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Winston Richards

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https://www.readbyqxmd.com/read/30454504/skin-sparing-wide-local-debridement-of-necrotizing-soft-tissue-infection-can-less-be-more
#1
Annie Laurie Benzie, Jason Clark, Jason Farrah, Alejandro Garcia, Joshua Hagan, Winston Richards, Darwin Ang
No abstract text is available yet for this article.
September 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/30367806/the-prevalence-and-volumetry-of-pituitary-cysts-in-children-with-growth-hormone-deficiency-and-idiopathic-short-stature
#2
Nicholas Krasnow, Bradley Pogostin, James Haigney, Brittany Groh, Winston Weiler, Michael Tenner, Marion Kessler, Michael Frey, Richard A Noto
Background Pituitary cysts have been speculated to cause endocrinopathies. We sought to describe the prevalence and volumetry of pituitary cysts in patients with growth hormone deficiency (GHD) and idiopathic short stature (ISS). Methods Six hundred and eighteen children evaluated for growth failure at the Division of Pediatric Endocrinology at New York Medical College between the years 2002 and 2012, who underwent GH stimulation testing and had a brain magnetic resonance imaging (MRI) prior to initiating GH treatment were randomly selected to be a part of this study...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30338131/pilot-study-of-an-intervention-to-increase-cultural-awareness-in-research-mentoring-implications-for-diversifying-the-scientific-workforce
#3
Angela Byars-Winston, Veronica Y Womack, Amanda R Butz, Richard McGee, Sandra C Quinn, Emily Utzerath, Carrie L Saetermoe, Stephen Thomas
Introduction: Innovative evidence-based-interventions are needed to equip research mentors with skills to address cultural diversity within research mentoring relationships. A pilot study assessed initial outcomes of a culturally tailored effort to create and disseminate a novel intervention titled Culturally Aware Mentoring (CAM) for research mentors. Intervention: Intervention development resulted in four products: a 6hr CAM training curriculum, a facilitator guide, an online pre-training module, and metrics to evaluate the effectiveness of CAM training...
April 2018: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/30337492/surveillance-for-variant-cjd-should-more-children-with-neurodegenerative-diseases-have-autopsies
#4
Christopher Verity, Anne Marie Winstone, Robert Will, Alison Powell, Peter Baxter, Carlos de Sousa, Paul Gissen, Manju Kurian, John Livingston, Robert McFarland, Suvankar Pal, Michael Pike, Richard Robinson, Evangeline Wassmer, Sameer Zuberi
OBJECTIVES: To report investigations performed in children with progressive neurodegenerative diseases reported to this UK study. DESIGN: Since 1997 paediatric surveillance for variant Creutzfeldt-Jakob disease (vCJD) has been performed by identifying children aged less than 16 years with progressive intellectual and neurological deterioration (PIND) and searching for vCJD among them. SETTING: The PIND Study obtains case details from paediatricians who notify via the British Paediatric Surveillance Unit...
October 18, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/30289809/pain-in-people-living-with-hiv-and-its-association-with-healthcare-resource-use-well-being-and-functional-status
#5
Caroline A Sabin, Richard Harding, Emmanouil Bagkeris, Kennedy Nkhoma, Frank A Post, Memory Sachikonye, Marta Boffito, Jane Anderson, Patrick W G Mallon, Ian Williams, Jaime Vera, Margaret Johnson, Daphne Babalis, Alan Winston
OBJECTIVE: We describe the prevalence of pain and its associations with healthcare resource utilisation and quality-of-life. DESIGN: The POPPY Study recruited three cohorts: older PLWH (≥50 years, n = 699), younger demographically/lifestyle similar PLWH (<50 years, n = 374) and older demographically/lifestyle similar HIV-negative (≥50 years, n = 304) people from April 2013-February 2016. METHODS: Current pain and pain-related healthcare use was collected via a self-reported questionnaire...
October 4, 2018: AIDS
https://www.readbyqxmd.com/read/30287068/role-of-genetic-susceptibility-in-the-development-of-bronchopulmonary-dysplasia
#6
Richard B Parad, Abigail B Winston, Leslie A Kalish, Munish Gupta, Ivana Thompson, Yvonne Sheldon, Joann Morey, Linda J Van Marter
OBJECTIVE: To assess heritable contributions to bronchopulmonary dysplasia (BPD) risk in a twin cohort restricted to gestational age at birth <29 weeks. STUDY DESIGN: A total of 250 twin pairs (192 dichorionic, 58 monochorionic) born <29 weeks gestational age with known BPD status were identified. Three statistical methods applicable to twin cohorts (χ2 test, intraclass correlations [ICCs], and ACE modeling [additive genetic or A, common environmental or C, and unique environmental or E components]) were applied...
