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Giant omphaloceles

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https://www.readbyqxmd.com/read/30538881/15q23-gain-in-a-neonate-with-a-giant-omphalocele-and-multiple-co-occurring-anomalies
#1
Hui-Fang Zhou, Christopher J O'Conor, Chiraag Gangahar, Louis P Dehner
Background: Omphalocele is a rare congenital abdominal wall defect. It is frequently associated with genetic abnormality and other congenital anomalies, although isolated omphalocele cases do exist. Data have shown that omphalocele with co-occurring genetic abnormality has worse prognosis than isolated omphalocele. Chromosomal analysis by a conventional technique such as karyotyping can only detect aneuploidy and large segmental duplication or deletion. Newer techniques such as high-resolution microarray analysis allow for the study of alterations in chromosomal segments that are less than 5 Mb in length; this has led to identification of critical region and genes in the pathogenesis of omphalocele...
2018: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/30503247/nonoperative-management-of-giant-omphalocele-leading-to-early-fascial-closure
#2
Kelly A Kogut, Nicholas F Fiore
PURPOSE: We describe our series of giant omphalocele patients treated with a serial taping method for gradual reduction of the abdominal contents and early fascial closure. METHODS: Between 2010 and 2017 we cared for ten newborns with giant omphaloceles. The average gestational age was 35.5 weeks (range 29-38) and average birthweight was 2.84 kg. Seven infants had other major anomalies, including one with a variant of Pentology of Cantrell. Four had abnormal chromosomes...
December 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30066722/omphaloceles-in-combination-with-a-self-made-hemispherical-cushion-a-report-of-12-cases
#3
Guoxian Huang, Lili Ma, Yonglong Wu
The aim of this study was to discuss the curative effect of applying "capsule-reserved normal saline bag and self-made hemi-spherical cushion oppression" for treating giant omphaloceles. Twelve patients with giant omphaloceles who were admitted to our hospital between January 2008 and June 2016 were selected for treatment as follows: a capsule-reserved normal saline bag was used to promote the gradual return of the abdominal contents into the abdominal cavity in phase I, and a self-made hemi-spherical cushion was used for compression combined with a local dressing change in phase II to treat the giant omphaloceles without surgical treatment...
July 30, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29803304/early-surgical-management-for-giant-omphalocele-results-and-prognostic-factors
#4
Nathalie Roux, Déborah Jakubowicz, Laurent Salomon, Gilles Grangé, Agnès Giuseppi, Véronique Rousseau, Naziha Khen-Dunlop, Sylvie Beaudoin
OBJECTIVES: Giant omphalocele often represents a major surgical challenge and is reported with high mortality and morbidity rates. The aim of this study was to assess the outcome of neonates with giant omphalocele managed with early operative surgical treatment, and subsequently to identify possible factors that could alter the prognosis. METHODS: We reviewed the medical records of 29 consecutive newborns with prenatally diagnosed giant omphalocele. In these cases one of two procedures had been performed: either staged closure after silo, or immediate closure with a synthetic patch...
October 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29660797/repair-of-a-giant-omphalocele-in-an-infant-with-a-pericardial-implant-crosslinked-with-oligourethane
#5
Juan Vargas-Mancilla, María A Torrero-Serrato, Aarón J Palacios-Rodríguez, Gloria B Rodríguez-de León, Metzeri I Montes-Rodríguez, Birzabith Mendoza-Novelo
The giant omphalocele (GO) represents a challenge for the pediatric surgeon in its management and wall abdominoplasty. Here, we report the outcome of a case in which a GO in a newborn patient was repaired with an implant derived from decellularized bovine pericardium crosslinked with oligourethane. The implantation time was extended for 6 months. This was then followed up by the retrieval of the implant and the subsequent reconstruction in a second surgical time by the closure of the abdominal wall fascia...
August 2018: Artificial Organs
https://www.readbyqxmd.com/read/29563149/omphalocele-from-diagnosis-to-growth-and-development-at-2-years-of-age
#6
Annelieke Hijkoop, Nina C J Peters, Rosan L Lechner, Yolande van Bever, Annabel P J M van Gils-Frijters, Dick Tibboel, René M H Wijnen, Titia E Cohen-Overbeek, Hanneke IJsselstijn
OBJECTIVES: To compare the prenatal frame of reference of omphalocele (ie, survival of fetuses) with that after birth (ie, survival of liveborn neonates), and to assess physical growth and neurodevelopment in children with minor or giant omphalocele up to 2 years of age. DESIGN: We included fetuses and neonates diagnosed in 2000-2012. Physical growth (SD scores, SDS) and mental and motor development at 12 and 24 months were analysed using general linear models, and outcomes were compared with reference norms...
