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Physical heart valve growth

Shaohua Wu, Bin Duan, Xiaohong Qin, Jonathan T Butcher
Regeneration and repair of injured or diseased heart valves remains a clinical challenge. Tissue engineering provides a promising treatment approach to facilitate living heart valve repair and regeneration. Three-dimensional (3D) biomimetic scaffolds that possess heterogeneous and anisotropic features that approximate those of native heart valve tissue are beneficial to the successful in vitro development of tissue engineered heart valves (TEHV). Here we report the development and characterization of a novel composite scaffold consisting of nano- and micro-scale fibrous woven fabrics and 3D hydrogels by using textile techniques combined with bioactive hydrogel formation...
March 15, 2017: Acta Biomaterialia
D Chelo, F Nguefack, A-P Menanga, H-D Mbassi Awa, S Nguefack, S Ngo Um, J-C Gody, P-O Koki Ndombo
BACKGROUND: Endomyocardial fibrosis is a restrictive cardiomyopathy that causes heart failure. It is characterized by the fibrotic thickening of the endocardium, sometimes involving the myocardium as well. The lesion generally lies at the apices or inflow tracts of one or both ventricles, associated with more or less severe alteration of the valves. It is a disease of the intertropical regions but is not well known in Cameroon. In this study we describe the first series seen in a pediatric hospital in Cameroon...
February 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Jian Wang, Zhi-wen Zhu, Guo-hua Xu, Yue An
Because of the excellent mechanical properties, biocompatibility and reasonable prices, biomedical metallic materials are widely used in the manufacture of vascular stents, heart valve membrane, artificial joints and other body implants. However, the physiological environment in the body is very complex, the long-term embedding of the metal implants may result in corrosion or some nonspecific effects. The properties of medical metal surfaces may decay, which can cause serious injury to human body. By means of the self-assembled monolayer(SAM) technology, the physical and chemical properties of the medical metal surfaces can be modified, and through the SAM medium, some functional materials can be grafted on the metal surfaces, which can largely improve the stability and compatibility of implants in the body, and find wide applications in promoting cell adhesion, improving hemocompatibility, inhibiting bacteria growth, and constructing drug delivery coatings...
September 2015: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
Asdren Zajmi, Najihah Mohd Hashim, Mohamed Ibrahim Noordin, Shaden A M Khalifa, Faiqah Ramli, Hapipah Mohd Ali, Hesham R El-Seedi
Staphylococci are facultative anaerobes, perfectly spherical un-encapsulated cocci, with a diameter not exceeding 1 micrometer in diameter. Staphylococcus aureus are generally harmless and remain confined to the skin unless they burrow deep into the body, causing life-threatening infections in bones, joints, bloodstream, heart valves and lungs. Among the 20 medically important staphylococci species, Staphylococcus aureus is one of the emerging human pathogens. Streptomycin had its highest potency against Staphylococcus infections despite the likelihood of getting a resistant type of staphylococcus strains...
2015: PloS One
Xiaoying Zhang, Yangde Zhang
Recent advances in tissue engineering have adapted the additive manufacturing technology, also known as three-dimensional printing, which is used in several industrial applications, for the fabrication of bioscaffolds and viable tissue and/or organs to overcome the limitations of other in vitro conventional methods. 3D bioprinting technology has gained enormous attention as it enabled 3D printing of a multitude of biocompatible materials, different types of cells and other supporting growth factors into complex functional living tissues in a 3D format...
July 2015: Cell Biochemistry and Biophysics
Arash Kheradvar, Elliott M Groves, Lakshmi P Dasi, S Hamed Alavi, Robert Tranquillo, K Jane Grande-Allen, Craig A Simmons, Boyce Griffith, Ahmad Falahatpisheh, Craig J Goergen, Mohammad R K Mofrad, Frank Baaijens, Stephen H Little, Suncica Canic
As the first section of a multi-part review series, this section provides an overview of the ongoing research and development aimed at fabricating novel heart valve replacements beyond what is currently available for patients. Here we discuss heart valve replacement options that involve a biological component or process for creation, either in vitro or in vivo (tissue-engineered heart valves), and heart valves that are fabricated from polymeric material that are considered permanent inert materials that may suffice for adults where growth is not required...
