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https://www.readbyqxmd.com/read/30537636/3%C3%A2-bromo%C3%A2-5%C3%A2-ethoxymethyl-%C3%A2-1-2%C3%A2-benzenediol-inhibits-lps-induced-pro-inflammatory-responses-by-preventing-ros-production-and-downregulating-nf-%C3%AE%C2%BAb-in-vitro-and-in-a-zebrafish-model
#1
Eun-Yi Ko, Soo-Jin Heo, Su-Hyeon Cho, WonWoo Lee, Seo-Young Kim, Hye-Won Yang, Ginnae Ahn, Seon-Heui Cha, Seung-Hae Kwon, Myeong Seon Jeong, Kang Pa Lee, You-Jin Jeon, Kil-Nam Kim
The anti-inflammatory effects of 3‑bromo‑5‑(ethoxymethyl)‑1,2‑benzenediol (BEMB) from Polysiphonia morrowii were evaluated in lipopolysaccharide (LPS)-induced RAW264.7 cells and zebrafish embryo. BEMB showed anti-inflammatory effects by inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS), and the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in the LPS-activated RAW264.7 cells and zebrafish embryo without cytotoxicity. Moreover, BEMB suppressed the protein and mRNA expression levels of nuclear factor (NF)-κB (p65 and inhibitor of NF-κB [IκB]-A) in RAW264...
December 8, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30537006/increased-risk-of-postoperative-complications-after-total-thyroidectomy-with-graves-disease
#2
Hyungju Kwon, Jong-Kyu Kim, Woosung Lim, Byung-In Moon, Nam Sun Paik
BACKGROUND: The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear. METHODS: The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group). RESULTS: The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation...
December 7, 2018: Head & Neck
https://www.readbyqxmd.com/read/30536876/increased-biomass-and-lipid-production-by-continuous-cultivation-of-nannochloropsis-salina-transformant-overexpressing-a-bhlh-transcription-factor
#3
Nam Kyu Kang, Eun Kyung Kim, Min-Gyu Sung, Young Uk Kim, Byeong-Ryool Jeong, Yong Keun Chang
Microalgae are promising feedstocks for sustainable and eco-friendly production of biomaterials, which can be improved by genetic engineering. It is also necessary to optimize the processes to produce biomaterials from engineered microalgae. We previously reported genetic improvements of an industrial microalga Nannochloropsis salina by overexpressing a basic helix-loop-helix transcription factor (NsbHLH2). These transformants showed improved growth and lipid production particularly during the early phase of culture under batch culture...
December 9, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/30536544/hypermutagenesis-in-untreated-adult-gliomas-due-to-inherited-mismatch-mutations
#4
Jason K Sa, Seung Won Choi, Junfei Zhao, Yeri Lee, Jing Zhang, Doo-Sik Kong, Jung Won Choi, Ho Jun Seol, Jung-Il Lee, Antonio Iavarone, Raul Rabadan, Do-Hyun Nam
Hypermutagenesis refers to marked increase in the number of mutations due to continuous mutagenic process. Hypermutated tumors, have being found in several tumor types, are associated with inherited or acquired alterations in DNA repair pathways. Hypermutation has been observed in a subset of adult glioma patients as a direct result of temozolomide(TMZ)-induced mutagenesis. In present study, we have identified a rare subset of treatment-naïve adult gliomas with de novo hypermutator phenotype and explored the evolution of spontaneous and treatment-induced hypermutagenesis...
December 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30536465/oncologic-outcomes-in-patients-with-1-cm-to-4-cm-differentiated-thyroid-carcinoma-according-to-extent-of-thyroidectomy
#5
Jung Bum Choi, Seul Gi Lee, Min Jhi Kim, Tae Hyung Kim, Eun Jeong Ban, Cho Rok Lee, Jandee Lee, Sang-Wook Kang, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Cheong Soo Park
BACKGROUND: Recent guidelines advocate unilateral thyroidectomy for low-risk 1-cm to 4-cm differentiated thyroid cancer (DTC). This study was designed to examine the association between the extent of thyroidectomy and oncologic outcomes in patients with 1-cm to 4-cm DTC. MATERIALS AND METHODS: From April 1978 to December 2011, 16 057 patients with DTC underwent thyroidectomy at Yonsei University Hospital. Among them, 5266 (32.8%) patients were classified as having 1-cm to 4-cm DTC and were enrolled in this study...
