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Bryce Nicholas Balmain, Neil Tuttle, Joseph Bailey, Katie Cheng, Mitchell Duryea, Josephine Houlihan, James Wotherspoon, Norman Morris
We examined the accuracy of Smart Socks - a device that measures foot pressure during gait for detecting step-count across various walking speeds. Thirty-six participants (17 men; 19 women) wore Smart Socks (Sock), a pedometer (Pedometer), and a smartphone with a commercially available Phone Application (Phone) pedometer to measure step-count during 3-min of treadmill or over-ground walking at 1.3, 2.2, 3.0, 3.8, and 4.7 km/h. Steps were compared to a gold-standard tally-counter (Count), collected by independent assessors...
December 13, 2018: International Journal of Sports Medicine
James R Broatch, David J Bishop, Emma K Zadow, Shona Halson
Broatch, JR, Bishop, DJ, Zadow, EK, and Halson, S. Effects of sports compression socks on performance, physiological, and hematological alterations after long-haul air travel in elite female volleyballers. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this investigation was to assess the merit of sports compression socks in minimizing travel-induced performance, physiological, and hematological alterations in elite female volleyball athletes. Twelve elite female volleyballers (age, 25 ± 2 years) traveled from Canberra (Australia) to Manila (Philippines), and were assigned to 1 of 2 conditions; compression socks (COMP, n = 6) worn during travel or a passive control (CON, n = 6)...
December 7, 2018: Journal of Strength and Conditioning Research
John Elson, Steve Eckels
Quantifying the impact of clothing thermal and evaporation resistance is essential to providing representative boundary conditions for physiological modeling. In many models, sweat is assumed to drip off the skin surface to the environment and is not captured in clothing. In high metabolic rate and high temperature and humidity conditions the sweat produced by the body has the potential to saturate semipermeable clothing ensembles, changing the assumptions of the model. Workers, athletes and soldiers commonly wear encapsulating versions of such clothing to protect against environmental hazards...
December 2018: Journal of Thermal Biology
Anouk W Vaes, Jeannet M L Delbressine, Rafael Mesquita, Yvonne M J Goertz, Daisy J A Janssen, Nienke Nakken, Frits M E Franssen, Lowie E G W Vanfleteren, Emiel F M Wouters, Martijn A Spruit
Introduction A high proportion of patients with COPD experience problems during the performance of activities of daily living (ADLs). We aimed to determine the effects of a comprehensive eight-week pulmonary rehabilitation program on the physiologic response to and performance of ADLs in patients with COPD. Methods Before and after pulmonary rehabilitation, 31 patients with COPD (71% men; mean age: 64.2±8.4 years; mean FEV1 : 54.6±19.9% predicted) performed physical function tests, the Canadian Occupational Performance Measure (COPM) and an ADL-test consisting of putting on socks, shoes and vest; stair climbing; washing up four dishes, cups and saucers; doing groceries and putting away groceries in a cupboard; folding eight towels; and vacuum cleaning for four minutes...
November 29, 2018: Journal of Applied Physiology
Junya Katayanagi, Takahiro Iida, Atsuki Hayamizu, Kazuyuki Matsumoto, Yasumasa Ohyama, Ken Mine, Satoru Ozeki
BACKGROUND: Spinal sagittal malalignment is managed by long spinal fusion including the pelvis, which reduces lumbar spine range of motion and impairs the activities of daily living. This study aimed to evaluate the changes in activities of daily living after long spinal fusion in adults with spinal deformity, and clarify the improvement or deterioration in the specific activities of daily living postoperatively. METHODS: We retrospectively reviewed 40 adults who underwent long spinal fusion in a single institution between 2014 and 2016 (female/male, 39/1; mean age, 68...
November 21, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Crystal Zy Phuan, Lucinda Sy Tan, Hong Liang Tey
No abstract text is available yet for this article.
October 2018: Annals of the Academy of Medicine, Singapore
Sock Hoai Chan, Winston Chew, Nur Diana Binte Ishak, Weng Khong Lim, Shao-Tzu Li, Sheng Hui Tan, Jing Xian Teo, Tarryn Shaw, Kenneth Chang, Yong Chen, Prasad Iyer, Enrica Ee Kar Tan, Michaela Su-Fern Seng, Mei Yoke Chan, Ah Moy Tan, Sharon Yin Yee Low, Shui Yen Soh, Amos Hong Pheng Loh, Joanne Ngeow
Assessment of cancer predisposition syndromes (CPS) in childhood tumours is challenging to paediatric oncologists due to inconsistent recognizable clinical phenotypes and family histories, especially in cohorts with unknown prevalence of germline mutations. Screening checklists were developed to facilitate CPS detection in paediatric patients; however, their clinical value have yet been validated. Our study aims to assess the utility of clinical screening checklists validated by genetic sequencing in an Asian cohort of childhood tumours...
