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Breast cancer meta-analysis

Nooshin Hashemi-Sadraei, Gaëlle M Müller-Greven, Fadi W Abdul-Karim, Ilya Ulasov, Erinn Downs-Kelly, Monica E Burgett, Adam Lauko, Maha A Qadan, Robert J Weil, Manmeet S Ahluwalia, Lingling Du, Richard A Prayson, Samuel T Chao, Thomas G Budd, Jill Barnholtz-Sloan, Amy S Nowacki, Ruth A Keri, Candece L Gladson
BACKGROUND: Macroautophagy/autophagy is considered to play key roles in tumor cell evasion of therapy and establishment of metastases in breast cancer. High expression of LC3, a residual autophagy marker, in primary breast tumors has been associated with metastatic disease and poor outcome. FIP200/Atg17, a multi-functional pro-survival molecule required for autophagy, has been implicated in brain metastases in experimental models. However, expression of these proteins has not been examined in brain metastases from patients with breast cancer...
August 9, 2018: Journal of Neuro-oncology
Angela K Green, Emeline M Aviki, Konstantina Matsoukas, Sujata Patil, Deborah Korenstein, Victoria Blinder
PURPOSE: We conducted a systematic review and meta-analysis to measure the extent to which race is associated with delayed initiation or receipt of inadequate chemotherapy among women with early-stage breast cancer. METHODS: We performed a systematic search of all articles published from January 1987 until June 2017 within four databases: PubMed/Medline, EMBASE, CINAHL, and Cochrane CENTRAL. Eligible studies were US-based and examined the influence of race on chemotherapy delays, cessation, or dose reductions among women with stage I, II, or III breast cancer...
August 9, 2018: Breast Cancer Research and Treatment
Yanal Alnimer, Zakaria Hindi, Khalil Katato
Introduction: Multiple trials demonstrated that adding Bevacizumab to the standard neoadjuvant chemotherapy in HER-2 negative breast cancer increases pathological complete response. We conducted this meta-analysis to evaluate that effect on survival. Methods: We performed a systematic search for randomized trials measuring the effect of adding either neoadjuvant or adjuvant Bevacizumab to the standard chemotherapy on disease-free and overall survival in breast cancer surgical candidates...
2018: Breast Cancer: Basic and Clinical Research
Sajjad Moradi, Amos Issah, Hamed Mohammadi, Khadijeh Mirzaei
OBJECTIVES: Dietary inflammatory index (DII) scores have been inconsistently linked to cancer risks. Therefore, a systematic review and meta-analysis was performed to examine the associations between the DII and the risks of breast and prostate cancer among men and women. METHODS: Relevant studies were identified by searching PubMed and EMBASE databases up to March 2018. Data were available from 13 studies; of these, four studies used a prospective cohort design and nine studies were case-control studies...
May 25, 2018: Nutrition
Wim G Groen, Wim H van Harten, Jeff K Vallance
BACKGROUND: Physically active cancer survivors have a reduced risk of cancer recurrence and mortality. Given the health advantages of active lifestyles in cancer survivorship, as well as the barriers preventing physical activity (e.g., geography, time) there is a need to develop and evaluate effective physical activity interventions that employ distance-based (i.e., non face-to-face) approaches. The primary objective of this study was to provide a systematic review and meta-analysis of present-day (2013-2018) distance-based physical activity behaviour change interventions for cancer survivors...
July 21, 2018: Cancer Treatment Reviews
Martijn de Roon, Anne M May, Anne McTiernan, Rob J P M Scholten, Petra H M Peeters, Christine M Friedenreich, Evelyn M Monninkhof
BACKGROUND: Physical inactivity and being overweight are modifiable lifestyle risk factors that consistently have been associated with a higher risk of postmenopausal breast cancer in observational studies. One biologic hypothesis underlying this relationship may be via endogenous sex hormone levels. It is unclear if changes in dietary intake, physical activity, or both, are most effective in changing these hormone levels. OBJECTIVE: This systematic review and meta-analysis examines the effect of reduced caloric dietary intake and/or increased exercise levels on breast cancer-related endogenous sex hormones...