March 21, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29519568/dressed-for-success-silver-impregnated-nanocrystalline-dressing-for-initial-treatment-of-giant-omphalocele
#7
Dean B Percy, Candace Haddock, Vivian Ma, Amie Nowak, Julia Panczuk, Sonia Butterworth
OBJECTIVE: The purpose of this study was to describe outcomes and resource utilization in patients treated with twice-weekly silver impregnated (SI) nanocrystalline dressings for initial non-operative management of giant omphalocele (GO). METHODS: A retrospective review of patients with GO treated with SI dressings was undertaken. Clinical parameters, cost, and complications were recorded. RESULTS: Five patients with GO were treated with SI dressings between 2014 and 2016...
May 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29515966/erratum-to-delayed-closure-of-giant-omphaloceles-in-west-africa-report-of-five-cases
#8
Oumama El Ezzi, Raymond Bossou, Olivier Reinberg, Sabine Vasseur Maurer, Anthony de Buys Roessingh
[This corrects the article DOI: 10.1055/s-0037-1599796.].
January 2018: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/29508360/ex-utero-intrapartum-treatment-for-giant-congenital-omphalocele
#9
Xu-Yong Chen, Ji-Xin Yang, Hong-Yi Zhang, Xiao-Feng Xiong, Khalid Mohamoud Abdullahi, Xiao-Juan Wu, Jie-Xiong Feng
BACKGROUND: To determine whether ex utero intrapartum treatment (EXIT) is an appropriate approach for managing fetuses antenatally diagnosed with giant congenital omphaloceles. METHODS: We retrospectively reviewed patients with omphaloceles who underwent either an EXIT procedure or a traditional repair surgery. Basic and clinical parameters including gender, gestational age, birth weight, maternal blood loss, operative times and operative complications were analyzed...
August 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29160639/predictors-of-mortality-in-neonates-with-giant-omphaloceles
#10
REVIEW
Amulya K Saxena, Maja Raicevic
INTRODUCTION: This analysis performed a review of giant-omphaloceles to determine the predictors of mortality. EVIDENCE ACQUISITION: PubMed and KoBson databases were searched for terms "giant," "omphalocele," and "mortality." Primary end points included mortality correlation with gestational age (GA), birth weight (BW), eviscerated organs, associated anomalies and management. To calculate mean and median values IBM SPSS v. 23.0 was used...
June 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/28686315/pentalogy-of-cantrell-in-a-monozygotic-twin-with-a-giant-omphalocele-firmly-attached-to-the-amniotic-membrane-successful-prenatal-diagnosis-and-cesarean-delivery
#11
Tomonobu Kanasugi, Akihiko Kikuchi, Noriyuki Uesugi, Daisuke Fukagawa, Hideyuki Chida, Yuri Sasaki, Gen Haba, Chizuko Isurugi, Rie Oyama, Tamotsu Sugai, Toru Sugiyama
No abstract text is available yet for this article.
March 2018: Congenital Anomalies
https://www.readbyqxmd.com/read/28397950/staged-closure-of-a-giant-omphalocele-with-amnion-preservation-modified-technique
#12
Akram H Aljahdali, Hussah M Al-Buainain, Erik D Skarsgard
Closure of a giant omphalocele can be challenging. Preservation of the amnion in staged closure is not commonly practiced. Here, we describe 2 cases of giant omphalocele treated with a modified amnion preservation, staged closure technique. This paper demonstrates the feasibility and safety of this technique, and the versatility of amnion to adapt to an escharization strategy if closure is not achievable.
April 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28352500/delayed-closure-of-giant-omphaloceles-in-west-africa-report-of-five-cases
#13
Oumama El Ezzi, Raymond Bossou, Olivier Reinberg, Sabine Vasseur Maurer, Anthony de Buys Roessingh
Giant omphalocele (GO) management is controversial and not easy. Conservative management at birth and delayed surgical closure is usually mandatory. Postponed surgery may be challenging and carry the risk of intensive care treatment. We report on five children who were treated in our department for GO between 2000 and 2010. Initially, the patients were managed conservatively in West Africa. Delayed closure of the ventral hernia was performed in Switzerland after patient transfer through a nongovernmental organization...
January 2017: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/28164002/giant-omphalocele-complicated-by-postoperative-duodenal-obstruction
#14
Sunita Ojha, Shobha Parashar, Dharmil Doshi, Rajiv Kumar Bansal
Omphalocele is a congenital defect in the abdominal wall, usually treated at birth or within 1-2 years of life depending on condition of patient and size and contents of the defect. We repaired a giant omphalocele without mesh in a 9-year-old girl. She developed duodenal obstruction in the postoperative period requiring another laparotomy and duodeno-jejunostomy to bypass obstruction.
