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https://www.readbyqxmd.com/read/30244038/carbapenem-resistant-pseudomonas-aeruginosa-carrying-bla-vim-36-assigned-as-st308-indicated-non-virulence-in-g-mellonella-model
#1
Patrícia R Neves, Lauro Vieira Perdigão Neto, Roberta Cristina Ruedas Martins, Jéssica F Ramos, Gleice Leite, Flavia Rossi, Sabri Saeed Sanabani, Vanderson Rocha, Marjorie Vieira Batista, Thais Guimaraes, Anna S Levin, Sílvia F Costa
OBJECTIVES: Based on pulsed field gel electrophoresis profile, whole genome sequencing (WGS) of 8 CarbR P. aeruginosa strains from a bone marrow transplant unit, in São Paulo, Brazil, was carried out to investigate which resistance and virulence genes are present as well as determine the multilocus sequence types (ST). METHODS: Initial susceptible pattern was obtained by Vitek 2. Minimal inhibitory concentrations (MICs) were determined by broth microdilution for amikacin, meropenem and colistin...
September 20, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/30239821/carriage-of-blakpc-2-by-a-virulence-plasmid-in-hypervirulent-klebsiella-pneumoniae
#2
Ning Dong, Dachuan Lin, Rong Zhang, Edward Wai-Chi Chan, Sheng Chen
Objectives: To characterize a plasmid in a K1 hypervirulent Klebsiella pneumoniae (HvKP) strain encoding both hypervirulence and carbapenem resistance phenotypes. Methods: Plasmids from HvKP strain KP70-2 were subjected to whole-plasmid sequencing using both the Illumina NextSeq 500 sequencing platform and Nanopore MinION sequencer platforms. Results: A hybrid virulence- and resistance-encoding plasmid of 240 kb, harbouring both the virulence gene rmpA2 and the carbapenemase gene blaKPC-2, was recovered from a clinical HvKP strain...
September 15, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30239728/antibiotic-consumption-in-germany-first-data-of-a-newly-implemented-web-based-tool-for-local-and-national-surveillance
#3
Birgitta Schweickert, Marcel Feig, Marc Schneider, Niklas Willrich, Michael Behnke, Luis Alberto Peña Diaz, Petra Gastmeier, Doreen Richter, Hans-Peter Blank, Tim Eckmanns, Muna Abu Sin
Objectives: The features of a newly established, web-based surveillance system for hospital antibiotic consumption are described and data on broad-spectrum antibiotic use in German acute care hospitals are presented. Methods: The watch- and reserve-group antibiotics, two categories of antibiotics derived from the WHO Essential Medicines List comprising key agents for antimicrobial stewardship, were used as a framework for data analysis. The median antibiotic consumption densities (ACDs; DDD/100 patient days) for the years 2015/16 based on data from 137 acute care hospitals have been calculated for whole facilities, ICUs and medical and surgical departments, stratified by type of care...
September 17, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30239622/increased-relative-abundance-of-klebsiella-pneumoniae-carbapenemase-producing-klebsiella-pneumoniae-within-the-gut-microbiota-is-associated-with-risk-of-bloodstream-infection-in-long-term-acute-care-hospital-patients
#4
Teppei Shimasaki, Anna Seekatz, Christine Bassis, Yoona Rhee, Rachel D Yelin, Louis Fogg, Thelma Dangana, Enrique Cornejo Cisneros, Robert A Weinstein, Koh Okamoto, Karen Lolans, Michael Schoeny, Michael Y Lin, Nicholas M Moore, Vincent B Young, Mary K Hayden
Background: An association between increased relative abundance of specific bacterial taxa in the intestinal microbiota and bacteremia has been reported in some high-risk patient populations. Methods: We collected weekly rectal swab samples from patients at one long-term acute care hospital (LTACH) in Chicago from May 2015 - May 2016. Samples were tested for Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) by PCR and culture. Positive samples underwent 16S rRNA gene sequence analysis; relative abundance of the operational taxonomic unit containing KPC-Kp was determined...