December 10, 2018: Head & Neck
https://www.readbyqxmd.com/read/30535953/serum-level-vitamin-d-and-parathyroid-hormone-and-mortality-with-or-without-chronic-kidney-disease
#6
Chang Kyun Choi, Sun-Seog Kweon, Young-Hoon Lee, Hae-Sung Nam, Kyeong-Soo Park, So-Yeon Ryu, Seong-Woo Choi, Sun A Kim, Min-Ho Shin
Levels of vitamin D and parathyroid hormone (PTH) are closely associated with renal function. We evaluated the associations among 25-hydroxyvitamin D (25OHD) levels, PTH levels, and mortality, and whether these associations varied by renal function. We used data from the Dong-gu Study, a population-based cohort in Korean adults. We analyzed the associations among intact PTH, 25OHD levels and mortality in 8580 participants. Hazard ratios (HRs) for mortality were calculated using Cox proportional hazards regression after adjusting for age, sex, month of sampling, lifestyle, and comorbidities...
December 7, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30535726/identification-sexual-dimorphism-and-aspects-of-the-natural-history-of-sapria-himalayana-rafflesiaceae-on-vietnam-s-lang-biang-plateau
#7
Hữu Đăng Trần, Hồng Trường Lưu, Quốc Đạt Nguyễn, Hiếu Cường Nguyễn, Parusuraman Athen, K M Wong
BACKGROUND: Sapria is a distinctive and narrowly host-specific holoparasitic genus belonging to the Rafflesiaceae. Sapria himalayana, rare throughout its range from NE India, SW China, Thailand to Vietnam, is a little-understood species first recorded for Vietnam in 1959, and only recollected there over half a century later in February 2017. This has facilitated an assessment of its taxonomic identity and our understanding of its morphology and natural history aspects. RESULTS: Six populations of Sapria at Vietnam's Tuyền Lâm Lake, and another two populations at the Nam Ban Protection Forest and the Cam Ly area were found, in an area of about 20 km in radius...
December 10, 2018: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/30535478/tp53-upregulates-%C3%AE-%C3%A2-smooth-muscle-actin-expression-in-tamoxifen%C3%A2-resistant-breast-cancer-cells
#8
Sangmin Kim, Daeun You, Yisun Jeong, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Jeong Eon Lee
In a previous study, we reported that α‑smooth muscle actin (α‑SMA), one of the mesenchymal marker proteins, is highly expressed in tamoxifen‑resistant breast cancer (TamR) cells. However, the exact mechanism of α‑SMA expression in TamR cells is not fully understood. Here, we investigated the effect of TP53 on α‑SMA expression in breast cancer cells. The levels of α‑SMA mRNA and protein expression were analyzed by real‑time PCR and western blotting, respectively. In estrogen receptor‑positive [ER(+)] breast cancer patients, aberrant α‑SMA expression was found to be associated with a poor prognosis...
December 6, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30535242/hmgb1-gene-polymorphism-is-associated-with-coronary-artery-lesions-and-intravenous-immunoglobulin-resistance-in-kawasaki-disease
#9
Jong Gyun Ahn, Yoonsun Bae, Dongjik Shin, Jiho Nam, Kyu Yeun Kim, Dong Soo Kim
Objectives: Kawasaki disease (KD) is an acute systemic vasculitis of unknown aetiology that affects infants and young children. Recent reports of elevated serum high mobility group box 1 (HMGB1) level during the acute phase of KD and its relationship to poor response to IVIG treatment suggest a possible association of HMGB1 polymorphisms with KD. We investigated the association between the polymorphisms of the HMGB1 gene, KD susceptibility, coronary artery lesions, and KD response to IVIG treatment...
December 7, 2018: Rheumatology
https://www.readbyqxmd.com/read/30534790/direct-observation-of-quantum-tunnelling-charge-transfers-between-molecules-and-semiconductors-for-sers
#10
Nam-Jung Kim, Jayeong Kim, Jun-Beom Park, Hyemin Kim, Gyu-Chul Yi, Seokhyun Yoon
We used high-quality ZnO nanostructures/graphene substrates for understanding the mechanisms of charge transfer (CT) that take place under nonplasmonic conditions. As the optimal conditions for CT processes are found, we studied the range of CT normal to the ZnO surface that is coated with nanoscale HfO2 layers with different thicknesses. We could observe that CT decays over a few nanometers. In addition, we also observed a unique oscillation of the SERS intensity in the atomically thin oxide layers, which reflects the quantum tunneling effects of CT electrons across the oxide layers...
December 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/30534579/shifting-retroviral-vector-integrations-away-from-transcriptional-start-sites-via-dna-binding-protein-domain-insertion-into-integrase
#11
Jung-Soo Nam, Ji-Eun Lee, Kwang-Hee Lee, Yeji Yang, Soo-Hyun Kim, Gyu-Un Bae, Hohsuk Noh, Kwang-Il Lim
The unique ability of retroviruses to integrate genes into host genomes is of great value for long-term expression in gene therapy, but only when integrations occur at safe genomic sites. To reap the benefit of using retroviruses without severe detrimental effects, we developed several murine leukemia virus (MLV)-based gammaretroviral vectors with safer integration patterns by perturbing the structure of the integrase via insertion of DNA-binding zinc-finger domains (ZFDs) into an internal position of the enzyme...
