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Resistance AND Training

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https://www.readbyqxmd.com/read/30334618/feasibility-of-early-multimodal-interventions-for-elderly-patients-with-advanced-pancreatic-and-non-small-cell-lung-cancer
#1
Tateaki Naito, Shuichi Mitsunaga, Satoru Miura, Noriatsu Tatematsu, Toshimi Inano, Takako Mouri, Tetsuya Tsuji, Takashi Higashiguchi, Akio Inui, Taro Okayama, Teiko Yamaguchi, Ayumu Morikawa, Naoharu Mori, Toshiaki Takahashi, Florian Strasser, Katsuhiro Omae, Keita Mori, Koichi Takayama
BACKGROUND: Combinations of exercise and nutritional interventions might improve the functional prognosis for cachectic cancer patients. However, high attrition and poor compliance with interventions limit their efficacy. We aimed to test the feasibility of the early induction of new multimodal interventions specific for elderly patients with advanced cancer Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) programme. METHODS: This was a multicentre prospective single-arm study...
October 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/30333748/using-machine-learning-to-predict-synergistic-antimalarial-compound-combinations-with-novel-structures
#2
Daniel J Mason, Richard T Eastman, Richard P I Lewis, Ian P Stott, Rajarshi Guha, Andreas Bender
The parasite Plasmodium falciparum is the most lethal species of Plasmodium to cause serious malaria infection in humans, and with resistance developing rapidly novel treatment modalities are currently being sought, one of which being combinations of existing compounds. The discovery of combinations of antimalarial drugs that act synergistically with one another is hence of great importance; however an exhaustive experimental screen of large drug space in a pairwise manner is not an option. In this study we apply our machine learning approach, Combination Synergy Estimation (CoSynE), which can predict novel synergistic drug interactions using only prior experimental combination screening data and knowledge of compound molecular structures, to a dataset of 1,540 antimalarial drug combinations in which 22...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30332990/predicting-bacterial-resistance-from-whole-genome-sequences-using-k-mers-and-stability-selection
#3
Pierre Mahé, Maud Tournoud
BACKGROUND: Several studies demonstrated the feasibility of predicting bacterial antibiotic resistance phenotypes from whole-genome sequences, the prediction process usually amounting to detecting the presence of genes involved in antibiotic resistance mechanisms, or of specific mutations, previously identified from a training panel of strains, within these genes. We address the problem from the supervised statistical learning perspective, not relying on prior information about such resistance factors...
October 17, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/30329166/effects-of-care-assistant-communication-style-on-communicative-behaviours-of-residents-with-dementia-a-systematic-multiple-case-study
#4
Miriam Stanyon, Shirley Thomas, Adam Gordon, Amanda Griffiths
OBJECTIVES: To determine whether varying the communication style of care assistants, encouraging them to use direct instructions and allowing more time for residents' responses influenced the communicative behaviour of care home residents living with dementia. DESIGN: This study used a multiple systematic case study design. Participants were video-recorded during morning care routines in three communication conditions: usual communication, direct instructions and pacing (allowing more time for resident responses)...
October 17, 2018: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/30328967/effects-of-resistance-exercise-training-and-stretching-on-chronic-insomnia
#5
Carolina V R D'Aurea, Dalva Poyares, Giselle S Passos, Marcos G Santana, Shawn D Youngstedt, Altay A Souza, Juliana Bicudo, Sergio Tufik, Marco T de Mello
OBJECTIVE: The aim of this study was to assess the effects of resistance exercise and stretching on sleep, mood, and quality of life in chronic insomnia patients. METHODS: Three 4-month treatments included: resistance exercise (n=10), stretching (n=10), and control (n=8). Sleep was evaluated with polysomnography, actigraphy, and questionnaires. Mood and quality of life were assessed with the Profile of Mood States (POMS) and the Medical Outcomes Study Short-Form 36-Item Health Survey (SF-36), respectively...