2018: NPJ Genomic Medicine
Florian Prüller, Lukasz Bis, Oliver Leopold Milke, Friedrich Fruhwald, Sascha Pätzold, Siegfried Altmanninger-Sock, Jolanta Siller-Matula, Friederike von Lewinski, Klemens Ablasser, Michael Sacherer, Dirk von Lewinski
Dual antiplatelet therapy is the standard of care for patients with myocardial infarction (MI), who have been resuscitated and treated with therapeutic hypothermia (TH). We compare the antiplatelet effect and bleeding risk of intravenous cangrelor to oral P2Y12-inhibitors in patients with MI receiving TH in a prospective comparison of two matched patient cohorts. Twenty-five patients within the CANGRELOR cohort were compared to 17 patients receiving oral P2Y12-inhibitors. CANGRELOR group (NCT03445546) and the ORAL P2Y12 Group (NCT02914795) were registered at clinicaltrials...
November 15, 2018: Journal of Clinical Medicine
Meghan Clayards
Speech perception requires multiple acoustic cues. Cue weighting may differ across individuals but be systematic within individuals. The current study compared individuals' cue weights within and across contrasts. Forty-two listeners performed a two-alternative forced choice task for four out of five sets of minimal pairs, each varying orthogonally in two dimensions. Individuals' cue weights within a contrast were positively correlated for bet-bat, Luce-lose , and sock-shock , but not for bog-dog and dear-tear ...
September 2018: Journal of the Acoustical Society of America
Katrina M Henrikson, Ethan J Weathersby, Brian G Larsen, John C Cagle, Jake B McLean, Joan E Sanders
The objective of this research was to assess the performance of an embedded sensing system designed to measure the distance between a prosthetic socket wall and residual limb. Low-profile inductive sensors were laminated into prosthetic sockets and flexible ferromagnetic targets were created from elastomeric liners with embedded iron particles for four participants with transtibial amputation. Using insights from sensor performance testing, a novel calibration procedure was developed to quickly and accurately calibrate the multiple embedded sensors...
November 9, 2018: Sensors
Marie Lutz, Christian M Sloane, Edward M Castillo, Jesse J Brennen, Christopher J Coyne, Sadie L Swift, Gary M Vilke
OBJECTIVES: Healthcare providers and law enforcement utilize spit socks to prevent exposure to communicable diseases transmitted by bodily fluid projection from agitated individuals. There are cases in which death is reported due to breathing being limited by a spit sock. There are no formally published studies on their use and safety. The aim of this study was to evaluate whether wearing a spit sock causes a clinically significant impact on breathing. METHODS: Subjects sat with the spit mask over their heads for 15 min and their vital signs and ventilatory parameters were recorded after 5 min, 10 min and 15 min...
October 3, 2018: American Journal of Emergency Medicine
Antonielle Vieira Monclaro, Guilherme Lima Recalde, Francides Gomes da Silva, Sonia Maria de Freitas, Edivaldo Ximenes Ferreira Filho
A 22 kDa xylanase (AtXyl1) from Aspergillus tamarii was purified by two chromatographic steps and presented preference for oat spelt (OSX), birchwood (BrX) and beechwood (BeX) xylans respectively, as substrates. AtXyl1 displays the highest activity at pH 5.5 and 55 °C and showed tolerance over a range of different phenolic compounds. The activity of AtXyl1 was not inhibited when the enzyme was incubated with ferulic acid (FA) using OSX or BrX as substrate. On the other hand, the incubation of AtXyl1 with BeX and FA resulted in an increase in enzyme activity...
January 2019: Enzyme and Microbial Technology
Elli-Anna Balta, Iris Schäffner, Marie-Theres Wittmann, Elisabeth Sock, Felix von Zweydorf, Julia von Wittgenstein, Kathrin Steib, Birgit Heim, Elisabeth Kremmer, Benjamin Martin Häberle, Marius Ueffing, Dieter Chichung Lie, Christian Johannes Gloeckner
The intellectual disability gene, Sox11, encodes for a critical neurodevelopmental transcription factor with functions in precursor survival, neuronal fate determination, migration and morphogenesis. The mechanisms regulating SOX11's activity remain largely unknown. Mass spectrometric analysis uncovered that SOX11 can be post-translationally modified by phosphorylation. Here, we report that phosphorylatable serines surrounding the high-mobility group box modulate SOX11's transcriptional activity. Through Mass Spectrometry (MS), co-immunoprecipitation assays and in vitro phosphorylation assays followed by MS we verified that protein kinase A (PKA) interacts with SOX11 and phosphorylates it on S133...
