keyword
MENU ▼
Read by QxMD icon Read
search

Cannabinoid depression

keyword
https://www.readbyqxmd.com/read/30531214/weeding-out-the-problem-the-impact-of-preoperative-cannabinoid-use-on-pain-in-the-perioperative-period
#1
Christopher W Liu, Anuj Bhatia, Arlene Buzon-Tan, Susan Walker, Dharini Ilangomaran, Jamal Kara, Lakshmikumar Venkatraghavan, Atul J Prabhu
BACKGROUND: The recreational and medical use of cannabinoids has been increasing. While most studies and reviews have focused on the role of cannabinoids in the management of acute pain, no study has examined the postoperative outcomes of surgical candidates who are on cannabinoids preoperatively. This retrospective cohort study examined the impact of preoperative cannabinoid use on postoperative pain scores and pain-related outcomes in patients undergoing major orthopedic surgery. METHODS: Outcomes of patients who had major orthopedic surgery at our hospital between April 1, 2015 and June 30, 2017 were reviewed...
December 7, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/30515077/exploiting-the-multifaceted-effects-of-cannabinoids-on-mood-to-boost-their-therapeutic-use-against-anxiety-and-depression
#2
Mario Stampanoni Bassi, Luana Gilio, Pierpaolo Maffei, Ettore Dolcetti, Antonio Bruno, Fabio Buttari, Diego Centonze, Ennio Iezzi
The endocannabinoid system (ECS) has been recently recognized as a prominent promoter of the emotional homeostasis, mediating the effects of different environmental signals including rewarding and stressing stimuli. The ECS modulates the rewarding effects of environmental stimuli, influencing synaptic transmission in the dopaminergic projections to the limbic system, and mediates the neurophysiological and behavioral consequences of stress. Notably, the individual psychosocial context is another key element modulating the activity of the ECS...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/30474579/aerobic-fitness-level-moderates-the-association-between-cannabis-use-and-executive-functioning-and-psychomotor-speed-following-abstinence-in-adolescents-and-young-adults
#3
Natasha E Wade, Alexander L Wallace, Ann M Swartz, Krista M Lisdahl
OBJECTIVES: The high rate of cannabis (CAN) use in emerging adults is concerning given prior research suggesting neurocognitive deficits associated with CAN use in youth. Regular CAN use downregulates endocannabinoid activity, while aerobic exercise upregulates cannabinoid receptor 1 activity and releases endocannabinoids. Here we investigate the influence of regular CAN use on neuropsychological performance, and whether aerobic fitness moderates these effects. METHODS: Seventy-nine young adults (37 CAN users) aged 16-26 participated...
November 26, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/30469079/beta-caryophyllene-alleviates-diet-induced-neurobehavioral-changes-in-rats-the-role-of-cb2-and-ppar-%C3%AE-receptors
#4
Dareen A Youssef, Hassan M El-Fayoumi, Mona F Mahmoud
BACKGROUND AND PURPOSE: Insulin resistance (IR) and obesity predispose diseases such as diabetes, cardiovascular and neurodegenerative disorders. Beta-caryophyllene (BCP), a natural sesquiterpene, exerts neuroprotective, anxiolytic and antidepressant effects via its selective agonism to cannabinoid receptor 2 (CB2R). BCP was shown to have an anti-diabetic effect, however, the implication of CB2R is yet to be elucidated. A link between CB2R agonism and PPAR-γ activation has been discussed, but the exact mechanism is not well-defined...
November 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30465881/activation-of-gpr55-induces-neuroprotection-of-hippocampal-neurogenesis-and-immune-responses-of-neural-stem-cells-following-chronic-systemic-inflammation
#5
Jeremy D Hill, Viviana Zuluaga-Ramirez, Sachin Gajghate, Malika Winfield, Uma Sriram, Slava Rom, Yuri Persidsky
New neurons are continuously produced by neural stem cells (NSCs) within the adult hippocampus. Numerous diseases, including major depressive disorder and HIV-1 associated neurocognitive disorder, are associated with decreased rates of adult neurogenesis. A hallmark of these conditions is a chronic release of neuroinflammatory mediators by activated resident glia. Recent studies have shown a neuroprotective role on NSCs of cannabinoid receptor activation. Yet, little is known about the effects of GPR55, a candidate cannabinoid receptor, activation on reductions of neurogenesis in response to inflammatory insult...
