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Maud Carron, Yu-Mei Chang, Kelvin Momanyi, James Akoko, John Kiiru, Judy Bettridge, Gemma Chaloner, Jonathan Rushton, Sarah O'Brien, Nicola Williams, Eric M Fèvre, Barbara Häsler
Campylobacteriosis is a leading foodborne zoonosis worldwide, and is frequently associated with handling and consumption of poultry meat. Various studies indicate that Campylobacter causes a substantial human disease burden in low to middle-income countries, but data regarding the organism's epidemiology in countries like Kenya are scarce. In sub-Saharan Africa, 3.8 million deaths of children under-5 years of age are reported annually. Of those, 25% are caused by diarrheal diseases, and Campylobacter is one of the most frequently isolated bacteria from diarrheic children...
August 13, 2018: PLoS Neglected Tropical Diseases
Mamdouh El-Nahas, Shaimaa El-Shazly, Fayrouz El-Gamel, Mohamed Motawea, Fady Kyrillos, Hatem Idrees
OBJECTIVE: Increased skin temperature at the plantar aspect of the foot can predict foot ulceration. However its relation to plantar pressure overload is unknown. The aim of this study was to assess the ability of 'smart socks', monitoring plantar temperature under real-life conditions, to predict plantar pressure distribution. METHOD: The 'smart socks' have seven thermal sensors woven into the fabric of the sock to measure the temperature beneath the foot in real-life conditions...
August 2, 2018: Journal of Wound Care
Kavita Reginald, Chye Ling Tan, Simin Chen, Liling Yuen, Sock Yong Goh, Fook Tim Chew
We previously identified an expressed sequence tag clone, Der f 22, showing 41% amino acid identity to published Der f 2, and show that both genes are possible paralogues. The objective of this study was to characterize the genomic, proteomic and immunological functions Der f 22 and Der f 2. The full-length sequence of Der f 2 and Der f 22 coded for mature proteins of 129 and 135 amino acids respectively, both containing 6 cysteine residues. Phylogenetic analysis of known group 2 allergens and their homologues from our expressed sequence tag library showed that Der f 22 is a paralogue of Der f 2...
August 6, 2018: Scientific Reports
Mohammad Iman Mokhlespour Esfahani, Maury A Nussbaum
Wearable sensors and systems have become increasingly popular in recent years. Two prominent wearable technologies for human activity monitoring are smart textile systems (STSs) and inertial measurement units (IMUs). Despite ongoing advances in both, the usability aspects of these devices require further investigation, especially to facilitate future use. In this study, 18 participants evaluate the preferred placement and usability of two STSs, along with a comparison to a commercial IMU system. These evaluations are completed after participants engaged in a range of activities (e...
August 1, 2018: Sensors
Sameh Fayek GamalEl Din, Ahmed Fathy Abo Sief, Emad Awny Fawzy, Mohamed Abd El Fatah, Wessam Gamal Abo Senna
A 46 year-old male presented suffering from refractory erectile dysfunction. The patient had a past history of pelvic chondro-sarcoma. This case was a challenge for us; the surgery performed for excision of the sarcoma has resulted in the elimination of both pubic ramia together with excision of part of both corpora and left hemiscrotum. The procedure included a sling application on one side with a mesh sock wrapped around the rear part of the extendor cylinder. Another sling was applied on the contra lateral side without a mesh sock...
January 2018: Revista Internacional de Andrología
Leonardo P de Carvalho, Sock Hwee Tan, Ghim-Siong Ow, Zhiqun Tang, Jianhong Ching, Jean-Paul Kovalik, Sock Cheng Poh, Chee-Tang Chin, A Mark Richards, Eliana C Martinez, Richard W Troughton, Alan Yean-Yip Fong, Bryan P Yan, Aruni Seneviratna, Vitaly Sorokin, Scott A Summers, Vladimir A Kuznetsov, Mark Y Chan
We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature...
April 2018: JACC. Basic to Translational Science
Difei Lu, Xiaohui Guo, Yun Li, Bo Zheng, Junqing Zhang
Our study investigated the effectiveness of bacteria-killing nanotechnology Bio-Kil socks on bacterial burden reduction in diabetic patients and healthy individuals. Four strains of S. aureus and four strains of E. coli were cultured and dropped on Bio-Kil socks and control socks for 0 h, 8 h, and 48 h of incubation. Diluted samples were inoculated and bacterial counts were recorded. Additionally, 31 patients with type 2 diabetes and 31 healthy controls were assigned to wear one Bio-Kil sock on one foot and a control sock on the other for four hours, and then they were told to exchange socks from one foot to the other for four hours...
