Byron Wp Reeve, Gcobisa Ndlangalavu, Hridesh Mishra, Zaida Palmer, Happy Tshivhula, Loren Rockman, Selisha Naidoo, Desiree L Mbu, Charissa C Naidoo, Brigitta Derendinger, Gerhard Walzl, Stephanus T Malherbe, Paul D van Helden, Fred C Semitala, Christina Yoon, Rishi K Gupta, Mahdad Noursadeghi, Robin M Warren, Grant Theron
BACKGROUND: Tuberculosis (TB), a major cause of death in people living with HIV (PLHIV), remains challenging to diagnose. Diagnostic accuracy data are lacking for promising triage tests, such as C-reactive protein (CRP), and confirmatory tests, such as sputum and urine Xpert MTB/RIF Ultra (Ultra), and urine LAM, without prior symptom selection. METHODS: 897 PLHIV initiating antiretroviral therapy were consecutively recruited in settings with high TB incidence, irrespective of symptoms...
June 5, 2023: medRxiv