November 19, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/30459224/association-of-mglur-dependent-ltd-of-excitatory-synapses-with-endocannabinoid-dependent-ltd-of-inhibitory-synapses-leads-to-epsp-to-spike-potentiation-in-ca1-pyramidal-neurons
#6
Hye-Hyun Kim, Joo Min Park, Suk-Ho Lee, Won-Kyung Ho
The input-output relationships in neural circuits are determined not only by synaptic efficacy but also by neuronal excitability. Activity-dependent alterations of synaptic efficacy have been extensively investigated, but relatively less is known about how the neuronal output is modulated when synaptic efficacy changes are associated with neuronal excitability changes. In this study, we demonstrate that paired pulses of low-frequency stimulation (PP-LFS) induced metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) at Schaffer collateral (SC)-CA1 synapses in Sprague-Dawley rats (both sexes), and this LTD was associated with excitatory postsynaptic potential to spike (E-S) potentiation, leading to the increase in action potential (AP) outputs...
November 20, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/30439379/cannabinoid-like-effects-of-five-novel-carboxamide-synthetic-cannabinoids
#7
Michael B Gatch, Michael J Forster
A new generation of novel cannabinoid compounds have been developed as marijuana substitutes to avoid drug control laws and cannabinoid blood tests. 5F-MDMB-PINACA (also known as 5F-ADB, 5F-ADB-PINACA), MDMB-CHIMICA, MDMB-FUBINACA, ADB-FUBINACA, and AMB-FUBINACA (also known as FUB-AMB, MMB-FUBINACA) were tested for in vivo cannabinoid-like effects to assess their abuse liability. Locomotor activity in mice was tested to screen for locomotor depressant effects and to identify behaviorally-active dose ranges and times of peak effect...
November 12, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/30407234/pain-and-depression-a-systematic-review
#8
Waguih William IsHak, Raymond Y Wen, Lancer Naghdechi, Brigitte Vanle, Jonathan Dang, Michelle Knosp, Julieta Dascal, Lobsang Marcia, Yasmine Gohar, Lidia Eskander, Justin Yadegar, Sophia Hanna, Antonious Sadek, Leslie Aguilar-Hernandez, Itai Danovitch, Charles Louy
BACKGROUND: Pain comorbid with depression is frequently encountered in clinical settings and often leads to significant impaired functioning. Given the complexity of comorbidities, it is important to address both pain and depressive symptoms when evaluating treatment options. AIM: To review studies addressing pain comorbid with depression, and to report the impact of current treatments. METHOD: A systematic search of the literature databases was conducted according to predefined criteria...
November 2018: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/30391203/role-of-palmitoylethanolamide-pea-in-depression-translational-evidence
#9
REVIEW
Danilo De Gregorio, Mirko Manchia, Bernardo Carpiniello, Flavia Valtorta, Maria Nobile, Gabriella Gobbi, Stefano Comai
BACKGROUND: Antidepressants have a low rate of response paired with a delayed onset of action. Translational studies are thus seeking for novel targets for antidepressant drug development. Preclinical evidence has demonstrated that the endocannabinoid system plays an important role in mood and stress response, even if drugs targeting this system have not yet become available for clinical use. The dietary supplement N-Palmitoylethanolamide (PEA) is a fatty acid amide belonging to the endocannabinoid system with potential antidepressant properties...
October 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/30361897/a-systematic-review-of-the-efficacy-of-cannabinoid-agonist-replacement-therapy-for-cannabis-withdrawal-symptoms
#10
REVIEW
Maira Aguiar Werneck, Guilherme Trevizan Kortas, Arthur Guerra de Andrade, João Mauricio Castaldelli-Maia
BACKGROUND: About 30% of regular cannabis users report withdrawal symptoms on cessation of prolonged use, such as irritability, insomnia, decreased appetite, depressed mood, anxiety, and restlessness. However, among highly dependent and/or in-treatment users, the incidence of withdrawal can be even higher, reaching up to 50-95% of individuals. This syndrome was only recognized by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) as a diagnosis with specific criteria in 2013...