2018: Journal of Diabetes Research
E K Zadow, M J Adams, S S X Wu, C M Kitic, I Singh, A Kundur, N Bost, A N B Johnston, J Crilly, A C Bulmer, S L Halson, J W Fell
PURPOSE: Compression socks are frequently used in the treatment and prevention of lower-limb pathologies; however, when combined with endurance-based exercise, the impact of compression socks on haemostatic activation remains unclear. OBJECTIVES: To investigate the effect of wearing compression socks on coagulation and fibrinolysis following a marathon. METHODS: Sixty-seven participants [43 males (mean ± SD: age: 46.7 ± 10.3 year) and 24 females (age: 40...
July 24, 2018: European Journal of Applied Physiology
Amanda L Zaleski, Linda S Pescatello, Kevin D Ballard, Gregory A Panza, William Adams, Yuri Hosokawa, Paul D Thompson, Beth A Taylor
CONTEXT: Compression socks have become increasingly popular with athletes due to perceived enhancement of exercise performance and recovery. However, research examining the efficacy of compression socks to reduce exercise-associated muscle damage has been equivocal, with few direct measurements of markers of muscle damage. OBJECTIVE: To examine the influence of compression socks worn during a marathon on creatine kinase (CK) levels. DESIGN: A Randomized-Controlled Trial...
July 24, 2018: Journal of Sport Rehabilitation
Deepak Jakhar, Ishmeet Kaur
Alopecia of the lower limbs is a rarely reported entity. Friction due to footwear, socks, and tight clothing is one of the causes of lower limb alopecia. The typical site of involvement and improvement after removal of triggering factor are an important clue to the diagnosis. Alopecia areata remains a close differential, and dermoscopy/trichoscopy can serve as an adjunctive aid in the diagnosis.
May 2018: International Journal of Trichology
Tatsuo Takamiya, Yukiko Kubo, Peyman Benharash, Wei Zhou
Augmentation of cardiac sympathetic tone has been shown to induce ventricular arrhythmias. Acupuncture has been clinically used to treat hypertension, angina pectoris, and atrial arrhythmias. However, the effects of acupuncture on ventricular electrophysiology and autonomic tone remain unknown. We hypothesized that acupuncture attenuates cardiac excitability and corrects the imbalance of autonomic tone during sympathetic hyperactivity. Fourteen Yorkshire pigs were randomized to electroacupuncture (EA, 2 Hz, 0...
September 2018: Autonomic Neuroscience: Basic & Clinical
Sock Mui Poh, Xiaoxu Zhao, Sherman Jun Rong Tan, Deyi Fu, Wenwen Fei, Leiqiang Chu, Dan Jiadong, Wu Zhou, Stephen J Pennycook, Antonio H Castro Neto, Kian Ping Loh
Molybdenum diselenide (MoSe2 ) is a promising two-dimensional material for next-generation electronics and optoelectronics. However, its application has been hindered by a lack of large-scale synthesis. Although chemical vapor deposition (CVD) using laboratory furnaces has been applied to grow two-dimensional (2D) MoSe2 cystals, no continuous film over macroscopically large area has been produced due to the lack of uniform control in these systems. Here, we investigate the molecular beam epitaxy (MBE) of 2D MoSe2 on hexagonal boron nitride (hBN) substrate, where highly crystalline MoSe2 film can be grown with electron mobility ∼15 cm2 /(V s)...
July 9, 2018: ACS Nano
Johannes Menzel-Severing, Matthias Zenkel, Naresh Polisetti, Elisabeth Sock, Michael Wegner, Friedrich E Kruse, Ursula Schlötzer-Schrehardt
Understanding transcription factor (TF) regulation of limbal epithelial stem/progenitor cells (LEPCs) may aid in using non-ocular cells to regenerate the corneal surface. This study aimed to identify and characterize TF genes expressed specifically in LEPCs isolated from human donor eyes by laser capture microdissection. Using a profiling approach, preferential limbal expression was found for SoxE and SoxF genes, particularly for Sox9, which showed predominantly cytoplasmic localization in basal LEPCs and nuclear localization in suprabasal and corneal epithelial cells, indicating nucleocytoplasmic translocation and activation during LEPC proliferation and differentiation...
