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Psoriasis comorbidities

Lin Li, Yonghong Lu, Lixin Fu, Peimei Zhou, Liwen Zhang, Wenju Wang, Jianjun Nie, Dawei Zhang, Yan Liu, Bo Wu, Yi Zhou, Tao Chen
BACKGROUND: A series of previous reports indicated that tumour necrosis factor-like ligand 1A (TL1A) and its receptor death receptor 3 (DR3) are involved in the pathogenesis of psoriasis vulgaris (PV), which is a common chronic skin disease accompanied by a number of comorbidities, although their exact roles remain unclear. Our previous studies demonstrated that serum TL1A levels were substantially elevated in patients with PV, but the detection of DR3 expression in peripheral blood mononuclear cells (PBMCs) of patients with PV had not been reported...
October 19, 2018: Postgraduate Medical Journal
Khalaf Kridin, Mouhammad Kridin, Guy Shalom, Arnon D Cohen
There is little consensus regarding the association between pemphigus and psoriasis. The aim of the current study is to synthesize existing data on the prevalence of psoriasis in patients with pemphigus and on the association between the two conditions. We performed a systematic review and meta-analysis of observational studies in Medline, Embase, and Web of Science (1900-2018). Reference lists of included studies were also searched for eligible studies. Quality of evidence was assessed using Newcastle-Ottawa scale (NOS)...
October 18, 2018: Immunologic Research
Christina Ryser, Adrian Ciurea
Therapy of Psoriasis Arthritis Taking into Account New Treatment Options Abstract. Psoriatic arthritis occurs in about 20-30 % of patients with psoriasis. The disease is heterogeneous and can involve a variety of the distinct anatomical sites. The choice of medication depends on the type and the severity of clinical features. The recommendations of EULAR and GRAPPA serve as a guide for the choice of medication, which is used in sequential treatment steps. This is presented in our review in usable, simplified terms...
2018: Praxis
Jui-Ming Liu, Chien-Yu Lin, Heng-Chang Chuang, Ren-Jun Hsu
Objective: Androgen deprivation therapy (ADT) use in prostate cancer (PCa) patients has been reported to exacerbate the course of psoriasis. We aimed to assess the impact of ADT on the subsequent risk of psoriasis. Methods: We utilized data from the National Health Insurance Research Database of Taiwan between 1996 and 2013. In total, 17,168 patients with PCa were identified; 5,141 ADT patients comprised the study group with 5,141 matched non-ADT controls. We used 1:1 propensity score-matched analysis...
2018: Therapeutics and Clinical Risk Management
Stephen Chu-Sung Hu, Chi-Ling Lin, Hung-Pin Tu
BACKGROUND: Psoriasis is a common skin disease that has been recently found to be associated with various systemic inflammatory disorders. However, the association between psoriasis and gout has not been well defined. OBJECTIVE: We investigated whether there is an association between psoriasis, psoriatic arthritis and gout in a large population of patients in Taiwan. METHODS: A nationwide population-based cross-sectional study was performed using the Taiwanese National Health Insurance Research Database (NHIRD)...
October 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Sydney E Liang, Jeffrey M Cohen, Roger S Ho
Psoriasis is a chronic systemic inflammatory skin disease, which has been associated with an increased risk of numerous medical and psychiatric comorbidities, including suicidality. Suicidality, which can be divided into the categories of suicidal ideation, suicide attempt, and completed suicide, is highly prevalent in the psoriasis population, and multiple studies have been published on the subject of psoriasis and suicidal ideation and behavior (SIB), including two recent meta-analyses. However, the available literature is limited and inconsistent, and the association between the two remains incompletely understood...
October 12, 2018: Dermatologic Therapy
Alejandro Molina-Leyva, Luis Salvador-Rodriguez, Antonio Martinez-Lopez, Jose Carlos Ruiz-Carrascosa, Salvador Arias-Santiago
Importance: Sexual health is a major aspect of life. Increasing scientific evidence shows a potential association between psoriasis and sexual dysfunction (SD) and erectile dysfunction (ED). Objective: To evaluate the available scientific evidence regarding epidemiologic associations and treatment outcomes between psoriasis and SD and ED. Evidence Review: Information sources were MEDLINE and Embase databases, using the Scopus search engine...
