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Jeong-Seob Won, Hyun Nam, Hye Won Lee, Ji-Yoon Hwang, Yu-Jeong Noh, Do-Hyun Nam, Sun-Ho Lee, Kyeung Min Joo
Stem cells could be the next generation therapeutic option for neurodegenerative diseases including spinal cord injury (SCI). However, several critical factors such as delivery method should be determined before their clinical applications. Previously, we have demonstrated that lateral ventricle (LV) injection as preclinical simulation could be used for intrathecal administration in clinical trials using rodent animal models. In this study, we further analyzed in vivo distribution of cells that were injected into LVs of rats with SCI at thoracic level using in vivo imaging techniques...
2018: PloS One
Hyunkoo Lee, Hyunsu Cho, Chun-Won Byun, Jun-Han Han, Byoung-Hwa Kwon, Sukyung Choi, Jonghee Lee, Nam Sung Cho
We demonstrate independently and simultaneously controlled color-tunable organic light-emitting diodes (OLEDs) with vertically stacked blue, green, and red elements. The blue, green, and red elements were placed at the bottom, middle, and top positions, respectively, forming color-tunable OLEDs. The independently driven blue, green, and red elements in the color-tunable OLEDs exhibited low driving voltages of 5.3 V, 3.0 V, and 4.6 V, as well as high external quantum efficiencies of 11.1%, 10.9%, and 9.6%, respectively, at approximately 1000 cd/m2 ...
July 9, 2018: Optics Express
Dae-Hyun Nam, Oleksandr S Bushuyev, Jun Li, Phil De Luna, Ali Seifitokaldani, Cao-Thang Dinh, F Pelayo Garcia de Arquer, Yuhang Wang, Zhiqin Liang, Andrew H Proppe, Chih Shan Tan, Petar Todorovic, Osama Shekhah, Christine M Gabardo, Jea Woong Jo, Jongmin Choi, Min-Jae Choi, Se-Woong Baek, Junghwan Kim, David Sinton, Shana O Kelley, Mohamed Eddaoudi, Edward H Sargent
The electrochemical carbon dioxide reduction reaction (CO2 RR) produces diverse chemical species. Cu clusters with a judiciously-controlled surface coordination number (CN) provide active sites that simultaneously optimize selectivity, activity, and efficiency for CO2 RR. Here we report a strategy involving metal-organic framework (MOF)-regulated Cu cluster formation that shifts CO2 electroreduction toward multiple-carbon product generation. Specifically, we promoted undercoordinated sites during the formation of Cu clusters by controlling the structure of the Cu dimer, the precursor for Cu clusters...
August 16, 2018: Journal of the American Chemical Society
Dae Gon Ryu, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Su Jin Kim, Hyeong Seok Nam
Endoscopic submucosal dissection (ESD) has been widely implemented for the treatment of gastric superficial neoplasia. However, the final pathologic diagnosis after ESD may be different from that indicated by the results of endoscopic forceps biopsy. This study identified risk factors for gastric epithelial lesions so that early gastric cancer (EGC) could be diagnosed after ESD.From December 2008 to January 2017, 1541 lesions (1410 patients) diagnosed as initial adenoma or indefinite for neoplasia by endoscopic forceps biopsy were enrolled...
August 2018: Medicine (Baltimore)
Seon Choi, Ji Hee Lee, Joo Won Kang, Han Na Choe, Chi Nam Seong
A Gram-stain-negative, non-spore-forming, rod-shaped, aerobic and diffusible yellow-coloured bacterial strain, designated strain ECD12T was isolated from a seaweed, Ecklonia cava. The isolate required sea salts for growth. Catalase-positive and oxidase-negative. A phylogenetic tree based on 16S rRNA gene sequences showed that strain ECD12T formed an evolutionary lineage within the radiation enclosing the members of genera Spongiibacterium and Flagellimonas sharing the highest similarity to Flagellimonas eckloniae DOKDO007T (96...
August 16, 2018: International Journal of Systematic and Evolutionary Microbiology
So Hun Kim, Seung Youn Lee, Chei Won Kim, Young Ju Suh, Seongbin Hong, Seong Hee Ahn, Da Hae Seo, Moon Suk Nam, Suk Chon, Jeong Taek Woo, Sei Hyun Baik, Yongsoo Park, Kwan Woo Lee, Young Seol Kim
BACKGROUND: The aim of the study was to assess the impact of socioeconomic status (SES) on health behaviors, metabolic control, and chronic complications in people with type 2 diabetes mellitus (T2DM) from South Korea, a country with universal health insurance coverage and that has experienced rapid economic and social transition. METHODS: A total of 3,294 Korean men and women with T2DM aged 30 to 65 years, participating in the Korean National Diabetes Program (KNDP) cohort who reported their SES and had baseline clinical evaluation were included in the current cross-sectional analysis...
