle molecular orbital approach (APMO/KT), for the quantitative prediction of gas phase proton affinities (PAs). The performance of these schemes has been tested on a set of 300 organic molecules containing diverse functional groups. The APMO/KT scheme scaled by functional group (APMO/KT-SC-FG) displays an overall mean absolute error of 1.1 kcal mol-1 with respect to experimental data...
September 27, 2017: Physical Chemistry Chemical Physics: PCCP
Roula Galland, Jules Traeger, Ehsan Delawari, Walid Arkouche, Elias Abdullah
Seven patients, mean age 42.57 ± 15.69 years (range 21 - 67 years), on standard hemodialysis (SHD), 4 - 5 hours, three times per week for 11.0 ± 6.63 years (range 1 - 18 years), were switched to daily hemodialysis (DHD), 2 - 2.5 hours, six times per week. For each type of treatment similar parameters were applied, and the total weekly time was the same. Mean duration of DHD was 15.4 ± 4.98 months (range 7 - 20 months). We report here our results of quantification in each method, including time-averaged concentration (TAC), normalized protein catabolic rate (PCRn), equilibrated Kt/V (eKt/V), equivalent normalized continuous standard clearance [std(Kt/V)], equivalent renal urea clearance (eKRn), and time-averaged deviation (TAD)...
January 1999: Home Hemodialysis International
Frank A Gotch
The equilibrated Kt/V (eKtV) is widely used in hemodialysis (HD) as a measure of the intensity (magnitude) of an individual dialysis treatment. Adequate eKt/V for thrice-weekly hemodialysis (twHD) has been extensively studied, and a value in the range 1.0 - 1.1 per treatment (3.0 - 3.3 weekly) is generally considered to represent adequate therapy for this specific frequency of dialysis. However, for other schedules, summing eKt/V's and time-averaging the clearance is not appropriate. This was first demonstrated several years ago by the observation that a weekly eKt/V of 2...
January 2001: Hemodialysis International
John T Daugirdas
OBJECTIVES: The protein catabolic rate normalized to body size (PCRn) often is computed in dialysis units to obtain information about protein ingestion. However, errors can manifest when inappropriate modeling methods are used. METHODS: We used a variable volume 2-pool urea kinetic model to examine the percent errors in PCRn due to use of a 1-pool urea kinetic model or after omission of residual urea clearance (Kru). RESULTS: When a single-pool model was used, 2 sources of errors were identified...
July 2017: Journal of Renal Nutrition
Yuqi Chen, Wensheng Guo, Peter Kotanko, Len Usvyat, Yuedong Wang
Modeling hospitalization is complicated because the follow-up time can be censored due to death. In this paper, we propose a shared frailty joint model for survival time and hospitalization. A random effect semi-parametric proportional hazard model is assumed for the survival time and conditional on the follow-up time, hospital admissions or total length of stay is modeled by a generalized linear model with a nonparametric offset function of the follow-up time. We assume that the hospitalization and the survival time are correlated through a latent subject-specific random frailty...
November 1, 2016: International Journal of Biostatistics
V Valdovinos, F Monroy-Guzmán, E Bustos
Control samples of scintillation liquids - Phaeozem soil mixtures were prepared with different scintillation liquids as the support electrolyte, Install Gel(®) XF, (Ultima Gold AB™ and Ultima Gold XR™), to construct the polarization curves, and to select the cell potential with the highest mass transfer to remove (24)Na (15 h) and (99m)Tc (6 h) as radiotracers from polluted Phaeozem soil. During the electrokinetic treatment (EKT), the removal of radionuclides contained in scintillation liquids absorbed in Phaeozem soil, liquid phase was characterized by Gas Chromatography coupled with a Flame Ionization Detector (GC-FID) and Fourier Transform Infrared Spectrometry (FTIR), solids by FTIR, before and after the application of cell potential...
October 2016: Journal of Environmental Radioactivity
Narong Touch, Tadashi Hibino, Shinya Nakashita, Kenji Nakamoto
Many studies have reported variation in properties of the sediment within electrokinetic treatments (EKTs). However, we aim to reveal the variation in properties of the sediment following EKTs through laboratory experiments. We collected sewage-derived sediment from a littoral region, and passed it through a 2-mm sieve. We used a potentiostat to cause electrical current in EKT. We measured the sediment properties such as pH, redox potential (ORP), and hydrogen sulphide (H2S) concentration at the end of EKT and at 30 days following EKT...