September 26, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30269713/skin-sparing-wide-local-debridement-of-necrotizing-soft-tissue-infection-can-less-be-more
#7
Annie Laurie Benzie, Jason Clark, Jason Farrah, Alejandro Garcia, Joshua Hagan, Winston Richards, Darwin Ang
No abstract text is available yet for this article.
September 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/30268204/skin-sparing-wide-local-debridement-of-necrotizing-soft-tissue-infection-can-less-be-more
#8
Annie Laurie Benzie, Jason Clark, Jason Farrah, Alejandro Garcia, Joshua Hagan, Winston Richards, Darwin Ang
No abstract text is available yet for this article.
September 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/30212435/self-management-interventions-for-pain-and-physical-symptoms-among-people-living-with-hiv-a-systematic-review-of-the-evidence
#9
Kennedy Nkhoma, Christine Norton, Caroline Sabin, Alan Winston, Jessica Merlin, Richard Harding
INTRODUCTION: Pain and symptoms still persist among people living with HIV/AIDS. Evidence-based self-management interventions have the potential to help people with HIV/AIDS to successfully manage pain and symptoms. We aimed to identify and appraise the evidence regarding the effectiveness of self-management interventions for pain and/or physical symptoms in people living with HIV/AIDS. METHODS: We searched for controlled intervention studies in Amed, Assian, CINAHL, Cochrane Library, Embase, Medline, PsycInfo, Scopus, and Web of Science data bases, from 1984 to February 2017...
October 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/30097600/biological-significance-and-prognostic-relevance-of-peripheral-blood-neutrophil-to-lymphocyte-ratio-in-soft-tissue-sarcoma
#10
Jason Yongsheng Chan, Zewen Zhang, Winston Chew, Grace Fangmin Tan, Chloe Liwen Lim, Lingyue Zhou, Wei Lin Goh, Eileen Poon, Nagavalli Somasundaram, Sathiyamoorthy Selvarajan, Kesavan Sittampalam, Francis Chin, Jonathan Teh, Mann Hong Tan, Khee Chee Soo, Melissa Teo, Mohamad Farid, Richard Quek
Peripheral blood indices of systemic inflammation such as the neutrophil-lymphocyte ratio (NLR) have been shown to be prognostic in various cancers. We aim to investigate the clinical significance of these indices in patients with soft tissue sarcoma (STS). Seven hundred and twelve patients with available blood counts at diagnosis and/or metastatic relapse were retrospectively examined. An optimal cutoff for NLR-high (>2.5) in predicting overall survival (OS) was determined using receiver operating curve analyses...
August 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29694815/tenecteplase-versus-alteplase-before-thrombectomy-for-ischemic-stroke
#11
RANDOMIZED CONTROLLED TRIAL
Bruce C V Campbell, Peter J Mitchell, Leonid Churilov, Nawaf Yassi, Timothy J Kleinig, Richard J Dowling, Bernard Yan, Steven J Bush, Helen M Dewey, Vincent Thijs, Rebecca Scroop, Marion Simpson, Mark Brooks, Hamed Asadi, Teddy Y Wu, Darshan G Shah, Tissa Wijeratne, Timothy Ang, Ferdinand Miteff, Christopher R Levi, Edrich Rodrigues, Henry Zhao, Patrick Salvaris, Carlos Garcia-Esperon, Peter Bailey, Henry Rice, Laetitia de Villiers, Helen Brown, Kendal Redmond, David Leggett, John N Fink, Wayne Collecutt, Andrew A Wong, Claire Muller, Alan Coulthard, Ken Mitchell, John Clouston, Kate Mahady, Deborah Field, Henry Ma, Thanh G Phan, Winston Chong, Ronil V Chandra, Lee-Anne Slater, Martin Krause, Timothy J Harrington, Kenneth C Faulder, Brendan S Steinfort, Christopher F Bladin, Gagan Sharma, Patricia M Desmond, Mark W Parsons, Geoffrey A Donnan, Stephen M Davis
BACKGROUND: Intravenous infusion of alteplase is used for thrombolysis before endovascular thrombectomy for ischemic stroke. Tenecteplase, which is more fibrin-specific and has longer activity than alteplase, is given as a bolus and may increase the incidence of vascular reperfusion. METHODS: We randomly assigned patients with ischemic stroke who had occlusion of the internal carotid, basilar, or middle cerebral artery and who were eligible to undergo thrombectomy to receive tenecteplase (at a dose of 0...
