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Upper gastrointestinal cancer

P Cresta Morgado, M Daud, M Carballido, G Méndez, S Iseas, V Lobbe, G De Simone, A Navigante
BACKGROUND: Muscle function and its correlation with body composition and weight loss have not been studied deeply in pancreas and gastrointestinal cancers. This research aims to determine the skeletal muscle function and its relationship with body compartments, significant weight loss, and performance status (ECOG) 0-2 in a population with advanced digestive cancers. METHODS: A cross-sectional study was designed to determine the relationship between muscular function, weight loss, and body composition...
August 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Ting Hway Wong, Zheng Yi Lau, Whee Sze Ong, Kelvin Bryan Tan, Yu Jie Wong, Mohamad Farid, Melissa Ching Ching Teo, Alethea Chung Pheng Yee, Hai V Nguyen, Marcus Eng Hock Ong, N Gopalakrishna Iyer
BACKGROUND: Cancer patients contribute significantly to emergency department (ED) utilization. The objective of this study was to identify factors associated with patients becoming ED frequent attenders (FA) after a cancer-related hospitalization. METHODS: A retrospective cohort study was conducted using national administrative, billing, and death records of Singapore residents discharged alive from Singapore public hospitals from January 2012 to December 2015, with a primary discharge diagnosis of cancer...
August 17, 2018: Cancer Medicine
Linkun Yin, Shuxin Wang, Siyang Zuo
BACKGROUND: Flexible endoscopes have become an important tool for the diagnosis and treatment of gastric cancer. However, there are several limitations to the use of endoscopes in rural areas, including their high cost, poor portability, and unstable platform. METHODS: This paper presents a novel low-cost outer sheath for stomach screening. The sheath uses braided shape memory polymer (SMP) tubes with a water-jet to control the stiffness and bending motion. The insertion part of the prototype is 250 mm long with a maximum outer diameter of 16 mm and incorporates an internal charge-coupled device camera...
August 14, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
Mika Miura, Masahiko Ohtaka, Mitsuhiko Hanawa, Atsuko Kitahashi, Yuichi Hirose, Kazuhiko Takaso, Yoshioki Yoda, Ichiro Takayama, Zentarou Yamagata, Nobuyuki Enomoto
The LZ test "Eiken" for H. pylori antibody (LZ test) was examined. In patients with an antibody titer of ≥3.0U/mL and <10.0U/mL among 698 patients who underwent breath tests, the status of H. pylori infection was assessed from the results of the 13 C urea breath test and the findings of gastric mucosal atrophy by performing an upper gastrointestinal endoscopy. A positive 13 C urea breath test was observed in 22.3% of these patients (156/698, 95% confidence interval 19.4-25.6%), and gastric mucosal atrophy of C-2 or greater was observed in 39...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Ioannis S Papanikolaou, Georgios Tziatzios, Paraskevas Gkolfakis, Konstantinos Triantafyllou
Patients with classical familial adenomatous polyposis (FAP) are at high risk for developing colorectal cancer (CRC) and duodenal adenomas. Current guidelines recommend to start duodenal screening at the age of 25-30 years and standard upper gastrointestinal (GI) endoscopy is considered inadequate for an optimal visualization of the duodenum. We used the Full-Spectrum Endoscopy® (FUSE® ; EndoChoice Inc., Atlanta, GA, USA) esophagogastroduodenoscope (FUSE-EGD) for an upper GI screening procedure of a 20-year-old Caucasian male with classical FAP...
July 2018: Annals of Translational Medicine
Andrew Hunt, Prajnan Das, Bruce D Minsky, Eugene J Koay, Sunil Krishnan, Joseph M Herman, Cullen Taniguchi, Albert Koong, Grace L Smith, Emma B Holliday
BACKGROUND: We sought to determine the role of abdominal reirradiation for patients presenting with recurrent or new primary gastrointestinal (GI) malignancies. At our institution, we have established a hyperfractionated, accelerated reirradiation regimen consisting of 39 Gray (Gy) in 26 twice-daily fractions. Although this regimen is used frequently in the pelvis, we sought to determine its toxicity and efficacy for abdominal tumors. METHODS: Twenty-four patients who received abdominal reirradiation with a hyperfractionated, accelerated approach from 2000 to 2017 were identified...
August 7, 2018: Radiation Oncology
I-Chan Huang, Nickhill Bhakta, Tara M Brinkman, James L Klosky, Kevin R Krull, DeoKumar Srivastava, Melissa M Hudson, Leslie L Robison
Background: Financial hardship among survivors of pediatric cancer has been understudied. We investigated determinants and consequences of financial hardship among adult survivors of childhood cancer. Methods: Financial hardship, determinants, and consequences were examined in 2811 long-term survivors (mean age at evaluation = 31.8 years, years postdiagnosis = 23.6) through the baseline survey and clinical evaluation. Financial hardship was measured by material, psychological, and coping/behavioral domains...