February 2017: Environmental Technology
Megumi Mizawa, Teruhiko Makino, Chieko Inami, Tadamichi Shimizu
Palmoplantar pustulosis (PPP) is a chronic skin disease characterized by sterile intraepidermal pustules associated with erythematous scaling on the palms and soles. Jumihaidokuto is a traditional herbal medicine composed of ten medical plants and has been given to patients with suppurative skin disease in Japan. This study investigated the effect of jumihaidokuto on the disease activity in PPP patients (n = 10). PPP patients were given jumihaidokuto (EKT-6; 6.0 g per day) for 4 to 8 weeks in addition to their prescribed medications...
2016: Dermatology Research and Practice
Matthias Ernzerhof
The generalized Koopmans' theorem (EKT) yields an estimate of ionization potentials (IPs) of an N-electron system. This estimate (IP(EKT)) is obtained as an eigenvalue of a generalized eigenvalue problem. Katriel and Davidson provided a proof [ Katriel , J. ; Davidson , E. R. Proc. Natl. Acad. Sci. U.S.A. , 1980, 77 , 1403. ] that the EKT predicts the exact lowest IP for ground states of Coulomb systems. However, subsequently, several articles have been published challenging the exactness of the EKT and providing disproofs...
April 14, 2009: Journal of Chemical Theory and Computation
Uğur Bozkaya
The extended Koopmans' theorem (EKT) provides a systematic way to compute electron affinities (EAs) from any level of theory. Although, it is widely applied to ionization potentials, the EKT approach has not been extensively applied to computations of electron affinities. We present the first benchmarking study to investigate the performances of the EKT methods for predictions of EAs. We assess the performances of the EKT approaches based on orbital-optimized methods [Bozkaya, U. J. Chem. Phys. 2013, 139, 154105], such as the orbital-optimized third-order Møller-Plesset perturbation theory and the orbital-optimized coupled-electron pair theory [OCEPA(0)], and their standard counterparts for EAs of the selected atoms, closed- and open-shell molecules...
May 13, 2014: Journal of Chemical Theory and Computation
Dilan Yildiz, Uğur Bozkaya
The extended Koopmans' theorem (EKT) provides a straightforward way to compute ionization potentials and electron affinities from any level of theory. Although it is widely applied to ionization potentials, the EKT approach has not been applied to evaluation of the chemical reactivity. We present the first benchmarking study to investigate the performance of the EKT methods for predictions of chemical potentials (μ) (hence electronegativities), chemical hardnesses (η), and electrophilicity indices (ω). We assess the performance of the EKT approaches for post-Hartree-Fock methods, such as Møller-Plesset perturbation theory, the coupled-electron pair theory, and their orbital-optimized counterparts for the evaluation of the chemical reactivity...
January 30, 2016: Journal of Computational Chemistry
Ezio Movilli, Corrado Camerini, Paola Gaggia, Roberto Zubani, Paolo Feller, Chiara Salviani, Annalisa Facchini, Giovanni Cancarini
BACKGROUND: Inflammation and increased erythropoiesis stimulating agents (ESA) requirement are frequently associated in patients on dialysis. On-line hemodiafiltration (ol-HDF), putting together high levels of diffusion, and convection could improve both conditions. However, it is still not known which depurative component plays a major role in determining this result. The aim of the study was to evaluate the role of convection and diffusion on long-term variations of serum β2 microglobulin (Δβ2M), high-sensitive C-reactive protein (ΔhsCRP) concentrations, and ESA requirement (ΔESA) in ol-HDF...
2015: American Journal of Nephrology
Paul Balter, Linda H Ficociello, Patrice B Taylor, Len Usvyat, Dixie-Ann Sawin, Claudy Mullon, Jose Diaz-Buxo, Paul Zabetakis
BACKGROUND: Inadequate removal of extracellular volume markedly increases blood pressure and contributes to high morbidity and mortality in hemodialysis patients. Advances in fluid management are needed to improve clinical outcomes. The aim of this quality improvement project was to examine the advantages of using a hematocrit-based, blood volume monitor (Crit-Line * ) for 12 months, as part of a clinic-wide, fluid management program in one dialysis facility. METHODS: Forty-five individuals were receiving hemodialysis at one facility at project initiation and are included in this analysis...
2015: Current Medical Research and Opinion
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