October 11, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/30327609/hemodynamic-responses-to-low-load-blood-flow-restriction-and-unrestricted-high-load-resistance-exercise-in-older-women
#6
Brendan R Scott, Jeremiah J Peiffer, Hannah J Thomas, Kieran J Marston, Keith D Hill
Introduction: Blood flow restriction (BFR) during low-load resistance exercise increases muscle size similarly to high-load training, and may be an alternative to lifting heavy weights for older people at risk of sarcopenia. However, few studies have addressed the safety of such exercise in older people, or whether this is impacted by the actual exercises performed during training. This study aimed to compare the acute hemodynamic and perceptual responses during low-load BFR exercise to unrestricted low-load and high-load exercise in older women, and to determine whether these responses depend on the type of exercise performed...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30326252/endurance-training-on-rodent-brain-antioxidant-capacity-a-meta-analysis
#7
REVIEW
Raphael Fabricio de Souza, Silvia Regina Arruda de Moraes, Ricielle Lopes Augusto, Aristela de Freitas Zanona, Dihogo Matos, Felipe J Aidar, Belmira Lara da Silveira Andrade-da-Costa
The influence of physical exercise on brain antioxidant defense mechanisms has been studied. Nevertheless, the effect of training volume on the brain`s redox balance remains unclear. In this meta-analysis, we compared the effect of training volume on antioxidant enzymatic resource and lipid peroxidation on various brain regions. The activities of the enzymes glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and the levels of thiobarbituric acid reactive substances (TBARS) were also evaluated...
October 13, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/30325913/the-influence-of-physical-training-modalities-on-basal-metabolic-rate-and-leptin-on-obese-adolescent-boys
#8
Meral Kucuk Yetgin, Ani Agopyan, Ferit Kerim Kucukler, Asuman Gedikbasi, Soner Yetgin, Fatma Celik Kayapinar, Nurper Ozbar, Bilal Bicer
The aim of this study was to investigate the effects of physical training modalities on basal metabolic rate, cardiovascular fitness and serum leptin level in obese adolescent boys. Sixteen obese adolescent boys (age: 16.81 +- 0.91 years) were randomly assigned to either resistance (RTG) (n=8) or endurance (ETG) (n=8) training and followed the respective training programmes for six months (3 days/wk, 60 min/day). Leptin, basal metabolism rate (BMR), and maximum oxygen consumption (VO2max) were evaluated at the beginning and end of the intervention...
June 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30325270/effects-of-upper-and-lower-body-wearable-resistance-on-spatio-temporal-and-kinetic-parameters-during-running
#9
Grace A Couture, Kim D Simperingham, John B Cronin, Anna V Lorimer, Andrew E Kilding, Paul Macadam
Wearable resistance training involves added load attached directly to the body during sporting movements. The effects of load position during running are not yet fully established. Therefore, the purpose of this research was to determine spatio-temporal and kinetic characteristics during submaximal running using upper, lower and whole-body wearable resistance (1-10% body mass (BM)). Twelve trained male runners completed eight 2-min treadmill running bouts at 3.9 m/s with and without wearable resistance. The first and last bouts were unloaded, while the middle 6 were randomised wearable resistance conditions: upper body (UB) 5% BM, lower body (LB) 1%, 3%, 5% BM and whole body (WB) 5%, 10% BM...
October 16, 2018: Sports Biomechanics
https://www.readbyqxmd.com/read/30324418/trained-females-exhibit-less-fatigability-than-trained-males-after-a-heavy-knee-extensor-resistance-exercise-session
#10
Emily Metcalf, Amanda D Hagstrom, Paul W Marshall
PURPOSE: We examined differences between trained males and females in measures of muscular fatigability and central motor output after a resistance exercise session. METHODS: Sixteen trained males (n = 8) and females (n = 8) participated in the study. Knee extensor maximal torque and rate of torque development were measured before and after the exercise session, and the twitch interpolation technique was used during the maximal efforts to derive measures of voluntary activation and muscle contractility by supramaximal stimulation of the femoral nerve using 10 and 100 Hz doublets...
