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Benoît Lamarche

Janie Allaire, Denis Talbot, Patrick Couture, André Tchernof, Peter J H Jones, Penny Kris-Etherton, Sheila G West, Philip W Connelly, David J A Jenkins, Benoît Lamarche
The purpose of this study was to examine how using the mean of two consecutive measurements vs. one measurement post-treatment influences the sample size required to detect changes in cardiometabolic risk factors in dietary studies. For a given statistical power, using the mean of two measurements taken on consecutive days post-treatment instead of a single measurement significantly reduces the sample size required to observe changes in triglyceride, total apolipoprotein B100, and C-reactive protein concentrations in the context of a supplementation study...
July 31, 2018: European Journal of Clinical Nutrition
Bénédicte L Tremblay, Frédéric Guénard, Benoît Lamarche, Louis Pérusse, Marie-Claude Vohl
Carotenoids have shown an interindividual variability that may be due to genetic factors. The only study that has reported heritability of serum α- and β-carotene has not considered the environmental component. This study aimed to estimate the contribution of both genetic and common environmental effects to the variance of carotenoid concentrations and to test whether their phenotypic correlations with cardiometabolic risk factors are explained by shared genetic and environmental effects. Plasma carotenoid concentrations (α-carotene, β-carotene, β-cryptoxanthin, lutein, lycopene, zeaxanthin, and total carotenoids) of 48 healthy subjects were measured...
July 31, 2018: Nutrients
Xiaoran Liu, Josephine Garban, Peter J Jones, Jack Vanden Heuvel, Benoît Lamarche, David J Jenkins, Philip W Connelly, Patrick Couture, Shuaihua Pu, Jennifer A Fleming, Sheila G West, Penny M Kris-Etherton
Background: Cholesterol efflux plays an important role in preventing atherosclerosis progression. Vegetable oils with varying unsaturated fatty acid profiles favorably affect multiple cardiovascular disease risk factors; however, their effects on cholesterol efflux remain unclear. Objective: The objectives of this study were to examine the effects of diets low in saturated fatty acids (SFAs) with varying unsaturated fatty acid profiles on serum-mediated cholesterol efflux and its association with the plasma lipophilic index and central obesity...
May 1, 2018: Journal of Nutrition
Jacynthe Lafrenière, Catherine Laramée, Julie Robitaille, Benoît Lamarche, Simone Lemieux
OBJECTIVE: To assess the relative validity of a new, web-based, self-administered 24 h dietary recall, the R24W, for assessment of energy and nutrient intakes among French Canadians. DESIGN: Each participant completed a 3d food record (FR) and the R24W on three occasions over a 4-week period. Intakes of energy and of twenty-four selected nutrients assessed by both methods were compared. SETTING: Québec City metropolitan area. SUBJECTS: Fifty-seven women and fifty men (mean (sd) age: 47·2 (13·3) years)...
July 6, 2018: Public Health Nutrition
Jean-Philippe Drouin-Chartier, André J Tremblay, Jean-Charles Hogue, Valéry Lemelin, Benoît Lamarche, Patrick Couture
Intestinal triglyceride (TG)-rich lipoproteins (TRLs) are important in the pathogenesis of atherosclerosis in insulin resistance (IR). We investigated the association of plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations with apoB-48-containing TRL metabolism in 148 men displaying various degrees of IR by measuring in vivo kinetics of TRL apoB-48 during a constant-fed state after a primed-constant infusion of L-[5,5,5-D3]leucine. Plasma PCSK9 concentrations positively correlated with TRL apoB-48 pool size ( r = 0...
August 2018: Journal of Lipid Research
Mohammad Mh Abdullah, Peter K Eck, Patrick Couture, Benoît Lamarche, Peter J H Jones
Existing evidence on influence of genetic architecture on serum cholesterol responsiveness to dietary interventions focuses on individual SNPs and single nutrients. We associated the combination of <i>ABCG5</i> rs6720173-C, <i>CYP7A1</i> rs3808607-TT, and <i>DHCR7</i> rs760241-GG genotypes with lower LDL-cholesterol concentrations relative to the combination of rs6720173-GG, rs3808607-G, and rs760241-A genotypes (-0.37 ± 0.12 (n = 9) vs. +0.38 ± 0.14 mmol/L (n = 7), p = 0...
June 19, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Janie Allaire, Cécile Vors, André J Tremblay, Johanne Marin, Amélie Charest, André Tchernof, Patrick Couture, Benoît Lamarche
Context: Supplementation with high dose of docosahexaenoic acid (DHA) increases serum LDL-cholesterol (C) concentrations more than high dose eicosapentaenoic acid (EPA). Mechanisms underlying this difference are unknown. Objective: To examine the phenotypic change in LDL and mechanisms responsible for the differential LDL-C response to EPA and DHA supplementation in men and women at risk for cardiovascular disease. Design, setting, participants and intervention: In a double-blind controlled crossover study, 48 men and 106 women with abdominal obesity and subclinical inflammation were randomized to a sequence of three treatment phases: 1- 2...
