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Insulin Resistance AND obstructive sleep apnea

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https://www.readbyqxmd.com/read/30279095/obstructive-sleep-apnea-and-the-metabolic-syndrome-the-road-to-clinically-meaningful-phenotyping-improved-prognosis-and-personalized-treatment
#1
REVIEW
Jordan Gaines, Alexandros N Vgontzas, Julio Fernandez-Mendoza, Edward O Bixler
Obstructive sleep apnea (OSA) is an increasingly prevalent sleep disorder characterized by upper airway obstruction during sleep, resulting in breathing pauses, intermittent hypoxia, and fragmented sleep. In parallel, the constellation of adverse health outcomes associated with prolonged obesity, such as insulin resistance, elevated blood pressure, triglycerides, and reduced high-density lipoprotein cholesterol - termed metabolic syndrome -raises the risk of cardiovascular morbidity and mortality, type 2 diabetes, and all-cause mortality...
September 3, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/30269329/-current-status-and-perspective-of-bariatric-surgery-in-the-treatment-of-type-1-diabetes-with-obesity
#2
Lun Wang, Tao Jiang, Jinfa Wang
With the development of social economy and the change of lifestyle and working environment, the number of obese and diabetic population has increased significantly. Obesity is closely related to diabetes mellitus with interaction. Among the patients with type 1 diabetes mellitus (T1DM), the cardiovascular risk of T1DM with obesity is significantly higher than those of lean T1DM. The mortality of T1DM with obesity is significantly higher than that of the general population, which poses a great threat to human health, making it become one of the serious public health problems we have to face at present...
September 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/30237409/intermittent-hypoxia-regulates-vasoactive-molecules-and-alters-insulin-signaling-in-vascular-endothelial-cells
#3
Pragya Sharma, Yu Dong, Virend K Somers, Timothy E Peterson, Yuebo Zhang, Shihan Wang, Guangxi Li, Prachi Singh
Vascular dysfunction and insulin resistance (IR) are associated with obstructive sleep apnea (OSA), which is characterized by frequent episodes of nocturnal intermittent hypoxia (IH). While it is recognized that the balance between vasoconstrictive (endothelin-1) and vasodilatory molecules (nitric oxide, NO) determine vascular profile, molecular mechanisms contributing to vascular dysfunction and IR in OSA are not completely understood. Caveolin-1 is a membrane protein which regulates endothelial nitric oxide synthase (eNOS) activity which is responsible for NO generation and cellular insulin-signaling...
September 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30211224/corrigendum-to-circulating-endocannabinoids-and-insulin-resistance-in-patients-with-obstructive-sleep-apnea
#4
Xiaoya Wang, Qin Yu, Hongmei Yue, Jiabin Zhang, Shuang Zeng, Fenfen Cui
[This corrects the article DOI: 10.1155/2016/9782031.].
2018: BioMed Research International
https://www.readbyqxmd.com/read/30209960/association-between-serum-level-of-advanced-glycation-end-products-and-obstructive-sleep-apnea-hypopnea-syndrome-a-meta-analysis
#5
Xingyu Wu, Wensheng She, Xun Niu, Xiong Chen
Objective This meta-analysis was performed to assess the difference in the serum level of advanced glycation end products (AGEs) between patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and controls. Methods A systematic literature search was performed using PubMed, Elsevier, SCI, Wanfang, Weipu, and China National Knowledge Internet. Eligible studies that reported the serum AGE level in patients with OSAHS were identified by two reviewers. Review Manager version 5.2 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) and R version 3...
September 13, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30167574/obesity-obstructive-sleep-apnea-and-type-2-diabetes-mellitus-epidemiology-and-pathophysiologic-insights
#6
Shazia Jehan, Alyson K Myers, Ferdinand Zizi, Seithikurippu R Pandi-Perumal, Girardin Jean-Louis, Samy I McFarlane
Obesity is a major global health issue, and its prevalence is increasing. Obesity is associated with much comorbidity such as obstructive sleep apnea (OSA), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). Obesity is also one of the major causative factors of OSA, and OSA itself can promote the onset of after T2DM because hypoxic episodes decrease insulin sensitivity, and activation of the sympathetic pathway leads to the release of inflammatory markers associated with insulin resistance...