October 15, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/30323787/intensive-multimodal-training-to-improve-gait-resistance-mobility-balance-and-cognitive-function-in-persons-with-multiple-sclerosis-a-pilot-randomized-controlled-trial
#11
Johanna Jonsdottir, Elisa Gervasoni, Thomas Bowman, Rita Bertoni, Eleonora Tavazzi, Marco Rovaris, Davide Cattaneo
Introduction: Persons with multiple sclerosis (MS) have deficits in many aspects of physical and cognitive functioning that can impact on mobility and participation in daily life. The effect of a 4 week intensive multimodal treadmill training on functional mobility, balance, executive functions and participation in persons with MS with moderate to severe disability was investigated. Methods: Thirty eight persons with MS admitted to a rehabilitation center participated in a two arm randomized 2:1 controlled trial...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30322711/from-paper-to-practice-strategies-for-improving-antibiotic-stewardship-in-the-pediatric-ambulatory-setting
#12
Michael J Bozzella, Nada Harik, Jason G Newland, Rana F Hamdy
Antibiotic stewardship aims to better patient outcomes, reduce antibiotic resistance, and decrease unnecessary health care costs by improving appropriate antibiotic use. More than half of annual antibiotic expenditures for antibiotics in the United States are prescribed in the ambulatory setting. This review provides a summary of evidence based strategies shown to improve antibiotic prescribing in ambulatory care settings including: providing education to patients and their families, providing education to clinicians regarding best practices for specific conditions, providing communications training to clinicians, implementing disease-specific treatment algorithms, implementing delayed prescribing for acute otitis media, supplying prescribing feedback to providers with peer comparisons, using commitment letters, and prompting providers to justify antibiotic prescribing for diagnoses for which antibiotics are not typically recommended...
October 13, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/30321613/a-post-exercise-facilitation-of-executive-function-is-independent-of-aerobically-supported-metabolic-costs
#13
Matthew Heath, Andrea Petrella, Jonathan Blazevic, David Lim, Andre Pelletier, Glen Belfry
A single-bout of aerobic or resistance training facilitates executive function and is a benefit thought to be specific to exercise durations greater than 20minutes. We sought to determine whether an executive benefit is observed for a session as brief as 10-minutes, and whether distinct and participant-specific exercise intensities - and associated metabolic costs - influence the magnitude of the benefit. Participants completed exercise sessions - via cycle ergometer - at moderate (80% of lactate threshold [LT]), heavy (15% of the difference between LT and VO2 peak ) and very-heavy (50% of the difference between LT and VO2 peak ) intensities determined via an incremental ramp test to volitional exhaustion...
October 12, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/30317063/the-role-of-parental-attributions-in-predicting-parenting-intervention-outcomes-in-the-treatment-of-child-conduct-problems
#14
Vilas Sawrikar, David J Hawes, Caroline Moul, Mark R Dadds
BACKGROUND: Parent attributions about the causes of their children's behaviour problems are a known predictor of problematic parenting and ongoing child problems. However, their importance in parenting interventions remains unknown as research has not addressed whether parental attributions predict outcomes associated with parenting training. The current study examined whether problematic pre-treatment and change resistant parental attributions during treatment uniquely predict child behaviour outcomes...
October 6, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/30317013/safety-and-feasibility-of-high-speed-resistance-training-with-and-without-balance-exercises-for-knee-osteoarthritis-a-pilot-randomised-controlled-trial
#15
Levinger Pazit, Dunn Jeremy, Bifera Nancy, Butson Michael, Elias George, Keith D Hill
OBJECTIVES: People with knee osteoarthritis (OA) have increased risk of falling with impaired ability to rapidly respond and generate lower limb muscle power to arrest a fall. We examined the feasibility and safety of a high speed resistance training program with and without balance exercises. DESIGN: A randomised controlled pilot trial comparing pre and post 8 weeks intervention within 3 groups: control, high speed resistance training (HSRT), high speed resistance training plus balance exercises (HSRTB)...