August 1, 2018: Journal of the National Cancer Institute
Fayaz Ahmad Wani, Gulnaz Bashir, Mushtaq Ahmad Khan, Showkat Ali Zargar, Zubaida Rasool, Qurteeba Qadri
Background: Helicobacter pylori infection is recognised as type 1 carcinogen by the International Agency of Research on Cancer. Previous studies in our hospital have revealed high prevalence of H. pylori in our population with a high recurrence rate after completion of treatment. This prompted us to undertake this study. Aim: This study aimed to determine common gene mutations leading to resistance to clarithromycin, metronidazole, tetracycline and quinolones in H...
April 2018: Indian Journal of Medical Microbiology
Parth Kanaiyalal Patel, Mishal Shah, Sanjeev Patni, Shashikant Saini
BACKGROUND: Anastomosis in gastrointestinal (GI) surgery is a commonly performed procedure. Irrelevant various methods of intestinal anastomosis were followed - recent advance is the use of a stapler as a device for GI anastomosis. Due to the use of staplers, technical failures are a rarity, anastomosis is more consistent and can be used at difficult locations. MATERIALS AND METHODS: : Between 2008 and August 2016, 75 patients with esophagus or gastroesophageal junction carcinoma underwent curative intent resection either via a right posterolateral thoracotomy (TTE) or transhiatal esophagectomy or video-assisted thoracoscopic surgery with linear stapler anastomosis...
October 2017: Indian Journal of Cancer
Tsugitoshi Onuki, Eri Morita, Noritaka Sakamoto, Yoshiaki Nagai, Masafumi Sata, Koichi Hagiwara
Pembrolizumab is an immune checkpoint inhibitor that induces side effects called "immune-related adverse events" (irAEs). Various types of organs are affected by irAEs, although reports of upper gastrointestinal disorders are rare. Here, we report a case of extensive inflammatory pathologies in the oesophagus, stomach, duodenum, and jejunum after the administration of pembrolizumab for non-small cell lung cancer.
August 2018: Respirology Case Reports
James Andrew Jones, James Catton, Glen Howard, Paul Leeder, Lesley Brewer, James Hatton, Dominick E Shaw
Background: Cancer survival in the UK has doubled in the last 40 years; however, 1-year and 5-year survival rates are still lower than other countries. One cause may be a delay between referral into secondary care and subsequent investigation. We set out to evaluate the impact of a straight to test pathway (STTP) on time to diagnosis for upper gastrointestinal (UGI) cancer. Methods: Six hospital Trusts across the East Midlands Clinical Network introduced a STTP enabling general practitioners to refer patients with suspected UGI cancer (oesophageal/gastric) for immediate investigation, without the need to see a hospital specialist first...
2018: BMJ Open Quality
A Kowada
Gastric cancer is the third leading cause of cancer death worldwide. Gastric cancer screening using upper gastrointestinal series, endoscopy and serological testing has been performed in population-based (employee-based and community-based) and opportunistic cancer screening in Japan. There were 45 531 gastric cancer deaths in 2016, with the low screening and detection rates. Helicobacter pylori (H. pylori) screening followed by eradication treatment is recommended in high-risk population settings to reduce gastric cancer incidence...
July 30, 2018: Epidemiology and Infection
Hiroshi Miyamoto, Kumiko Tanaka, Fumika Nakamura, Takahiro Ikeda, Shinji Kitamura, Tetsuo Kimura, Koichi Okamoto, Masahiro Sogabe, Naoki Muguruma, Yoshimi Bando, Tetsuji Takayama
Hemobilia is defined as bleeding into the biliary tract. Herein, we report a very rare case of massive hemobilia following plastic stent (PS) removal in common bile duct (CBD) cancer. A 72-year-old man with primary sclerosing cholangitis had undergone repeated insertion of a PS into the CBD. Biliary tract biopsy was performed based on suspicion of combined CBD cancer. Biopsy revealed poorly differentiated adenocarcinoma of the CBD. One month after the biliary tract biopsy, he was admitted for acute cholangitis, and endoscopic retrograde cholangiography was performed for the exchange of the PS...
