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Breast cancer meta-analysis

Alison Chopel, Danielle Soto, Bre'Jaynae Joiner, Tina Benitez, Ruth Konoff, Lucy Rios, Elva Castellanos
BACKGROUND: Young mothers (age 14-24 years), who are often low income, are less likely than other mothers to breastfeed for 6 months. They also are more likely to be diagnosed with aggressive forms of breast cancer; breastfeeding significantly reduces this risk. While adolescent breastfeeding has been investigated from the perspective of the individual, the social ecological model recognizes the influence of factors at multiple levels. RESEARCH AIM: The aim was to identify social and structural barriers to and motivators of breastfeeding that young mothers may encounter...
December 5, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
Abdolkarim Moazeni-Roodi, Saeid Ghavami, Mohammad Hashemi
Growing evidence propose an association between miRNA polymorphisms and cancer susceptibility. This study aimed to examine the impact of miR-605 rs2043556 polymorphism on cancer risk through a meta-analysis based on 3198 cancer cases and 4943 controls. Eligible studies were retrieved by searching Web of Science, PubMed, Scopus, and Google scholar databases up to August 27, 2018. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effect model to estimate the strength of association between rs2043556 variant of miR-605 and cancer risk...
December 3, 2018: MicroRNA
Vincenza Gianfredi, Daniele Nucci, Angela Abalsamo, Mattia Acito, Milena Villarini, Massimo Moretti, Stefano Realdon
Breast cancer (BC) is the most common cancer in women and several factors are involved in its onset. Green tea (GT) has been shown to have potential beneficial effects on different types of cancer. The aim of this review was to evaluate the association between GT regular consumption and risk of BC in women. The risk of BC recurrence and risk of BC in relation to menopausal status were also evaluated. A literature search of PubMed, Scopus, and Web of Science was conducted. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed to perform the systematic review and meta-analysis...
December 3, 2018: Nutrients
Ellen Warner
Women with BRCA mutations, who choose to decline or defer risk-reducing mastectomy, require a highly sensitive breast screening regimen they can begin by age 25 or 30. Meta-analysis of multiple observational studies, in which both mammography and magnetic resonance imaging (MRI) were performed annually, demonstrated a combined sensitivity of 94% for MRI plus mammography compared to 39% for mammography alone. There was negligible benefit from adding screening ultrasound or clinical breast examination to the other two modalities...
November 30, 2018: Cancers
David J Finitsis, Brittany A Vose, Justin G Mahalak, Andrew L Salner
OBJECTIVE: Adjuvant Endocrine Therapy (AET) significantly reduces risk of breast cancer recurrence in those patients whose tumor tests hormone (estrogen and/or progesterone) receptor positive. Many who are prescribed AET do not adhere adequately. Studies have sought to examine the effects of interventions to enhance patients' AET adherence, with strikingly mixed results. In order to reconcile a disparate literature, this paper aims to (1) quantitatively review the aggregate effect of interventions designed to optimize AET adherence within the current literature; and (2)meta-analyze these effects across studies' by intervention design...
December 4, 2018: Psycho-oncology
Shuyu Liu, Dan Zhang, Jiarui Wu, Kaihuan Wang, Yi Zhao, Mengwei Ni, Ziqi Meng, Xiaomeng Zhang
OBJECTIVE: This meta-analysis synthesized the available evidence on the effectiveness and safety of Shenqi Fuzheng injection (SQFZI) combined with chemotherapy for breast cancer. METHOD: A comprehensive systematic literature search was conducted to identify the randomized controlled trials (RCTs) on breast cancer treated by SQFZI in several electronic database up to October 29, 2017. The included RCTs were assessed using the Cochrane Collaboration tool; data were extracted and analyzed via RevMan 5...
December 4, 2018: Integrative Cancer Therapies
Tingting Zhang, Fubin Feng, Wenge Zhao, Yan Yao, Jinhui Tian, Chao Zhou, Chuanxin Zang, Cun Liu, Xue Wang, Changgang Sun
Background: We performed a network meta-analysis of randomized controlled trials (RCTs) to indirectly compare the efficacy of different targeted agents with fulvestrant for patients with hormone-receptor-positive (HR+) and human epidermal growth factor receptor type 2-negative (HER2-) advanced breast cancer (ABC) following progression on prior endocrine therapy. Methods: The titles/abstracts were searched from the PubMed, EMBASE, and the Cochrane Library databases for RCTs to evaluate the efficacy of palbociclib plus fulvestrant vs alternative targeted therapies plus fulvestrant for postmenopausal HR+/HER2- ABC following progression on prior endocrine therapy...