April 26, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29566407/intracranial-hemorrhage-and-early-mortality-in-patients-receiving-extracorporeal-membrane-oxygenation-for-severe-respiratory-failure
#12
REVIEW
Deepa R J Arachchillage, Maurizio Passariello, Michael Laffan, T C Aw, Leah Owen, Winston Banya, Richard Trimlett, Cliff Morgan, Brijesh V Patel, John Pepper, Stephane Ledot
Intracranial hemorrhage (ICH) is a serious complication in patients receiving veno-venous extracorporeal membrane oxygenation (VV-ECMO) and is associated with high mortality. It is unknown whether ICH may be a consequence of the ECMO or of an underlying disease. The authors first aimed to assess the incidence of ICH at initiation and during the course of VV-ECMO and its associated mortality. The second aim was to identify clinical and laboratory measures that could predict the development of ICH in severe respiratory failure...
April 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29538381/taxonomy-based-on-science-is-necessary-for-global-conservation
#13
Scott A Thomson, Richard L Pyle, Shane T Ahyong, Miguel Alonso-Zarazaga, Joe Ammirati, Juan Francisco Araya, John S Ascher, Tracy Lynn Audisio, Valter M Azevedo-Santos, Nicolas Bailly, William J Baker, Michael Balke, Maxwell V L Barclay, Russell L Barrett, Ricardo C Benine, James R M Bickerstaff, Patrice Bouchard, Roger Bour, Thierry Bourgoin, Christopher B Boyko, Abraham S H Breure, Denis J Brothers, James W Byng, David Campbell, Luis M P Ceríaco, István Cernák, Pierfilippo Cerretti, Chih-Han Chang, Soowon Cho, Joshua M Copus, Mark J Costello, Andras Cseh, Csaba Csuzdi, Alastair Culham, Guillermo D'Elía, Cédric d'Udekem d'Acoz, Mikhail E Daneliya, René Dekker, Edward C Dickinson, Timothy A Dickinson, Peter Paul van Dijk, Klaas-Douwe B Dijkstra, Bálint Dima, Dmitry A Dmitriev, Leni Duistermaat, John P Dumbacher, Wolf L Eiserhardt, Torbjørn Ekrem, Neal L Evenhuis, Arnaud Faille, José L Fernández-Triana, Emile Fiesler, Mark Fishbein, Barry G Fordham, André V L Freitas, Natália R Friol, Uwe Fritz, Tobias Frøslev, Vicki A Funk, Stephen D Gaimari, Guilherme S T Garbino, André R S Garraffoni, József Geml, Anthony C Gill, Alan Gray, Felipe G Grazziotin, Penelope Greenslade, Eliécer E Gutiérrez, Mark S Harvey, Cornelis J Hazevoet, Kai He, Xiaolan He, Stephan Helfer, Kristofer M Helgen, Anneke H van Heteren, Francisco Hita Garcia, Norbert Holstein, Margit K Horváth, Peter H Hovenkamp, Wei Song Hwang, Jaakko Hyvönen, Melissa B Islam, John B Iverson, Michael A Ivie, Zeehan Jaafar, Morgan D Jackson, J Pablo Jayat, Norman F Johnson, Hinrich Kaiser, Bente B Klitgård, Dániel G Knapp, Jun-Ichi Kojima, Urmas Kõljalg, Jenő Kontschán, Frank-Thorsten Krell, Irmgard Krisai-Greilhuber, Sven Kullander, Leonardo Latella, John E Lattke, Valeria Lencioni, Gwilym P Lewis, Marcos G Lhano, Nathan K Lujan, Jolanda A Luksenburg, Jean Mariaux, Jader Marinho-Filho, Christopher J Marshall, Jason F Mate, Molly M McDonough, Ellinor Michel, Vitor F O Miranda, Mircea-Dan Mitroiu, Jesús Molinari, Scott Monks, Abigail J Moore, Ricardo Moratelli, Dávid Murányi, Takafumi Nakano, Svetlana Nikolaeva, John Noyes, Michael Ohl, Nora H Oleas, Thomas Orrell, Barna Páll-Gergely, Thomas Pape, Viktor Papp, Lynne R Parenti, David Patterson, Igor Ya Pavlinov, Ronald H Pine, Péter Poczai, Jefferson Prado, Divakaran Prathapan, Richard K Rabeler, John E Randall, Frank E Rheindt, Anders G J Rhodin, Sara M Rodríguez, D Christopher