April 2015: Annals of Biomedical Engineering
Nishant Gupta, Naser Mohammad, Sharad Bajaj, Priyank Shah, Mahesh Bikkina, Fayez Shamoon
SESSION TYPE: Cardiovascular Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Giant ascending aortic aneurysm is a rare finding, defined as an aneurysm in the ascending aorta that is more than 10 cm in diameter. Etiological factors include atherosclerosis, Marfan's syndrome, giant cell arteritis, tuberculosis, syphilis, HIV-associated vasculitis, hereditary hemorrhagic telengectasia, and medial agenesis. We report a unique case of giant dissecting aortic aneurysm discovered in an asymptomatic outpatient...
October 1, 2012: Chest
Feridoun Sabzi, Heidar Dadkhah, Sharam Shojaei, Masoume Mahdavi, Alireza Poormotaabed, Nasrin Javid, Samsam Dabiri
This paper presents the case of a 35 year-old woman with symptoms of heart failure from the last month. A physical examination at admission showed paleness, dyspnea, peripheral edema and fatigue. In a two-dimensional echocardiography and transesophageal echocardiography, normal thickness but severe left and right ventricular dysfunction with severe pericardial effusion and thickened pericardium were found. In the enlarged right atrium, an oval-shaped structure was found with features of continuity with lateral right atrial wall and also a bulging of the structure through the orifice of the tricuspid valve to the right ventricle...
2013: Acta Medica Iranica
Irene C Huffnagel, Sally-Ann B Clur, Annemieke M Bams-Mengerink, Nico A Blom, Ronald J A Wanders, Hans R Waterham, Bwee Tien Poll-The
BACKGROUND: Rhizomelic chondrodysplasia punctata (RCDP) is an autosomal recessive peroxisomal disorder characterised by rhizomelia, contractures, congenital cataracts, facial dysmorphia, severe psychomotor defects and growth retardation. Biochemically, the levels of plasmalogens (major constituents of cellular membranes) are low due to a genetic defect in their biosynthesis. Cardiac muscle contains high concentrations of plasmalogens. Recently cardiac dysfunction was found in a mouse model for RCDP with undetectable plasmalogen levels in all tissues including the heart...
July 2013: Journal of Medical Genetics
Sushma Reddy, Mingming Zhao, Dong-Qing Hu, Giovanni Fajardo, Ethan Katznelson, Rajesh Punn, Joshua M Spin, Frandics P Chan, Daniel Bernstein
Pulmonary insufficiency (PI) is a common long-term sequel after repair of tetralogy of Fallot, causing progressive right ventricular (RV) dilation and failure. We describe the physiologic and molecular characteristics of the first murine model of RV volume overload. PI was created by entrapping the pulmonary valve leaflets with sutures. Imaging, catheterization, and exercise testing were performed at 1, 3, and 6 mo and compared with sham controls. RNA from the RV free wall was hybridized to Agilent whole genome oligonucleotide microarrays...
May 15, 2013: American Journal of Physiology. Heart and Circulatory Physiology
Oliver Bloch, Wilhelm Erdbrügger, Wolfgang Völker, Alexander Schenk, Steffen Posner, Wolfgang Konertz, Pascal M Dohmen
BACKGROUND: Only limited information is available regarding the influence of decellularization on the extracellular matrix in heart valves. Within the extracellular matrix proteoglycans (PG) play a central role in the structural organization and physical functioning of valves and in their capability of settling with endothelial and interstitial cells partially myofibroblasts. We have therefore estimated the effects of decellularization using deoxycholic acid on the structure of the extracellular matrix and PG´s in porcine aortic valves...
December 2012: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Chen Li, Songyi Xu, Avrum I Gotlieb
Calcific aortic valve disease (CAVD) is the most common form of heart valve disease in Western society and results in the second most common cardiovascular surgery performed. Despite its prevalence, high morbidity, and high mortality, the pathogenesis of CAVD still eludes our understanding. This review article brings together experimental in vivo and in vitro as well as human in vivo research in cell and molecular pathobiology to construct an overarching hypothesis regarding the development and progression of CAVD...
January 2013: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Charles I Fisher, Joseph Chen, W David Merryman
Calcific aortic valve disease (CAVD) results in impaired function through the inability of valves to fully open and close, but the causes of this pathology are unknown. Stiffening of the aorta is associated with CAVD and results in exposing the aortic valves to greater mechanical strain. Transforming growth factor β1 (TGF-β1) is enriched in diseased valves and has been shown to combine with strain to synergistically alter aortic valve interstitial cell (AVIC) phenotypes. Therefore, we investigated the role of strain and TGF-β1 on the calcification of AVICs...