October 25, 2018: CNS Drugs
https://www.readbyqxmd.com/read/30307491/neural-stem-cell-lineage-specific-cannabinoid-type-1-receptor-regulates-neurogenesis-and-plasticity-in-the-adult-mouse-hippocampus
#11
Tina Zimmermann, Mattia Maroso, Annika Beer, Sarah Baddenhausen, Susann Ludewig, Wenqiang Fan, Constance Vennin, Sebastian Loch, Benedikt Berninger, Clementine Hofmann, Martin Korte, Ivan Soltesz, Beat Lutz, Julia Leschik
Neural stem cells (NSCs) in the adult mouse hippocampus occur in a specific neurogenic niche, where a multitude of extracellular signaling molecules converges to regulate NSC proliferation as well as fate and functional integration. However, the underlying mechanisms how NSCs react to extrinsic signals and convert them to intracellular responses still remains elusive. NSCs contain a functional endocannabinoid system, including the cannabinoid type-1 receptor (CB1). To decipher whether CB1 regulates adult neurogenesis directly or indirectly in vivo, we performed NSC-specific conditional inactivation of CB1 by using triple-transgenic mice...
December 1, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/30298064/translational-investigation-of-the-therapeutic-potential-of-cannabidiol-cbd-toward-a-new-age
#12
REVIEW
José A Crippa, Francisco S Guimarães, Alline C Campos, Antonio W Zuardi
Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana. Objectives: The aim of the present review is to describe the main advances in the development of the experimental and clinical use of cannabidiol CBD in neuropsychiatry. Methods: A non-systematic search was performed for studies dealing with therapeutic applications of CBD, especially performed by Brazilian researchers. Results: CBD was shown to have anxiolytic, antipsychotic and neuroprotective properties...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30297193/coma-seizures-atrioventricular-block-and-hypoglycemia-in-an-adb-fubinaca-body-packer
#13
Nicholas Nacca, Rachel Schult, Robert Loflin, Adam Weltler, Rachel Gorodetsky, Sherri Kacinko, Jeffery Moran, Alex Krotulski, Timothy Wiegand
BACKGROUND: Synthetic cannabinoid intoxication has become difficult to diagnose and manage in the United States, in part due to varying clinical effects within this heterogeneous group of compounds. CASE REPORT: A 38-year-old man was admitted with altered mental status and bradycardia. He demonstrated progressive encephalopathy, seizure activity, second-degree atrioventricular block type I, respiratory failure, hypotension, hypothermia, and hypoglycemia. A computed tomography scan of the abdomen and pelvis revealed multiple packages in the patient's stomach and rectum...
October 5, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30290188/cannabinoids-in-depressive-disorders
#14
REVIEW
Ewa Poleszak, Sylwia Wośko, Karolina Sławińska, Aleksandra Szopa, Andrzej Wróbel, Anna Serefko
Cannabis sativa is one of the most popular recreational and medicinal plants. Benefits from use of cannabinoid agents in epilepsy, multiple sclerosis, Parkinson's disease, Alzheimer's disease, and others have been suggested. It seems that the endocannabinoid system is also involved in the pathogenesis and treatment of depression, though its role in this mental disease has not been fully understood yet. Both the pro- and antidepressant activity have been reported after cannabis consumption and a number of pre-clinical studies have demonstrated that both agonist and antagonist of the endocannabinoid receptors act similarly to antidepressants...
November 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/30281175/a-systematic-review-on-the-neuroprotective-perspectives-of-beta-caryophyllene
#15
REVIEW
Keylla da Conceição Machado, Muhammad Torequl Islam, Eunüs S Ali, Razina Rouf, Shaikh Jamal Uddin, Shrabanti Dev, Jamil A Shilpi, Manik Chandra Shill, Hasan Mahmud Reza, Asish Kumar Das, Subrata Shaw, Mohammad S Mubarak, Siddhartha Kumar Mishra, Ana Amelia de Carvalho Melo-Cavalcante
Beta (β)-caryophyllene (BCAR) is a major sesquiterpene of various plant essential oils reported for several important pharmacological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective, hepatoprotective, gastroprotective, nephroprotective, antimicrobial, and immune-modulatory activity. Recent studies suggest that it also possesses neuroprotective effect. This study reviews published reports pertaining to the neuropharmacological activities of BCAR. Databases such as PubMed, Scopus, MedLine Plus, and Google Scholar with keywords "beta (β)-caryophyllene" and other neurological keywords were searched...