Rogers, Fabio de O Roque, Kevin C Rowe, Luis A Ruedas, Jorge Salazar-Bravo, Rodrigo B Salvador, George Sangster, Carlos E Sarmiento, Dmitry S Schigel, Stefan Schmidt, Frederick W Schueler, Hendrik Segers, Neil Snow, Pedro G B Souza-Dias, Riaan Stals, Soili Stenroos, R Douglas Stone, Charles F Sturm, Pavel Štys, Pablo Teta, Daniel C Thomas, Robert M Timm, Brian J Tindall, Jonathan A Todd, Dagmar Triebel, Antonio G Valdecasas, Alfredo Vizzini, Maria S Vorontsova, Jurriaan M de Vos, Philipp Wagner, Les Watling, Alan Weakley, Francisco Welter-Schultes, Daniel Whitmore, Nicholas Wilding, Kipling Will, Jason Williams, Karen Wilson, Judith E Winston, Wolfgang Wüster, Douglas Yanega, David K Yeates, Hussam Zaher, Guanyang Zhang, Zhi-Qiang Zhang, Hong-Zhang Zhou
No abstract text is available yet for this article.
March 2018: PLoS Biology
https://www.readbyqxmd.com/read/29424786/no-neurocognitive-advantage-for-immediate-antiretroviral-treatment-in-adults-with-greater-than-500-cd4-t-cell-counts
#14
Edwina J Wright, Birgit Grund, Kevin R Robertson, Lucette Cysique, Bruce J Brew, Gary L Collins, Mollie Poehlman-Roediger, Michael J Vjecha, Augusto César Penalva de Oliveira, Barbara Standridge, Cate Carey, Anchalee Avihingsanon, Eric Florence, Jens D Lundgren, Alejandro Arenas-Pinto, Nicolas J Mueller, Alan Winston, Moses S Nsubuga, Luxshimi Lal, Richard W Price
OBJECTIVE: To compare the effect of immediate versus deferred antiretroviral treatment (ART) on neuropsychological test performance in treatment-naive HIV-positive adults with more than 500 CD4 cells/μl. DESIGN: Randomized trial. METHODS: The START parent study randomized participants to commence immediate versus deferred ART until CD4 less than 350 cells/μl. The START Neurology substudy used eight neuropsychological tests, at baseline, months 4, 8, 12 and annually, to compare groups for changes in test performance...
May 15, 2018: AIDS
https://www.readbyqxmd.com/read/29325951/shunt-nephritis-an-increasingly-unfamiliar-diagnosis
#15
Tessa A Harland, Ken R Winston, Anna J Jovanovich, Richard J Johnson
BACKGROUND: Shunt nephritis is a rare, reversible immune-complex mediated complication of cerebrospinal fluid (CSF) shunt infection that can progress to end-stage renal disease and even death if diagnosis is delayed. CASE DESCRIPTION: The present case report details the manifestation and clinical course of shunt nephritis in a 50-year-old patient who presented with symptoms of nephrotic syndrome 30 years after ventriculojugular shunt placement. Diagnosis was delayed due to initial negative CSF and blood cultures, but a later CSF culture was positive for Propionibacterium acnes...
March 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29072523/sir-winston-churchill-s-doctors-on-the-riviera-1949-1965-herbert-robert-burnett-gibson-1885-1967-and-dafydd-david-myrddin-roberts-1906-1977
#16
Richard W Griffiths
In May 1940, Sir Charles McMoran Wilson (later Lord Moran) was on the instigation of Lord Max Beaverbrook and Brendan Bracken, (both patients, then friends of Wilson) introduced to Winston Churchill. Thereafter, he remained Churchill's personal physician until Churchill's death. In his controversial book detailing Winston Churchill's health, Lord Moran refers briefly to two doctors resident in Monaco, who were involved in the management of Churchill's declining health from 1949. One was Scottish, Herbert Robert Burnett Gibson and the other Welsh, Dafydd Myrddin Roberts...