August 2, 2018: Breast Cancer Research: BCR
Naseem Akhter, Sajad A Dar, Shilpi Chattopadhyay, Shafiul Haque, Razique Anwer, Mohd Wahid, Arshad Jawed, Mohtashim Lohani, Raju K Mandal, N K Shukla, Yasir Abdul, Syed Akhtar Husain
Background: Genetic changes in p53 gene contribute to breast cancer susceptibility. Objective and Methods: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk...
August 2018: Current Genomics
Jiaqi Li, Bo Li, Qiyu Jiang, Yingshi Zhang, Aixia Liu, Huan Wang, Juling Zhang, Qin Qin, Zhixian Hong, Bo-An Li
BACKGROUND: To identify the most suitable genetic model for detecting the risk of breast cancer (BC)/ovarian cancer (OC) in specific populations. METHODS: Databases were searched for related studies published up to October 2017. First, VDR genetic polymorphisms were compared in patients with and without cancer. Second, a network meta-analysis was used to reveal the relation between VDR genetic polymorphisms with disease outcomes. Subgroup analyses and a meta-regression were performed according to cancer types, ethnicity and genotypic method...
July 27, 2018: Gene
Carlo Messina, Carlo Cattrini, Giulia Buzzatti, Luigi Cerbone, Elisa Zanardi, Marco Messina, Francesco Boccardo
PURPOSE: Combining CDK4/6 inhibitors and endocrine therapy (ET) improved outcomes for the treatment of metastatic HR+/HER2- breast cancers. Here, we performed a meta-analysis of randomized clinical trials (RCTs) to better define the benefit and the risk of CDK4/6 inhibitors plus ET for endocrine-sensitive or endocrine-resistant population in metastatic HR+/HER2- breast cancer. METHOD: A systematic literature search of Pubmed, Embase, and the Cochrane Library was carried out up to 30 June 2018...
July 27, 2018: Breast Cancer Research and Treatment
Francisca Honold, Mauricio Camus
INTRODUCTION: Women who have mutations in BRCA genes have a high risk of developing breast cancer. Therefore, multiple preventive strategies have been proposed, within which is prophylactic mastectomy. Considering physical and psychological effects of surgery, the controversy is established as to whether the preventive effect exceeds that of active vigilance. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
July 9, 2018: Medwave
Ricvan Dana Nindrea, Teguh Aryandono, Lutfan Lazuardi, Iwan Dwiprahasto
Objective: The aim of this study was to determine the diagnostic accuracy of different machine learning algorithms for breast cancer risk calculation. Methods: A meta-analysis was conducted of published research articles on diagnostic test accuracy of different machine learning algorithms for breast cancer risk calculation published between January 2000 and May 2018 in the online article databases of PubMed, ProQuest and EBSCO. Paired forest plots were employed for the analysis. Numerical values for sensitivity and specificity were obtained from false negative (FN), false positive (FP), true negative (TN) and true positive (TP) rates, presented alongside graphical representations with boxes marking the values and horizontal lines showing the confidence intervals (CIs)...
July 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Fatemeh Salamat, Babak Niakan, Abbasali Keshtkar, Elahe Rafiei, Manoosh Zendehdel
Background: Researchers suggest that benign breast disease (BBD) is a key risk factor for breast cancer. The present study aimed to determinate the risk level of breast cancer in terms of various BBD subgroups. Methods: A meta-analysis was performed to determinate the risk of breast cancer associated with BBD. Observational studies (traditional case-control studies, nested case-control studies, and cohort studies) published from January 2000 to June 2015 were assessed to evaluate the risk of developing breast cancer related to BBD...
July 2018: Iranian Journal of Medical Sciences
Ahmad Jayedi, Alireza Emadi, Sakineh Shab-Bidar
Existing evidence suggests a link between the inflammatory potential of diet and risk of cancer. This study aimed to test the linear and potential nonlinear dose-response associations of the Dietary Inflammatory Index (DII), as being representative of inflammatory features of the diet, and site-specific cancer risk. A systematic search was conducted with the use of PubMed and Scopus from 2014 to November 2017. Prospective cohort or case-control studies reporting the risk estimates of any cancer type for ≥3 categories of the DII were selected...