January 2017: APSP Journal of Case Reports
https://www.readbyqxmd.com/read/28051055/thoracic-heteropagus-conjoined-twins-associated-to-an-omphalocele-report-of-a-case-and-complete-review-of-the-literature
#15
REVIEW
Kotti Ahmed, Ben Dhaou Mahdi, Zitouni Hayet, Louati Hamdi, Jallouli Mohamed, Mhiri Riadh
Heteropagus twins are an extremely rare event with an incidence of 1-2 million live births that represents, sometimes, a real challenge for paediatric surgeons. The majority of cases have complete or partial duplication of the pelvis and/or lower extremities. Thoracic heteropagus conjoined twins is a rare condition in which a grossly defective foetus (the parasite) is attached to the thorax of the main foetus (the autosite). We describe a case of a parasitic heteropagus attached at the chest wall with a rare presentation of giant exomphalos on the autosite...
October 2016: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/27834001/thorax-to-head-ratio-and-defect-diameter-to-head-ratio-in-giant-omphaloceles-as-predictor-for-fetal-outcome
#16
Nina Diemon, Katrin Funke, Mareike Möllers, Kerstin Hammer, Johannes Steinhard, Cristina Sauerland, Volker Müller, Walter Klockenbusch, Ralf Schmitz
PURPOSE: To investigate the relationship between the thorax diameter and defect diameter of giant omphaloceles as a predictor for fetal outcome. METHODS: In a retrospective study, 17 fetuses with isolated giant omphaloceles were included for evaluation. The anterior-posterior thorax diameter and the defect diameter were measured from ultrasound images. For analysis, the thorax-to-head ratio (T/HC), the defect diameter-to-head ratio (DD/HC), and the quotient of the defect diameter and the thorax diameter (DD/T) were calculated...
February 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27820755/the-impact-of-breast-milk-respiratory-insufficiency-and-gerd-on-enteral-feeding-in-infants-with-omphalocele
#17
Shelly Haug, Shawn St Peter, Sandhya Ramlogan, Donna Goff, Donna Thorpe, Andrew Hopper, Joanne Baerg
OBJECTIVES: The aim of this study was to document the process of achieving full enteral feeding in infants with omphalocele and to identify factors that affect feeding success. METHODS: After Institutional Review Board approval (5100169), 123 infants with omphalocele, born between 1993 and 2011 were reviewed. Mortalities were excluded. All survivors had complete follow-up. Variables suspected to impact enteral feeding in infants with non-giant versus giant omphalocele were compared...
November 5, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27570242/management-of-giant-omphaloceles-a-systematic-review-of-methods-of-staged-surgical-vs-nonoperative-delayed-closure
#18
REVIEW
Brent Bauman, Daniel Stephens, Hannah Gershone, Connie Bongiorno, Erin Osterholm, Robert Acton, Donavon Hess, Daniel Saltzman, Bradley Segura
PURPOSE: Despite the numerous methods of closure for giant omphaloceles, uncertainty persists regarding the most effective option. Our purpose was to review the literature to clarify the current methods being used and to determine superiority of either staged surgical procedures or nonoperative delayed closure in order to recommend a standard of care for the management of the giant omphalocele. METHODS: Our initial database search resulted in 378 articles. After de-duplification and review, we requested 32 articles relevant to our topic that partially met our inclusion criteria...
October 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27569456/-tissue-expansion-in-management-of-giant-omphalocele-parietal-sequelae
#19
A Binet, E Supply, S De Napoli Cocci, M De Cornulier, H Lardy, A Le Touze
OBJECTIVE: According to major difficulty for the giant omphalocele management in the visceral reintegration and the parietal closure, many teams use currently conservative treatment by topical application. These techniques are suppliers of a covered eventration and a scar sequela requiring a complementary treatment. We report the place of the tissue expansion as complementary treatment. PATIENTS AND METHODS: Two patients with a giant omphalocele benefited from a protocol of cutaneous expansion for the correction of their abdominal scar±of their residual eventration...
April 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/27551578/topical-iodine-induced-thyrotoxicosis-in-a-newborn-with-a-giant-omphalocele
#20
Sonali Malhotra, Shilpa Kumta, Alok Bhutada, Elka Jacobson-Dickman, Roja Motaghedi
INTRODUCTION: Neonatal thyrotoxicosis is a life-threatening condition with potentially irreversible neurologic sequelae. Most cases are seen in neonates born to mothers with Graves' disease. Topical iodine-induced hypothyroidism has been reported in neonates, but iodine-induced neonatal hyperthyroidism has not been described; albeit a familiar entity in adults. CASE DESCRIPTION: Herein we present a unique case of a neonate, born with a giant omphalocele, who was treated with topical povidone-iodine dressings to promote escharification, in preparation for delayed surgical closure...
April 2016: American Journal of Perinatology Reports
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