January 1, 2017: Journal of Medical Biography
https://www.readbyqxmd.com/read/29040166/measurement-of-retinal-vessels-as-a-biomarker-of-cerebrovascular-aging-in-older-hiv-positive-men-compared-with-controls
#17
Lewis Haddow, Rosanna Laverick, Irene Leung, Frank Post, Jaime Vera, Richard Gilson, Ian Williams, Marta Boffito, Caroline Sabin, Alan Winston, Tunde Peto
BACKGROUND: To compare retinal vascular measurements, biomarkers of cerebral small vessel disease, in HIV-positive men aged 50 years and older with similarly aged HIV-negative men and younger HIV-positive men. METHODS: We recruited white, nondiabetic men into a cross-sectional substudy of a larger cohort including 3 demographically matched groups. Optic disc-centered 45-degree color fundus photographs were used to calculate central retinal arterial and venous caliber and the arterial-venous ratio (AVR)...
February 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28952914/tenecteplase-versus-alteplase-before-endovascular-thrombectomy-extend-ia-tnk-a-multicenter-randomized-controlled-study
#18
Bruce Cv Campbell, Peter J Mitchell, Leonid Churilov, Nawaf Yassi, Timothy J Kleinig, Bernard Yan, Richard J Dowling, Steven J Bush, Helen M Dewey, Vincent Thijs, Marion Simpson, Mark Brooks, Hamed Asadi, Teddy Y Wu, Darshan G Shah, Tissa Wijeratne, Timothy Ang, Ferdinand Miteff, Christopher Levi, Martin Krause, Timothy J Harrington, Kenneth C Faulder, Brendan S Steinfort, Peter Bailey, Henry Rice, Laetitia de Villiers, Rebecca Scroop, Wayne Collecutt, Andrew A Wong, Alan Coulthard, P A Barber, Ben McGuinness, Deborah Field, Henry Ma, Winston Chong, Ronil V Chandra, Christopher F Bladin, Helen Brown, Kendal Redmond, David Leggett, Geoffrey Cloud, Anoop Madan, Neil Mahant, Bill O'Brien, John Worthington, Geoffrey Parker, Patricia M Desmond, Mark W Parsons, Geoffrey A Donnan, Stephen M Davis
Background and hypothesis Intravenous thrombolysis with alteplase remains standard care prior to thrombectomy for eligible patients within 4.5 h of ischemic stroke onset. However, alteplase only succeeds in reperfusing large vessel arterial occlusion prior to thrombectomy in a minority of patients. We hypothesized that tenecteplase is non-inferior to alteplase in achieving reperfusion at initial angiogram, when administered within 4.5 h of ischemic stroke onset, in patients planned to undergo endovascular therapy...
April 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28952163/performance-assessments-of-a-novel-well-design-for-reducing-exposure-to-bedrock-derived-arsenic
#19
Richard B Winston, Joseph D Ayotte
Arsenic in groundwater is a serious problem in New England, particularly for domestic well owners drawing water from bedrock aquifers. The overlying glacial aquifer generally has waters with low arsenic concentrations but is less used because of frequent loss of well water during dry periods and the vulnerability to surface-sourced bacterial contamination. An alternative, novel design for shallow wells in glacial aquifers is intended to draw water primarily from unconsolidated glacial deposits, while being resistant to drought conditions and surface contamination...
September 2018: Ground Water
https://www.readbyqxmd.com/read/28934388/loss-of-slc25a46-causes-neurodegeneration-by-affecting-mitochondrial-dynamics-and-energy-production-in-mice
#20
Zhuo Li, Yanyan Peng, Robert B Hufnagel, Yueh-Chiang Hu, Chuntao Zhao, Luis F Queme, Zaza Khuchua, Ashley M Driver, Fei Dong, Q Richard Lu, Diana M Lindquist, Michael P Jankowski, Rolf W Stottmann, Winston W Y Kao, Taosheng Huang
Recently, we identified biallelic mutations of SLC25A46 in patients with multiple neuropathies. Functional studies revealed that SLC25A46 may play an important role in mitochondrial dynamics by mediating mitochondrial fission. However, the cellular basis and pathogenic mechanism of the SLC25A46-related neuropathies are not fully understood. Thus, we generated a Slc25a46 knock-out mouse model. Mice lacking SLC25A46 displayed severe ataxia, mainly caused by degeneration of Purkinje cells. Increased numbers of small, unmyelinated and degenerated optic nerves as well as loss of retinal ganglion cells indicated optic atrophy...
October 1, 2017: Human Molecular Genetics
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