October 10, 2018: JAMA Dermatology
Zhen Tian, Yike Huang, Tao Yue, Jiaqing Zhou, Lu Tao, Ling Han, Kexiang Yan, Qiong Huang, Zhenghua Zhang, Chunhong Shao
Previous studies have reported a higher incidence of depression and anxiety in psoriasis patients compared to the general population, which has important implications for assessment and treatment. In this study, we determined the frequency of depression and anxiety in Chinese patients with psoriasis and its relationship with disease severity and other demographic variables. The study included 208 Chinese patients with psoriasis vulgaris. The Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder scale (GAD-7) were used to screen for depression and anxiety...
October 7, 2018: Psychology, Health & Medicine
F Sampogna, L Puig, P Spuls, G Girolomoni, M A Radtke, B Kirby, M Brunori, P Bergmans, P Smirnov, J Rundle, A Castiglia, F Lavie, C Paul
BACKGROUND: Alexithymia refers to the difficulty in identifying and expressing emotions. Alexithymia is associated with high burden of disease in psoriasis patients. OBJECTIVES: The objective of this study was to investigate if alexithymia was reversible in patients with psoriasis following real-life therapeutic intervention. METHODS: The EPidemiological Study In Patients With Recently DiagnosEd PSOriasis (EPIDEPSO. NCT01964443) was a 1-year multicentre observational study investigating the prevalence of alexithymia and other psychosocial comorbidities in psoriasis patients with ≤10 years disease duration eligible for systemic treatment...
September 30, 2018: British Journal of Dermatology
Adameck Abraham Hernández-Collazo, Guadalupe Villanueva-Quintero, Marco Antonio Rodríguez-Castellanos, Eduardo David Poletti-Vázquez, Anabell Alvarado-Navarro
Introducción: La hiperuricemia es común en pacientes con psoriasis. Se ha sugerido que la elevación de ácido úrico en psoriasis está fuertemente asociada con morbilidad cardiovascular. Objetivo: Determinar la relación entre niveles de ácido úrico, gravedad clínica medida por Psoriasis Area Severity Index (PASI), Body Surface Area (BSA) y static Physician's Global Assessment (sPGA) en pacientes con psoriasis en placas y comorbilidades ungueales y artritis psoriásica...
2018: Gaceta Médica de México
Annunziata Bartolotta, Elisa Postorino, Emanuela Aragona, Valeria Papaianni, Claudio Guarnieri, Serafinella P Cannavò
Ocular comorbidity has been reported in 10-15% of patients with plaque psoriasis. This paper reports successful treatment with secukinumab of a patient with plaque psoriasis and dry eye syndrome. Both the skin condition and the ocular disease improved after treatment.
September 24, 2018: Journal of Dermatological Treatment
Alexey A Kubanov, Andrey L Bakulev, Tatiana V Fitileva, Evgenia Novoderezhkina, Isabelle Gilloteau, Haijun Tian, Tanya Howe, Guilhem Pietri
INTRODUCTION: Data regarding disease burden and quality of life (QoL) for patients with psoriasis from Russia are limited. The objective of this study was to describe the demographic and clinical characteristics, comorbidities, and treatment patterns of systemic therapy eligible psoriasis patients in Russia in order to assess the impact of psoriasis on the QoL and work productivity of the patients and to evaluate patient/dermatologist concordance on disease severity, signs/symptoms, and satisfaction with psoriasis treatment...
September 19, 2018: Dermatology and Therapy
Scott A Elman, Michael Weinblatt, Joseph F Merola
Dermatologists are on the front line to identify psoriatic arthritis (PsA) in their patients with psoriasis. PsA is a prevalent and underdiagnosed disease with potential long-term complications and sequelae for patients. Targeted biologics have transformed the landscape of psoriasis and PsA therapy. These medications variably treat clinical manifestations of psoriatic disease: skin psoriasis, peripheral and axial arthritis, enthesitis, and nail disease. With many new medications either on the market or currently being evaluated by the Food and Drug Administration, the purpose of this article is to review PsA for the dermatologist, to identify the current therapies that are available, and to help select which patients may benefit from these medications...