September 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30237728/appropriate-composites-of-cefoperazone-sulbactam-against-multidrug-resistant-organisms
#5
Chih-Cheng Lai, Chi-Chung Chen, Ying-Chen Lu, Tsuey-Pin Lin, Yin-Ching Chuang, Hung-Jen Tang
Objectives: This study aims to assess the in vitro activity of different cefoperazone-sulbactam ratios against different multidrug-resistant organisms (MDROs). Materials and methods: Minimum inhibitory concentrations (MICs) and susceptibility rates of cefoperazone, sulbactam and cefoperazone-sulbactam at fixed ratios of 2:1, 1:1 and 1:2 against 344 MDRO clinical isolates, including extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (n=58), ESBL-producing Klebsiella pneumoniae (n=58), carbapenem-resistant Enterobacteriaceae (n=57), carbapenem-resistant Pseudomonas aeruginosa (n=49) and carbapenem-resistant Acinetobacter baumannii (n=122), were measured...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/30235768/medical-evacuation-from-abroad-of-critically-ill-patients-a-case-report-and-ethical-issues
#6
Jérôme Allyn, Nathalie Coolen-Allou, Bénédicte de Parseval, Thomas Galas, Olivier Belmonte, Nicolas Allou, Guillaume Miltgen
RATIONALE: Patients repatriated from foreign hospitals are sources of extensively drug-resistant (XDR) bacteria outbreaks. Thus, an individual benefit potential for the patient opposes a collective ecological risk potential. These ethical issues have not been well studied. PATIENT CONCERNS: We report the case of a 74-year-old patient repatriated from Mauritius to the French island of Reunion who presented mesenteric infarction evolving over several days, and who suffered a cardiac arrest before transfer...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30235729/extended-spectrum-%C3%AE-lactamase-producing-e-coli-septicemia-among-rectal-carriers-in-the-icu
#7
Minxue Liu, Mengjiao Li, Lijuan Wu, Qifei Song, Dan Zhao, Zhixing Chen, Mei Kang, Yi Xie
The aim of this study was to identify risk factors for extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E coli) bloodstream infection (BSI) among carriers hospitalized between March 2011 and June 2016 at the ICU of the West China Hospital.The cases were patients with at least 1 episode of ESBL-producing E coli BSI within 1 week after a positive rectal swab. Controls were selected randomly 1:2 among ESBL-producing E coli rectal carriers who did not develop BSI.Among 19,429 ICU patients, 9015 (46...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30235686/etiology-and-clinical-manifestations-of-bacterial-liver-abscess-a-study-of-102-cases
#8
Wen-Jing Wang, Zhen Tao, Hui-Ling Wu
This study aimed to analyze the clinical manifestations of patients with pyogenic liver abscess and characteristics of pathogenic that caused their infections, in order to provide guidance for the identification of the pathogens that cause liver abscess and selection of antibiotics for treatment of this disease.In the present study, the clinical characteristics, laboratory results, as well as the species and drug resistance of pathogens in patients with bacterial liver abscesses admitted to our hospital from January 2013 to December 2015 were retrospectively analyzed...
September 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30233559/the-fluorescent-d-amino-acid-nada-as-a-tool-to-study-the-conditional-activity-of-transpeptidases-in-escherichia-coli
#9
Alejandro Montón Silva, Christian Otten, Jacob Biboy, Eefjan Breukink, Michael VanNieuwenhze, Waldemar Vollmer, Tanneke den Blaauwen
The enzymes responsible for the synthesis of the peptidoglycan (PG) layer constitute a fundamental target for a large group of antibiotics. The family of β-lactam antibiotics inhibits the DD-transpeptidase (TPase) activity of the penicillin binding proteins (PBPs), whereas its subgroup of carbapenems can also block the TPase activity of the LD-TPases. D-Ala fluorescent probes, such as NADA, are incorporated into the PG presumably by TPases in Escherichia coli and can be used to study conditions that are required for their function...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30233535/spread-of-carbapenem-resistance-by-transposition-and-conjugation-among-pseudomonas-aeruginosa
#10
Anneke van der Zee, W Bart Kraak, Arjan Burggraaf, Wil H F Goessens, Walter Pirovano, Jacobus M Ossewaarde, Jan Tommassen
The emergence of carbapenem-resistant Pseudomonas aeruginosa represents a worldwide problem. To understand the carbapenem-resistance mechanisms and their spreading among P. aeruginosa strains, whole genome sequences were determined of two extensively drug-resistant strains that are endemic in Dutch hospitals. Strain Carb01 63 is of O-antigen serotype O12 and of sequence type ST111, whilst S04 90 is a serotype O11 strain of ST446. Both strains carry a gene for metallo-β-lactamase VIM-2 flanked by two aacA29 genes encoding aminoglycoside acetyltransferases on a class 1 integron...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30233529/characterizing-mobilized-virulence-factors-and-multidrug-resistance-genes-in-carbapenemase-producing-klebsiella-pneumoniae-in-a-sri-lankan-hospital