October 3, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/30194657/ameliorative-effect-of-xiaoyao-jieyu-san-on-post-stroke-depression-and-its-potential-mechanisms
#16
Changde Wang, Chunlan Wu, Zhenguo Yan, Xiao Cheng
A stroke is a severe life-threatening disease with high fatality and disability rate. This investigation aimed to study the effect of Xiaoyao-jieyu-san (XYJY) on post-stroke depression (PSD) and its potential mechanisms. PSD rats were prepared using middle cerebral artery embolization (MCAO) and chronic unpredictable mild stress (CUMS), and divided into six groups (n = 10)-sham; MCAO; MCAO + CUMS (PSD); PSD + fluoxetine (1.84 mg/kg/day, 4 weeks); and PSD + XYJY (450 mg/kg/day and 900 mg/kg/day, 4 weeks)...
September 7, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30126012/faah-variant-pro129thr-modulates-subjective-effects-produced-by-cocaine-administration
#17
Marguerite M Patel, David A Nielsen, Thomas R Kosten, Richard De La Garza, Thomas F Newton, Christopher D Verrico
BACKGROUND AND OBJECTIVES: The endogenous cannabinoid anandamide (AEA), an agonist at type-1 cannabinoid (CB1) receptors, is metabolized by fatty acid amide hydrolase (FAAH). The common variant rs324420 C->A within the FAAH gene on chromosome 1 codes for a missense substitution (Pro129Thr), resulting in decreased FAAH activity and increased endocannabinoid potentiation. This FAAH variant has been linked to alterations in mood and stress reactivity, as well as being independently linked to increased risk for addiction...
August 20, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/30109642/cannabinoid-based-therapies-and-brain-development-potential-harmful-effect-of-early-modulation-of-the-endocannabinoid-system
#18
Patrícia Schonhofen, Ivi Juliana Bristot, José Alexandre Crippa, Jaime Eduardo Cecílio Hallak, Antônio Waldo Zuardi, Richard B Parsons, Fábio Klamt
The endocannabinoid retrograde signaling pathway is widely expressed in the central nervous system, where it plays major roles in regulating synaptic plasticity (excitatory and inhibitory) through long-term potentiation and long-term depression. The endocannabinoid system (ECS) components-cannabinoid receptors, endocannabinoids and synthesis/degradation enzymes-are expressed and are functional from early developmental stages and throughout adolescent cortical development, regulating progenitor cell fate, neural differentiation, migration and survival...
August 2018: CNS Drugs
https://www.readbyqxmd.com/read/30105471/fatal-poisonings-associated-with-new-psychoactive-substances
#19
Robert Kronstrand, Davide Guerrieri, Svante Vikingsson, Ariane Wohlfarth, Henrik Gréen
This chapter describes how new psychoactive substances (NPS) have been involved in fatal intoxications from 2010 and onwards. It summarizes the circumstances, antemortem symptoms, and adverse effects that have led to death after ingestion of one or more NPS and tabulates concentrations, and postmortem findings from these intoxications.Consumption of NPS exerts health problems and unknown risks for the users. Data on toxicity of many NPS are scarce or nonexistent and long-term toxicity and risks are still largely unknown...
August 14, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/30099006/selective-up-regulation-of-cannabinoid-cb-1-receptor-coupling-to-go-proteins-in-suicide-victims-with-mood-disorders
#20
Susana Mato, Fuencisla Pilar-Cuéllar, Elsa M Valdizán, Javier González-Maeso, Rafael Rodríguez-Puertas, Javier Meana, Joan Sallés, Benedicto Crespo-Facorro, Ángel Pazos
Brain endocannabinoid system is proposed to play a role in the pathogenesis of affective disorders. In the present study, we analyzed the functionality of the cannabinoid receptor type 1 (CB1 receptor) at different transduction levels in prefrontal cortex (PFC) of depressed suicide victims. We examined stimulation of [35 S]GTPγS binding, activation of Gα protein subunits and inhibition of adenylyl cyclase by the cannabinoid agonist WIN55,212-2, as well as [3 H]CP55,940 binding, in PFC homogenates from suicide victims with major depression (MD) and matched control subjects...
November 2018: Biochemical Pharmacology
keyword
keyword
167025
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"