2018: Cancer Management and Research
Violante Di Donato, Michele Carlo Schiavi, Valentina Iacobelli, Ottavia D'oria, Evangelos Kontopantelis, Tommaso Simoncini, Ludovico Muzii, Pierluigi Benedetti Panici
OBJECTIVE: To evaluate the tolerability and safety of ospemifene in treating dyspareunia associated with postmenopausal vulvo- vaginal atrophy (VVA). METHODS: The literature was searched through to 31 July 2018 to identify randomized controlled trials comparing ospemifene 60 mg against placebo for the treatment of VVA. Two groups of outcomes were selected: 1) side-effects, including hot flushes, urinary tract infection (UTI), headache, deep venous thrombosis (DVT), coronary heart disease (CHD), cardiovascular event (CVE), discontinuation due to side-effects, serious adverse event (SAE); 2) Safety, in relation to endometrial thickness, vaginal bleeding, breast tenderness, breast and endometrial cancer...
November 28, 2018: Maturitas
Yu Deng, Jialing Zou, Ting Deng, Junying Liu
BACKGROUND: Previous studies examining the prognostic value of glucose transporter 1 in breast cancer have yielded inconsistent results. We, therefore, performed a meta-analysis to clarify this issue. METHODS: The research was reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Relevant studies were retrieved from PubMed, Web of Science, EMBASE, and Cochrane library. RESULTS: A total of 7 reports with 1861 patients were finally chosen...
November 2018: Medicine (Baltimore)
Jue-Sheng Ong, Puya Gharahkhani, Jiyuan An, Matthew H Law, David C Whiteman, Rachel E Neale, Stuart MacGregor
There is considerable debate regarding the role that 25-hydroxyvitamin D [25(OH)D] concentrations play in cancer risk or mortality, with earlier studies drawing mixed conclusions. Using data from the UK Biobank (UKB), we evaluate whether genetically predicted 25(OH)D concentrations are associated with overall cancer susceptibility and cancer mortality using five 25(OH)D genetic markers. Data comprised 438 870 white British UKB participants aged 37-73, including 46 155 cancer cases and 6998 cancer-specific deaths...
December 15, 2018: Human Molecular Genetics
Zackariah Clement, James Kollias, Janne Bingham, Robert Whitfield, Melissa Bochner
Background: The risk of hormone positive breast cancer extends beyond 5 years. Extended duration of tamoxifen to 10 years has been shown to improve overall survival (OS) and disease-free survival (DFS). In post-menopausal women aromatase inhibitor (AI) is the gold standard for adjuvant endocrine therapy. Several randomized controlled trials (RCTs) showed benefit with extending the duration of AIs in post-menopausal women. However, the duration and the overall benefit is still controversial...
October 2018: Gland Surgery
Ritika Gera, Salim Tayeh, Hiba El-Hage Chehade, Kefah Mokbel
BACKGROUND/AIM: Hypoactive sexual desire disorder (HSDD) is hypothesised to manifest in postmenopausal women at onset of menopause due to decreased oestrogen levels. Transdermal testosterone is a potential treatment option. This systematic review explores the relationship between the incidence of breast cancer and transdermal testosterone use. MATERIALS AND METHODS: Searches were conducted on the PubMed and Ovid databases. In Ovid, the advanced search function was used: 'transdermal testosterone not male'...
December 2018: Anticancer Research
Lei Yuan, Jun Liu, Wenhui He, Youmei Bao, Lei Sheng, Chunyang Zou, Baichun Hu, Wentao Ge, Yang Liu, Jian Wang, Bin Lin, Yanchun Li, Enlong Ma
Drug resistance and cancer cells metastasis have been the leading causes of chemotherapy failure and cancer-associated death in breast cancer patients. In present, various active molecules either exhibiting novel mechanism of action such as inducing autophagy or inhibiting metastasis have been developed to address these problems. However, the compounds exhibiting such dual functions have rarely been described. Previous work in our group showed that TSA, as a synthetic analog of asperphenamate, induced autophagic cell death in breast cancer cells instead of apoptosis...
November 22, 2018: Bioorganic Chemistry
Volkan Turan, Molly M Quinn, Nurten Dayioglu, Mitchell P Rosen, Kutluk Oktay
OBJECTIVE: To evaluate the impact of cancer diagnosis on response to ovarian stimulation for fertility preservation. DESIGN: Meta-analysis. SETTING: Not applicable. PATIENT(S): An electronic-based search was performed with the use of PubMed until May 2018 limited to English-language articles. In the final analysis, 10 case-controlled retrospective cohort studies were included, comparing ovarian response to stimulation between women with cancer and age-matched healthy women (control group)...