#11
Chendi Zhu, Veranja Liyanapathirana, Carmen Li, Vasanthi Pinto, Mamie Hui, Norman Lo, Kam T Wong, Nilanthi Dissanayake, Margaret Ip
Limited data is available on the epidemiology and characteristics of carbapenem-resistant Enterobacteriaceae (CRE) and their associated plasmids or virulence determinants from Sri Lanka. Through whole genome sequencing of CREs from the intensive care units of a Sri Lankan teaching hospital, we identified a carbapenemase gene, bla OXA-181 in 10 carbapenemase-producing Klebsiella pneumoniae isolates (two strains of ST437 and eight strains of ST147) from 379 respiratory specimens. bla OXA-181 was carried in three variants of ColE-type plasmids...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30232129/evaluation-of-risk-factors-for-clostridium-difficile-infection-based-on-immunochromatography-testing-and-toxigenic-culture-assay
#12
Toshio Ohshima, Takako Osaki, Yukari Yamamoto, Satomi Asai, Hayato Miyachi, Shigeru Kamiya
In recent years, the diagnostic method of choice for Clostridium difficile infection (CDI) is a rapid enzyme immunoassay in which glutamate dehydrogenase (GDH) antigen and C. difficile toxin can be detected ( C. DIFF QUIK CHEK COMPLETE®: Alere Inc.) (QUIK CHEK). However, the clinical significance remains unclear in cases which demonstrate a positive result for GDH antigen and are negative for toxin. In this study, we used the QUIK CHEK test kit on fecal samples with an additional toxin detection step using toxigenic culture assay for the above cases...
September 19, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/30230939/endogenous-endophthalmitis-caused-by-carbapenem-resistant-hypervirulent-klebsiella-pneumoniae-a-case-report-and-literature-review
#13
Yun Zhou, Xing Wang, Jun Shen, Zhaozeng Lu, Yang Liu
PURPOSE: To report a rare case of endogenous endophthalmitis caused by carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). METHODS: A retrospective chart review was conducted. The isolates were characterized by hypermucoviscosity, resistance genes, virulence genes, and multilocus sequence typing. RESULTS: A 47-year-old diabetic woman acquired carbapenem-resistant K. pneumoniae (CRKP) nosocomial pneumonia. Metastatic endophthalmitis occurred in the right eye a week after the occurrence of CRKP bloodstream infection (BSI)...
September 19, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/30230363/presence-of-carbapenem-resistant-bacteria-in-soils-affected-by-illegal-waste-dumps
#14
Jasna Hrenovic, Tomislav Ivankovic, Goran Durn, Svjetlana Dekic, Snjezana Kazazic, Ivica Kisic
The carbapenem-resistant bacteria (CRB) are currently at the top of the WHO priority list of bacteria that pose the greatest threat to human health. Considering that soil is one of the important environments for the emergence of antibiotic-resistant bacteria, we isolated and quantified cultivable CRB in soils across Croatia, including ones affected by illegal dumps. We cultivated CRB at two temperatures, distinguishing between the intrinsically resistant CRB (37°C, mostly Stenotrophomonas spp.) and the ones that are presumably human-associated and clinically relevant (42°C, Acinetobacter sp...
September 19, 2018: International Journal of Environmental Health Research
https://www.readbyqxmd.com/read/30228833/surveillance-of-antibiotic-prescribing-in-intensive-care-units-in-poland
#15
Ewa Trejnowska, Aleksander Deptuła, Magda Tarczyńska-Słomian, Piotr Knapik, Miłosz Jankowski, Agnieszka Misiewska-Kaczur, Barbara Tamowicz, Jakub Śmiechowicz, Remigiusz Antończyk, Paul Armatowicz, Wiktor Sułkowski, Grażyna Durek
Antibiotic use and microbial resistance in health care-associated infections are increasing globally and causing health care problems. Intensive Care Units (ICUs) represent the heaviest antibiotic burden within hospitals, and sepsis is the second noncardiac cause of mortality in ICUs. Optimizing appropriate antibiotic treatment in the management of the critically ill in ICUs became a major challenge for intensivists. We performed a surveillance study on the antibiotic consumption in 108 Polish ICUs. We determined which classes of antibiotics were most commonly consumed and whether they affected the length of ICU stay and the size and category of the hospital...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/30227898/antimicrobial-stewardship-for-acute-care-hospitals-an-asian-perspective
#16
Anucha Apisarnthanarak, Andrea Lay-Hoon Kwa, Cheng-Hsun Chiu, Suresh Kumar, Le Thi Anh Thu, Ban Hock Tan, Zhiyong Zong, Yin Ching Chuang, Anis Karuniawati, Maria Fe Tayzon, Thomas Man-Kit So, Lance R Peterson
Inappropriate use of antibiotics is contributing to a serious antimicrobial resistance problem in Asian hospitals. Despite resource constraints in the region, all Asian hospitals should implement antimicrobial stewardship (AMS) programs to optimize antibiotic treatment, improve patient outcomes, and minimize antimicrobial resistance. This document describes a consensus statement from a panel of regional experts to help multidisciplinary AMS teams design programs that suit the needs and resources of their hospitals...