September 2018: Seminars in Cutaneous Medicine and Surgery
Eric J Yang, Kristen M Beck, Isabelle M Sanchez, John Koo, Wilson Liao
Psoriasis is a chronic immune-mediated inflammatory disease with significant medical and psychological comorbidities. In addition to having increased cardiovascular risk and mortality, psoriasis patients are more likely to be depressed, anxious, and endorse suicidal ideation than the general population. These patients often have low self-esteem and feel stigmatized due to their skin disease, which can prevent them from pursuing relationships, dating, and attending social activities. Up to 63% of adult psoriasis patients experience psoriatic lesions on their genital area during their lifetime, but often do not discuss these issues with their physicians due to embarrassment, stigmatization, or shyness about this sensitive location...
2018: Psoriasis: Targets and Therapy
Jason E Hawkes, Bernice Y Yan, Tom C Chan, James G Krueger
Psoriasis vulgaris is a common, heterogeneous, chronic inflammatory skin disease characterized by thickened, red, scaly plaques and systemic inflammation. Psoriasis is also associated with multiple comorbid conditions, such as joint destruction, cardiovascular disease, stroke, hypertension, metabolic syndrome, and chronic kidney disease. The discovery of IL-17-producing T cells in a mouse model of autoimmunity transformed our understanding of inflammation driven by T lymphocytes and associations with human inflammatory diseases, such as psoriasis...
September 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Mwangi J Murage, Vanita Tongbram, Steven R Feldman, William N Malatestinic, Cynthia J Larmore, Talia M Muram, Russel T Burge, Charles Bay, Nicole Johnson, Sarah Clifford, Andre B Araujo
Purpose: Proper adherence and persistence to medications are crucial for better quality of life and improved outcomes in rheumatoid arthritis (RA), psoriasis (PsO), and psoriatic arthritis (PsA). We systematically describe current adherence and persistence patterns for RA, PsO, and PsA, with a focus on biologics and identifying factors associated with adherence and persistence. Patients and methods: Using various databases, a systematic literature review of US-based studies published from 2000 to 2015 on medication adherence and persistence to biologics and associated factors was conducted among patients with RA, PsO, and PsA...
2018: Patient Preference and Adherence
Joseph F Merola, Luis R Espinoza, Roy Fleischmann
Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) have key differences in clinical presentation, radiographic findings, comorbidities and pathogenesis to distinguish between these common forms of chronic inflammatory arthritis. Joint involvement is typically, but not always, asymmetric in PsA, while it is predominantly symmetric in RA. Bone erosions, without new bone growth, and cervical spine involvement are distinctive of RA, while axial spine involvement, psoriasis and nail dystrophy are distinctive of PsA...
2018: RMD Open
S Garcovich, C De Simone, G Giovanardi, E Robustelli, A V Marzano, K Peris
BACKGROUND: Bariatric surgery (BS) represents the most effective treatment for morbid obesity and its related complications, potentially ameliorating chronic comorbid inflammatory skin conditions, such as psoriasis and hidradenitis suppurativa (HS). Weight-loss interventions are strongly encouraged in patients with HS, but the resulting effect on the course of the disease has been poorly reported. AIM: To describe the effect of BS-associated weight-loss on the course of HS...
August 24, 2018: Clinical and Experimental Dermatology
Ha-Na Kim, Kyungdo Han, Sang-Wook Song, Ji Hyun Lee
Psoriasis is a chronic inflammatory skin disease that is characterized by T-cell mediated immune response, and has been known to increase the risk of developing hypertension. However, the risk of psoriasis in patients with hypertension is not clear. Therefore, we investigated the risk of psoriasis in patients with hypertension. A total of 256,356 adults (42,726 in the hypertension group and 213,630 in the control group) were followed from 2003 to 2013 in a nationwide population-based cohort study. During the follow-up, 9,254 participants (3...
2018: PloS One
Dinesh Aggarwal, Nikita Arumalla, Hannah Jethwa, Sonya Abraham
Psoriatic disease is a relatively new term which encompasses psoriatic arthritis, psoriasis, and associated comorbidities. In this heterogeneous condition, the study of biomarkers is necessary to direct best therapy. Resulting in significant disability and socioeconomic burden, recent recommendations stress the need for tight control in psoriatic disease. Areas covered: The authors outline recent advances in the understanding of psoriatic disease pathogenesis which has highlighted multiple biomarkers that have been pursued as drug targets with varying degrees of success...
September 2018: Expert Opinion on Drug Discovery
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