July 6, 2018: Scientific Reports
Elli-Anna Balta, Marie-Theres Wittmann, Matthias Jung, Elisabeth Sock, Benjamin Martin Haeberle, Birgit Heim, Felix von Zweydorf, Jana Heppt, Julia von Wittgenstein, Christian Johannes Gloeckner, Dieter Chichung Lie
SOX11 is a key Transcription Factor (TF) in the regulation of embryonic and adult neurogenesis, whose mutation has recently been linked to an intellectual disability syndrome in humans. SOX11's transient activity during neurogenesis is critical to ensure the precise execution of the neurogenic program. Here, we report that SOX11 displays differential subcellular localizations during the course of neurogenesis. Western-Blot analysis of embryonic mouse brain lysates indicated that SOX11 is post-translationally modified by phosphorylation...
2018: Frontiers in Molecular Neuroscience
Andrea P Marshall
No abstract text is available yet for this article.
July 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
Daniel Slunge, Anders Boman
The purpose of this study is to analyse the role of risk perceptions and exposure for protective behaviour against tick bites and the related diseases Lyme borreliosis (LB) and tick-borne encephalitis (TBE), both of which are growing health concerns. We use data from a national survey in Sweden with respondents in geographical areas with substantial differences in both abundance of ticks and incidence of LB and TBE. We find that the share of respondents who frequently use protective clothing (64%), perform tick checks (63%) or avoid tall grass while in areas with ticks (48%) is relatively high...
2018: PloS One
Akiko Hanai, Hiroshi Ishiguro, Takashi Sozu, Moe Tsuda, Ikuko Yano, Takayuki Nakagawa, Satoshi Imai, Yoko Hamabe, Masakazu Toi, Hidenori Arai, Tadao Tsuboyama
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting and disabling side effect of taxane anticancer agents. We prospectively evaluated the efficacy of cryotherapy for CIPN prevention. Methods: Breast cancer patients treated weekly with paclitaxel (80 mg/m2 for one hour) wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion. Symptoms on the treated sides were compared with those on the untreated (nondominant) sides...
February 1, 2018: Journal of the National Cancer Institute
Monica Rosales Santillan, Jessica B Dietert, Richard Jahan-Tigh
Papular purpuric gloves and socks syndrome (PPGSS) is a self-limited exanthem that presents as painful or pruritic edema, erythema, petechiae, and purpura of the palms and soles with occasional extension to the dorsal hands and feet. The majority of PPGSS cases reported in the literature are associated with parvovirus B19 and occur in children and young adults. In a recent literature search, there were 11 PPGSS cases in adults with none reporting Epstein-Barr virus (EBV) as a viral etiology. However, there have been PPGSS cases related to EBV in children...
April 15, 2018: Dermatology Online Journal
Raul Carneiro Lins, Epitácio Leite Rolim, Fernando DE Santa Cruz Oliveira, Saulo Monteiro Dos Santos, Tale Lucas Vieira Rolim, Flávio Kreimer
Objectives: To evaluate the effectiveness of aspirin as prophylaxis for deep venous thrombosis (DVT) in patients undergoing total hip arthroplasty (THA), and to analyze the incidence of bleeding during the post-operative period. Methods: This prospective study carried out in 2017 consisted of 37 patients indicated for THA with high risk for DVT. Immediately after the procedure, aspirin, elastic compression socks and early deambulation were initiated. Doppler ultrasound was performed in the legs 6 days and 6 weeks post-procedure to rule out venous thromboembolism...
March 2018: Acta Ortopedica Brasileira
Dorit Hockman, Igor Adameyko, Marketa Kaucka, Perrine Barraud, Tomoki Otani, Adam Hunt, Anna C Hartwig, Elisabeth Sock, Dominic Waithe, Marina C M Franck, Patrik Ernfors, Sean Ehinger, Marthe J Howard, Naoko Brown, Jeffrey Reese, Clare V H Baker
Carotid body glomus cells mediate essential reflex responses to arterial blood hypoxia. They are dopaminergic and secrete growth factors that support dopaminergic neurons, making the carotid body a potential source of patient-specific cells for Parkinson's disease therapy. Like adrenal chromaffin cells, which are also hypoxia-sensitive, glomus cells are neural crest-derived and require the transcription factors Ascl1 and Phox2b; otherwise, their development is little understood at the molecular level. Here, analysis in chicken and mouse reveals further striking molecular parallels, though also some differences, between glomus and adrenal chromaffin cell development...
May 25, 2018: Developmental Biology
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