July 28, 2018: Clinical Journal of Gastroenterology
Philip R Harvey, Byron T Theron, Nigel J Trudgill
A woman aged 47 years reported the feeling of a lump in her throat for the past year. The sensation was present intermittently and usually improved when she ate. She noted it was worse with dry swallows when she felt like a tablet was stuck in her throat. The sensation had become more persistent in recent weeks leading her to worry that she had cancer. She had no cough, sore throat or hoarseness. There were no precipitating factors and no symptoms of weight loss, dysphagia, odynophagia or change in her voice...
July 2018: Frontline Gastroenterology
Ole Steen Bjerring, Søren Hess, Claus Wilki Fristrup, Poul Flemming Høilund-Carlsen, Michael Bau Mortensen
BACKGROUND:  Modern cancer diagnostic work-up is based on multiple modalities within a short time period. The interplay between these modalities is complex and not well known. Performing biopsy procedures prior to (18)F-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) is considered to pose a risk of false-positive imaging results; however, this is not based on solid scientific evidence. The use of endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) is commonly used in upper gastrointestinal malignancies, is proven safe, and has very little risk of complications...
July 23, 2018: Endoscopy
Alberto Pagan, Alessandro Bianchi, José Antonio Martínez, Marina Jiménez, Francisco Javier Gonzalez
In cancer patients with tumors of the upper gastrointestinal tract, dysphagia and cachexia require gastrostomy or jejunostomy as the only options for enteral access for long-term feeding. In this article, the authors describe a modified placement of laparoscopic feeding jejunostomy applied during laparoscopic oncology layering technique. After performing an exploratory laparoscopy, a feeding jejunostomy is performed using a Foley silicon catheter, through an eyelet in the mesentery of the descending colon. After completing the introduction of the jejunal probe according to the Witzel technique, the intestinal segment of jejunum is attached to the internal sheath of the mesocolon using sutures polysorb 2/0, with the aim of removing the possible internal hernia and a jejunal torque that could cause an intestinal obstruction...
2018: Turkish Journal of Surgery
Arif Emre, Mehmet Sertkaya, Sami Akbulut, Ozan Erbil, Nursel Yurttutan, İlhami Taner Kale, Ertan Bülbüloğlu
Objective: The aim of the present study was to share our experiences of the use of self-expandable metallic stent for the upper gastrointestinal tract disease. Material and Methods: We retrospectively reviewed the medical records of 18 patients who underwent self-expandable metallic stent implantation procedure for anastomosis stricture, anastomosis leak, or spontaneous fistula of the upper gastrointestinal tract at two different surgery clinics. Self-expandable metallic stent implantation procedures were performed while keeping the patient under sedation and the correct stent localization was verified using fluoroscopy...
2018: Turkish Journal of Surgery
Yosuke Seki, Kazunori Kasama, Tatsuro Tanaka, Satoshi Baba, Masayoshi Ito, Yoshimochi Kurokawa
This case involved a 64-year-old female patient with a BMI of 35.3 kg/m2 and poorly controlled type 2 diabetes mellitus. Preoperative upper gastrointestinal endoscopy revealed chronic, atrophic gastritis. Helicobacter pylori antibody was negative. The patient underwent laparoscopic sleeve gastrectomy with duodenal-jejunal bypass as a metabolic surgery to treat obesity and type 2 diabetes mellitus. At 1 year postoperatively, routine endoscopy detected a flat elevated lesion at the distal gastric sleeve, near the posterior wall of the antrum; biopsy revealed adenocarcinoma...
July 17, 2018: Asian Journal of Endoscopic Surgery
Andrzej Nowicki, Zbigniew Kula, Alicja Świerszczyńska
OBJECTIVE: The aim of the study was to evaluate the prevalence and clinical aspects of Barrett&apos;s esophagus and adenocarcinoma of the lower part of esophagus in gastroscopy. MATERIAL AND METHODS: Retrospective review of 10000 upper gastrointestinal endoscopic examinations were performed at the Department of Oncology Endoscopy in Bydgoszcz from 2004 to 2014 in terms of incidence of Barrett&apos;s esophagus and adenocarcinoma in the lower part of esophagus...
May 16, 2018: Polski Przeglad Chirurgiczny
John Lahoud, Khalil Bazzi, David Yeo, Sharon Carey
AIM: Total gastrectomy and Ivor Lewis oesophagectomy procedures are the mainstay of upper gastrointestinal cancer management. Maintenance of adequate nutritional intake is essential for positive patient outcomes. Although numerous nutritional support options exist, clear evidence-based guidelines on the optimal means and duration of nutritional support are lacking. The aim of this study is to establish preliminary data on the current perioperative nutritional practices of upper gastrointestinal surgeons performing these procedures across Australia and New Zealand...
July 15, 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
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