June 29, 2018: Diabetes & Metabolism Journal
Myungseo Park, Daesil Nam, Dae-Hyuk Kweon, Dongwoo Shin
RpoS is one of several alternative sigma factors known to alter gene expression profiles by RpoS-associated RNA polymerase in response to a variety of stresses. The enteric bacteria Salmonella enterica and Escherichia coli accumulate RpoS under low Mg2+ concentrations via a common mechanism in which the PhoP regulator activates expression of antiadaptor proteins that, by sequestering the adaptor RssB, prevent RpoS degradation by the protease ClpXP. Here, we demonstrate that this genetic program alone does not fully support RpoS accumulation when cytoplasmic Mg2+ concentration drops to levels that impair protein synthesis...
August 15, 2018: Molecular Microbiology
Suengmok Lee, Kyung-A Hwang, Ji-Hoon Ahn, Jae-Hwan Nam
Purpose: Tuberculosis (TB) is mainly caused by Mycobacterium tuberculosis , which is a pathogenic mycobacterial species grouped under Mycobacterium tuberculosis complex (MTBC) with four other pathogenic mycobacterial species. The mycobacteria not included in MTBC are known as nontuberculous mycobacteria (NTM), and cause several pulmonary diseases including pneumonia. Currently, NTM occurrences in TB-suspected respiratory specimens have increased, due to which, precise detection of MTBC and NTM is considered critical for the diagnosis and vaccination of TB...
July 2018: Clinical and Experimental Vaccine Research
Jun Won Park, Ki Taek Nam, Jae Hoon Shin, Il Yong Kim, Kyung Mi Choi, Kyung-Jin Roh, Seung Hyun Oh, Young-Min Yun, Jun-Gyo Suh, Yang-Seok Oh, Yeo Sung Yoon, Je Kyung Seong
Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in Spontaneously Hypertensive Rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC)...
August 16, 2018: Journal of Veterinary Medical Science
Eric S Muckley, Liam F Collins, Anton V Ievlev, Xinyi Ye, Kim Kisslinger, Bobby G Sumpter, Nickolay V Lavrik, Chang-Yong Nam, Ilia N Ivanov
Oxygen and water vapor sensing properties are investigated in metal-oxide- hybrid polymer nanocomposite thin films generated by infiltration synthesis, which incorporates molecular ZnO into the matrix of SU-8 polymer, a common negative-tone photoresist. The hybrid thin films display 20-fold higher gravimetric responses to oxygen and water vapor than those of control ZnO thin films in the dark. An additional 50 - 500% enhanced responses are detected under ultraviolet (UV) irradiation. The overall enhanced gravimetric response in the hybrid film is attributed to the ZnO molecules distributed in the polymer matrix while the UV enhancement is explained by the light-induced, reversible generation of hydrophilic fluoroantimonic acid from triarylsulfonium hexafluoroantimonate photo-acids, which leads to the increased surface potential and adsorption energies for oxygen and water...
August 16, 2018: ACS Applied Materials & Interfaces
Artit Chingsungnoen, Sujira Maneerat, Poramate Chunpeng, Phitsanu Poolcharuansin, Rachanee Nam-Matra
A low-pressure capacitively coupled discharge was used to study antimicrobial treatment in herbal tea. Ambient air with a relative humidity of 40% was used as a precursor gas and fed into the chamber via a perforated power electrode. An electrical discharge plasma was produced at a radio frequency of 10 kHz and power of 80 W. The operating pressure during treatment was kept constant at 260 Pa. The target microorganisms, Escherichia coli and Staphylococcus aureus, isolated from the herbal tea were inoculated on nutrient agar petri dishes and exposed to the plasma for 0...
August 15, 2018: Journal of Food Protection
Hoang Thi Nam Giang, Keita Banno, Le Huu Nhat Minh, Lam Tuyet Trinh, Le Thai Loc, Asmaa Eltobgy, Luu Lam Thang Tai, Adnan Khan, Nguyen Hoang Tuan, Yaser Reda, Maryan Samsom, Nguyen Tran Nam, Nguyen Tien Huy, Kenji Hirayama
We systematically searched and meta-analyzed the epidemiological characteristics, frequency of clinical signs, and outcomes of dengue-associated hemophagocytic lymphohistiocytosis. Ten electronic databases were searched systematically plus manual search of reference lists to identify relevant articles published until May 2017. The highest number of reported cases were from South-East Asia region (62 cases), followed by Western Pacific region (20 cases), and America (31 cases). The term "dengue hemorrhagic fever" predominated in studies that used the World Health Organization 1997 definition (59...
August 15, 2018: Reviews in Medical Virology
Da Jeong Nam, Hyuk Won Kwon, Haeyeon Lee, Eun Kyung Ahn
No abstract text is available yet for this article.