May 25, 2018: Journal of Clinical Endocrinology and Metabolism
Elise Carbonneau, Maude Bradette-Laplante, Benoît Lamarche, Véronique Provencher, Catherine Bégin, Julie Robitaille, Sophie Desroches, Marie-Claude Vohl, Louise Corneau, Simone Lemieux
OBJECTIVE: The present study aimed to develop and validate a questionnaire assessing social support for healthy eating in a French-Canadian population. DESIGN: A twenty-one-item questionnaire was developed. For each item, participants were asked to rate the frequency, in the past month, with which the actions described had been done by family and friends in two different environments: (i) at home and (ii) outside of home. The content was evaluated by an expert panel...
September 2018: Public Health Nutrition
David J A Jenkins, Cyril W C Kendall, Benoît Lamarche, Monica S Banach, Korbua Srichaikul, Edward Vidgen, Sandy Mitchell, Tina Parker, Stephanie Nishi, Balachandran Bashyam, Russell J de Souza, Christopher Ireland, Sathish C Pichika, Joseph Beyene, John L Sievenpiper, Robert G Josse
AIMS/HYPOTHESIS: In line with current advice, we assessed the effect of replacing carbohydrate consumption with mixed nut consumption, as a source of unsaturated fat, on cardiovascular risk factors and HbA1c in type 2 diabetes. The data presented here are from a paper that was retracted at the authors' request ( ) owing to lack of adjustment for repeated measures in the same individual. Our aim, therefore, was to fix the error and add new complementary data of interest, including information on clotting factors and LDL particle size...
August 2018: Diabetologia
Bénédicte L Tremblay, Frédéric Guénard, Benoît Lamarche, Louis Pérusse, Marie-Claude Vohl
BACKGROUND: Considering the implication of gene expression in the susceptibility of chronic diseases and the familial clustering of chronic diseases, the study of familial resemblances in gene expression levels is then highly relevant. Few studies have considered the contribution of both genetic and common environmental effects to familial resemblances in whole blood gene expression levels. The objective is to quantify the contribution of genetic and common environmental effects in the familial resemblances of whole blood genome-wide gene expression levels...
April 27, 2018: BMC Genomics
Jean-Philippe Drouin-Chartier, André J Tremblay, Valéry Lemelin, Benoît Lamarche, Patrick Couture
The mechanisms underlying the oversecretion of apolipoprotein (apo)B-48-containing triglyceride-rich lipoproteins (TRL) in insulin-resistance (IR) states in humans remain to be fully understood. The objective of this study was to evaluate the association between the plasma levels of insulin and glucose and the intestinal expression of key genes involved in chylomicron metabolism in a large sample of nondiabetic men displaying various degrees of IR. Duodenal biopsies were obtained by gastroduodenoscopy in 127 men free of intestinal disease...
August 1, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
Didier Brassard, Benoît J Arsenault, Marjorie Boyer, Daniela Bernic, Maude Tessier-Grenier, Denis Talbot, Angelo Tremblay, Emile Levy, Bela Asztalos, Peter J H Jones, Patrick Couture, Benoît Lamarche
Background: Recent evidence suggests that the association between dietary saturated fatty acids (SFAs) and coronary artery disease risk varies according to food sources. How SFAs from butter and cheese influence HDL-mediated cholesterol efflux capacity (CEC), a key process in reverse cholesterol transport, is currently unknown. Objective: In a predefined secondary analysis of a previously published trial, we have examined how diets rich in SFAs from either cheese or butter influence HDL-mediated CEC, compared with diets rich in either monounsaturated fatty acids (MUFAs) or polyunsaturated fatty acids (PUFAs)...
April 1, 2018: Journal of Nutrition
Cécile Vors, Charles Couillard, Marie-Eve Paradis, Iris Gigleux, Johanne Marin, Marie-Claude Vohl, Patrick Couture, Benoît Lamarche
Background: High-fat meals induce postprandial inflammation. Resveratrol is a polyphenol known to prevent comorbidities associated with cardiovascular disease and exerts an anti-inflammatory action. There is also an increasing body of evidence supporting the role of curcumin, a polyphenol from the curcuminoid family, as a modulator of proinflammatory processes. Objective: The objectives of this study were to investigate the following: 1) the bioavailability of resveratrol consumed in combination with curcumin after consumption of a high-fat meal; and 2) the acute combined effects of this combination on the postprandial inflammatory response of subjects with abdominal obesity...