2018: Sleep medicine and disorders: international journal
https://www.readbyqxmd.com/read/30151379/adiponectin-omentin-ghrelin-and-visfatin-levels-in-obese-patients-with-severe-obstructive-sleep-apnea
#7
Dong-Mei Zhang, Xing-Long Pang, Rong Huang, Feng-Ying Gong, Xu Zhong, Yi Xiao
Objectives: Obstructive sleep apnea (OSA) is closely associated with obesity, insulin resistance, and inflammation. Adiponectin, omentin, ghrelin, and visfatin are adipokines involved in insulin sensitivity or regulation of inflammatory disease. This study aims to clarify the relationship between OSA and associated adipokines. Patients and Methods: Thirty overweight male patients with severe OSA and twenty controls underwent standard diagnostic polysomnography (PSG), and 10 patients underwent overnight continuous positive airway pressure (CPAP) treatment...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30147722/the-polycystic-ovary-syndrome-and-the-metabolic-syndrome-a-possible-chronobiotic-cytoprotective-adjuvant-therapy
#8
REVIEW
Eduardo Spinedi, Daniel P Cardinali
Polycystic ovary syndrome is a highly frequent reproductive-endocrine disorder affecting up to 8-10% of women worldwide at reproductive age. Although its etiology is not fully understood, evidence suggests that insulin resistance, with or without compensatory hyperinsulinemia, and hyperandrogenism are very common features of the polycystic ovary syndrome phenotype. Dysfunctional white adipose tissue has been identified as a major contributing factor for insulin resistance in polycystic ovary syndrome. Environmental (e...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/30120048/insulin-resistance-is-associated-with-sfrp5-in-obstructive-sleep-apnea
#9
Shibo Sun, Huifen Zhai, Mei Zhu, Peili Wen, Xin He, Haoyan Wang
INTRODUCTION: Obstructive sleep apnea, a common disease, is usually complicated by insulin resistance and type 2 diabetes mellitus. Adipokine is considered to play an important role in the development of insulin resistance and type 2 diabetes mellitus in obstructive sleep apnea. OBJECTIVE: To assess whether secreted frizzled-related protein 5, a new adipokine, is involved in untreated obstructive sleep apnea patients. METHODS: Seventy-six subjects with obstructive sleep apnea and thirty-three control subjects without obstructive sleep apnea were recruited and matched in terms of body mass index and age...
August 4, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/30074565/prevalence-of-potential-modifiable-factors-of-hypertension-in-patients-with-difficult-to-control-hypertension
#10
Nicolette G C Van Der Sande, Peter J Blankestijn, Frank L J Visseren, Martine M Beeftink, Michiel Voskuil, Jan Westerink, Michiel L Bots, Wilko Spiering
BACKGROUND: A comprehensive diagnostic evaluation of potential modifiable factors of difficult-to-control hypertension would enable clinicians to target-specific amendable causes. Therefore, we assessed the prevalence of underlying medical conditions, lifestyle factors, and concomitant medication use in an integrated diagnostic evaluation in patients with difficult-to-control hypertension, referred to a tertiary center. METHODS: The study population consisted of 653 patients referred between 2006 and 2016 for difficult-to-control hypertension to the University Medical Center Utrecht...