March 15, 2019: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/30534135/genetic-properties-of-a-nested-association-mapping-population-constructed-with-semi-winter-and-spring-oilseed-rapes
#12
Jianlin Hu, Chaocheng Guo, Bo Wang, Jiaqing Ye, Meng Liu, Zhikun Wu, Yingjie Xiao, Qinghua Zhang, Haitao Li, Graham J King, Kede Liu
Nested association mapping (NAM) populations have been widely applied to dissect the genetic basis of complex quantitative traits in a variety of crops. In this study, we developed a Brassica napus NAM (BN-NAM) population consisting of 15 recombination inbred line (RIL) families with 2,425 immortal genotypes. Fifteen high-density genetic linkage maps were constructed by genotyping by sequencing (GBS) based on all RIL families, with further integration into a joint linkage map (JLM) having 30,209 unique markers in common with multiple linkage maps...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/30534000/upregulation-of-microrna-344a-3p-is-involved-in-curcumin-induced-apoptosis-in-rt4-schwannoma-cells
#13
Eun Jung Sohn, Kyoung-Mi Bak, Yun-Kyeong Nam, Hwan Tae Park
Background: Schwannoma arising from peripheral nervous sheaths is a benign tumor. Methods: To evaluate cell cytotoxicity, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction and terminal deoxynucleotidyltransferase UTP nick-end labeling (TUNEL) assays were used. A microRNA (miRNA) array was used to identify the miRNAs involved in curcumin-induced apoptosis. To examine miRNA expression, quantitative RT-PCR was used. Results: In this study, curcumin exerted cellular cytotoxicity against RT4 schwannoma cells, with an increase in TUNEL-positive cells...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/30533895/draft-genome-sequence-of-deinococcus-koreensis-sjw1-2-t-a-gamma-radiation-resistant-bacterium-isolated-from-river-water
#14
Kiwoon Baek, Eu Jin Chung, Gang-Guk Choi, Young Ho Nam, Ahyoung Choi
Deinococcus koreensis SJW1-2T was isolated from river water and was observed to be highly resistant to gamma radiation. In this study, we report a draft genome sequence which revealed that SJW1-2T possesses genes involved in nucleotide excision repair. The primary genomic information will aid in elucidating the DNA repair mechanism during ionizing radiation.
August 2018: Microbiology resource announcements
https://www.readbyqxmd.com/read/30533435/comparison-of-landmark-and-outline-based-geometric-morphometrics-for-discriminating-mosquito-vectors-in-ratchaburi-province-thailand
#15
Tanawat Chaiphongpachara
It is often challenging to identify mosquito vectors in the field based on morphological features due to their similar morphologies and difficulties in obtaining undamaged samples but is required for their successful control. Geometric morphometrics (GM) overcomes this issue by analyzing a suite of traits simultaneously and has the added advantages of being easy to use, low cost, and quick. Therefore, this research compared the efficiency and precision of landmark- and outline-based GM techniques for separating species of mosquitoes in Huay Nam Nak village, Ratchaburi Province, Thailand...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30532438/osc47-efficacy-of-four-different-types-of-bleaching-agents-on-stained-natural-teeth-using-spectrophotometer
#16
Shivani Kohli, Amanda Siew Yan Yin, Woon Lai Nam, Husna Dayana Hamdan, Qistina Amani Roslan
No abstract text is available yet for this article.
October 2018: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/30532128/the-incidence-of-left-atrial-appendage-thrombi-on-transesophageal-echocardiography-after-pretreatment-with-apixaban-for-cardioversion-in-the-real-world-practice
#17
Jongmin Hwang, Hyoung-Seob Park, Seung-Woon Jun, Sang-Woong Choi, Cheol Hyun Lee, In-Cheol Kim, Yun-Kyeong Cho, Hyuck-Jun Yoon, Hyungseop Kim, Chang-Wook Nam, Seung-Ho Hur, Sang Hoon Lee, Seongwook Han
The risk of thromboembolisms during the post-cardioversion period is high. For patients with persistent atrial fibrillation (AF), anticoagulation with warfarin (INR 2.0~3.0) is recommended for at least three weeks prior and four weeks after cardioversion. We aimed to evaluate the efficacy of apixaban in preventing thromboembolic events during post-cardioversion. We enrolled 127 consecutive persistent AF patients (83 persistent, 44 longstanding persistent AF), scheduled to undergo cardioversion and were pretreated with apixaban...