September 19, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/30225102/crystal-structure-of-tebipenem-pivoxil
#17
Chao Tang, Li Cai, Shuai Liu, Zhiwei Zheng, Gen Li, Jianli Chen, Qiang Sui
The mol-ecular structure of the first orally active carbapenem anti-bacterial agent, tebipenem pivoxil (systematic name: (2,2-di-methyl-propano-yloxy)methyl (4 R ,5 S ,6 S )-3-{[1-(4,5-di-hydro-1,3-thia-zol-2-yl)azetidin-3-yl]sulfanyl}-6-[(1 R )-1-hy-droxy-eth-yl]-4-methyl-7-oxo-1-aza-bicyclo-[3.2.0]hept-2-ene-2-carboxyl-ate), C22 H31 N3 O6 S2 , has been determined and the configurations of the four chiral centers validated. The title compound crystallizes in the triclinic space group P 1 with one mol-ecule in the unit cell...
September 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/30224972/first-report-of-colistin-resistance-among-carbapenem-resistant-acinetobacter-baumannii-isolates-recovered-from-hospitalized-patients-in-egypt
#18
Amani T Abdulzahra, Mahmoud A F Khalil, Walid F Elkhatib
Acinetobacter baumannii is an opportunistic pathogen that poses an increasing threat in the health-care community. Colistin is one of the promising options for treatment of multidrug-resistant A. baumannii . The current study investigated the emergence of colistin resistance among carbapenem-resistant strains of A. baumannii in Egypt. It involved identification of clinically recovered A . baumannii isolates using the VITEK-2 system, and screening of their antimicrobial susceptibilities using broth microdilution techniques...
November 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/30223584/the-use-of-liquids-ionic-fluids-as-pharmaceutically-active-substances-helpful-in-combating-nosocomial-infections-induced-by-klebsiella-pneumoniae-new-delhi-strain-acinetobacter-baumannii-and-enterococcus-species
#19
REVIEW
Andrzej Miskiewicz, Piotr Ceranowicz, Mateusz Szymczak, Krzysztof Bartuś, Paweł Kowalczyk
This review deals with various microbiological activities of ionic liquids, which constitute the first anti-infective defense against multi-drug-resistant bacteria-with a particular emphasis placed on medicine and pharmacology. The quoted data on the biological activity of ionic liquids including their antimicrobial properties (depending on the type of a cation or an anion) and are discussed in view of possible applications in nosocomial infections. Dedicated attention is given to finding infections with the Klebsiella pneumoniae New Delhi strain, Acinetobacter baumannii , and Enterococcus species, which are responsible for the induction of antibiotic resistance in intensive care units...
September 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30220999/predictive-factors-for-multidrug-resistant-gram-negative-bacteria-among-hospitalised-patients-with-complicated-urinary-tract-infections
#20
Aina Gomila, Evelyn Shaw, Jordi Carratalà, Leonard Leibovici, Cristian Tebé, Irith Wiegand, Laura Vallejo-Torres, Joan M Vigo, Stephen Morris, Margaret Stoddart, Sally Grier, Christiane Vank, Nienke Cuperus, Leonard Van den Heuvel, Noa Eliakim-Raz, Cuong Vuong, Alasdair MacGowan, Ibironke Addy, Miquel Pujol
Background: Patients with complicated urinary tract infections (cUTIs) frequently receive broad-spectrum antibiotics. We aimed to determine the prevalence and predictive factors of multidrug-resistant gram-negative bacteria in patients with cUTI. Methods: This is a multicenter, retrospective cohort study in south and eastern Europe, Turkey and Israel including consecutive patients with cUTIs hospitalised between January 2013 and December 2014. Multidrug-resistance was defined as non-susceptibility to at least one agent in three or more antimicrobial categories...
2018: Antimicrobial Resistance and Infection Control
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