March 1, 2018: Journal of Nutrition
Jean-Philippe Drouin-Chartier, André J Tremblay, Jean Bergeron, Benoît Lamarche, Patrick Couture
BACKGROUND AND AIMS: Maximizing the acute reduction of LDL-cholesterol (C) and lipoprotein (a) (Lp(a)) concentrations in patients with homozygous familial hypercholesterolemia (HoFH) is the main goal of lipoprotein apheresis (LA). The objective of this study was to examine how the pre-LA serum TG concentrations influence the efficacy of LA to acutely reduce LDL-C and Lp(a) concentrations in HoFH patients. METHODS: Data from 1761 LA treatments of HoFH patients (n = 10) and compound heterozygous patients (n = 5) collected between 2008 and 2016 were analyzed...
March 2018: Atherosclerosis
Jean-Philippe Drouin-Chartier, André J Tremblay, Marie-Claude Lépine, Valéry Lemelin, Benoît Lamarche, Patrick Couture
Background: The substitution of omega (ω)-6 (n-6) polyunsaturated fatty acids (PUFAs) for saturated fatty acids (SFAs) is advocated in cardiovascular disease prevention. The impact of this substitution on lipoprotein metabolism in subjects with dyslipidemia associated with insulin resistance (IR) remains unknown. Objective: In men with dyslipidemia and IR, we evaluated the impact of substituting ω-6 PUFAs for SFAs on the in vivo kinetics of apolipoprotein (apo) B-containing lipoproteins and on the intestinal expression of key genes involved in lipoprotein metabolism...
January 1, 2018: American Journal of Clinical Nutrition
Hélène Arguin, Angelo Tremblay, John E Blundell, Jean-Pierre Després, Denis Richard, Benoît Lamarche, Vicky Drapeau
The aim of this study was to evaluate the impact of a non-restrictive satiating diet in men displaying various degrees of satiety efficiency. In all, sixty-nine obese men aged 41·5 (sd 5·7) years were randomly assigned to a control (10-15, 55-60 and 30 % energy as protein, carbohydrate and lipid, respectively; n 34) or satiating (20-25, 45-50 and 30-35 % energy as protein, carbohydrate and lipid, respectively; n 35) diet for 16 weeks, and were classified as having a low (LSP) or high (HSP) satiety phenotype...
November 2017: British Journal of Nutrition
Benoit J Arsenault, Benoît Lamarche, Jean-Pierre Després
Chronic overconsumption of sugar-sweetened beverages (SSBs) is amongst the dietary factors most consistently found to be associated with obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD) risk in large epidemiological studies. Intervention studies have shown that SSB overconsumption increases intra-abdominal obesity and ectopic lipid deposition in the liver, and also exacerbates cardiometabolic risk. Similar to the prevalence of obesity and T2D, national surveys of food consumption have shown that chronic overconsumption of SSBs is skyrocketing in many parts of the world, yet with marked heterogeneity across countries...
June 13, 2017: Nutrients
Véronique Desgagné, Renée Guérin, Simon-Pierre Guay, François Corbin, Patrick Couture, Benoit Lamarche, Luigi Bouchard
AIM: High-density lipoproteins (HDLs) are associated to cardioprotection and transport functional miRNAs in circulation. The aim of this study is to assess whether consumption of trans fatty acids (TFAs) modifies the HDL-carried miRNA concentration and their contribution to the plasmatic pool. METHODS: In a double-blind, randomized crossover controlled study, nine healthy men were fed each of three isoenergetic 4-week diets: first, rich in industrial TFAs; second, rich in TFAs from ruminants; third, low in TFAs...
May 2017: Epigenomics
Claire Dahyot-Fizelier, Solène Lamarche, Thomas Kerforne, Thierry Bénard, Benoit Giraud, Rémy Bellier, Elsa Carise, Denis Frasca, Olivier Mimoz
OBJECTIVES: To compare accuracy of a continuous noninvasive cutaneous temperature using zero-heat-flux method to esophageal temperature and arterial temperature. DESIGN: Prospective study. SETTING: ICU and NeuroICU, University Hospital. PATIENTS: Fifty-two ICU patients over a 4-month period who required continuous temperature monitoring were included in the study, after informed consent. INTERVENTIONS: All patients had esophageal temperature probe and a noninvasive cutaneous device to monitor their core temperature continuously...
July 2017: Critical Care Medicine
Sophia Morel, Jade Leahy, Maryse Fournier, Benoit Lamarche, Carole Garofalo, Guy Grimard, Floriane Poulain, Edgard Delvin, Caroline Laverdière, Maja Krajinovic, Simon Drouin, Daniel Sinnett, Valérie Marcil, Emile Levy
Survivors of acute lymphoblastic leukemia (ALL), the most common cancer in children, are at increased risk of developing late cardiometabolic conditions. However, the mechanisms are not fully understood. This study aimed to characterize the plasma lipid profile, Apo distribution, and lipoprotein composition of 80 childhood ALL survivors compared with 22 healthy controls. Our results show that, despite their young age, 50% of the ALL survivors displayed dyslipidemia, characterized by increased plasma triglyceride (TG) and LDL-cholesterol, as well as decreased HDL-cholesterol...
May 2017: Journal of Lipid Research
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