January 2013: Biomechanics and Modeling in Mechanobiology
Peter F Davies, Marie A Guerraty
No abstract text is available yet for this article.
March 2011: Arteriosclerosis, Thrombosis, and Vascular Biology
Yakup Ergül, Kemal Nişli, Arda Saygılı, Aygün Dindar
Kearns-Sayre syndrome (KSS) is a rare mitochondrial disease in which neuromuscular structures, endocrine glands, and cardiac conduction systems are most commonly involved. An 11-year-old boy was admitted with blurred consciousness, respiratory instability, and bradycardia of two-hour onset. He was immediately intubated. His medical history included growth retardation and myopic refractive defect for six years, therapy for somatomedin C deficiency for 15 months, and bilateral ptosis for three months. On physical examination, he was unconscious, had a peak heart rate of 40/min, blood pressure of 60/20 mmHg, and a weak pulse...
December 2010: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
David W Murphy, Lakshmi P Dasi, Jelena Vukasinovic, Ari Glezer, Ajit P Yoganathan
Current designs of bileaflet mechanical heart valves put patients at an increased risk of thromboembolism. In particular, regurgitant flow through the b-datum line is associated with nonphysiologic flow characteristics such as elevated shear stresses, regions of recirculation, and increased mixing, all of which may promote thrombus formation. We have previously shown that passive flow control in the form of vortex generators mounted on the downstream leaflet surfaces can effectively diminish turbulent stresses...
July 2010: Journal of Biomechanical Engineering
Esra Tanyel, Nuriye Taşdelen Fişgin, Saban Esen, Ozge Darka, Muzaffer Bahçivan, Hakan Leblebicioğlu, Necla Tülek
Moraxella catarrhalis is a gram-negative, catalase and oxidase positive diplococcus. While it causes otitis media, sinusitis, bronchitis and conjunctivitis in children and adults, it has a tendency to cause lower respiratory tract infections in older ages. More severe clinical pictures with the range of sepsis to endocarditis are also seen in immunocompromised patients. In this report, a case of M. catarrhalis endocarditis in an immunocompetent host who needed valve replacement has been presented. Forty three years old female patient was admitted to our hospital with the complaints of fever, nausea, night sweating and arthralgia for 20 days...
October 2009: Mikrobiyoloji Bülteni
Ralph M Vicari, Enrique Polanco, Norberto Schechtmann, José O Santiago, Kautilya Shaurya, Michael Halstead, Danielle Marszal, Tamsin Grosskreutz, Shalini Thareja
INTRODUCTION: Left atrial myxomas remain the most common benign primary cardiac tumors, and these cardiac growths can masquerade as mitral stenosis, infective endocarditis and collagen vascular disease. Atrial myxomas are found in approximately 14-20% of the population and can lead to embolization, intercardiac obstructions, conduction disturbances and lethal valve obstructions. CASE PRESENTATION: An 84-year-old Hispanic man presented with complaints of dizziness upon standing, and with no prior history of heart murmurs, syncope, shortness of breath, or chest pain...
2009: Journal of Medical Case Reports
Johannes L Bjørnstad, Nils O Neverdal, Oystein A Vengen, Cathrine Wold Knudsen, Trygve Husebye, John Pepper, Mons Lie, Geir Christensen, Theis Tønnessen
BACKGROUND: Patients with aortic stenosis (AS) develop left ventricular remodelling with cardiomyocyte hypertrophy and increased fibrosis. Following aortic valve replacement (AVR) reverse remodelling usually takes place. AIMS: To examine circulating levels of members of the transforming growth factor (TGF) beta superfamily and matrix metalloproteinases (MMP), known to have important effects on hypertrophy and extracellular matrix, in patients operated for AS. METHODS: Circulating levels of activin A, GDF-15, TGF-beta3, MMP-2, -3, and -9 were measured in twenty-two patients undergoing AVR preoperatively, and 2 days, six months and 12 months postoperatively...
December 2008: European Journal of Heart Failure
R L Knight, H E Wilcox, S A Korossis, J Fisher, E Ingham
Tissue-engineering approaches to cardiac valve replacement have made considerable advances over recent years and it is likely that this application will realize clinical success in the near future. Research in this area has been driven by the inadequacy of the currently available cardiac valve prostheses for younger patients who require multiple reoperations as they grow and develop. Tissue engineering has the potential to provide a valve capable of the same growth, repair, and regeneration as a natural valve and could improve outcomes for patients of all ages...
January 2008: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
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