August 1, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/30042734/sex-differences-in-the-impact-of-obstructive-sleep-apnea-on-glucose-metabolism
#11
Karla A Temple, Rachel Leproult, Lisa Morselli, David A Ehrmann, Eve Van Cauter, Babak Mokhlesi
Objectives: Obstructive sleep apnea (OSA) is more prevalent in men and is an independent risk factor for type 2 diabetes. We aimed to determine if there are sex differences in the impact of OSA on glucose metabolism in nondiabetic overweight and obese adults. Methods: One hundred and forty-five men and women (age 33.4 ± 0.6, BMI 37.2 ± 0.7, 70.3% blacks) from the community underwent in-laboratory polysomnography. Severity of OSA was assessed by the apnea-hypopnea index (AHI). Glucose tolerance was assessed using fasting glucose, 1-h glucose, 2-h glucose and the area under the curve (AUC) during the 2-h oral glucose tolerance test (OGTT)...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/30042730/poor-sleep-and-obesity-concurrent-epidemics-in-adolescent-youth
#12
REVIEW
Anisha Gohil, Tamara S Hannon
Poor sleep and obesity are both extraordinarily common in the US adolescent population and often occur simultaneously. This review explores the links between obesity and sleep, outlining what is known about the relationships between sleep characteristics, obesity, and cardiometabolic risk factors in youth. Sleep duration is less than optimal in teens, and decreases as age increases. This is detrimental to overall well-being and is associated with obesity in children, adolescents, and young adults. Accordingly, inadequate sleep duration is associated with poor diet quality, decreased insulin sensitivity, hyperglycemia, and prevalent cardiometabolic risk factors...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29997573/obstructive-sleep-apnea-with-or-without-excessive-daytime-sleepiness-clinical-and-experimental-data-driven-phenotyping
#13
Sergio Garbarino, Egeria Scoditti, Paola Lanteri, Luana Conte, Nicola Magnavita, Domenico M Toraldo
Introduction: Obstructive sleep apnea (OSA) is a serious and prevalent medical condition with major consequences for health and safety. Excessive daytime sleepiness (EDS) is a common-but not universal-accompanying symptom. The purpose of this literature analysis is to understand whether the presence/absence of EDS is associated with different physiopathologic, prognostic, and therapeutic outcomes in OSA patients. Methods: Articles in English published in PubMed, Medline, and EMBASE between January 2000 and June 2017, focusing on no-EDS OSA patients, were critically reviewed...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29991422/adropin-and-inflammation-biomarker-levels-in-male-patients-with-obstructive-sleep-apnea-a-link-with-glucose-metabolism-and-sleep-parameters
#14
Josko Bozic, Josip A Borovac, Tea Galic, Tina Ticinovic Kurir, Daniela Supe-Domic, Zoran Dogas
STUDY OBJECTIVES: The main objectives of the study were to determine plasma adropin, systemic inflammation biomarker levels, and glucose metabolism parameters in patients with moderate and severe obstructive sleep apnea (OSA) compared to healthy controls. METHODS: In this study, we included 50 male patients with OSA (25 moderate and 25 severe) and 25 age- and sex-matched control subjects. All subjects underwent fasting sampling of peripheral blood for laboratory analyses...