November 1, 2018: Scientific Reports
Dustin H Marks, Azam Qureshi, Adam Friedman
Importance: Chemotherapy-induced alopecia as well as nail and cutaneous changes occur in up to 89% of patients receiving taxane-based chemotherapy and are associated with cosmetic concerns, psychosocial distress, and overall morbidity. Objective: To review the efficacy and safety of interventions to prevent taxane-induced dermatologic adverse events. Evidence Review: PubMed and Scopus databases were systematically reviewed for studies published in the English language from January 1, 1980, to August 13, 2018...
October 31, 2018: JAMA Dermatology
Dangge Gao, Yajuan Li, Bin Lyu, Leihong Lyu, Shaowei Chen, Jianzhong Ma
To prepare antibacterial cotton fabrics with laundering durability, an organic-inorganic P(DMDAAC-AGE)/Ag/ZnO composite was synthesized by free radical polymerization where the epoxy groups were utilized to form covalent bonds with the hydroxyl groups of cotton fabrics. The surface morphology, crystal phase and chemical structure of the obtained P(DMDAAC-AGE)/Ag/ZnO composite were characterized by XRD, FT-IR and TEM measurements. The resulting P(DMDAAC-AGE)/Ag/ZnO composite-functionalized cotton fabrics exhibited outstanding antibacterial activity and excellent laundering durability...
January 15, 2019: Carbohydrate Polymers
Raymond Heymans, Amir Vila, Caroliene A M van Heerwaarden, Claudia C C Jansen, Greetje A A Castelijn, Menno van der Voort, Elisabeth G Biesta-Peters
A multiplex quantitative PCR (qPCR) was developed and evaluated for the simultaneous detection of Salmonella spp., S. enterica serovar Typhimurium and S. enterica serovar Enteritidis in various (food) matrices. Early and fast detection of these pathogens facilitates effective intervention and prevents further distribution of contaminated food products on the market. Three primer and probe sets were designed to target the invA gene, the STM4200 gene, and the SEN1392 gene to detect and differentiate Salmonella spp...
2018: PloS One
Larissa Neves Pavin, Anthony S Leicht, Samuel Valencia Gimenes, Bruno Victor Corrêa da Silva, Mário Antônio de Moura Simim, Moacir Marocolo, Gustavo Ribeiro da Mota
Soccer-induced fatigue and performance are different between the sexes. The effect of compression stockings (CS) use on fatigue during the soccer match in females is unknown. Thus, we evaluated the impact of CS use during a female soccer match on match-induced fatigue. Twenty soccer players were randomly allocated to two groups (n = 10 for each group): CS and Control (regular socks), and equally distributed within two teams. At rest (baseline 48-h before the match) and immediately post-match, we assessed agility T-test, standing heel-rise test and YoYo Intermittent Endurance Test level 2 (YoYoIE2) performance...
October 14, 2018: Research in Sports Medicine
Sock Yin Tan, Sarva Mangala Praveena, Emilia Zainal Abidin, Manraj Singh Cheema
This study aimed to determine bioavailable heavy metal concentrations (As, Cd, Co, Cu, Cr, Ni, Pb, Zn) and their potential sources in classroom dust collected from children's hand palms in Rawang (Malaysia). This study also aimed to determine the association between bioavailable heavy metal concentration in classroom dust and children's respiratory symptoms. Health risk assessment (HRA) was applied to evaluate health risks (non-carcinogenic and carcinogenic) due to heavy metals in classroom dust. The mean of bioavailable heavy metal concentrations in classroom dust found on children's hand palms was shown in the following order: Zn (1...
December 2018: Environmental Science and Pollution Research International
Gang Lu, Stephanie Weng, Mary Matyskiela, Xinde Zheng, Wei Fang, Scott Wood, Christine Surka, Reina Mizukoshi, Chin-Chun Lu, Derek Mendy, In Sock Jang, Kai Wang, Mathieu Marella, Suzana Couto, Brian Cathers, James Carmichael, Philip Chamberlain, Mark Rolfe
The cereblon modulating agents (CMs) including lenalidomide, pomalidomide and CC-220 repurpose the Cul4-RBX1-DDB1-CRBN (CRL4CRBN ) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in conjunction with E2 ubiquitin-conjugating enzymes, which have until now remained elusive. Here we show that the ubiquitin-conjugating enzymes UBE2G1 and UBE2D3 cooperatively promote the K48-linked polyubiquitination of CRL4CRBN neomorphic substrates via a sequential ubiquitination mechanism...
September 20, 2018: ELife
Hadley J Pearson, Robert T Brodell, C Ralph Daniel Iii
Onychomadesis occurs when the proximal nail plate becomes unattached to the underlying structures. When only one or a few nails are involved, the cause is usually physical trauma. A 23-year-old female presented with a 4-year history of recurrent onychomadesis involving her bilateral great toes that occurred during the springtime. While recurrent trauma from winter shoes or athletic activities may be a contributing factor, our patient was convinced that wearing tight-fitting socks during winter nights was the primary pathophysiologic process...
August 2018: Skin Appendage Disorders
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