July 2018: Healthcare Informatics Research
Anna R Zuena, Luisa Iacovelli, Rosamaria Orlando, Luisa Di Menna, Paola Casolini, Giovanni Sebastiano Alemà, Gabriele Di Cicco, Giuseppe Battaglia, Ferdinando Nicoletti
mGlu5 receptor-mediated polyphosphoinositide (PI) hydrolysis is classically measured by determining the amount of radioactivity incorporated in inositolmonophosphate (InsP) after labeling of membrane phospholipids with radioactive inositol. Although this method is historically linked to the study of mGlu receptors, it is inappropriate for the assessment of mGlu5 receptor signaling in vivo . Using a new ELISA kit we showed that systemic treatment with the selective positive allosteric modulator (PAM) of mGlu5 receptors VU0360172 enhanced InsP formation in different brain regions of CD1 or C57Black mice...
2018: Frontiers in Pharmacology
Nam X Nguyen, Jean-Paul Armache, Changkeun Lee, Yi Yang, Weizhong Zeng, Vamsi K Mootha, Yifan Cheng, Xiao-Chen Bai, Youxing Jiang
In this Article, ref. 15 has been replaced and references 32 to 50 have been renumbered online.
August 14, 2018: Nature
Florian D Grill, Lucas M Ritschl, Hannes Dikel, Andrea Rau, Maximilian Roth, Markus Eblenkamp, Klaus-Dietrich Wolff, Denys J Loeffelbein, Franz X Bauer
Nasoalveolar molding (NAM) aims to improve nasal symmetry with a nasal stent in cleft lip and palate (CLP) patients. When plates have to be exchanged because of dentoalveolar growth or cleft reduction, the nasal stent has to be mounted onto a new plate. This procedure elongates visiting hours for patients and parents or requires second treatment sessions. This study introduces a quick-lock additive manufacturing solution for chairside nasal stent exchange called RapidNAM. A novel taping retention pin has been designed that enables nasal stent insertion...
August 14, 2018: Scientific Reports
Fei Shang, Jinli Chen, Lulu Wang, Liming Jin, Linhai Zou, Tingting Bu, Yuesheng Dong, Nam-Chul Ha, Ki Hyun Nam, Chunshan Quan, Yongbin Xu
The nicotinamidase/pyrazinamidase PncA is a member of a large family of hydrolase enzymes that catalyze the deamination of nicotinamide to nicotinic acid. PncA also functions as a pyrazinamidase in a wide variety of eubacteria and is an essential coenzyme in many cellular redox reactions in living systems. We report the crystal structure of substrate-free PncA from Bacillus subtilis (BsPncA) at 2.0 Å resolution to improve our understanding of the PncA family. The structure of BsPncA consists of an α/β domain and a subdomain...
August 11, 2018: Biochemical and Biophysical Research Communications
Jung Youn Kim, Ji Eun Park, Youngheun Jo, Woo Hyun Shim, Soo Jung Nam, Jeong Hoon Kim, Roh-Eul Yoo, Seung Hong Choi, Ho Sung Kim
Background: Pseudoprogression is a diagnostic challenge in early post-treatment glioblastoma. We therefore developed and validated a radiomics model using multiparametric MRI to differentiate pseudoprogression from early tumor progression in patients with glioblastoma. Methods: The model was developed from the enlarging contrast-enhancing portions of 61 glioblastomas within 3 months after standard treatment with 6472 radiomic features being obtained from contrast-enhanced T1-weighted imaging, fluid-attenuated inversion recovery imaging, and apparent diffusion coefficient (ADC), and cerebral blood volume (CBV) maps...
August 11, 2018: Neuro-oncology
Shuai Wang, Gyutae Nam, Ping Li, Haeseong Jang, Jia Wang, Min Gyu Kim, Zexing Wu, Xien Liu, Jaephil Cho
Developing highly efficient non-noble metal electrocatalysts for oxygen electrode reactions is highly desirable for industrial scale application in energy related devices. Herein, two new kinds of Ni (POxN3-x)2/NPC and Co (POxN3-x)2/NPC (NPC: N, P-co-doped carbon) are synthesized through a facile post-treatment of nickel- or cobalt-phytic acid xerogel, followed by an annealing procedure under an argon and ammonia atmosphere at 800 °C. The as-prepared catalysts exhibit outstanding catalytic activities for both the oxygen reduction and evolution reactions, which are comparable to those of Pt/C and IrO2...
August 14, 2018: Nanoscale
Nicholas T Gamboa, Michael Karsy, Joseph T Gamboa, Nam K Yoon, Meghan J Driscoll, Joshua A Sonnen, Karen L Salzman, Randy L Jensen
Background: Ependymomas are rare neuroepithelial tumors thought to arise from radial glial precursor cells lining the walls of the ventricles and central canal of the brain and spinal cord, respectively. Histopathological classification, according to World Health Organization criteria, has only recently defined the RELA-fusion positive ependymoma. These tumors may account for 70% of supratentorial ependymomas in children and represent an aggressive entity distinct from other ependymomas...
2018: Surgical Neurology International
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