December 2018: Fertility and Sterility
Yanli Yan, Long Zhang, Li Tan, Xiaowei Ma, Yong Zhang, Shuai Shao, Jiaxin Liu, Chaofan Xue, Zongfang Li, Xiaozhi Zhang, Emmanuel Kwateng Drokow, Xiaoting Shi, Juan Ren
The management of ductal carcinoma in situ (DCIS) with endocrine therapy remains controversial. A meta-analysis was conducted to evaluate the role of endocrine therapy for DCIS with breast conserving surgery (BCS) and radiotherapy (RT). A total of 7 articles with randomized controlled trials were included. Five articles compared the effects of BCS and RT followed by tamoxifen (TAM) or not (BCS + RT + TAM vs BCS + RT) and 2 compared the effects of TAM and anastrozole (ANA). TAM obviously reduced the rates of recurrence of ipsilateral breast cancer (IBCR), recurrence of contralateral breast cancer (CBCR), recurrence of ipsilateral invasive breast cancer (IBCR-INV) and recurrence of contralateral DCIS (CBCR-DCIS), and increased the rate of event-free survival (EFS)...
November 29, 2018: Pathology Oncology Research: POR
Anne T Collins, Shona H Lang
Patient-derived xenograft (PDX) models are increasingly being used in oncology drug development because they offer greater predictive value than traditional cell line models. Using novel tools to critique model validity and reliability we performed a systematic review to identify all original publications describing the derivation of PDX models of colon, prostate, breast and lung cancer. Validity was defined as the ability to recapitulate the disease of interest. The study protocol was registered with the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES)...
2018: PeerJ
Hilde Tinderholt Myrhaug, Julia Aneth Mbalilaki, Nataskja-Elena Kersting Lie, Tone Hansen, Jan Egil Nordvik
PURPOSE: To summarize evidence on the effects of multidisciplinary psychosocial rehabilitation interventions for adult cancer patients on fatigue, quality of life, participation, coping, and self-efficacy. MATERIALS AND METHODS: We searched MEDLINE, Embase, PyscINFO, PEDro, OT Seeker, Sociological Abstracts, CINAHL, and Cochrane CENTRAL for randomized controlled trials. Two reviewers selected articles independently. RESULTS: Thirty-one articles were included and four meta-analyses were conducted...
November 29, 2018: Disability and Rehabilitation
Leimarembi Devi Naorem, Mathavan Muthaiyan, Amouda Venkatesan
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor clinical outcomes and lack of approved targeted therapy. Dysregulated microRNAs (miRNAs) have been considered a promising biomarker, which plays an important role in the tumorigenesis of human cancer. Due to the increase in miRNA profiling datasets of TNBC, a proper analysis is required for studying. Therefore, this study used meta-analysis to amalgamate ten miRNA profiling studies of TNBC. By the robust rank aggregation method, metasignatures of six miRNAs (4 upregulated: hsa-miR-135b-5p, hsa-miR-18a-5p, hsa-miR-9-5p and hsa-miR-522-3p; 2 downregulated: hsa-miR-190b and hsa-miR-449a) were obtained...
November 29, 2018: Journal of Cellular Physiology
Qiuxiang Zhang, Heng Zhao, Yaning Zheng
OBJECTIVE: The purpose of this systematic review and meta-analysis was to evaluate the effectiveness of mindfulness-based stress reduction (MBSR) in breast cancer patients. METHODS: A systematic search of Cochrane Library, Cochrane Central Register of Controlled Trials, PsycINFO database, Web of science, Medline, EMBASE, CNKI, and CBM database was carried out from February to May 2018, with no language restrictions. Trials examining the effects of MBSR versus control group on symptom variables and health-related quality of life were included...
November 28, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Mansour Moghimi, Saeed Kargar, Mohammad Ali Jafari, Hossein Ahrar, Mohammad Hossein Jarahzadeh, Hossein Neamatzadeh, Jalal Sadeghizadeh- Yazdi
Background: A number of case-control studies were conducted to investigate the association of angiotensin converting enzyme insertion/deletion (ACE I/D) polymorphism with breast cancer. But the results remain controversial. This meta-analysis aims to comprehensively evaluate the association of ACE I/D polymorphism with breast cancer. Method: A comprehensive literature search on PubMed, Google Scholar, SCOPUS and ISI Web of Knowledge databases for studies published up to June 01, 2018 was performed. Summary odds ratios (ORs) and 95% confidence intervals (CI) were estimated...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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