July 1, 2018: Advances in Nutrition
Leandro Fórnias Machado de Rezende, Leandro Martin Totaro Garcia, Grégore Iven Mielke, Dong Hoon Lee, Kana Wu, Edward Giovannucci, José Eluf-Neto
BACKGROUND: Physical activity is associated with lower risk of colon and breast cancers. Herein we estimated preventable fractions of colon and breast cancers in Brazil by increasing population-wide physical activity to different counterfactual scenarios. METHODS: We used data from a representative national survey in Brazil and corresponding relative risks of colon and postmenopausal breast cancers from a meta-analysis. Estimated cancer incidence was retrieved from GLOBOCAN and Brazilian National Cancer Institute...
July 19, 2018: Cancer Epidemiology
H-F Li, Q Xie, Q-W Nie, X Ye
OBJECTIVE: To determine whether prostate-specific antigen (PSA) could serve as a biomarker for breast cancer. MATERIALS AND METHODS: We performed an electronic search on Medline, PubMed, SPRINGER, John Wiley, Science Direct, EBSCO, CNKI and Wanfang Data to identify relevant studies for our meta-analysis. The search terms included ['prostate specific antigen' or 'PSA' (MESH)] and ['breast cancer' or 'breast carcinoma' (MESH)]. RESULTS: A comprehensive meta-analysis of 10 studies comprising of 770 cases and 799 controls were included...
July 2018: European Review for Medical and Pharmacological Sciences
Li Gu, Chang Cao, Jing Fu, Qian Li, De-Hua Li, Ming-Yao Chen
BACKGROUND: Accumulating data have found that adiponectin is involved in development of breast cancer (BC). However, these results were inconsistent. METHOD: A systematic search in PubMed, Embase, ISI Web of Science, and Chinese National Knowledge Infrastructure databases were conducted up to October 1, 2017. The standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size. RESULTS: Finally, 31 eligible studies were included in this meta-analysis...
July 2018: Medicine (Baltimore)
Wen Gao, Ning Guo, Ting Dong
BACKGROUND: Diffusion-weighted imaging (DWI) is suggested as an non-invasive and non-radioactive imaging modality in the identification of pathological complete response (pCR) in breast cancer patients receiving neoadjuvant chemotherapy (NACT). A growing number of trials have been investigating in this aspect and some studies found a superior performance of DWI compared with conventional imaging techniques. However, the efficiency of DWI is still in dispute. This meta-analysis aims at evaluating the accuracy of DWI in the detection of pCR to NACT in patients with breast cancer...
July 18, 2018: World Journal of Surgical Oncology
Wei Diao, Fangfang Tian, Zhiyun Jia
PURPOSE: To evaluate the prognostic value of maximum standardized uptake values (SUVmax ) measured in the primary lesion and axillary lymph nodes (ALN) by pretreatment fluorine-18-fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET) or positron emission tomography/computed tomography (PET/CT) in patients with breast cancer. METHODS: We systematically searched PubMed, Embase, and the Cochrane Library. The primary prognosis endpoint was event-free survival (EFS), and the secondary endpoint was overall survival (OS)...
August 2018: European Journal of Radiology
S F McGee, S Mazzarello, J M Caudrelier, M A G Lima, B Hutton, M Sienkiewicz, C Stober, R Fernandes, M F K Ibrahim, L Vandermeer, J Hilton, R Shorr, D Fergusson, M Clemons
IMPORTANCE: Clinical equipoise exists around the optimal time to start adjuvant endocrine therapy in patients who will receive post-operative radiotherapy for breast cancer. Concerns continue to exist regarding potential reduced efficacy, or increased toxicity, when radiation, and endocrine therapy are administered concurrently. OBJECTIVE: To perform a systematic review of studies comparing outcomes between sequential and concurrent adjuvant radiation and endocrine therapy in early-stage breast cancer...
June 28, 2018: Cancer Treatment Reviews
Sara Miranda, Alda Marques
OBJECTIVES: Chronic cardiovascular diseases, cancer, chronic respiratory diseases and diabetes are the four major groups of non-communicable diseases (NCDs) and the main cause of mortality worldwide. Pilates has been described as an effective intervention to promote healthy behaviors and physical activity in people with chronic diseases. However, the evidence of its effects in NCDs have not been systematized. We investigated the effects of Pilates in the four major groups of NCDs. DESIGN: A systematic review was performed...
August 2018: Complementary Therapies in Medicine
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