July 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29915639/a-case-of-concomitant-obstructive-sleep-apnea-and-non-alcoholic-steatohepatitis-treated-with-cpap-therapy
#15
Bharat Bajantri, Dmitry Lvovsky
Obstructive sleep apnea syndrome is a disorder of sleep breathing that is a result of recurrent and intermittent hypoxia during sleep induced by the repeated partial or complete collapse of the upper airway, eventually causing chronic intermittent hypoxia. Non-alcoholic fatty liver disease is divided into non-alcoholic fatty liver and non-alcoholic steatohepatitis. Animal and human studies showed that obesity is associated with chronic liver hypoxia, even in the presence of systemic normoxia causing inflammation and release of cytokines...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29896159/blockade-of-endothelin-1-receptor-type-b-ameliorates-glucose-intolerance-and-insulin-resistance-in-a-mouse-model-of-obstructive-sleep-apnea
#16
Jan Polak, Naresh M Punjabi, Larissa A Shimoda
Obstructive sleep apnea (OSA) is associated with insulin resistance (IR) and glucose intolerance. Elevated endothelin-1 (ET-1) levels have been observed in OSA patients and in mice exposed to intermittent hypoxia (IH). We examined whether pharmacological blockade of type A and type B ET-1 receptors (ETA and ETB ) would ameliorate glucose intolerance and IR in mice exposed to IH. Subcutaneously implanted pumps delivered BQ-123 (ETA antagonist; 200 nmol/kg/day), BQ-788 (ETB antagonist; 200 nmol/kg/day) or vehicle (saline or propyleneglycol [PG]) for 14 days in C57BL6/J mice (10/group)...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29843131/intermittent-hypoxia-disrupts-glucose-homeostasis-in-liver-cells-in-an-insulin-dependent-and-independent-manner
#17
Chen Juan Gu, Hua Hua Yi, Jing Feng, Zhi Guo Zhang, Jun Zhou, Li Na Zhou, Jian Ping Zhou, Min Li, Qing Yun Li
BACKGROUND/AIMS: Obstructive sleep apnea is associated with diabetes and insulin resistance, but the underlying mechanisms remain unclear. The purpose of the current study was to determine the molecular effects of intermittent hypoxia (IH) on hepatic insulin signaling and glucose homeostasis, and whether c-Jun NH2-terminal-kinase (JNK) contributed to metabolic responses to IH in liver cells. METHODS: The human HepG2 cells and rat FAO cells were exposed to 10, 30, 120, 240 or 360 cycles of IH (1% O2 for 60 s followed by 21% O2 for 60s, 7...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29804216/oxidative-stress-in-obese-children-and-adolescents-with-and-without-type-2-diabetes-mellitus-is-not-associated-with-obstructive-sleep-apnea
#18
Riva Tauman, Shlomit Shalitin, Lena Lavie
PURPOSE: Obesity, obstructive sleep apnea (OSA), and type 2 diabetes mellitus (T2DM) are associated with chronic low-grade inflammation and oxidative stress. In adults, increased lipid peroxidation, a marker of oxidative stress, was found in both metabolic syndrome and OSA. Studies on oxidative stress in children with T2DM and OSA are scarce. METHODS: Plasma oxidized low-density lipoprotein (Ox-LDL) levels were evaluated in obese children and adolescents with/without T2DM, and the contribution of OSA to oxidative stress was investigated...
May 26, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29798073/-expression-and-significance-of-serum-insulin-like-growth-factor-1-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#19
C B Xie, X Q Huang, P Wu, X Luo, J He, J F Zeng, W Wang, Y Y Tang
Objective: To investigate the expression and significance of serum insulinlike growth factor-1(IGF-1) in adult patients with obstructive sleep apnea hypopnea syndrome(OSAHS). Method: One hundred and seven patients of OSAHS diagnosed with PSG were included in the observation group,which were divided into heavy, medium and light group according to AHI.Fifty case of healthy people without OSAHS were included in control group.Serum IGF-1 were measured by ELISA. Thirty patients of heavy OSAHS received surgery and CPAP treatment for three months,and were retested the levels of IGF-1 and PSG six months later...
April 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29789952/carotid-body-ablation-a-new-target-to-address-central-autonomic-dysfunction
#20
REVIEW
Rodrigo Iturriaga
PURPOSE OF REVIEW: An abnormal heightened carotid body (CB) chemoreflex, which produces autonomic dysfunction and sympathetic overactivation, is the common hallmark of obstructive sleep apnea (OSA), resistant hypertension, systolic heart failure (HF), and cardiometabolic diseases. Accordingly, it has been proposed that the elimination of the CB chemosensory input to the brainstem may reduce the autonomic and cardiorespiratory alterations in sympathetic-associated diseases in humans. RECENT FINDINGS: A growing body of evidence obtained in preclinical animal models support that an enhanced CB discharge produces sympathetic hyperactivity, baroreflex sensitivity and heart rate variability impairment, breathing instability, hypertension, and insulin resistance...
May 22, 2018: Current Hypertension Reports
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