2018: PloS One
https://www.readbyqxmd.com/read/30532077/differential-effects-of-arterial-stiffness-and-fluid-overload-on-blood-pressure-according-to-renal-function-in-patients-at-risk-for-cardiovascular-disease
#18
Seohyun Park, Chan Joo Lee, Misol Lee, Min-Uk Cha, Seong Yeong An, Ki Heon Nam, Jong Hyun Jhee, Hae-Ryong Yun, Hyoungnae Kim, Youn Kyung Kee, Jung Tak Park, Hyeon Chang Kim, Tae-Hyun Yoo, Shin-Wook Kang, Sungha Park, Seung Hyeok Han
The pathogenesis of hypertension is multifactorial in patients with chronic kidney disease (CKD). We explored the relative contribution of arterial stiffness and fluid overload to blood pressure (BP) in these patients. We evaluated 1531 patients from a prospective observational cohort study of high-risk patients with cardiovascular disease. BP, arterial stiffness, and volume status expressed as the extracellular water/total body water ratio (ECW/TBW) were measured by 24-h BP monitoring, pulse-wave velocity (PWV), and bioelectrical impedance analysis, respectively...
December 10, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30531922/the-molecular-landscape-of-glioma-in-patients-with-neurofibromatosis-1
#19
Fulvio D'Angelo, Michele Ceccarelli, Tala, Luciano Garofano, Jing Zhang, Véronique Frattini, Francesca P Caruso, Genevieve Lewis, Kristin D Alfaro, Luc Bauchet, Giulia Berzero, David Cachia, Mario Cangiano, Laurent Capelle, John de Groot, Francesco DiMeco, François Ducray, Walid Farah, Gaetano Finocchiaro, Stéphane Goutagny, Carlos Kamiya-Matsuoka, Cinzia Lavarino, Hugues Loiseau, Véronique Lorgis, Carlo E Marras, Ian McCutcheon, Do-Hyun Nam, Susanna Ronchi, Veronica Saletti, Romuald Seizeur, John Slopis, Mariona Suñol, Fanny Vandenbos, Pascale Varlet, Dominique Vidaud, Colin Watts, Viviane Tabar, David E Reuss, Seung-Ki Kim, David Meyronet, Karima Mokhtari, Hector Salvador, Krishna P Bhat, Marica Eoli, Marc Sanson, Anna Lasorella, Antonio Iavarone
Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the prevalent tumors. Gliomagenesis in NF1 results in a heterogeneous spectrum of low- to high-grade neoplasms occurring during the entire lifespan of patients. The pattern of genetic and epigenetic alterations of glioma that develops in NF1 patients and the similarities with sporadic glioma remain unknown. Here, we present the molecular landscape of low- and high-grade gliomas in patients affected by NF1 (NF1-glioma)...
December 10, 2018: Nature Medicine
https://www.readbyqxmd.com/read/30531022/a-multi-institution-consensus-on-how-to-perform-eus-guided-biliary-drainage-for-malignant-biliary-obstruction
#20
Jintao Guo, Marc Giovannini, Anand V Sahai, Adrian Saftoiu, Christoph F Dietrich, Erwin Santo, Pietro Fusaroli, Ali A Siddiqui, Manoop S Bhutani, Anthony Yuen Bun Teoh, Atsushi Irisawa, Brenda Lucia Arturo Arias, Chalapathi Rao Achanta, Christian Jenssen, Dong-Wan Seo, Douglas G Adler, Evangelos Kalaitzakis, Everson Artifon, Fumihide Itokawa, Jan Werner Poley, Girish Mishra, Khek Yu Ho, Hsiu-Po Wang, Hussein Hassan Okasha, Jesse Lachter, Juan J Vila, Julio Iglesias-Garcia, Kenji Yamao, Kenjiro Yasuda, Kensuke Kubota, Laurent Palazzo, Luis Carlos Sabbagh, Malay Sharma, Mitsuhiro Kida, Mohamed El-Nady, Nam Q Nguyen, Peter Vilmann, Pramod Kumar Garg, Praveer Rai, Shuntaro Mukai, Silvia Carrara, Sreeram Parupudi, Subbaramiah Sridhar, Sundeep Lakhtakia, Surinder S Rana, Takeshi Ogura, Todd H Baron, Vinay Dhir, Siyu Sun
Background and Objectives: EUS-guided biliary drainage (EUS-BD) was shown to be useful for malignant biliary obstruction (MBO). However, there is lack of consensus on how EUS-BD should be performed. Methods: This was a worldwide multi-institutional survey among members of the International Society of EUS conducted in February 2018. The survey consisted of 10 questions related to the practice of EUS-BD. Results: Forty-six endoscopists of them completed the survey...
November 2018: Endoscopic Ultrasound
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