October 3, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/30316811/effects-of-linear-periodization-versus-daily-undulating-periodization-on-neuromuscular-performance-and-activities-of-daily-living-in-an-elderly-population
#16
Andrew Buskard, Brian Zalma, Nicholes Cherup, Catherine Armitage, Craig Dent, Joseph F Signorile
BACKGROUND: Periodization is a systematic training calendar designed to provide variations in performance targeting, while maximizing results and reducing the potential for overtraining. When provided across multiple weeks, termed a mesocycle, it may also incorporate active recovery periods using specified drills designed to translate neuromuscular gains into targeted functional abilities. There are a number of models that can be used when applying periodization to resistance training (RT)...
October 11, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/30315071/generalized-polyspike-train-an-eeg-biomarker-of-drug-resistant-idiopathic-generalized-epilepsy
#17
Yanping Sun, Udaya Seneviratne, Piero Perucca, Zhibin Chen, Meng Kee Tan, Terence J O'Brien, Wendyl D'Souza, Patrick Kwan
OBJECTIVE: To identify clinical and EEG biomarkers of drug resistance in adults with idiopathic generalized epilepsy. METHODS: We conducted a case-control study consisting of a discovery cohort and a replication cohort independently assessed at 2 different centers. In each center, patients with the idiopathic generalized epilepsy phenotype and generalized spike-wave discharges on EEG were classified as drug-resistant or drug-responsive. EEG changes were classified into predefined patterns and compared between the 2 groups in the discovery cohort...
October 12, 2018: Neurology
https://www.readbyqxmd.com/read/30312703/effects-of-different-types-of-exercise-on-skeletal-muscle-atrophy-antioxidant-capacity-and-growth-factors-expression-following-myocardial-infarction
#18
Mengxin Cai, Qing'an Wang, Zhiwei Liu, Dandan Jia, Rui Feng, Zhenjun Tian
AIMS: Myocardial infarction (MI) is accompanied with skeletal muscle abnormalities. The aims are to explore an optimal exercise mode to improve cardiac function and prevent skeletal muscle atrophy, and detected the possible mechanisms of exercise-induced inhibition of muscle atrophy. MAIN METHODS: Rats were subjected to four weeks of different types of exercise after MI surgery (resistance training, RT; moderated-intensity continuous aerobic exercise, MCE and high-intensity intermittent aerobic exercise, HIA)...
October 9, 2018: Life Sciences
https://www.readbyqxmd.com/read/30312665/virtual-reality-for-spinal-cord-injury-associated-neuropathic-pain-systematic-review
#19
REVIEW
B Chi, B Chau, E Yeo, P Ta
BACKGROUND: Treatment of spinal cord injury (SCI)-associated neuropathic pain is challenging, with limited efficacy and no definitive options, and SCI patients often show resistance to pharmacologic treatment. Virtual reality (VR) therapy is a non-invasive, non-pharmacologic alternative with minimal adverse effects. OBJECTIVE: To investigate the effect of VR therapy on SCI-associated neuropathic pain in a systematic review. METHODS: Articles needed to 1) be written in English; 2) include adult subjects, with at least half the study population with a SCI diagnosis; 3) involve any form of VR therapy; and 4) assess neuropathic pain by quantitative outcome measures...
October 9, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/30311313/low-intensity-exercise-therapy-with-high-frequency-improves-physical-function-and-mental-and-physical-symptoms-in-patients-with-haematological-malignancies-undergoing-chemotherapy
#20
Takuya Fukushima, Jiro Nakano, Shun Ishii, Ayumi Natsuzako, Junya Sakamoto, Minoru Okita
This study aimed to investigate the effects of low-intensity exercise therapy (LIET) on the physical and mental symptoms and functions in patients with haematological malignancies undergoing chemotherapy. Forty-four patients hospitalised for chemotherapy performed LIET. The exercise intensity of LIET was defined as achieving <40% of the predicted maximum heart rate calculated using the Karvonen formula. LIET consisted of aerobic and resistance training, which was carried out on weekdays. The intervention was omitted in the case of poor general health status and strong patient refusal...
October 12, 2018: European Journal of Cancer Care
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